Rafael Franco Fernandez

Rafael Franco Fernandez

Catedràtic d'Universitat

Scopus Author ID: 7202551094
Researcher ID: C-3694-2015
Àrea de coneixement : Bioquímica i Biologia Molecular

Grup UABUB de recerca en Medicina traslacional (GRUABUB21)

Informació de contacte
Departament de Bioquímica i Biomedicina Molecular
Universidad de Barcelona. Facultad de Biología. Departamento de Bioquímica y Biomedicina Molecular. Avda. Diagonal 643, 08028 Barcelona
934021208
rfranco(a)ub.edu

Altres Mèrits o aclariments

Scores and History of the research laboratory

2020-dated Stanford analysis: RF in top 2% scientists (Ioannidis et al., 2020: doi:10.1371/journal.pbio.3000918). In 1% (0.3%) top-rated experts in Alzheimer's Disease (AD) 2011-2021 (https://expertscape.com)

Researcher ID: C-3694-2015.

"All" Research sexenios:6.

"All" Techtransfer sexenios:1.

End 2021-dated: Publications: >470 (350 in Q1). h-index=78 (Scopus), 90 (real). Citations:19K (Scopus) >22K (Res Gate) Last 5 years: >1200 citations/year.

History

Founder of GPCR Mol Res lab (after 1985 stay in Prof Burnstock's lab). Describing first GPCR heteromer (Het) formed by 2 receptors for 2 neurotransmitters. Later: i) development of nomenclature & technology in the field ii) reporting Het disruption in neurodegenerative disease & iii) the first reliable structure of a heterotetramer coupled to 1 Gs & 1 Gi protein

The interaction between AR types broadens the physiological perspective of GPCRs, the A2A-A2BHet is a recent example increasing knowledge of Immune function & allowing to better understand physiological aging & the role of brown adipocytes in obesity (papers: Oncotarget & Cell Metabolism)

Since 1988 Franco's lab has received continued support (competitive tenders by public or private bodies), mainly for research on GPCRs, with focus on CNS function & potential as targets for neurological & neuropsychiatric diseases & drug addiction. The last three MICINN/AEI & the "Heteropark" Eranet-neuron (coordinator of 4 labs) projects related to GPCR Hets

2009-2013: Head of lab in CIMA (Pamplona): developing GPCR platform with CIMA proprietary molecules for translational research in PD & AD. Franco's CIMA members co- inventors of patents, the scientific production increased qual/quantitatively.

2014- Back as Professor in UB (head of Mol Neurobiol laboratory)

 (Mèrits no classificats)

PREMIO CIUDAD DE BARCELONA

- Premio Ciudad de Barcelona de Investigación Biomédica. Año 1998 (Mèrits no classificats)

COORDINACION DE REDES

- Coordinador de la “Xarxa Temática” de Química Médica (Generalitat de Cataluña) desde su creación en el año 1998 (Mèrits no classificats)

BECAS, AYUDAS Y PREMIOS

- Adjudicación de una Ayuda para el Intercambio de Personal Investigador entre Industrias y Centros Públicos de Investigación. Duración 9 meses: 01-01-91 / 30-09-91. Industria: Laboratorios Echevarne S.A.. Ministerio de Educación y Ciencia. Dirección General de Investigación Científica y Técnica (Mèrits no classificats)

Formació acadèmica

Química . Universitat de Barcelona . 1979 . (Diplomatura / Llicenciatura / Grau)
Química . Universitat de Barcelona . 1982 . (Doctorat )

Patents, Programari i Bases de dades

Mallol, J.; Mirabet, M.; Canela, E.I.; Lluis, C.; Franco, R. Ref. es9900373. Anticuerpos policlonales antireceptor A2B de adenosina (ESPANYA, 1999 ) . Universitat de Barcelona
Ciruela F, Lluis C, Müller C, Hove-Madsen L, Cinca J, Franco, R. Ref. ES20060005. Compuestos para el tratamiento de la fibrilación auricular Patente licenciada a CIMA (CANADÀ, 2006 ; BRASIL / ESPANYA / JAPÓ / ESTATS UNITS D'AMÈRICA) . Universitat de Barcelona
Jagerovic, Nadine; Morales Lázaro, Paula; Figuerola Asencio, Laura; Franco Fernández, Rafael; Navarro Brugal, Gemma Ref. EP23382728.6. Synthetic cannabinoids based on chromenopyrimidine scaffold and use thereof (Països Membres de la Convenció Europea de Patents, 14/07/2023 ) . Consejo Superior de Investigaciones Científicas (CSIC) / Universitat de Barcelona
Franco R, Ventura R, Lluis C, Casadó V, Albericio F, Royo M Ref. P200502546. Compuestos para el tratamiento de la enfermedad de Parkinson. Patente no activa (ESPANYA, 2005 ) . Universitat de Barcelona
Lluis Biset, M. del Carmen; Müller, Christa; Ciruela Alférez, Francisco; Franco Fernández, Rafael; Cinca Cuscullola, Joan; Hove-Madsen, Leif Ref. ES200502545. Compuestos para el tratamiento de la fibrilación auricular (ESPANYA, 14/10/2005 ) . Universitat de Barcelona
Franco R, Aguirre N, García Osta A, Cuadrado-Tejedor M Ref. EP11382205.0.. Tadalafil for the treatment of dementia (ESPANYA, 2011 ; UNIÓ EUROPEA / ESTATS UNITS D'AMÈRICA) . Fundación para la investigación médica aplicada
Franco Fernández, Rafael; Lillo Jové, Jaume; Rivas Santisteban, Rafael; Garrigós García, Claudia; Hove Madsen, Leif; Casabella Ramón, Sergi Ref. EP24383293.8. Compositions comprising cannabigerol for use in the prevention and/or treatment of arrythmias (Països Membres de la Convenció Europea de Patents, 28/11/2024 ) . Universitat de Barcelona / Consejo Superior de Investigaciones Científicas (CSIC)
CUADRADO TEJEDOR M;Rafael FRANCO FERNÁNDEZ R; GARCÍA OSTA AM; OYARZABAL SANTAMARINA J; RABAL GRACIA MO Ref. EP13382065. Novel compounds as dual inhibitors of Phosphodiesterases and Histone Deacetylases (---, 01/03/2013 ) . ---

Publicacions en revistes

Franco Rafael; Garrigos Claudia; Capo Toni; Serrano-Marin Joan; Rivas-Santisteban Rafael; Lillo Jaume (2025). Olfactory receptors in neural regeneration in the central nervous system. Neural Regeneration Research, 20(9), pp. 2480 - 2494 . ISSN: 1673-5374
Rivas-Santisteban, R.; Lillo, J.; Garrigós, C.; Navarro, G.; Franco, R. (2025). GPR88 impairs the signaling of kappa opioid receptors in a heterologous system and in primary striatal neurons. Neuropharmacology, 265 . ISSN: 0028-3908
Rivas-Santisteban, R.; Muñoz, A.; Lillo, J.; Raïch, I.; Rodríguez-Pérez, A.I.; Navarro, G.; Labandeira-García, J.L.; Franco, R. (2024). Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons. npj Parkinson's Disease, 10(1) . ISSN: 2373-8057
Franco, R. (2024). Vitactions: vitamins for the brain. Explorations of Neuroprotective Therapy, 4(4), pp. 300 - 307 . ISSN: 2769-6510
Franco Rafael; Garrigos Claudia; Lillo Jaume; Rivas-Santisteban Rafael (2024). The Potential of Metabolomics to Find Proper Biomarkers for Addressing the Neuroprotective Efficacy of Drugs Aimed at Delaying Parkinson's and Alzheimer's Disease Progression. Cells, 13(15) . ISSN: 2073-4409
Franco Rafael; Garrigos Claudia; Lillo Jaume (2024). The Olfactory Trail of Neurodegenerative Diseases. Cells, 13(7) . ISSN: 2073-4409
Bernal-Casas, D.; Serrano-Marín J.; Sánchez-Navés, J.; Oller, J.M.; Franco, R. (2024). Advancing Personalized Medicine by Analytical Means: Selection of Three Metabolites That Allows Discrimination between Glaucoma, Diabetes, and Controls. Metabolites, 14(3), pp. 1 - 14 . Repositori Institucional . ISSN: 2218-1989
Raïch, I.; Lillo, J.; Ferreiro-Vera, C.; Sánchez de Medina, V.; Navarro, G.; Franco, R. (2023). Cannabidiol at nanomolar concentrations negatively affects signaling through the adenosine A2A receptor. International Journal of Molecular Sciences, 24(24) . https://doi.org/10.3390/ijms242417500 . ISSN: 1661-6596
Serrano-Marín, J.; Marin , S.; Bernal-Casas, D.; Lillo, A.; González-Subías, M.; Navarro, G.; Cascante, M.; Sánchez-Navés, J.; Franco, R. (2023). A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson's disease. Fluids and Barriers of the CNS, 20(1), p. 90 . https://doi.org/10.1186/s12987-023-00494-5 . ISSN: 2045-8118
Volonté, C.; Franco, R. (2023). Further arguments in favor of the biological relevance of purinergic receptors: the novel emergence of a purinergic signature. Explorations of Neuroprotective Therapy, 3, pp. 429 - 434 . https://doi.org/10.37349/ent.2023.00059 . ISSN: 2769-6510
Rosier, N.; Mönnich, D.; Nagl, M.; Schihada, H.; Sirbu, A.; Konar, N.; Reyes-Resina, I.; Navarro, G.; Franco, R.; Kolb, P.; Annibale, P.; Pockes, S. (2023). Shedding light on the D1-like receptors: A fluorescence-based toolbox for visualization of the D1 and D5 receptors. ChemBioChem . https://doi.org/10.1002/cbic.202300658 . ISSN: 1439-4227
Nagl ,M.; Mönnich, D.; Rosier, N.; Schihada, H.; Sirbu, A.; Konar, N.; Reyes-Resina, I.; Navarro, G.; Franco, R.; Kolb, P.; Annibale, P.; Pockes, S. (2023). Fluorescent tools for the imaging of dopamine D2-like receptors. ChemBioChem . https://doi.org/10.1002/cbic.202300659 . ISSN: 1439-4227
Rivas-Santisteban, R.; Rico, A.J.; Muñoz, A.; Rodriguez-Perez, A.I.; Reyes-Resina, I.; Navarro, G.; Labandeira-García, J.L.; Lanciego, J.L.; Franco, R. (2023). Boolean analysis shows a high proportion of dopamine D2 receptors interacting with adenosine A2A receptors in striatal medium spiny neurons of mouse and non-human primate models of Parkinson's disease. Neurobiology of Disease, 188(106341), pp. 1 - 14 . Repositori Institucional . ISSN: 0969-9961
Franco, R.; Joan Serrano-Marín, J.; Navarro, G. ; Rivas-Santisteban, R. (2023). The NADPH link between the renin angiotensin system and the antioxidant mechanisms in dopaminergic neurons. Antioxidants . https://doi.org/10.3390/antiox12101869 . ISSN: 2076-3921
Garrido-Gil, P.; Rodriguez-Perez, A.I.; Pedrosa, M.A.; Garcia-Garrote, M.; Valenzuela, R.; Navarro, G.; Franco, R.; Labandeira-Garcia, J.L. (2023). The angiotensin-type-2 receptors are involved in age-related changes and neuroinflammation in the substantia nigra. IBRO Neuroscience Reports, 15, pp. S412 - S413 . https://doi.org/10.1016/j.ibneur.2023.08.787
Gonçalves-Ribeiro, J.; Savchak, O.; Costa-Pinto, S.; Rivas-Santisteban, R.; Lillo, A.; Navarro, G.; Franco, R.; Sebastião, A.; Vaz, S.H. (2023). Astroglial CB1R-A1R and CB1R-A2AR heteromers influence MPFC synaptic function. IBRO Neuroscience Reports, 15, pp. S228 - S229 . https://doi.org/10.1016/j.ibneur.2023.08.373
Lillo, A.; Serrano-Marín, J.; Lillo, J.; Raïch, I.; Navarro, G.; Franco, R. (2023). Differential gene expression in activated microglia treated with adenosine A2A receptor antagonists highlights olfactory receptor 56 and T-Cell activation GTPase-activating protein 1 as potential biomarkers of the polarization of activated microglia. Cells, 18(12), p. 2213 . https://doi.org/10.3390/cells12182213 . ISSN: 2073-4409
Llinas del Torrent, C.; Raïch, I.; Gonzalez, A.; Casajuana-Martin, N.; Lillo, J.; Rebassa, J. B.; Ferreiro-Vera, C.; Sanchez de Medina, V.; Franco, R.; Navarro, G.; Pardo, L. (2023). The Leu/Val6.51 side chain of cannabinoid receptors regulates the binding mode of the alkyl chain of ∆9-tetrahydrocannabinol. Journal of Chemical Information and Modeling, 18(25), pp. 5927 - 5935 . https://doi.org/10.1021/acs.jcim.3c01054 . ISSN: 1549-9596
Franco, R.; Navarro, G. (2023). Neuroprotection afforded by targeting G protein-coupled receptors in heteromers and by heteromer-selective drugs. Frontiers in Pharmacology, 14 . https://doi.org/10.3389/fphar.2023.1222158 . ISSN: 1663-9812
Lillo, J.; García-Pérez, I.; Lillo, A.; Serrano-Marín, J.; Martínez-Pinilla, E.; Navarro, G.; Franco, R. (2023). The olfactory Olfr-78/51E2 receptor interacts with the adenosine A2A receptor. Effect of menthol and 1,8-cineole on A2A receptor-mediated signaling. Frontiers in Pharmacology, 14 . https://doi.org/10.3389/fphar.2023.1108617 . ISSN: 1663-9812
Rivas-Santisteban, R.; Lillo, J.; Raïch, I.; Muñoz, A.; Lillo, A.; Rodríguez-Pérez, A.I.; Labandeira-García, J.L.; Navarro, G.; Franco, R. (2023). The cannabinoid CB1 receptor interacts with the angiotensin AT2 receptor. Overexpression of AT2-CB1 receptor heteromers in the striatum of 6-hydroxydopamine hemilesioned rats. Experimental Neurology, 362 . https://doi.org/10.1016/j.expneurol.2023.114319 . ISSN: 0014-4886
Rafael Franco; Joan Serrano-Marín (2023). The unbroken Krebs cycle. Hormonal-like regulation and mitochondrial signaling to control mitophagy and prevent cell death. BioEssays, 45(3), p. e2200194 . Repositori Institucional . ISSN: 0265-9247
Franco, R.; Serrano-Marin, J. (2023). Can chronic therapeutic drug use by the elderly affect Alzheimer's disease risk and rate of progression?. Explorations of Neuroprotective Therapy, 3, pp. 8 - 23 . https://doi.org/10.37349/ent.2023.00035 . ISSN: 2769-6510
Tarifa, C.; Jiménez-Sábado, V.; Franco, R.; José Montiel, J.; Guerra, J.; Ciruela, F.; Hove-Madsen, L. (2023). Expression and impact of Adenosine A3 receptors on calcium homeostasis in human right atrium. International Journal of Molecular Sciences, 24 . Repositori Institucional . ISSN: 1661-6596
Lillo, A.; Serrano-Marín, J.; Lillo, J.; Raïch, I.; Navarro, G.; Franco, R. (2023). Gene regulation in activated microglia by adenosine A3 receptor agonists: a transcriptomics study. Purinergic Signalling . Repositori Institucional . ISSN: 1573-9538
Marcoli, M.; Agnati, L.F.; Franco, R.; Cortelli, P.; Anderlini, D.; Guidolin, D.; Cervetto, C.; Maura, G. (2023). Modulating brain integrative actions as a new perspective on pharmacological approaches to neuropsychiatric diseases. Frontiers In Endocrinology . https://doi.org/10.3389/fendo.2022.1038874 . ISSN: 1664-2392
Rivas-Santisteban, R.; Raïch, I.; Aguinaga, D.; Saura, C.A.; Franco, R.; Navarro, G. (2023). The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons. Cells, 12(2) . https://doi.org/10.3390/cells12020283 . ISSN: 2073-4409
Franco Rafael; Navarro Gemma; Martinez-Pinilla Eva (2023). The adenosine A2A receptor in the basal ganglia: Expression heteromerization functional selectivity and signalling. International Review of Neurobiology, 170, pp. 49 - 71 . ISSN: 0074-7742
Navarro, G., Rivas‐Santisteban, R.; Lillo, A.; Lillo, J.; Franco, R. (2022). Cannabinoids as a potent therapeutic target for Alzheimer's disease. Alzheimer's & Dementia, 18(S4) . https://doi.org/10.1002/alz.066502 . ISSN: 1552-5260
Casajuana-Martin N; Navarro G; Gonzalez A; Llinas Del Torrent C; Gómez-Autet M; Quintana García A; Franco R; Pardo L. (2022). A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB2 Receptor via the Lipid Bilayer. Journal of Chemical Information and Modeling, 62(22), pp. 5771 - 5779 . Repositori Institucional . ISSN: 1549-9596
Franco Fernández, Rafael (2022). On the Mechanistic Perceptions of Consciousness: From Quantum Mechanics to Consciousness and Free Will and from David Bohm to Benjamin Libet. Journal Of Integrative Neuroscience, 21(6), pp. 153 - 156 . Repositori Institucional . ISSN: 0219-6352
Raïch, I.; Rebassa, J.B.; Lillo, J.; Cordomi, A.; Rivas-Santisteban, R.; Lillo, A.; Reyes-Resina, I.; Franco, R.; Navarro, G (2022). Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in Microglia from APPSw/Ind Mice Model. International Journal of Molecular Sciences, 21, p. 12801 . https://doi.org/10.3390/ijms232112801 . ISSN: 1661-6596
Lillo A; Marin S, Serrano-Marín J; Bernal-Casas D; Binetti N; Navarro G; Cascante M; Sánchez-Navés J; Franco R. (2022). Biogenic Amine Levels Markedly Increase in the Aqueous Humor of Individuals with Controlled Type 2 Diabetes. International Journal of Molecular Sciences, 23(21), pp. 1 - 11 . Repositori Institucional . ISSN: 1661-6596
Rafael Franco; Alejandro Lillo; Gemma Navarro; Irene Reyes-Resina (2022). The adenosine A2A receptor is a therapeutic target in neurological, heart and oncogenic diseases. Expert Opinion On Therapeutic Targets, 9, pp. 791 - 800 . https://doi.org/10.1080/14728222.2022.2136570 . ISSN: 1472-8222
Lillo J; Raïch I; Silva L; Zafra DA; Lillo A; Ferreiro-Vera C; Sánchez de Medina V; Martínez-Orgado J; Franco R*; Navarro G* (2022). Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons. International Journal of Molecular Sciences, 23(17), pp. 1 - 15 . Repositori Institucional . ISSN: 1661-6596
Goncalves-Ribeiro Joana; Magalhaes Daniela; Costa-Pinto Sara; Sottomayor Mariana; Savchak Oksana; Lopes Rafael Faria; Meneses Carlos; Santisteban Rafael; Lillo Alejandro; Navarro-Brugal Gemma; Franco Rafael; Sebastiao Ana M.; Vaz Sandra (2022). Adenosine-CB1 receptors crosstalk in astrocytes: implications in medial prefrontal cortex synaptic function. Journal of Neurochemistry, 162, pp. 141 - 141 . ISSN: 0022-3042
Lillo, A.*; Marin, S.*; Serrano-Marín, J.; Binetti, N.; Navarro, G.; Cascante, M.; Sánchez-Navés, J.*; Franco R.* (*: equal contribution) (2022). Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients. Frontiers in Medicine, 9, p. 935084 . Repositori Institucional . ISSN: 2296-858X
Franco, R.; Serrano-Marín, J (2022). Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies. Biomedicines, 10(5), pp. 1 - 14 . Repositori Institucional . ISSN: 2227-9059
Franco R; Morales P; Navarro G; Jagerovic N; and Reyes-Resina I (2022). The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors. Frontiers in Pharmacology, 13, p. 852631 . https://doi.org/10.3389/fphar.2022.852631 . ISSN: 1663-9812
Lillo, A.; Raïch, I.; Lillo, J.; Pérez-Olives, C.; Navarro, G.; Franco, R. (2022). Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimers Disease Model. Biomedicines, 10(2), pp. 1 - 16 . Repositori Institucional . ISSN: 2227-9059
Lillo, A.; Lillo, J.; Raïch, I.; Miralpeix, C.; Dosrius, F.; Franco, R.; Navarro, G. (2021). Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet. Frontiers in Cellular Neuroscience, 15(786597) . Repositori Institucional . ISSN: 1662-5102
Brugal, G.N.; Rivas-Santisteban, R.; Reyes, I.; Marquez, A.L.; Raïch, I.; Franco, R. (2021). PrNP-induced effect over NMDA expression and signalling. Alzheimer's & Dementia, 17 . https://doi.org/10.1002/alz.053486 . ISSN: 1552-5260
Rivas-Santisteban, Rafael; Lillo, Alejandro; Lillo, Jaume; Rebassa, Joan-Biel; Contesti, Joan S.; Saura, Carlos A.; Franco, Rafael; Navarro, Gemma (2021). N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors. Alzheimers Research & Therapy, 13(1), pp. 1 - 15 . Repositori Institucional . ISSN: 1758-9193
Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. (2021). Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors. Pharmacological Research, 174, p. 105970 . Repositori Institucional . ISSN: 1043-6618
Rafael Franco; Rafael Rivas-Santisteban; Gemma Navarro Brugal; Irene Reyes-Resina. (2021). Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy. Cells . https://doi.org/10.3390/cells10112831 . ISSN: 2073-4409
Lillo, Jaume; Lillo, Alejandro; Zafra, David A.; Miralpeix, Cristina; Rivas-Santisteban, Rafael; Casals, Núria; Navarro, Gemma; Franco, Rafael (2021). Identification of the Ghrelin and Cannabinoid CB2 Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet. International Journal of Molecular Sciences, 22(16), pp. 1 - 17 . Repositori Institucional . ISSN: 1661-6596
Franco, R. (2021). Science plus technology to address challenges in determining the efficacy of neuroprotective/neurorestorative therapies. Explorations of Neuroprotective Therapy, 1, pp. 1 - 6 . https://doi.org/10.37349/ent.2021.00001 . ISSN: 2769-6510
Franco, R.; Rivas-Santisteban, R.; Navarro, G.; Reyes-Resina, I. (2021). Cholesterol in autism spectrum disorders. Explorations of Neuroprotective Therapy, 1, pp. 10 - 18 . https://doi.org/10.37349/ent.2021.00003 . ISSN: 2769-6510
Valenzuela, R.; Rodriguez-Perez, A.I.; Costa-Besada, M.A.; Rivas-Santisteban, R.; Garrido-Gil, P.; Lopez-Lopez, A.; Navarro, G.; Lanciego, J.K.; Franco, R.; Labandeira-Garcia, J.L (2021). An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria. Redox Biology . https://doi.org/10.1016/j.redox.2021.102078 . ISSN: 2213-2317
Franco, R.; Casanovas, B.; Camps, J.; Navarro, G.; Martínez-Pinilla, E. (2021). Antioxidant Supplements versus Health Benefits of Brief/Intermittent Exposure to Potentially Toxic Physical or Chemical Agents. Current Issues In Molecular Biology, 43(2), pp. 650 - 664 . Repositori Institucional . ISSN: 1467-3037
Navarro, Gemma; Gonzalez, Angel; Sanchez-Morales, Adria; Casajuana-Martin, Nil; Gomez-Ventura, Marc; Cordomi, Arnau; Busque, Felix; Alibes, Ramon; Pardo, Leonardo; Franco, Rafael (2021). Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol. Journal of Medicinal Chemistry, 64(13), pp. 9354 - 9364 . https://doi.org/10.1021/acs.jmedchem.1c00561 . ISSN: 0022-2623
Goncalves-Ribeiro J.; Savchak O.; Morais T. P.; Lopes R. F.; Meneses C.; Santisteban R.; Lillo A.; Crunelli V.; Navarro-Brugal G.; Franco R.; Sebastiao A. M.; Vaz S. (2021). Dual effect of A1R and A2AR upon CB1R signalling in cortical astrocytes: Ca2+ dependent modulation of glutamate transporters. Glia, 69, pp. E319 - E320 . ISSN: 0894-1491
Casanovas M.; Lillo A.; Lillo J.; Rivas-Santisteban R.; Munoz A.; Rodriguez-Perez A. I.; Rebassa J. B.; Contesti J. S.; Labandeira-Garcia J. L.; Navarro G.; Franco R. (2021). Angiotensin II AT1-cannabinoid CB1 receptor heteromer implication in Parkinson's disease. Glia, 69, pp. E154 - E154 . ISSN: 0894-1491
Franco, R.; Casanovas, B.; Camps, J.; Navarro, G.; Martínez-Pinilla, E. (2021). Health benefits are not afforded by antioxidants but by poten-tiating the innate detoxification molecular mechanisms. Current Issues In Molecular Biology . ISSN: 1467-3037
Mallo-Abreu, Ana; Reyes-Resina, Irene; Azuaje, Jhonny; Franco, Rafael; Garcia-Rey, Aitor; Majellaro, Maria; Miranda-Pastoriza, Dario; Garcia-Mera, Xerardo; Jespers, Willem; Gutierrez-de-Teran, Hugo; Navarro, Gemma; Sotelo, Eddy (2021). Potent and Subtype-Selective Dopamine D-2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach. Journal of Medicinal Chemistry, 64(12), pp. 8710 - 8726 . https://doi.org/10.1021/acs.jmedchem.1c00704 . ISSN: 0022-2623
Franco, R. (2021). Current Issues in Molecular Biology Journal Enters a New Era. Current Issues In Molecular Biology, 43(1), pp. 384 - 388 . https://doi.org/10.3390/cimb43010031 . ISSN: 1467-3037
Franco, Rafael; Lillo, Alejandro; Rivas-Santisteban, Rafael; Reyes-Resina, Irene; Navarro, Gemma (2021). Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells. Cells, 10(5), pp. 1 - 18 . Repositori Institucional . ISSN: 2073-4409
Rafael Franco; Rafael Rivas-Santisteban; Gemma Navarro; Annalisa Pinna, Irene Reyes-Resina. (2021). Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage. International Journal of Molecular Sciences, 22(9), pp. 1 - 26 . Repositori Institucional . ISSN: 1661-6596
Osorio-Barrios, Francisco; Navarro, Gemma; Campos, Javier; Ugalde, Valentina; Prado, Campos; Raïch, Iu; Contreras, Frnacisco; López, Ernesto; Espinoza, Alexandra; Lladser, Alvaro; Franco, Rafael; Pacheco, Rodrigo (2021). The Heteromeric Complex Formed by Dopamine Receptor D 5 and CCR9 Leads the Gut Homing of CD4 + T Cells Upon Inflammation. Cellular and Molecular Gastroenterology and Hepatology, 12(2), pp. 489 - 506 . Repositori Institucional . ISSN: 2352-345X
Franco, R.; Ribas-Santisteban, R.; Lillo, J.; Camps, J.; Navarro, G.; Reyes-Resina, I. (2021). 5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters. Frontiers in Cell and Developmental Biology, 9(667815) . Repositori Institucional . ISSN: 2296-634X
Pedrosa, M.A.; Valenzuela, R.; Garrido-Gil, P.; Labandeira, C.M.; Navarro, G.; Franco, R.; Labandeira-Garcia J.L.; Rodriguez-Perez, A.I.; (2021). Interactions between ibuprofen, ACE2, renin-angiotensin system, and spike protein in the lung. Implications for COVID-19. Clinical and Translational Medicine . https://doi.org/10.1002/ctm2.371 . ISSN: 2001-1326
Franco, R. (2021). Qué es el estrés oxidativo y cómo afecta al envejecimiento. The Conversation . Repositori Institucional . ISSN: 2201-5639
Casanovas, M.; Reyes-Resina, I.; Lillo, A.; Lillo, J.; López-Arnau, R.; Camarasa, J.; Escubedo, E.; Navarro *, G.; Franco, R. (2021). Methamphetamine blocks adenosine A2A receptor activation via sigma 1 and cannabinoid CB1 receptors. International Journal of Molecular Sciences . Repositori Institucional . ISSN: 1661-6596
Martínez-Pinilla, E.; Rubio-Sardón, N.; Villar-Conde, S.; Navarro, G.; Del Valle, E.; Tolivia, J.; Franco , R.; Navarro, A. (2021). Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models. Brain Sciences . Repositori Institucional . ISSN: 2076-3425
Pedrosa, M.A.; Valenzuela, R.; Garrido-Gil, P.; Labandeira, C.M.; Navarro, G.; Franco, R.; Labandeira-Garcia, J.L.; Rodriguez-Perez, A.I. (2021). Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical Science . https://doi.org/10.1042/CS20201511 . ISSN: 0143-5221
Franco, R.; Cordomí, A.; Llinas del Torrent, C.; Lillo, A.; Serrano-Marín, J.; Navarro G.; Pardo, L. (2021). Structure and function of adenosine receptor heteromers. Cellular and Molecular Life Sciences, 78(8), pp. 3957 - 3968 . https://doi.org/10.1007/s00018-021-03761-6 . ISSN: 1420-682X
Rafael Franco; Rafael R. Santisteban; Irene Reyes-Resina; Gemma Navarro (2021). The old and new visions of biased agonism through the prism of adenosine receptor signaling and receptor/receptor and receptor/protein interactions. Frontiers in Pharmacology, 11 . Repositori Institucional . ISSN: 1663-9812
Franco, R.; Reyes-Resina, I.; Navarro, G. (2021). Dopamine in health and disease: much more than a neurotransmitter. Biomedicines, 9(2), p. 109 . Repositori Institucional . ISSN: 2227-9059
Rafael Rivas-Santisteban; Jaume Lillo; Ana Muñoz; Ana I. Rodríguez-Pérez,;José Luís Labandeira-García; Gemma Navarro; Rafael Franco (2021). Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia. Neurotherapeutics, 18(2), pp. 998 - 1016 . https://doi.org/10.1007/s13311-020-00986-4 . ISSN: 1933-7213
Miralpeix, C.; Reguera, A.C.; Fosch, A.; Casas, M.; Lillo, J.; Navarro, G.; Franco, R.; Casas, J.; Alexander, S.P.H; Casals N.; Rodríguez-Rodríguez R. (2021). Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. British Journal of Pharmacology, 178(7), pp. 1507 - 1523 . https://doi.org/10.1111/bph.15377 . ISSN: 0007-1188
Casanovas, M.; Jiménez-Rosés, M.; Cordomí, A.; Lillo, A.; Vega-Quiroga, I.; Izquierdo, J.; Medrano, M.; Gysling, K.; Pardo, L.; Navarro, G.; Franco, R. (2021). Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties. Addiction Biology . https://doi.org/10.1111/adb.13017 . ISSN: 1355-6215
Catalina Pérez-Olives; Rafael Rivas-Santisteban; Jaume Lillo; Gemma Navarro; Rafael Franco (2020). Recent Advances in the Potential of Cannabinoids for Neuroprotection in Alzheimer's, Parkinson's, and Huntington's Diseases. Advances in Experimental Medicine and Biology, 1264, pp. 81 - 92 . https://doi.org/10.1007/978-3-030-57369-0_6 . ISSN: 0065-2598
Franco, Rafael; Lillo, Alejandro; Rivas-Santisteban, Rafael; Rodríguez-Pérez, Ana I. ; Reyes-Resina, Irene; Labandeira-García, José L.; Navarro, Gemma (2020). Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue. International Journal of Molecular Sciences, 21(24)(9602) . Repositori Institucional . ISSN: 1661-6596
Morales, Paula; Navarro, Gemma; Gomez-Autet, Marc; Redondo, Laura; Fernandez-Ruiz, Javier; Perez-Benito, Laura; Cordomi, Arnau; Pardo, Leonardo; Franco, Rafael; Jagerovic, Nadine (2020). Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**. Chemistry-A European Journal, 26(68), pp. 15839 - 15842 . Repositori Institucional . ISSN: 0947-6539
Serrano-Marin, Joan; Reyes-Resina, Irene; Martinez-Pinilla, Eva; Navarro, Gemma; Franco, Rafael (2020). Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors. Molecules, 25(21), pp. 1 - 14 . Repositori Institucional . ISSN: 1420-3049
Martínez-Pinilla, E.; Rico, A.;Rivas-Santisteban, R.; Lillo, J.; Roda, E.; Navarro, G.; Lanciego, J.L.; Franco, R. (2020). Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen and accumbens nuclei of control, parkinsonian and dyskinetic non-human primates. Brain Structure and Function . ISSN: 1863-2653
Gemma Navarro; Angel Gonzalez; Stefano Campanacci; Rafael Rivas-Santisteban; Irene Reyes-Resina; Nil Casajuana-Martin; Arnau Cordomí; Leonardo Pardo; Rafael Franco (2020). Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. Computational And Structural Biotechnology Journal, 18, pp. 2723 - 2732 . Repositori Institucional . ISSN: 2001-0370
Navarro, G.; Varanic, K.; Lillo, A.; Vincenzi, F.; Rivas-Santisteban, R.; Raïch, I.;Reyes-Resina, I.;Ferreiro-Vera, C.;Andrea Borea, P.; Sánchez de Medina, V.; Nadal, X.;Franco, R. (2020). Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB1, CB2 and CB1/CB2 heteromer receptors. Pharmacological Research, 159:104940, pp. 1 - 12 . https://doi.org/10.1016/j.phrs.2020.104940 . ISSN: 1043-6618
Franco, Rafael; Rivas-Santisteban, Rafael; Serrano-Marin, Joan; Rodriguez-Perez, Ana, I; Labandeira-Garcia, Jose L.; Navarro, Gemma (2020). SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production. Journal of Immunology, 205(5), pp. 1198 - 1206 . https://doi.org/10.4049/jimmunol.2000642 . ISSN: 0022-1767
Rafael Rivas-Santisteban; Ana I. Rodriguez-Perez; Ana Muñoz; Irene Reyes-Resina; José Luis Labandeira-García; Gemma Navarro; Rafael Franco (2020). Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia. Journal of Neuroinflammation . Repositori Institucional . ISSN: 1742-2094
Franco, R; Rivas-Santisteban, R; Reyes-Resina, I; Casanovas, M; Pérez-Olives, C; Ferreiro-Vera, C; Navarro, G; Sánchez de Medina, V; Nadal, X. (2020). Pharmacological potential of varinic-, minor-, and acidic phytocannabinoids. Pharmacological Research, 158(104801), pp. 1 - 15 . https://doi.org/10.1016/j.phrs.2020.104801 . ISSN: 1043-6618
Martinez-Pinilla, Eva; Rico, Alberto J.; Rivas-Santisteban, Rafael; Lillo, Jaume; Roda, Elvira; Navarro, Gemma; Luis Lanciego, Jose; Franco, Rafael (2020). Expression of GPR55 and either cannabinoid CB(1)or CB(2)heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates. Brain Structure and Function, 225(7), pp. 2153 - 2164 . https://doi.org/10.1007/s00429-020-02116-4 . ISSN: 1863-2653
Lillo, A.; Martínez-Pinilla, E.; Reyes-Resina, I.; Navarro, G.; Franco, R. (2020). Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences, 21(14), p. 5070 . Repositori Institucional . ISSN: 1661-6596
Martinez-Pinilla, Eva; Rico, Alberto J.; Rivas-Santisteban, Rafael; Lillo, Jaume; Roda, Elvira; Navarro, Gemma; Franco, Rafael; Luis Lanciego, Jose (2020). Expression of cannabinoid CB1R-GPR55 heteromers in neuronal subtypes of theMacaca fascicularisstriatum. Annals of the New York Academy of Sciences, 1475(1), pp. 34 - 42 . https://doi.org/10.1111/nyas.14413 . ISSN: 0077-8923
Gnad, T; Navarro, G.; Lahesmaa, M.; Reverte-Salisa, L.; Copperi, F.; Cordomi, A.; Naumann, J.; Hochhäuser, A.; Haufs-Brusberg, S.; Wenzel, D.; Suhr, F; Jespersen, H.J.; Scheele, C.; Tsvilovskyy, V.; Brinkmann C.; Rittweger, J.; Dani C., C; Kranz, M.; Deuther-Conrad, W.; Eltzschig, H.K.; Niemi, T.; Taittonen, M.; Brust, P.; Nuutila, P.; Pardo L.; Fleischmann B.K.; Blüher M.; Franco, R.; Bloch W.; Virtanen K.A.; Pfeifer, A. (2020). Adenosine/A2B receptor signaling ameliorates the effects of ageing and counteracts obesity. Cell Metabolism, 32(1), pp. 56 - 70 . Repositori Institucional . ISSN: 1550-4131
Franco, R.; Rivas-Santisteban, R.; Casanovas, M.; Lillo, A.; Saura, C.A.; Navarro, G. (2020). Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease. Cells, 9(5), p. 1075 . Repositori Institucional . ISSN: 2073-4409
Rafael Franco, Rafael Rivas-Santisteban, Irene Reyes-Resina, Gemma Navarro, Eva Martínez-Pinilla (2020). Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson's Disease. Frontiers in Aging Neuroscience, 12(12) . Repositori Institucional . ISSN: 1663-4365
Navarro, G.; Rivas-Santisteban, R.; Reyes-Resina, I.; Lillo, A.; Lillo, J.; Cano, JJ.; and Franco, R.; (2020). Trends in pharmaceutical and food sciences Chapter 1.Different Techniques to Detect G Protein Coupled Receptor Heteromers. Journal of Pharmaceutical Sciences . ISSN: 0022-3549
Garcia-Recio, A.; Navarro, G.; Franco, R.; Olivella, M.; Guixà-González,R.; Cordomí, A. (2020). DIMERBOW: exploring possible GPCR dimer interfaces. Bioinformatics . ISSN: 1367-4803
De Filippo, Elisabetta; Hinz, Sonja; Pellizzari, Veronica; Deganutti, Giuseppe; El-Tayeb, Ali; Navarro, Gemma; Franco, Rafael; Moro, Stefano; Schiedel, Anke C.; Mueller, Christa E. (2020). A(2A) and A(2B) adenosine receptors: The extracellular loop 2 determines high (A(2A)) or low affinity (A(2B)) for adenosine. Biochemical Pharmacology, 172 . https://doi.org/10.1016/j.bcp.2019.113718 . ISSN: 0006-2952
Rivas-Santisteban, R.;Rodriguez-Perez, A.;Reyes-Resina, I.; Labandeira-García, J.L.; Navarro,G.*; Franco,R. (2020). Angiotensin AT1 and AT2 receptors heteromer expression in microglia correlates with Parkinson's disease progression in the hemilesioned rat model of the disease. Cellular Physiology and Biochemistry . Repositori Institucional . ISSN: 1015-8987
Reyes-Resina I; Awad Alkozi H; Del Ser-Badia A; Sánchez-Naves J; Lillo J; Jiménez J; Pintor J; Navarro G; Franco R. (2020). Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension. Cells, 9(152) . Repositori Institucional . ISSN: 2073-4409
Alkozi HA; Navarro G; Aguinaga D; Reyes-Resina I; Sanchez-Naves J; Pérez de Lara MJ; Pintor J*; Franco R* (2020). Adrenergic-melatonin receptor complexes control ion homeostasis and intraocular pressure and their disruption contributes to hypertensive glaucoma. British Journal of Pharmacology, 45, pp. 1 - 15 . https://doi.org/10.1111/bph.14971 . ISSN: 0007-1188
Rodriguez-Perez, A.I.; Garrido-Gil, P.; Pedrosa, M.A.; Garcia-Garrote, M.; Valenzuela, R.; Navarro, G.; Franco, R.; Labandeira-Garcia, J.L. (2019). Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra. Brain, Behavior, and Immunity, 56, pp. 1 - 10 . https://doi.org/10.1016/j.bbi.2019.12.011 . ISSN: 0889-1591
Rivas-Santisteban, R.; Reyes-Resina, I.; Raïch, I.; Pintor, J.;, Alkozi, H.A.; Navarro, G.; Franco, R. (2019). Specificity and nanomolar potency of melatonin on G-protein coupled melatonin MT1 and MT2 receptors expressed in HEK-293T human embryo kidney cells. Melatonin Research, 2(4) . Repositori Institucional . ISSN: 2641-0281
Franco R, Navarro G, Martínez-Pinilla E. (2019). Antioxidants versus Food Antioxidant Additives and Food Preservatives. Antioxidants, 8(11 pii: E542. ), pp. 1 - 11 . Repositori Institucional . ISSN: 2076-3921
Gallo M, Navarro G, Andreu D*, Franco R*, (2019). A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector. International Journal of Molecular Sciences, 20(19 pii: E4937. ), pp. 1 - 11 . Repositori Institucional . ISSN: 1661-6596
Franco, R.;, Castelló, J.; Canela, E.I. (2019). The kinetic component in drug discovery: Using the most basic pharmacological concepts to advance in selecting drugs to combat CNS diseases. Current Neuropharmacology, 18(2), pp. 120 - 127 . https://doi.org/10.2174/1570159X17666191001144309 . ISSN: 1570-159X
Reyes-Resina I, Jiménez J, Navarro N, Franco R (2019). Identification of Heteroreceptors Complexes and Signal Transduction Events Using Bioluminescence Resonance Energy Transfer (BRET). Bio-protocol, 9(19 e3385), pp. 1 - 16 . https://doi.org/10.21769/BioProtoc.3385 . ISSN: 2331-8325
Aguinaga, A.; Casanovas, M.; Rivas-Santisteban, R.; Reyes-Resina, I.; Navarro, G.; Franco, R. (2019). The sigma-1 receptor as key common factor in cocaine and food seeking behaviors. Journal of Molecular Endocrinology, 63(4), pp. 81 - 92 . Repositori Institucional . ISSN: 0952-5041
Franco R, Navarro G, Martínez-Pinilla E. (2019). Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals. Antioxidants, 8(9 pii: E373.), pp. 1 - 11 . https://doi.org/10.3390/antiox8090373 . ISSN: 2076-3921
Franco, R.; Reis-Resina, I.; Aguinaga, D.; Lillo, A.; Jiménez, J.; Raïch I.; Borroto-Escola, D. O.; Ferreiro-Vera, C.; Canela, E.I.; Sánchez de Medina, V.; del Ser-Badia, A.; Fuxe, K.; Saura, C.A.; Navarro G. (2019). Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists. Glia, 67(12), pp. 2410 - 2423 . https://doi.org/10.1002/glia.23694 . ISSN: 0894-1491
Martinez-Pinilla, Eva; Aguinaga, David; Navarro, Gemma; Rico, Alberto J.; Oyarzabal, Julen; Sanchez-Arias, Juan A.; Luis Lanciego, Jose; Franco, Rafael (2019). Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease. Molecular Neurobiology, 56(8), pp. 5900 - 5910 . https://doi.org/10.1007/s12035-019-1495-4 . ISSN: 0893-7648
Franco, R.; Navarro, G.; Martínez-Pinilla, E. (2019). Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson's and Alzheimer's Diseases. International Journal of Molecular Sciences, 20(13) . Repositori Institucional . ISSN: 1661-6596
Franco, Rafael; Villa, Maria; Morales, Paula; Reyes-Resina, Irene; Gutierrez-Rodriguez, Ana; Jimenez, Jasmina; Jagerovic, Nadine; Martinez-Orgado, Jose; Navarro, Gemma (2019). Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage. Neuropharmacology, 152, pp. 58 - 66 . https://doi.org/10.1016/j.neuropharm.2019.02.004 . ISSN: 0028-3908
Franco, Rafael; Martinez-Pinilla, Eva; Navarro, Gemma (2019). Why have transgenic rodent models failed to successfully mimic Alzheimer's disease. How can we develop effective drugs without them?. Expert Opinion on Drug Discovery, 14(4), pp. 327 - 330 . https://doi.org/10.1080/17460441.2019.1581169 . ISSN: 1746-0441
Franco, R.; Navarro, G.; Martínez-Pinilla, E. (2019). Antioxidant defense mechanisms in erythrocytes and in the central nervous system. Antioxidants, 2(8), p. 46 . https://doi.org/10.3390/antiox8020046 . ISSN: 2076-3921
Franco, Rafael; Aguinaga, David; Jiménez, Jasmina; Lillo, Jaume; Martínez-Pinilla, Eva; Navarro, Gemma (2018). Biased receptor functionality versus biased agonism in G-protein-coupled receptors. Biomolecular concepts, 9(1), pp. 143 - 154 . Repositori Institucional . ISSN: 1868-503X
Reyes-Resina, Irene; Samadi, Abdelouahid; Navarro, Gemma; Saadeh, Haythem A.; Khasawneh, Mohammad A.; Mestres, Jordi; Marco-Contelles, Jose; Franco, Rafael (2018). Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D-2 and D-3 Dopamine Receptors. ACS Omega , 3(12), pp. 17368 - 17375 . Repositori Institucional . ISSN: 2470-1343
Franco R.; Navarro G.; Pardo L.; Cordomi A.; Fuxe K.; Borotto-Escuela D.; Mueller C. E. (2018). Functional selectivity and biased agonism in individual receptors and in receptor heteromers. Purinergic Signalling, 14, pp. S8 - S8 . ISSN: 1573-9538
Navarro G; Medrano M; Aguinaga D; Vega-Quiroga I; Lillo A; Jiménez J; Casanovas M; Canela EI; Mallol J; Gysling K; Franco R. (2018). Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex. Neuropharmacology, 152, pp. 102 - 111 . Repositori Institucional . ISSN: 0028-3908
Navarro G; Reyes-Resina I; Rivas-Santisteban R; Sánchez de Medina V; Morales P; Casano S; Ferreiro-Vera C; Lillo A; Aguinaga D; Jagerovic N; Nadal X; Franco R. (2018). Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1-CB2 heteroreceptor complexes. Biochemical Pharmacology, 157, pp. 148 - 158 . https://doi.org/10.1016/j.bcp.2018.08.046 . ISSN: 0006-2952
Franco, R.; Aguinaga, D.; Reyes, I.; Canela, E.I.; Lillo, J.; Tarutani, A.; Hasegawa, M.; del Ser-Badia, A.; del Rio, J.A.; Kreutz, M.R.; Saura, C.A.; and Navarro, G. (2018). N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical and hippocampal neurons and microglia is dependent on calcium sensors and is blocked by α-synuclein, tau, and phospho-tau in non-transgenic and transgenic APPSw,Ind mice. Frontiers In Molecular Neuroscience, 11(273) . Repositori Institucional . ISSN: 1662-5099
Angelats, E.; Requesens, M.; Aguinaga, D.; Kreutz, M.R.; Franco, R.; Navarro, G. (2018). Neuronal calcium and cAMP cross-talk mediated by cannabinoid CB1 receptor and EF-hand calcium sensor interactions. Frontiers in Cell and Developmental Biology, 6(67), pp. 1 - 9 . Repositori Institucional . ISSN: 2296-634X
María S. García-Gutiérrez; Francisco Navarrete; Gemma Navarro; Irene Reyes-Resina; Rafael Franco; Jose Luis Lanciego; Salvador Giner; Jorge Manzanares (2018). Alterations of cannabinoid CB2 and GPR55 receptors gene and protein expression in the dorsolateral prefrontal cortex of suicide victims. Neurotherapeutics, 15(3), pp. 796 - 806 . https://doi.org/10.1007/s13311-018-0610-y . ISSN: 1933-7213
Borroto-Escuela, D.O.; Perez De La Mora, M.; Manger, P.; Narváez, M.; Beggiato, S.; Crespo-Ramírez, M.; Navarro, G.; Wydra, K.; Díaz-Cabiale, Z.; Rivera, A.; Ferraro, L.; Tanganelli, S.; Filip, M.; Franco, R.; Fuxe, K. (2018). Brain dopamine transmission in health and Parkinson's disease: modulation of synaptic transmission and plasticity through volume transmission and dopamine heteroreceptors. Frontiers In Synaptic Neuroscience, 10(20), pp. 1 - 24 . Repositori Institucional . ISSN: 1663-3563
Navarro, G; Aguinaga D; Reyes I; Del Rio JA; Ávila J; Saura C & R. Franco (2018). Interaction between n-methyl aspartate (NMDA) glutamate receptors and calcium sensors in neurons: Alterations and calcium-sensor modulation in the APP-PS1 model of AD. Alzheimer's & Dementia, 14(7), p. 371 . https://doi.org/10.1016/j.jalz.2018.06.247 . ISSN: 1552-5260
Franco, R.; Sánchez-Arias, J.A.; Navarro, G.; Lanciego, J.L. (2018). Glucocerebrosidase mutations and synucleinopathies. Potential role of sterylglucosides and relevance of studying both GBA1 and GBA2 genes. Frontiers In Neuroanatomy, 12(52), pp. 1 - 8 . Repositori Institucional . ISSN: 1662-5129
Navarro, G.; Varani, K.; Reyes-Resina, I.; Sánchez de Medina, V.; Rivas-Santisteban, R.; Sánchez-Carnerero Callado, C.; Vincenzi, F.; Casano, S.; Ferreiro-Vera, C., Canela, E. I.; Borea Pier, A.; Nadal, X.; Franco, R. (2018). Cannabigerol action at cannabinoid CB1 and CB2 receptors and at CB1-CB2 heteroreceptor complexes. Frontiers in Pharmacology, 9, p. 632 . Repositori Institucional . ISSN: 1663-9812
Aguinaga, D.; Medrano, M.; Cordomí, A.; Jiménez-Rosés, M.; Angelats, E.; Casanovas, M.; Vega-Quiroga, I.; Canela, E.I.; Petrovic, M.; Gysling, K.; Pardo, L.; Franco, R.; Navarro, G. (2018). Cocaine blocks effects of hunger hormone, ghrelin, via interaction with neuronal sigma-1 receptors. Molecular Neurobiology, 200, pp. 1 - 10 . Repositori Institucional . ISSN: 0893-7648
Reyes-Resina, I.; Navarro, G.; Aguinaga, D.; Canela, E.I.; Schoeder, C.T.; Zaluski, M.; Kiec-Kononowicz, K.; Saura, C.A.; Müller, C.E.; Franco, R. (2018). Molecular and functional interaction between GPR18 and cannabinoid CB2 G-protein-coupled receptors. Relevance in neurodegenerative diseases. Biochemical Pharmacology . Repositori Institucional . ISSN: 0006-2952
Zamarbide M; Gil-Bea FJ; Bannenberg P; Martínez-Pinilla E; Sandoval J, Franco R; Pérez-Mediavilla A. (2018). Maternal imprinting on cognition markers of wild type and transgenic Alzheimer's disease model mice. Scientific Reports, 8(6434), pp. 1 - 13 . Repositori Institucional . ISSN: 2045-2322
Navarro, G.; Martínez -Pinilla, E.; Ortiz, R.; Noé, V.; Ciudad, C.J. and Franco, R. (2018). Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action. Comprehensive Reviews in Food Science and Food Safety, 8(63), pp. 106693 - 106706 . https://doi.org/10.1111/1541-4337.12359 . ISSN: 1541-4337
Franco, R.; Navarro, G. (2018). Adenosine A2A receptor antagonists in neurodegenerative diseases: Huge potential and huge challenges. Frontiers In Psychiatry, 9(68) . Repositori Institucional . ISSN: 1664-0640
Navarro G; Cordomí A; Brugarolas M; Moreno E; Aguinaga D; Pérez-Benito L; Ferré S; Cortés A; Casadó V; Mallol J; Canela EI; Lluís C; Pardo L; McCormick PJ; Franco R (2018). Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. BMC Biology, 16(1), p. 24 . Repositori Institucional . ISSN: 1741-7007
Aguinaga, D.; Medrano, M.; Vega-Quiroga, I.; Gysling, K.; Canela, E.I.; Navarro, G.; Franco, R. (2018). Cocaine effects on dopaminergic transmission depend on a balance between Sigma-1 and Sigma-2 receptor expression. Frontiers In Molecular Neuroscience, 11, p. 17 . Repositori Institucional . ISSN: 1662-5099
Dasiel Oscar Borroto-Escuela; Sonja Hinz; Gemma Navarro; Rafael Franco; Christa Elisabeth Müller; Kjell Fuxe (2018). Understanding the role of adenosine A2AR heteroreceptor complexes in neurodegeneration and neuroinflammation. Frontiers in Neuroscience, 12, p. 43 . Repositori Institucional . ISSN: 1662-4548
Hinz, S.; Navarro, G.; Borroto-Escuela, D.; Seibt, B.J.; Ammon, Y.C.; de Filippo, E.; Danish, A.; Lacher, s.K.; Cervinkova, B.; Rafehi, M.; Fuxe, K.; Schiedel, A.C.; Franco, R.; Muller, C.E. (2018). Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors. Oncotarget, 9(17), pp. 13593 - 13611 . Repositori Institucional . ISSN: 1949-2553
Irene Reyes-Resina; David Aguinaga; José L. Labandeira García; José L. Lanciego; Gemma Navarro; Rafael Franco (2018). Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas. Histology and Histopathology, 16, p. 11963 . Repositori Institucional . ISSN: 0213-3911
Navarro, Gemma; Borroto-Escuela, Dasiel; Angelats, Edgar; Etayo, Inigo; Reyes-Resina, Irene; Pulido-Salgado, Marta; Rodriguez-Perez, Ana I.; Canela, Enric I.; Saura, Josep; Luis Lanciego, Jose; Luis Labandeira-Garcia, Jose; Saura, Carlos A.; Fuxe, Kjell; Franco, Rafael (2018). Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia. Brain, Behavior, and Immunity, 67, pp. 139 - 151 . https://doi.org/10.1016/j.bbi.2017.08.015 . ISSN: 0889-1591
Borroto-Escuela, Dasiel O.; Narvaez, Manuel; Valladolid-Acebes, Ismael; Shumilov, Kirill; Di Palma, Michael; Wydra, Karolina; Schaefer, Thorsten; Reyes-Resina, Irene; Navarro, Gemma; Mudo, Giuseppa; Filip, Malgorzata; Sartini, Stefano; Friedland, Kristina; Schellekens, Harriet; Beggiato, Sarah; Ferraro, Luca; Tanganelli, Sergio; Franco, Rafael; Belluardo, Natale; Ambrogini, Patrizia; Perez de la Mora, Miguel; Fuxe, Kjell (2018). Detection, Analysis, and Quantification of GPCR Homo- and Heteroreceptor Complexes in Specific Neuronal Cell Populations Using the In Situ Proximity Ligation Assay. Neuromethods, 140, pp. 299 - 315 . ISSN: 0893-2336
Reyes-Resina, Irene; Martinez-Pinilla, Eva; Borroto-Escuela, Dasiel O.; Fuxe, Kjell; Navarro, Gemma; Franco, Rafael (2018). Methods to Identify the Signature of Trimers Formed by Three G Protein-Coupled Receptors or by Two G Protein-Coupled and One Ionotropic Receptor with Special Emphasis in the Functional Role in the Central Nervous System. Neuromethods, 140, pp. 187 - 203 . ISSN: 0893-2336
Navarro, G; Franco, N; Martínez-Pinilla, E; Franco, R (2017). The epigenetic Cytocrin pathway to the nucleus. Epigenetic factors, epigenetic mediators, and epigenetic traits. A biochemist perspective. Frontiers In Genetics, 8:179, pp. 1 - 7 . Repositori Institucional . ISSN: 1664-8021
Martinez-Pinilla, Eva; Varani, Katia; Reyes-Resina, Irene; Angelats, Edgar; Vincenzi, Fabrizio; Ferreiro-Vera, Carlos; Oyarzabal, Julen; Canela, Enric I.; Lanciego, Jose L.; Nadal, Xavier; Navarro, Gemma; Borea, Pier Andrea; Franco, Rafael (2017). Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors. Frontiers in Pharmacology, 8 . Repositori Institucional . ISSN: 1663-9812
Alkozi, H.A.; Franco, R.; Pintor, J.J. (2017). Epigenetics in the eye: an overview of the most relevant ocular diseases. Frontiers In Genetics, 8, p. 144 . Repositori Institucional . ISSN: 1664-8021
Celorrio M; Rojo-Bustamante E; Fernández-Suárez D; Sáez E; Estella-Hermoso de Mendoza A; Müller CE; Ramírez MJ; Oyarzábal J; Franco R; Aymerich MS. (2017). GPR55: A therapeutic target for Parkinson's disease?. Neuropharmacology, 125, pp. 319 - 332 . https://doi.org/10.1016/j.neuropharm.2017.08.017 . ISSN: 0028-3908
Rodríguez-Ruiz, M.; Moreno, E.; Moreno-Delgado, D.; Navarro, G.; Mallol, J.; Cortés, A.; Lluís, C.; Canela, E,I; Casadó, V.; McCormick, P.J.; Franco, R. (2017). Heteroreceptor complexes formed by dopamine D1, histamine H3, and N-methyl-D-aspartate glutamate receptors as targets to prevent neuronal death in Alzheimer's disease. Molecular Neurobiology, 54(6), pp. 4537 - 4550 . https://doi.org/10.1007/s12035-016-9995-y . ISSN: 0893-7648
Medrano, M; Aguinaga, D; Reyes-Resina, I; Canela, EI; Mallol, J; Navarro, G*; Franco, R* (2017). Orexin A/hypocretin modulates leptin receptor-mediated signaling by allosteric modulations mediated by the ghrelin GHS-R1A receptor in hypothalamic neurons. Molecular Neurobiology . https://doi.org/10.1007/s12035-017-0670-8 . ISSN: 0893-7648
Edgar Angelats; Eva Martínez-Pinilla; Ainhoa Oñatibia-Astibia; Nuria Franco; Gemma Navarro; Rafael Franco (2017). Humans and caffeine - a very long relationship. Frontiers for Young Minds . https://doi.org/10.3389/frym.2017.00027 . ISSN: 2296-6846
Elgueta D.; Aymerich M. S.; Contreras F.; Celorrio M.; Rojo-Bustamente E.; Franco R.; Pacheco R. (2017). Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Glia, 65, pp. E422 - E423 . ISSN: 0894-1491
Rafael Franco; Eva Martínez-Pinilla (2017). Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration. Food Chemistry, 235, pp. 318 - 323 . https://doi.org/10.1016/j.foodchem.2017.05.040 . ISSN: 0308-8146
Angelats, E; Martínez-Pinilla, E; Oñatibia-Astibia, A; Franco, N; Navarro, G; Franco, R (2017). Natural Selection of caffeine consumtion. Frontiers for Young Minds . ISSN: 2296-6846
Navarro, G; Martínez-Pinilla, E; Sánchez-Melgar, A; Ortiz, R; Noé N; Martín, M; Ciudad C; Franco, R (2017). A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression. PLoS One, 12(4), p. e0176067 . Repositori Institucional . ISSN: 1932-6203
Cuadrado-Tejedor M; Garcia-Barroso C; Sánchez-Arias JA; Rabal O; Pérez-González M; Mederos S; Ugarte A; Franco R; Segura V; Perea G; Oyarzabal J; Garcia-Osta A (2017). A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology, 42(2), pp. 524 - 539 . https://doi.org/10.1038/npp.2016.163 . ISSN: 0893-133X
Oñatibia-Astibia A, Franco R*, Martínez-Pinilla E* . (2017). Health benefits of methylxanthines in neurodegenerative diseases. Molecular Nutrition & Food Research, 61 . https://doi.org/10.1002/mnfr.201600670 . ISSN: 1613-4125
Franco, R; Martínez-Pinilla, E; Navarro, G; Zamarbide, M (2017). Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. Progress in Neurobiology, 149, pp. 21 - 38 . https://doi.org/10.1016/j.pneurobio.2017.01.004 . ISSN: 0301-0082
Elgueta D, Aymerich MS, Contreras F, Montoya A, Celorrio M, Rojo-Bustamante E, Riquelme E, González H, Vásquez M, Franco R, Pacheco R. (2017). Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Neuropharmacology, 113(A), pp. 110 - 123 . https://doi.org/10.1016/j.neuropharm.2016.09.028 . ISSN: 0028-3908
Borroto-Escuela DO, Wydra K, Pintsuk J, Narvaez M, Corrales F, Zaniewska M, Agnati LF, Franco R, Tanganelli S, Ferraro L, Filip M, Fuxe K. (2016). Understanding the functional plasticity in neural networks of the basal ganglia in cocaine use disorder: a role for allosteric receptor-receptor interactions in A2A-D2 heteroreceptor complexes. Neural Plasticity, 2016(4827268), pp. 1 - 12 . Repositori Institucional . ISSN: 2090-5904
Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL. (2016). Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death and Disease, 7(10 (e2427), pp. 1 - 10 . https://doi.org/10.1038/cddis.2016.327 . ISSN: 2041-4889
Franco, Rafael; Casado-Anguera, Veronica; Munoz, Ana; Petrovic, Milos; Navarro, Gemma; Moreno, Estefania; Luis Lanciego, Jose; Luis Labandeira-Garcia, Jose; Cortes, Antoni; Casado, Vicent (2016). Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum. Molecular Neurobiology, 53(8), pp. 5436 - 5445 . https://doi.org/10.1007/s12035-015-9468-8 . ISSN: 0893-7648
Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco* and Aymerich MS* (2016). Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain, Behavior, and Immunity, 57, pp. 94 - 105 . https://doi.org/10.1016/j.bbi.2016.06.010 . ISSN: 0889-1591
Martinez-Pinilla E, Rabal O, Reyes-Resina I, Zamarbide M, Navarro G, Sanchez-Arias JA, de Miguel I, Lanciego JL, Oyarzabal J, Franco R (2016). Two affinity sites of cannabinoid CB2 receptor identified by a novel homogeneous binding assay. Journal of Pharmacology and Experimental Therapeutics, 358(3), pp. 580 - 587 . https://doi.org/10.1124/jpet.116.234948 . ISSN: 0022-3565
Navarro, Gemma; Morales, Paula; Rodriguez-Cueto, Carmen; Fernandez-Ruiz, Javier; Jagerovic, Nadine; Franco, Rafael (2016). Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in Neuroscience, 10 . Repositori Institucional . ISSN: 1662-4548
Rico AJ; Dopeso-Reyes IG; Martínez-Pinilla E; Sucunza D; Pignataro D; Roda E; Marín-Ramos D; Labandeira-García JL; George SR; Franco R; Lanciego JL (2016). Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain Structure and Function, 222(4), pp. 1767 - 1784 . https://doi.org/10.1007/s00429-016-1306-x . ISSN: 1863-2653
Perreault ML; Hasbi A; Shen MY; Fan T; Navarro G; Fletcher PJ; Franco R; Lanciego JL; George SR (2016). Disruption of a dopamine receptor complex amplifies the actions of cocaine. European Neuropsychopharmacology, 26(9), pp. 1366 - 1377 . https://doi.org/10.1016/j.euroneuro.2016.07.008 . ISSN: 0924-977X
Medrano, M.; Navarro, G.; Aguinaga, D.; Mallol, J.; Franco, R. (2016). Evidence for human ghrelin GHS-R1a and orexin OX1 heteroreceptor complex formation in a heterologous system. The FEBS Journal, 283, pp. 172 - 172 . ISSN: 1742-464X
Morales, Paula; Gomez-Canas, Maria; Navarro, Gemma; Hurst, Dow P.; Carrillo-Salinas, Francisco J.; Lagartera, Laura; Pazos, Ruth; Goya, Pilar; Reggio, Patricia H.; Guaza, Carmen; Franco, Rafael; Fernandez-Ruiz, Javier; Jagerovic, Nadine (2016). Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. Journal of Medicinal Chemistry, 59(14), pp. 6753 - 6771 . Repositori Institucional . ISSN: 0022-2623
Navarro, G.; Borroto-Escuela, DO.; Fuxe, K.; Franco, R. (2016). Purinergic signaling in Parkinson's disease. Relevance for treatment. Neuropharmacology, 104, pp. 161 - 168 . https://doi.org/10.1016/j.neuropharm.2015.07.024 . ISSN: 0028-3908
Aymerich MS; Rojo-Bustamante E; Molina C; Celorrio M; Sánchez-Arias JA; Franco R. (2016). Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors. Molecular Neurobiology, 53(4), pp. 2312 - 2319 . https://doi.org/10.1007/s12035-015-9213-3 . ISSN: 0893-7648
Navarro, G; Cordomí, A; Zelman-Femiak, M; Brugarolas, M; Moreno, E; Aguinaga, D; Perez-Benito, L; Cortés, A; Casadó, V; Mallol, J; Canela, EI; Lluís, C; Pardo, L; García-Saez, AJ; McCormick, PJ; Franco, R (2016). Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with to Gi and Gs. BMC Biology, 14(26), pp. 1 - 10 . Repositori Institucional . ISSN: 1741-7007
Franco, Rafael; Martinez-Pinilla, Eva; Lanciego, Jose L.; Navarro, Gemma (2016). Basic pharmacological and structural evidence for class a G-protein-coupled receptor heteromerization. Frontiers in Pharmacology, 7, p. 76 . Repositori Institucional . ISSN: 1663-9812
Oliva, H.; Pacheco, R.; Martinez-Navio, J.M.; Rodríguez-García, M.; Naranjo-Gómez, M.; Climent, N.; Prado, C.; Gil, C.; Plana, M.; García, F.; Miró, J.M.; Franco, R.; Borras, F.E.; Navaratnam, N.; Gatell, J.M.; Gallart, T. (2016). Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation. Immunology and Cell Biology, 94(7), pp. 689 - 700 . https://doi.org/10.1038/icb.2016.28 . ISSN: 0818-9641
Naval-Macabuhay I; Casanova V; Navarro G; García F; León A; Miralles L; Rovira C; Martinez-Navio JM; Gallart T; Mallol J; Gatell JM; Lluís C; McCormick PJ; Climent N; Franco R; (2016). Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. Journal of Leukocyte Biology, 99(2), pp. 349 - 359 . https://doi.org/10.1189/jlb.3A1214-580RR . ISSN: 0741-5400
Gómez-Vallejo V; Ugarte A; García-Barroso C; Cuadrado-Tejedor M; Szczupak B; Dopeso-Reyes IG; Lanciego JL; García-Osta A; Llop J; Oyarzabal J; Franco R. (2016). Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels. Journal of Neurochemistry, 136(2), pp. 403 - 415 . https://doi.org/10.1111/jnc.13454 . ISSN: 0022-3042
Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A. (2016). Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus. Neuropharmacology, 105, pp. 241 - 257 . https://doi.org/10.1016/j.neuropharm.2016.01.022 . ISSN: 0028-3908
Oñatibia-Astibia A; Martínez-Pinilla E; Franco R. (2016). The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. Respiratory Medicine, 112, pp. 1 - 9 . https://doi.org/10.1016/j.rmed.2016.01.022 . ISSN: 0954-6111
Farré, D.; Muñoz, A.; Moreno, E.; Reyes-Resina, I.; Canet-Pons, J.; Dopeso-Reyes, I.G.; Rico, A.J.; Lluís, C.; Mallol, J.; Navarro, G.; Canela, E.I.; Cortés, A.; Labandeira-García, J.L.; Casadó, V.; Lanciego, J.L.; Franco, R. (2015). Stronger dopamine D1 receptor-mediated neurotransmission in dyskinesia. Molecular Neurobiology, 52(3), pp. 1408 - 1420 . https://doi.org/10.1007/s12035-014-8936-x . ISSN: 0893-7648
Cuadrado-Tejedor M; Garcia-Barroso C; Sanzhez-Arias J; Mederos S; Rabal O; Ugarte A; Franco R; Pascual-Lucas M; Segura V; Perea G; Oyarzabal J; Garcia-Osta A. (2015). Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease. Clinical Epigenetics, 7(108) . Repositori Institucional . ISSN: 1868-7075
Franco R; Petrovic M. (2015). Suggesting a way to understand the actual potential of anti-alzheimer's disease drugs that show promise in transgenic mouse models. Frontiers In Neurology, pp. 206 - 206 . Repositori Institucional . ISSN: 1664-2295
Cordomí A; Navarro G; Aymerich MS; Franco R. (2015). Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins. Trends in Biochemical Sciences, 40(10), pp. 548 - 551 . https://doi.org/10.1016/j.tibs.2015.07.007 . ISSN: 0968-0004
Sierra S, Luquin N, Rico AJ, Gómez-Bautista V, Roda E, Dopeso-Reyes IG, Vázquez A, Martínez-Pinilla E, Labandeira-García JL, Franco R, Lanciego JL. (2015). Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. Brain Structure and Function, 220(5), pp. 2721 - 2738 . https://doi.org/10.1007/s00429-014-0823-8 . ISSN: 1863-2653
Anandhan A; Rodriguez-Rocha H; Bohovych I; Griggs AM; Zavala-Flores L; Reyes-Reyes EM; Seravalli J; Stanciu LA; Lee J; Rochet JC; Khalimonchuk O; Franco R. (2015). Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiology of Disease, 81, pp. 76 - 92 . http://www.annexpublishers.com/articles/JNND/volume-1-issue-1/Amyloid-Beta-Precursor-Protein-Proper-Credit-for-the-Basic-Biochemical-Properties-of-the . ISSN: 0969-9961
Navarro Brugal, G.; Aguinaga, D.; Cortes, A.; Lluis, C.; Mallol, J.; Moreno, E.; Quiroz, C.; Franco, R.; Casado, V.; Canela, E. I.; Ferre, S. (2015). Orexin-CRF1-sigma-1 complexes as targets for cocaine. The FEBS Journal, 282, pp. 298 - 298 . ISSN: 1742-464X
Aguinaga, D.; Navarro, G.; Cordomi, A.; Zelman-Femiak, M.; Brugarolas, M.; Moreno, E.; Cortes, A.; Casado, V.; Mallol, J.; Canela, E.; Lluis, C.; Pardo, L.; Garcia-Saez, A. J.; Franco, R. (2015). Adenosine A(1) and A(2A) receptor heterotetramers simultaneously bind to G(i) and G(s) protein. The FEBS Journal, 282, pp. 295 - 295 . ISSN: 1742-464X
Ugarte A; Gil-Bea F; García-Barroso C; Cedazo-Minguez A; Ramírez MJ; Franco R; García-Osta ; Oyarzabal J; Cuadrado-Tejedor M (2015). Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathology and Applied Neurobiology, 41(4), pp. 471 - 482 . https://doi.org/10.1111/nan.12203 . ISSN: 0305-1846
Martínez-Pinilla, E; Rodríguez-Pérez, A.I.; Navarro, G.;Aguinaga, D; Moreno, E; Lanciego J.L.; Labandeira-García, J.L.; Franco, R. (2015). Dopamine D2 and angiotensin II type 1 receptors are co-expressed and form heteromers in rat striatum. Biochemical Pharmacology, 15(252), pp. 131 - 142 . https://doi.org/10.1016/j.bcp.2015.05.006 . ISSN: 0006-2952
Martínez-Pinilla E.; Oñatibia-Astibia A.; Franco R. (2015). The relevance of theobromine for the beneficial effects of cocoa consumption. Frontiers in Pharmacology, 6, pp. 1 - 5 . Repositori Institucional . ISSN: 1663-9812