Rafael Franco Fernandez

Full professor

Scopus Author ID: 7202551094

Researcher ID: C-3694-2015

Knowledge area: Bioquímica i Biologia Molecular

Grup UABUB de recerca en Medicina traslacional (GRUABUB21)

Contact Information
Department of Biochemistry and Molecular Biomedicine
Universidad de Barcelona. Facultad de Biología. Departamento de Bioquímica y Biomedicina Molecular. Avda. Diagonal 643, 08028 Barcelona
934021208
rfranco(a)ub.edu

Other Achievements

Scores and History of the research laboratory

2020-dated Stanford analysis: RF in top 2% scientists (Ioannidis et al., 2020: doi:10.1371/journal.pbio.3000918). In 1% (0.3%) top-rated experts in Alzheimer's Disease (AD) 2011-2021 (https://expertscape.com)

Researcher ID: C-3694-2015.

"All" Research sexenios:6.

"All" Techtransfer sexenios:1.

End 2021-dated: Publications: >470 (350 in Q1). h-index=78 (Scopus), 90 (real). Citations:19K (Scopus) >22K (Res Gate) Last 5 years: >1200 citations/year.

History

Founder of GPCR Mol Res lab (after 1985 stay in Prof Burnstock's lab). Describing first GPCR heteromer (Het) formed by 2 receptors for 2 neurotransmitters. Later: i) development of nomenclature & technology in the field ii) reporting Het disruption in neurodegenerative disease & iii) the first reliable structure of a heterotetramer coupled to 1 Gs & 1 Gi protein

The interaction between AR types broadens the physiological perspective of GPCRs, the A2A-A2BHet is a recent example increasing knowledge of Immune function & allowing to better understand physiological aging & the role of brown adipocytes in obesity (papers: Oncotarget & Cell Metabolism)

Since 1988 Franco's lab has received continued support (competitive tenders by public or private bodies), mainly for research on GPCRs, with focus on CNS function & potential as targets for neurological & neuropsychiatric diseases & drug addiction. The last three MICINN/AEI & the "Heteropark" Eranet-neuron (coordinator of 4 labs) projects related to GPCR Hets

2009-2013: Head of lab in CIMA (Pamplona): developing GPCR platform with CIMA proprietary molecules for translational research in PD & AD. Franco's CIMA members co- inventors of patents, the scientific production increased qual/quantitatively.

2014- Back as Professor in UB (head of Mol Neurobiol laboratory)

(Other Merits)

PREMIO CIUDAD DE BARCELONA

- Premio Ciudad de Barcelona de Investigación Biomédica. Año 1998 (Other Merits)

COORDINACION DE REDES

- Coordinador de la “Xarxa Temática” de Química Médica (Generalitat de Cataluña) desde su creación en el año 1998 (Other Merits)

BECAS, AYUDAS Y PREMIOS

- Adjudicación de una Ayuda para el Intercambio de Personal Investigador entre Industrias y Centros Públicos de Investigación. Duración 9 meses: 01-01-91 / 30-09-91. Industria: Laboratorios Echevarne S.A.. Ministerio de Educación y Ciencia. Dirección General de Investigación Científica y Técnica (Other Merits)

Academic training

Química . Universitat de Barcelona . 1979 . (Diploma / Degree / Activities)

Química . Universitat de Barcelona . 1982 . (Ph.D.)

Patents, Software and Database

Mallol, J.; Mirabet, M.; Canela, E.I.; Lluis, C.; Franco, R. Ref. es9900373. Anticuerpos policlonales antireceptor A_2B de adenosina (SPAIN, 1999 ) . Universitat de Barcelona

Ciruela F, Lluis C, Müller C, Hove-Madsen L, Cinca J, Franco, R. Ref. ES20060005. Compuestos para el tratamiento de la fibrilación auricular Patente licenciada a CIMA (CANADA, 2006 ; BRAZIL / SPAIN / JAPAN / UNITED STATES) . Universitat de Barcelona

Franco R, Ventura R, Lluis C, Casadó V, Albericio F, Royo M Ref. P200502546. Compuestos para el tratamiento de la enfermedad de Parkinson. Patente no activa (SPAIN, 2005 ) . Universitat de Barcelona

Franco R, Aguirre N, García Osta A, Cuadrado-Tejedor M Ref. EP11382205.0.. Tadalafil for the treatment of dementia (SPAIN, 2011 ; EUROPEAN UNION / UNITED STATES) . Fundación para la investigación médica aplicada

CUADRADO TEJEDOR M;Rafael FRANCO FERNÁNDEZ R; GARCÍA OSTA AM; OYARZABAL SANTAMARINA J; RABAL GRACIA MO Ref. EP13382065. Novel compounds as dual inhibitors of Phosphodiesterases and Histone Deacetylases (---, 01/03/2013 ) . ---

Journal Publications

Cuadrado-Tejedor, M.; Ricobaraza, A.L.; Torrijo, R.; Franco, R.; Garcia-Osta, A. (2013). Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model. Current Pharmaceutical Design, 19(28), pp. 5076 - 5084 . ISSN: 1381-6128

Franco, R.; Martínez-Pinilla, E.; Ricobaraza, A.; McCormick, P.J. (2013). Challenges in the development of heteromer-GPCR-based drugs. Progress in Molecular Biology and Translational Science, 117, pp. 143 - 162 . https://doi.org/10.1016/B978-0-12-386931-9.00006-4 . ISSN: 1877-1173

García-Barroso, C.; Ricobaraza, A.; Pascual-Lucas, M.; Unceta, N.; Rico, A.J.; Goicolea, M.A.; Sallés, J.; Lanciego, J.L.; Oyarzabal, J.; Franco, R.; Cuadrado-Tejedor, M.; García-Osta, A. (2013). Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD. Neuropharmacology, 64, pp. 114 - 123 . https://doi.org/10.1016/j.neuropharm.2012.06.052 . ISSN: 0028-3908

Gracia, E.; Farré, D.; Cortés, A.; Ferrer-Costa, C.; Orozco, M.; Mallol, J.; Lluís, C.; Canela, E.I.; McCormick, P.J.; Franco, R.; Fanelli, F.; Casadó, V. (2013). The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors. The FASEB Journal , 27(3), pp. 1048 - 1061 . https://doi.org/10.1096/fj.12-212621 . ISSN: 0892-6638

Solas, M.; Francis, P.T.; Ramirez, M.J.; Franco, R. (2013). CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients. Neurobiology of Aging, 34(3), pp. 805 - 808 . https://doi.org/10.1016/j.neurobiolaging.2012.06.005 . ISSN: 0197-4580

Navarro, G.; Moreno, E.; Bonaventura, J.; Brugarolas, M.; Farré, D.; Aguinaga, D.; Mallol, J.; Cortés, A.; Casadó, V.; Lluís, C.; Ferré, S.; Franco, R.; Canela, E.; McCormick, P.J. (2013). Cocaine inhibits dopamine D₂ receptor signaling via sigma-1-D₂ receptor heteromers. PLoS One, 8(4), p. e61245 . Institutional Repository . ISSN: 1932-6203

Cuadrado-Tejedor, M.; Cabodevilla, J.F.; Zamarbide, M.; Gómez-Isla, T.; Perez-Mediavilla, A.; Franco, R. (2013). Age-related mitochondrial alterations without neuronal loss in the hippocampus of a transgenic model of Alzheimer's disease. Current Alzheimer Research, 10(4), pp. 390 - 405 . ISSN: 1567-2050

Zamarbide, M.; Martinez-Pinilla, E.; Ricobaraza, A.; Aragón, T.; Franco, R.; Pérez-Mediavilla, A. (2013). Phenyl acyl acids attenuate the unfolded protein response in tunicamycin-treated neuroblastoma cells. PLoS One, 8(8), pp. 1 - 7 . Institutional Repository . ISSN: 1932-6203

Pazos M, Mohammed N.; Lafuente H.; Santos M.; Martínez-Pinilla E.; Moreno E.; Valdizan E.; Romero J.; Pazos A.; Franco R.; Hillard C.; Alvarez F.; Martínez-Orgado J. (2013). Mechanisms of cannabidiol neuroprotection in hypoxiceischemic newborn pigs: Role of 5HT1A and CB2 receptors. Neuropharmacology, 71, pp. 282 - 291 . https://doi.org/10.1016/j.neuropharm.2013.03.027 . ISSN: 0028-3908

Cristóvão-Ferreira, S.; Navarro, G.; Brugarolas, M.; Pérez- Capote, K.; Vaz, S.H.; Fattorini, G.; Conti, F.; Lluis, C.; Ribeiro, J.A.; McCormick, P.J.; Casadó, V.; Franco, R.; Sebastião, A.M. (2013). A1R-A2AR heteromers coupled to Gs and G i/0 proteins modulate GABA transport into astrocytes. Purinergic Signalling, 9(3), pp. 433 - 449 . https://doi.org/10.1007/s11302-013-9364-5 . ISSN: 1573-9538

Cuadrado-Tejedor M; Oyarzabal J; Lucas MP; Franco R; García-Osta A. (2013). Epigenetic drugs in Alzheimer's disease. Biomolecular concepts, 4(5), pp. 433 - 445 . https://doi.org/10.1515/bmc-2013-0012 . ISSN: 1868-503X

Franco, R.; Oñatibia-Astibia, A.; Martínez-Pinilla, E. (2013). Health benefits of methylxanthines in cacao and chocolate. Nutrients, 5(10), pp. 4159 - 4173 . Institutional Repository . ISSN: 2072-6643

Ferrero, J.J.; Alvarez, A.M.; Ramírez-Franco, J.J.; Torres, M.; Luján, R.; Ciruela, F.; Sanchez-Prieto, J. (2013). β-Adrenergic receptors activate exchange protein directly activated by cAMP (Epac), translocate Munc13-1, and enhance the Rab3A-RIM1α interaction to potentiate glutamate release at cerebrocortical nerve terminal. Journal of Biological Chemistry, 288(43), pp. 31370 - 31385 . Institutional Repository . ISSN: 0021-9258

Moreno, B.; Lopez, I.; Fernández-Díez, B.; Gottlieb, M.; Matute, C.; Sánchez-Gómez, M.V.; Domercq, M.; Giralt, A.; Alberch, J.; Collon, K.W.; Zhang, H.; Parent, J.M.; Teixido, M.; Giralt, E.; Ceña, V.; Posadas, I.; Martínez-Pinilla, E.; Villoslada, P.; Franco, R. (2014). Differential neuroprotective effects of 5'-deoxy-5'-methylthioadenosine. PLoS One, 9(3), p. e90671 . Institutional Repository . ISSN: 1932-6203

Pinna, A.; Bonaventura, J.; Farré, D.; Sánchez, M.; Simola, N.; Mallol, J.; Lluís, C.; Costa, G.; Baqi, Y.; Müller, C.E.; Cortés, A.; McCormick, P.; Canela, E.I.; Martínez-Pinilla, E.; Lanciego, J.L.; Casadó, V.; Armentero, M.T.; Franco R. (2014). L-DOPA disrupts adenosine A_2A-cannabinoid CB₁-dopamine D₂ receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: Biochemical and behavioral studies. Experimental Neurology, 253(March), pp. 180 - 191 . https://doi.org/10.1016/j.expneurol.2013.12.021 . ISSN: 0014-4886

Bonaventura, J.; Rico, A.J.; Moreno, E.; Sierra, S.; Sánchez, M.; Luquin, N.; Farré, D.; Müller, C.E.; Martínez, E.; Cortés, A.; Mallol, J.; Armentero, M.T.; Pinna, A.; Canela, E.I.; Lluís, C.; McCormick, P.J.; Lanciego, J.L.; Casadó, V.; Franco, R. (2014). L-DOPA-treatment in primates disrupts the expression of A_2A adenosine-CB₁ cannabinoid-D₂ dopamine receptor heteromers in the caudate nucleus. Neuropharmacology, 79, pp. 90 - 100 . https://doi.org/10.1016/j.neuropharm.2013.10.036 . ISSN: 0028-3908

Franco N; Franco R (2014). Understanding the Added Value of G-Protein-Coupled Receptor Heteromers. Scientifica, 2014(362937), pp. 1 - 7 . Institutional Repository . ISSN: 2090-908X

Cerri S; Levandis G; Ambrosi G; Montepeloso E; Antoninetti GF; Franco R; Lanciego JL; Baqi Y; Müller CE; Pinna A; Blandini F; Armentero MT (2014). Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease. Journal of Neuropathology and Experimental Neurology, 73(5), pp. 414 - 424 . https://doi.org/10.1097/NEN.0000000000000064 . ISSN: 0022-3069

Martínez-Muñoz, L.; Barroso, R.; Dyrhaug, S.Y.; Navarro, G.; Lucasa, P.S.; Soriano, S.; Vega, B.; Costas, C.; Muñoz-Fernández, M.A.; Santiago, C.; Rodríguez, J.M.; Franco, R.; Mellado, M. (2014). CCR5/CD4/CXCR4 oligomerization prevents HIV-1 gp120IIIB binding to the cell Q:4; 5; 6 surface. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 111(19), pp. 1960 - 1969 . https://doi.org/10.1073/pnas.1322887111 . ISSN: 0027-8424

George SR, Kern A, Smith RG, Franco R. (2014). Dopamine receptor heteromeric complexes and their emerging functions. Progress in Brain Research, 211, pp. 183 - 200 . https://doi.org/10.1016/B978-0-444-63425-2.00008-8 . ISSN: 0079-6123

Franco R, Cedazo-Minguez A. (2014). Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?. Frontiers in Pharmacology, 5, pp. 1 - 13 . Institutional Repository . ISSN: 1663-9812

Zamarbide, M.; Etayo-Labiano, I.; Ricobaraza, A.; Martínez-Pinilla, E.; Aymerich, M.S.; Lanciego, J.L.; Pérez-Mediavilla, A.; Franco, R. (2014). GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. Hippocampus, 24(7), pp. 733 - 739 . https://doi.org/10.1002/hipo.22263 . ISSN: 1050-9631

Brugarolas, M.; Navarro, G.; Martínez Pinilla, E.; Angelats, E.; Casadó, V.; Lanciego, J.L.; Franco, R. (2014). G-protein-coupled receptor heteromers as key players in the molecular architecture of the central nervous system. CNS Neuroscience & Therapeutics, 20(8), pp. 703 - 709 . https://doi.org/10.1111/cns.12277 . ISSN: 1755-5930

Gaja, V.; Gómez-Vallejo, V.; Puigivila, M.; Pérez-Campaña, C.; Martin, A.; García-Osta, A.; Calvo-Fernández, T.; Cuadrado-Tejedor, M.; Franco, R.; Llop, J. (2014). Synthesis and Evaluation of 13N-Labelled Azo Compounds for β-Amyloid Imaging in Mice. Molecular Imaging and Biology, 16(4), pp. 538 - 549 . https://doi.org/10.1007/s11307-013-0708-x . ISSN: 1536-1632

Martínez-Pinilla, E.; Reyes-Resina, I.; Oñatibia-Astibia, A.; Zamarbide, M.; Ricobaraza, A.; Navarro, G.; Moreno, E.; Dopeso-Reyes, I.G.; Sierra, S.; Rico, A.J.; Roda, E.; Lanciego, J.L.; Franco, R. (2014). CB1 and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum. Experimental Neurology, 261, pp. 44 - 52 . https://doi.org/10.1016/j.expneurol.2014.06.017 . ISSN: 0014-4886

Navarro G, Borroto-Escuela DO, Fuxe K, Franco R. (2014). Potential of caveolae in the therapy of cardiovascular and neurological diseases. Frontiers in Physiology, 5, pp. 1 - 8 . Institutional Repository . ISSN: 1664-042X

García-Barroso C, Ugarte A, Martínez M, Rico AJ, Lanciego JL, Franco R, Oyarzabal J, Cuadrado-Tejedor M, García-Osta A. (2014). Phosphodiesterase inhibition in cognitive decline. Journal of Alzheimer's Disease, 42, pp. S561 - S573 . https://doi.org/10.3233/JAD-141341 . ISSN: 1387-2877

Diana Fernández-Suárez; Marta Celorrio; Jose I Riezu-Boj; Ana Ugarte; Rodrigo Pacheco; Hugo González; Julen Oyarzabal; Cecilia J Hillard; Maria Soledad Aymerich, Rafael Franco; (2014). The monoacylglycerol lipase inhibitor JZL184 is neuroprotective and alters glial cell phenotype in the chronic MPTP mouse model. Neurobiology of Aging, 35(11), pp. 2603 - 2616 . https://doi.org/10.1016/j.neurobiolaging.2014.05.021 . ISSN: 0197-4580

Franco, Rafael; Cordomi, Arnau; Zelman-Femiak, Monika; Brugarolas, Marc; Moreno, Estefania; Cortes, Antoni; Casado, Vicent; Mallol, Josefa; Canela, Enric I.; Lluis, Carme; Pardo, Leonardo; Garcia-Saez, Ana J.; McCormick, Peter J.; Navarro, Gemma (2014). Allosteric communication between Gi and Gs in the adenosine A1-A(2A) receptor tetrameric complex. Purinergic Signalling, 10(4), pp. 738 - 738 . ISSN: 1573-9538

Navarro, Gemma; Cordom, Arnau; Zelman-Femiak, Monika; Brugarolas, Marc; Aguinaga, David; Medrano, Mireia; Moreno, Estefania; Cortes, Antoni; Casado, Vicent; Mallol, Josefa; Canela, Enric I.; Lluis, Carme; Pardo, Leonardo; Garcia-Saez, Ana J.; McCormick, Peter J.; Franco, Rafael (2014). Evidence for adenosine A(1)-A(2A) receptor heteromers in neurons and astrocytes. Purinergic Signalling, 10(4), pp. 738 - 738 . ISSN: 1573-9538

Franco, R. (2014). Enhancing cognition before clinical symptoms of dementia. Frontiers In Systems Neuroscience, 8, pp. 1 - 3 . Institutional Repository . ISSN: 1662-5137

Balenga NA, Martínez-Pinilla E, Kargl J, Schröder R, Peinhaupt M, Platzer W, Bálint Z, Zamarbide M, Dopeso-Reyes IG, Ricobaraza A, Pérez-Ortiz JM, Kostenis E, Waldhoer M, Heinemann A, Franco R. (2014). Heteromerization of GPR55 and cannabinoid CB2 receptors modulates signalling. British Journal of Pharmacology, 171(23), pp. 5387 - 5406 . https://doi.org/10.1111/bph.12850 . ISSN: 0007-1188

Franco, R; Navarro, G; Martínez-Pinilla, E; Moreno, E. (2014). Amyloid Beta Precursor Protein: Proper Credit for the Basic Biochemical Properties of the Most Studied Protein in the 21st Century. Journal of Neurology and Neurological Disorders, 1(1), pp. 1 - 6 . Institutional Repository . ISSN: 2454-4981

Martínez-Pinilla E.; Oñatibia-Astibia A.; Franco R. (2015). The relevance of theobromine for the beneficial effects of cocoa consumption. Frontiers in Pharmacology, 6, pp. 1 - 5 . Institutional Repository . ISSN: 1663-9812

Martínez-Pinilla, E; Rodríguez-Pérez, A.I.; Navarro, G.;Aguinaga, D; Moreno, E; Lanciego J.L.; Labandeira-García, J.L.; Franco, R. (2015). Dopamine D2 and angiotensin II type 1 receptors are co-expressed and form heteromers in rat striatum. Biochemical Pharmacology, 15(252), pp. 131 - 142 . https://doi.org/10.1016/j.bcp.2015.05.006 . ISSN: 0006-2952

Ugarte A; Gil-Bea F; García-Barroso C; Cedazo-Minguez A; Ramírez MJ; Franco R; García-Osta ; Oyarzabal J; Cuadrado-Tejedor M (2015). Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease. Neuropathology and Applied Neurobiology, 41(4), pp. 471 - 482 . https://doi.org/10.1111/nan.12203 . ISSN: 0305-1846

Aguinaga, D.; Navarro, G.; Cordomi, A.; Zelman-Femiak, M.; Brugarolas, M.; Moreno, E.; Cortes, A.; Casado, V.; Mallol, J.; Canela, E.; Lluis, C.; Pardo, L.; Garcia-Saez, A. J.; Franco, R. (2015). Adenosine A(1) and A(2A) receptor heterotetramers simultaneously bind to G(i) and G(s) protein. The FEBS Journal, 282, pp. 295 - 295 . ISSN: 1742-464X

Navarro Brugal, G.; Aguinaga, D.; Cortes, A.; Lluis, C.; Mallol, J.; Moreno, E.; Quiroz, C.; Franco, R.; Casado, V.; Canela, E. I.; Ferre, S. (2015). Orexin-CRF1-sigma-1 complexes as targets for cocaine. The FEBS Journal, 282, pp. 298 - 298 . ISSN: 1742-464X

Franco R; Fernández-Suárez D. (2015). Alternatively activated microglia and macrophages in the central nervous system. Progress in Neurobiology, 131, pp. 65 - 86 . https://doi.org/10.1016/j.pneurobio.2015.05.003 . ISSN: 0301-0082

Anandhan A; Rodriguez-Rocha H; Bohovych I; Griggs AM; Zavala-Flores L; Reyes-Reyes EM; Seravalli J; Stanciu LA; Lee J; Rochet JC; Khalimonchuk O; Franco R. (2015). Overexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways. Neurobiology of Disease, 81, pp. 76 - 92 . http://www.annexpublishers.com/articles/JNND/volume-1-issue-1/Amyloid-Beta-Precursor-Protein-Proper-Credit-for-the-Basic-Biochemical-Properties-of-the . ISSN: 0969-9961

Sierra S, Luquin N, Rico AJ, Gómez-Bautista V, Roda E, Dopeso-Reyes IG, Vázquez A, Martínez-Pinilla E, Labandeira-García JL, Franco R, Lanciego JL. (2015). Detection of cannabinoid receptors CB1 and CB2 within basal ganglia output neurons in macaques: changes following experimental parkinsonism. Brain Structure and Function, 220(5), pp. 2721 - 2738 . https://doi.org/10.1007/s00429-014-0823-8 . ISSN: 1863-2653

Cordomí A; Navarro G; Aymerich MS; Franco R. (2015). Structures for G-Protein-Coupled Receptor Tetramers in Complex with G Proteins. Trends in Biochemical Sciences, 40(10), pp. 548 - 551 . https://doi.org/10.1016/j.tibs.2015.07.007 . ISSN: 0968-0004

Franco R; Petrovic M. (2015). Suggesting a way to understand the actual potential of anti-alzheimer's disease drugs that show promise in transgenic mouse models. Frontiers In Neurology, pp. 206 - 206 . Institutional Repository . ISSN: 1664-2295

Cuadrado-Tejedor M; Garcia-Barroso C; Sanzhez-Arias J; Mederos S; Rabal O; Ugarte A; Franco R; Pascual-Lucas M; Segura V; Perea G; Oyarzabal J; Garcia-Osta A. (2015). Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer's disease. Clinical Epigenetics, 7(108) . Institutional Repository . ISSN: 1868-7075

Farré, D.; Muñoz, A.; Moreno, E.; Reyes-Resina, I.; Canet-Pons, J.; Dopeso-Reyes, I.G.; Rico, A.J.; Lluís, C.; Mallol, J.; Navarro, G.; Canela, E.I.; Cortés, A.; Labandeira-García, J.L.; Casadó, V.; Lanciego, J.L.; Franco, R. (2015). Stronger dopamine D₁ receptor-mediated neurotransmission in dyskinesia. Molecular Neurobiology, 52(3), pp. 1408 - 1420 . https://doi.org/10.1007/s12035-014-8936-x . ISSN: 0893-7648

Oñatibia-Astibia A; Martínez-Pinilla E; Franco R. (2016). The potential of methylxanthine-based therapies in pediatric respiratory tract diseases. Respiratory Medicine, 112, pp. 1 - 9 . https://doi.org/10.1016/j.rmed.2016.01.022 . ISSN: 0954-6111

Gómez-Vallejo V; Ugarte A; García-Barroso C; Cuadrado-Tejedor M; Szczupak B; Dopeso-Reyes IG; Lanciego JL; García-Osta A; Llop J; Oyarzabal J; Franco R. (2016). Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels. Journal of Neurochemistry, 136(2), pp. 403 - 415 . https://doi.org/10.1111/jnc.13454 . ISSN: 0022-3042

Rodrigues, R.J.; Almeida, T.; Díaz-Hernández, M.; Marques, J.M.; Franco, R.; Solsona, C.; Miras-Portugal, M.T.; Ciruela, F.; Cunha, R.A. (2016). Presynaptic P2X1-3 and α3-containing nicotinic receptors assemble into functionally interacting ion channels in the rat hippocampus. Neuropharmacology, 105, pp. 241 - 257 . https://doi.org/10.1016/j.neuropharm.2016.01.022 . ISSN: 0028-3908

Naval-Macabuhay I; Casanova V; Navarro G; García F; León A; Miralles L; Rovira C; Martinez-Navio JM; Gallart T; Mallol J; Gatell JM; Lluís C; McCormick PJ; Climent N; Franco R; (2016). Adenosine deaminase regulates Treg expression in autologous T cell-dendritic cell cocultures from patients infected with HIV-1. Journal of Leukocyte Biology, 99(2), pp. 349 - 359 . https://doi.org/10.1189/jlb.3A1214-580RR . ISSN: 0741-5400

Oliva, H.; Pacheco, R.; Martinez-Navio, J.M.; Rodríguez-García, M.; Naranjo-Gómez, M.; Climent, N.; Prado, C.; Gil, C.; Plana, M.; García, F.; Miró, J.M.; Franco, R.; Borras, F.E.; Navaratnam, N.; Gatell, J.M.; Gallart, T. (2016). Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation. Immunology and Cell Biology, 94(7), pp. 689 - 700 . https://doi.org/10.1038/icb.2016.28 . ISSN: 0818-9641

Franco, Rafael; Martinez-Pinilla, Eva; Lanciego, Jose L.; Navarro, Gemma (2016). Basic pharmacological and structural evidence for class a G-protein-coupled receptor heteromerization. Frontiers in Pharmacology, 7, p. 76 . Institutional Repository . ISSN: 1663-9812

Navarro, G; Cordomí, A; Zelman-Femiak, M; Brugarolas, M; Moreno, E; Aguinaga, D; Perez-Benito, L; Cortés, A; Casadó, V; Mallol, J; Canela, EI; Lluís, C; Pardo, L; García-Saez, AJ; McCormick, PJ; Franco, R (2016). Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with to Gi and Gs. BMC Biology, 14(26), pp. 1 - 10 . Institutional Repository . ISSN: 1741-7007

Aymerich MS; Rojo-Bustamante E; Molina C; Celorrio M; Sánchez-Arias JA; Franco R. (2016). Neuroprotective Effect of JZL184 in MPP+-Treated SH-SY5Y Cells Through CB2 Receptors. Molecular Neurobiology, 53(4), pp. 2312 - 2319 . https://doi.org/10.1007/s12035-015-9213-3 . ISSN: 0893-7648

Navarro, G.; Borroto-Escuela, DO.; Fuxe, K.; Franco, R. (2016). Purinergic signaling in Parkinson's disease. Relevance for treatment. Neuropharmacology, 104, pp. 161 - 168 . https://doi.org/10.1016/j.neuropharm.2015.07.024 . ISSN: 0028-3908

Morales, Paula; Gomez-Canas, Maria; Navarro, Gemma; Hurst, Dow P.; Carrillo-Salinas, Francisco J.; Lagartera, Laura; Pazos, Ruth; Goya, Pilar; Reggio, Patricia H.; Guaza, Carmen; Franco, Rafael; Fernandez-Ruiz, Javier; Jagerovic, Nadine (2016). Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis. Journal of Medicinal Chemistry, 59(14), pp. 6753 - 6771 . Institutional Repository . ISSN: 0022-2623

Medrano, M.; Navarro, G.; Aguinaga, D.; Mallol, J.; Franco, R. (2016). Evidence for human ghrelin GHS-R1a and orexin OX1 heteroreceptor complex formation in a heterologous system. The FEBS Journal, 283, pp. 172 - 172 . ISSN: 1742-464X

Perreault ML; Hasbi A; Shen MY; Fan T; Navarro G; Fletcher PJ; Franco R; Lanciego JL; George SR (2016). Disruption of a dopamine receptor complex amplifies the actions of cocaine. European Neuropsychopharmacology, 26(9), pp. 1366 - 1377 . https://doi.org/10.1016/j.euroneuro.2016.07.008 . ISSN: 0924-977X

Rico AJ; Dopeso-Reyes IG; Martínez-Pinilla E; Sucunza D; Pignataro D; Roda E; Marín-Ramos D; Labandeira-García JL; George SR; Franco R; Lanciego JL (2016). Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain Structure and Function, 222(4), pp. 1767 - 1784 . https://doi.org/10.1007/s00429-016-1306-x . ISSN: 1863-2653

Navarro, Gemma; Morales, Paula; Rodriguez-Cueto, Carmen; Fernandez-Ruiz, Javier; Jagerovic, Nadine; Franco, Rafael (2016). Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders. Frontiers in Neuroscience, 10 . Institutional Repository . ISSN: 1662-4548

Martinez-Pinilla E, Rabal O, Reyes-Resina I, Zamarbide M, Navarro G, Sanchez-Arias JA, de Miguel I, Lanciego JL, Oyarzabal J, Franco R (2016). Two affinity sites of cannabinoid CB2 receptor identified by a novel homogeneous binding assay. Journal of Pharmacology and Experimental Therapeutics, 358(3), pp. 580 - 587 . https://doi.org/10.1124/jpet.116.234948 . ISSN: 0022-3565

Celorrio M, Fernández-Suárez D, Rojo-Bustamante E, Echeverry-Alzate V, Ramírez MJ, Hillard CJ, López-Moreno JA, Maldonado R, Oyarzábal J, Franco* and Aymerich MS* (2016). Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease. Brain, Behavior, and Immunity, 57, pp. 94 - 105 . https://doi.org/10.1016/j.bbi.2016.06.010 . ISSN: 0889-1591

Franco, Rafael; Casado-Anguera, Veronica; Munoz, Ana; Petrovic, Milos; Navarro, Gemma; Moreno, Estefania; Luis Lanciego, Jose; Luis Labandeira-Garcia, Jose; Cortes, Antoni; Casado, Vicent (2016). Hints on the Lateralization of Dopamine Binding to D-1 Receptors in Rat Striatum. Molecular Neurobiology, 53(8), pp. 5436 - 5445 . https://doi.org/10.1007/s12035-015-9468-8 . ISSN: 0893-7648

Valenzuela R, Costa-Besada MA, Iglesias-Gonzalez J, Perez-Costas E, Villar-Cheda B, Garrido-Gil P, Melendez-Ferro M, Soto-Otero R, Lanciego JL, Henrion D, Franco R, Labandeira-Garcia JL. (2016). Mitochondrial angiotensin receptors in dopaminergic neurons. Role in cell protection and aging-related vulnerability to neurodegeneration. Cell Death and Disease, 7(10 (e2427), pp. 1 - 10 . https://doi.org/10.1038/cddis.2016.327 . ISSN: 2041-4889

Borroto-Escuela DO, Wydra K, Pintsuk J, Narvaez M, Corrales F, Zaniewska M, Agnati LF, Franco R, Tanganelli S, Ferraro L, Filip M, Fuxe K. (2016). Understanding the functional plasticity in neural networks of the basal ganglia in cocaine use disorder: a role for allosteric receptor-receptor interactions in A2A-D2 heteroreceptor complexes. Neural Plasticity, 2016(4827268), pp. 1 - 12 . Institutional Repository . ISSN: 2090-5904

Elgueta D, Aymerich MS, Contreras F, Montoya A, Celorrio M, Rojo-Bustamante E, Riquelme E, González H, Vásquez M, Franco R, Pacheco R. (2017). Pharmacologic antagonism of dopamine receptor D3 attenuates neurodegeneration and motor impairment in a mouse model of Parkinson's disease. Neuropharmacology, 113(A), pp. 110 - 123 . https://doi.org/10.1016/j.neuropharm.2016.09.028 . ISSN: 0028-3908

Franco, R; Martínez-Pinilla, E; Navarro, G; Zamarbide, M (2017). Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease. Progress in Neurobiology, 149, pp. 21 - 38 . https://doi.org/10.1016/j.pneurobio.2017.01.004 . ISSN: 0301-0082

Oñatibia-Astibia A, Franco R*, Martínez-Pinilla E* . (2017). Health benefits of methylxanthines in neurodegenerative diseases. Molecular Nutrition & Food Research, 61 . https://doi.org/10.1002/mnfr.201600670 . ISSN: 1613-4125

Cuadrado-Tejedor M; Garcia-Barroso C; Sánchez-Arias JA; Rabal O; Pérez-González M; Mederos S; Ugarte A; Franco R; Segura V; Perea G; Oyarzabal J; Garcia-Osta A (2017). A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice. Neuropsychopharmacology, 42(2), pp. 524 - 539 . https://doi.org/10.1038/npp.2016.163 . ISSN: 0893-133X

Navarro, G; Martínez-Pinilla, E; Sánchez-Melgar, A; Ortiz, R; Noé N; Martín, M; Ciudad C; Franco, R (2017). A genomics approach identifies selective effects of trans-resveratrol in cerebral cortex neuron and glia gene expression. PLoS One, 12(4), p. e0176067 . Institutional Repository . ISSN: 1932-6203

Angelats, E; Martínez-Pinilla, E; Oñatibia-Astibia, A; Franco, N; Navarro, G; Franco, R (2017). Natural Selection of caffeine consumtion. Frontiers for Young Minds . ISSN: 2296-6846

Rafael Franco; Eva Martínez-Pinilla (2017). Chemical rules on the assessment of antioxidant potential in food and food additives aimed at reducing oxidative stress and neurodegeneration. Food Chemistry, 235, pp. 318 - 323 . https://doi.org/10.1016/j.foodchem.2017.05.040 . ISSN: 0308-8146

Edgar Angelats; Eva Martínez-Pinilla; Ainhoa Oñatibia-Astibia; Nuria Franco; Gemma Navarro; Rafael Franco (2017). Humans and caffeine - a very long relationship. Frontiers for Young Minds . https://doi.org/10.3389/frym.2017.00027 . ISSN: 2296-6846

Medrano, M; Aguinaga, D; Reyes-Resina, I; Canela, EI; Mallol, J; Navarro, G*; Franco, R* (2017). Orexin A/hypocretin modulates leptin receptor-mediated signaling by allosteric modulations mediated by the ghrelin GHS-R₁A receptor in hypothalamic neurons. Molecular Neurobiology . https://doi.org/10.1007/s12035-017-0670-8 . ISSN: 0893-7648

Rodríguez-Ruiz, M.; Moreno, E.; Moreno-Delgado, D.; Navarro, G.; Mallol, J.; Cortés, A.; Lluís, C.; Canela, E,I; Casadó, V.; McCormick, P.J.; Franco, R. (2017). Heteroreceptor complexes formed by dopamine D₁, histamine H₃, and N-methyl-D-aspartate glutamate receptors as targets to prevent neuronal death in Alzheimer's disease. Molecular Neurobiology, 54(6), pp. 4537 - 4550 . https://doi.org/10.1007/s12035-016-9995-y . ISSN: 0893-7648

Celorrio M; Rojo-Bustamante E; Fernández-Suárez D; Sáez E; Estella-Hermoso de Mendoza A; Müller CE; Ramírez MJ; Oyarzábal J; Franco R; Aymerich MS. (2017). GPR55: A therapeutic target for Parkinson's disease?. Neuropharmacology, 125, pp. 319 - 332 . https://doi.org/10.1016/j.neuropharm.2017.08.017 . ISSN: 0028-3908

Alkozi, H.A.; Franco, R.; Pintor, J.J. (2017). Epigenetics in the eye: an overview of the most relevant ocular diseases. Frontiers In Genetics, 8, p. 144 . Institutional Repository . ISSN: 1664-8021

Martinez-Pinilla, Eva; Varani, Katia; Reyes-Resina, Irene; Angelats, Edgar; Vincenzi, Fabrizio; Ferreiro-Vera, Carlos; Oyarzabal, Julen; Canela, Enric I.; Lanciego, Jose L.; Nadal, Xavier; Navarro, Gemma; Borea, Pier Andrea; Franco, Rafael (2017). Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors. Frontiers in Pharmacology, 8 . Institutional Repository . ISSN: 1663-9812

Navarro, G; Franco, N; Martínez-Pinilla, E; Franco, R (2017). The epigenetic Cytocrin pathway to the nucleus. Epigenetic factors, epigenetic mediators, and epigenetic traits. A biochemist perspective. Frontiers In Genetics, 8:179, pp. 1 - 7 . Institutional Repository . ISSN: 1664-8021

Navarro, Gemma; Borroto-Escuela, Dasiel; Angelats, Edgar; Etayo, Inigo; Reyes-Resina, Irene; Pulido-Salgado, Marta; Rodriguez-Perez, Ana I.; Canela, Enric I.; Saura, Josep; Luis Lanciego, Jose; Luis Labandeira-Garcia, Jose; Saura, Carlos A.; Fuxe, Kjell; Franco, Rafael (2018). Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia. Brain, Behavior, and Immunity, 67, pp. 139 - 151 . https://doi.org/10.1016/j.bbi.2017.08.015 . ISSN: 0889-1591

Irene Reyes-Resina; David Aguinaga; José L. Labandeira García; José L. Lanciego; Gemma Navarro; Rafael Franco (2018). Usefulness of identifying G-protein-coupled receptor dimers for diagnosis and therapy of neurodegenerative diseases and of gliomas. Histology and Histopathology, 16, p. 11963 . Institutional Repository . ISSN: 0213-3911

Dasiel Oscar Borroto-Escuela; Sonja Hinz; Gemma Navarro; Rafael Franco; Christa Elisabeth Müller; Kjell Fuxe (2018). Understanding the role of adenosine A2AR heteroreceptor complexes in neurodegeneration and neuroinflammation. Frontiers in Neuroscience, 12, p. 43 . Institutional Repository . ISSN: 1662-4548

Hinz, S.; Navarro, G.; Borroto-Escuela, D.; Seibt, B.J.; Ammon, Y.C.; de Filippo, E.; Danish, A.; Lacher, s.K.; Cervinkova, B.; Rafehi, M.; Fuxe, K.; Schiedel, A.C.; Franco, R.; Muller, C.E. (2018). Adenosine A2A receptor ligand recognition and signaling is blocked by A2B receptors. Oncotarget, 9(17), pp. 13593 - 13611 . Institutional Repository . ISSN: 1949-2553

Aguinaga, D.; Medrano, M.; Vega-Quiroga, I.; Gysling, K.; Canela, E.I.; Navarro, G.; Franco, R. (2018). Cocaine effects on dopaminergic transmission depend on a balance between Sigma-1 and Sigma-2 receptor expression. Frontiers In Molecular Neuroscience, 11, p. 17 . Institutional Repository . ISSN: 1662-5099

Navarro G; Cordomí A; Brugarolas M; Moreno E; Aguinaga D; Pérez-Benito L; Ferré S; Cortés A; Casadó V; Mallol J; Canela EI; Lluís C; Pardo L; McCormick PJ; Franco R (2018). Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain. BMC Biology, 16(1), p. 24 . Institutional Repository . ISSN: 1741-7007

Franco, R.; Navarro, G. (2018). Adenosine A2A receptor antagonists in neurodegenerative diseases: Huge potential and huge challenges. Frontiers In Psychiatry, 9(68) . Institutional Repository . ISSN: 1664-0640

Navarro, G.; Martínez -Pinilla, E.; Ortiz, R.; Noé, V.; Ciudad, C.J. and Franco, R. (2018). Resveratrol and Related Stilbenoids, Nutraceutical/Dietary Complements with Health-Promoting Actions: Industrial Production, Safety, and the Search for Mode of Action. Comprehensive Reviews in Food Science and Food Safety, 8(63), pp. 106693 - 106706 . https://doi.org/10.1111/1541-4337.12359 . ISSN: 1541-4337

Zamarbide M; Gil-Bea FJ; Bannenberg P; Martínez-Pinilla E; Sandoval J, Franco R; Pérez-Mediavilla A. (2018). Maternal imprinting on cognition markers of wild type and transgenic Alzheimer's disease model mice. Scientific Reports, 8(6434), pp. 1 - 13 . Institutional Repository . ISSN: 2045-2322

Reyes-Resina, I.; Navarro, G.; Aguinaga, D.; Canela, E.I.; Schoeder, C.T.; Zaluski, M.; Kiec-Kononowicz, K.; Saura, C.A.; Müller, C.E.; Franco, R. (2018). Molecular and functional interaction between GPR18 and cannabinoid CB₂ G-protein-coupled receptors. Relevance in neurodegenerative diseases. Biochemical Pharmacology . Institutional Repository . ISSN: 0006-2952

Aguinaga, D.; Medrano, M.; Cordomí, A.; Jiménez-Rosés, M.; Angelats, E.; Casanovas, M.; Vega-Quiroga, I.; Canela, E.I.; Petrovic, M.; Gysling, K.; Pardo, L.; Franco, R.; Navarro, G. (2018). Cocaine blocks effects of hunger hormone, ghrelin, via interaction with neuronal sigma-1 receptors. Molecular Neurobiology, 200, pp. 1 - 10 . Institutional Repository . ISSN: 0893-7648

Navarro, G.; Varani, K.; Reyes-Resina, I.; Sánchez de Medina, V.; Rivas-Santisteban, R.; Sánchez-Carnerero Callado, C.; Vincenzi, F.; Casano, S.; Ferreiro-Vera, C., Canela, E. I.; Borea Pier, A.; Nadal, X.; Franco, R. (2018). Cannabigerol action at cannabinoid CB₁ and CB₂ receptors and at CB₁-CB₂ heteroreceptor complexes. Frontiers in Pharmacology, 9, p. 632 . Institutional Repository . ISSN: 1663-9812

Franco, R.; Sánchez-Arias, J.A.; Navarro, G.; Lanciego, J.L. (2018). Glucocerebrosidase mutations and synucleinopathies. Potential role of sterylglucosides and relevance of studying both GBA1 and GBA2 genes. Frontiers In Neuroanatomy, 12(52), pp. 1 - 8 . Institutional Repository . ISSN: 1662-5129

Navarro, G; Aguinaga D; Reyes I; Del Rio JA; Ávila J; Saura C & R. Franco (2018). Interaction between n-methyl aspartate (NMDA) glutamate receptors and calcium sensors in neurons: Alterations and calcium-sensor modulation in the APP-PS1 model of AD. Alzheimer's & Dementia, 14(7), p. 371 . https://doi.org/10.1016/j.jalz.2018.06.247 . ISSN: 1552-5260

Borroto-Escuela, D.O.; Perez De La Mora, M.; Manger, P.; Narváez, M.; Beggiato, S.; Crespo-Ramírez, M.; Navarro, G.; Wydra, K.; Díaz-Cabiale, Z.; Rivera, A.; Ferraro, L.; Tanganelli, S.; Filip, M.; Franco, R.; Fuxe, K. (2018). Brain dopamine transmission in health and Parkinson's disease: modulation of synaptic transmission and plasticity through volume transmission and dopamine heteroreceptors. Frontiers In Synaptic Neuroscience, 10(20), pp. 1 - 24 . Institutional Repository . ISSN: 1663-3563

María S. García-Gutiérrez; Francisco Navarrete; Gemma Navarro; Irene Reyes-Resina; Rafael Franco; Jose Luis Lanciego; Salvador Giner; Jorge Manzanares (2018). Alterations of cannabinoid CB2 and GPR55 receptors gene and protein expression in the dorsolateral prefrontal cortex of suicide victims. Neurotherapeutics, 15(3), pp. 796 - 806 . https://doi.org/10.1007/s13311-018-0610-y . ISSN: 1933-7213

Angelats, E.; Requesens, M.; Aguinaga, D.; Kreutz, M.R.; Franco, R.; Navarro, G. (2018). Neuronal calcium and cAMP cross-talk mediated by cannabinoid CB1 receptor and EF-hand calcium sensor interactions. Frontiers In Cell And Developmental Biology, 6(67), pp. 1 - 9 . Institutional Repository . ISSN: 2296-634X

Franco, R.; Aguinaga, D.; Reyes, I.; Canela, E.I.; Lillo, J.; Tarutani, A.; Hasegawa, M.; del Ser-Badia, A.; del Rio, J.A.; Kreutz, M.R.; Saura, C.A.; and Navarro, G. (2018). N-methyl-D-aspartate receptor link to the MAP kinase pathway in cortical and hippocampal neurons and microglia is dependent on calcium sensors and is blocked by α-synuclein, tau, and phospho-tau in non-transgenic and transgenic APP_Sw,Ind mice. Frontiers In Molecular Neuroscience, 11(273) . Institutional Repository . ISSN: 1662-5099

Navarro G; Reyes-Resina I; Rivas-Santisteban R; Sánchez de Medina V; Morales P; Casano S; Ferreiro-Vera C; Lillo A; Aguinaga D; Jagerovic N; Nadal X; Franco R. (2018). Cannabidiol skews biased agonism at cannabinoid CB₁ and CB₂ receptors with smaller effect in CB₁-CB₂ heteroreceptor complexes. Biochemical Pharmacology, 157, pp. 148 - 158 . https://doi.org/10.1016/j.bcp.2018.08.046 . ISSN: 0006-2952

Navarro G; Medrano M; Aguinaga D; Vega-Quiroga I; Lillo A; Jiménez J; Casanovas M; Canela EI; Mallol J; Gysling K; Franco R. (2018). Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex. Neuropharmacology, 152, pp. 102 - 111 . Institutional Repository . ISSN: 0028-3908

Reyes-Resina, Irene; Samadi, Abdelouahid; Navarro, Gemma; Saadeh, Haythem A.; Khasawneh, Mohammad A.; Mestres, Jordi; Marco-Contelles, Jose; Franco, Rafael (2018). Identification of a Tool Compound to Study the Mechanisms of Functional Selectivity between D-2 and D-3 Dopamine Receptors. ACS Omega , 3(12), pp. 17368 - 17375 . Institutional Repository . ISSN: 2470-1343

Franco, Rafael; Aguinaga, David; Jiménez, Jasmina; Lillo, Jaume; Martínez-Pinilla, Eva; Navarro, Gemma (2018). Biased receptor functionality versus biased agonism in G-protein-coupled receptors. Biomolecular concepts, 9(1), pp. 143 - 154 . Institutional Repository . ISSN: 1868-503X

Franco, R.; Navarro, G.; Martínez-Pinilla, E. (2019). Antioxidant defense mechanisms in erythrocytes and in the central nervous system. Antioxidants, 2(8), p. 46 . https://doi.org/10.3390/antiox8020046 . ISSN: 2076-3921

Franco, Rafael; Martinez-Pinilla, Eva; Navarro, Gemma (2019). Why have transgenic rodent models failed to successfully mimic Alzheimer's disease. How can we develop effective drugs without them?. Expert Opinion on Drug Discovery, 14(4), pp. 327 - 330 . https://doi.org/10.1080/17460441.2019.1581169 . ISSN: 1746-0441

Franco, Rafael; Villa, Maria; Morales, Paula; Reyes-Resina, Irene; Gutierrez-Rodriguez, Ana; Jimenez, Jasmina; Jagerovic, Nadine; Martinez-Orgado, Jose; Navarro, Gemma (2019). Increased expression of cannabinoid CB2 and serotonin 5-HT1A heteroreceptor complexes in a model of newborn hypoxic-ischemic brain damage. Neuropharmacology, 152, pp. 58 - 66 . https://doi.org/10.1016/j.neuropharm.2019.02.004 . ISSN: 0028-3908

Franco, R.; Navarro, G.; Martínez-Pinilla, E. (2019). Lessons on Differential Neuronal-Death-Vulnerability from Familial Cases of Parkinson's and Alzheimer's Diseases. International Journal of Molecular Sciences, 20(13) . Institutional Repository . ISSN: 1661-6596

Martinez-Pinilla, Eva; Aguinaga, David; Navarro, Gemma; Rico, Alberto J.; Oyarzabal, Julen; Sanchez-Arias, Juan A.; Luis Lanciego, Jose; Franco, Rafael (2019). Targeting CB1 and GPR55 Endocannabinoid Receptors as a Potential Neuroprotective Approach for Parkinson's Disease. Molecular Neurobiology, 56(8), pp. 5900 - 5910 . https://doi.org/10.1007/s12035-019-1495-4 . ISSN: 0893-7648

Franco, R.; Reis-Resina, I.; Aguinaga, D.; Lillo, A.; Jiménez, J.; Raïch I.; Borroto-Escola, D. O.; Ferreiro-Vera, C.; Canela, E.I.; Sánchez de Medina, V.; del Ser-Badia, A.; Fuxe, K.; Saura, C.A.; Navarro G. (2019). Potentiation of cannabinoid signaling in microglia by adenosine A_2A receptor antagonists. Glia, 67(12), pp. 2410 - 2423 . https://doi.org/10.1002/glia.23694 . ISSN: 0894-1491

Franco R, Navarro G, Martínez-Pinilla E. (2019). Hormetic and Mitochondria-Related Mechanisms of Antioxidant Action of Phytochemicals. Antioxidants, 8(9 pii: E373.), pp. 1 - 11 . https://doi.org/10.3390/antiox8090373 . ISSN: 2076-3921

Aguinaga, A.; Casanovas, M.; Rivas-Santisteban, R.; Reyes-Resina, I.; Navarro, G.; Franco, R. (2019). The sigma-1 receptor as key common factor in cocaine and food seeking behaviors. Journal of Molecular Endocrinology, 63(4), pp. 81 - 92 . Institutional Repository . ISSN: 0952-5041

Alkozi, HA.; Navarro, G.; Franco, R.; Pintor, J. (2019). Melatonin and the control of intraocular pressure. Progress in Retinal and Eye Research . https://doi.org/10.1016/j.preteyeres.2019.100798 . ISSN: 1350-9462

Reyes-Resina I, Jiménez J, Navarro N, Franco R (2019). Identification of Heteroreceptors Complexes and Signal Transduction Events Using Bioluminescence Resonance Energy Transfer (BRET). Bio-protocol, 9(19 e3385), pp. 1 - 16 . https://doi.org/10.21769/BioProtoc.3385 . ISSN: 2331-8325

Gallo M, Navarro G, Andreu D*, Franco R*, (2019). A2A Receptor Homodimer-Disrupting Sequence Efficiently Delivered by a Protease-Resistant, Cyclic CPP Vector. International Journal of Molecular Sciences, 20(19 pii: E4937. ), pp. 1 - 11 . Institutional Repository . ISSN: 1661-6596

Franco R, Navarro G, Martínez-Pinilla E. (2019). Antioxidants versus Food Antioxidant Additives and Food Preservatives. Antioxidants, 8(11 pii: E542. ), pp. 1 - 11 . Institutional Repository . ISSN: 2076-3921

Rivas-Santisteban, R.; Reyes-Resina, I.; Raïch, I.; Pintor, J.;, Alkozi, H.A.; Navarro, G.; Franco, R. (2019). Specificity and nanomolar potency of melatonin on G-protein coupled melatonin MT1 and MT2 receptors expressed in HEK-293T human embryo kidney cells. Melatonin Research, 2(4) . Institutional Repository . ISSN: 2641-0281

Rodriguez-Perez, A.I.; Garrido-Gil, P.; Pedrosa, M.A.; Garcia-Garrote, M.; Valenzuela, R.; Navarro, G.; Franco, R.; Labandeira-Garcia, J.L. (2019). Angiotensin type 2 receptors: Role in aging and neuroinflammation in the substantia nigra. Brain, Behavior, and Immunity, 56, pp. 1 - 10 . https://doi.org/10.1016/j.bbi.2019.12.011 . ISSN: 0889-1591

Alkozi HA; Navarro G; Aguinaga D; Reyes-Resina I; Sanchez-Naves J; Pérez de Lara MJ; Pintor J*; Franco R* (2020). Adrenergic-melatonin receptor complexes control ion homeostasis and intraocular pressure and their disruption contributes to hypertensive glaucoma. British Journal of Pharmacology, 45, pp. 1 - 15 . https://doi.org/10.1111/bph.14971 . ISSN: 0007-1188

Reyes-Resina I; Awad Alkozi H; Del Ser-Badia A; Sánchez-Naves J; Lillo J; Jiménez J; Pintor J; Navarro G; Franco R. (2020). Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension. Cells, 9(152) . Institutional Repository . ISSN: 2073-4409

De Filippo, Elisabetta; Hinz, Sonja; Pellizzari, Veronica; Deganutti, Giuseppe; El-Tayeb, Ali; Navarro, Gemma; Franco, Rafael; Moro, Stefano; Schiedel, Anke C.; Mueller, Christa E. (2020). A(2A) and A(2B) adenosine receptors: The extracellular loop 2 determines high (A(2A)) or low affinity (A(2B)) for adenosine. Biochemical Pharmacology, 172 . https://doi.org/10.1016/j.bcp.2019.113718 . ISSN: 0006-2952

Rivas-Santisteban, R.;Rodriguez-Perez, A.;Reyes-Resina, I.; Labandeira-García, J.L.; Navarro,G.*; Franco,R. (2020). Angiotensin AT1 and AT2 receptors heteromer expression in microglia correlates with Parkinson's disease progression in the hemilesioned rat model of the disease. Cellular Physiology and Biochemistry . Institutional Repository . ISSN: 1015-8987

Garcia-Recio, A.; Navarro, G.; Franco, R.; Olivella, M.; Guixà-González,R.; Cordomí, A. (2020). DIMERBOW: exploring possible GPCR dimer interfaces. Bioinformatics . ISSN: 1367-4803

Navarro, G.; Rivas-Santisteban, R.; Reyes-Resina, I.; Lillo, A.; Lillo, J.; Cano, JJ.; and Franco, R.; (2020). Trends in pharmaceutical and food sciences Chapter 1.Different Techniques to Detect G Protein Coupled Receptor Heteromers. Journal of Pharmaceutical Sciences . ISSN: 0022-3549

Rafael Franco, Rafael Rivas-Santisteban, Irene Reyes-Resina, Gemma Navarro, Eva Martínez-Pinilla (2020). Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson's Disease. Frontiers in Aging Neuroscience, 12(12) . Institutional Repository . ISSN: 1663-4365

Franco, R.; Rivas-Santisteban, R.; Casanovas, M.; Lillo, A.; Saura, C.A.; Navarro, G. (2020). Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer's Disease. Cells, 9(5), p. 1075 . Institutional Repository . ISSN: 2073-4409

Gnad, T; Navarro, G.; Lahesmaa, M.; Reverte-Salisa, L.; Copperi, F.; Cordomi, A.; Naumann, J.; Hochhäuser, A.; Haufs-Brusberg, S.; Wenzel, D.; Suhr, F; Jespersen, H.J.; Scheele, C.; Tsvilovskyy, V.; Brinkmann C.; Rittweger, J.; Dani C., C; Kranz, M.; Deuther-Conrad, W.; Eltzschig, H.K.; Niemi, T.; Taittonen, M.; Brust, P.; Nuutila, P.; Pardo L.; Fleischmann B.K.; Blüher M.; Franco, R.; Bloch W.; Virtanen K.A.; Pfeifer, A. (2020). Adenosine/A2B receptor signaling ameliorates the effects of ageing and counteracts obesity. Cell Metabolism, 32(1), pp. 56 - 70 . Institutional Repository . ISSN: 1550-4131

Martinez-Pinilla, Eva; Rico, Alberto J.; Rivas-Santisteban, Rafael; Lillo, Jaume; Roda, Elvira; Navarro, Gemma; Franco, Rafael; Luis Lanciego, Jose (2020). Expression of cannabinoid CB1R-GPR55 heteromers in neuronal subtypes of theMacaca fascicularisstriatum. Annals of the New York Academy of Sciences, 1475(1), pp. 34 - 42 . https://doi.org/10.1111/nyas.14413 . ISSN: 0077-8923

Lillo, A.; Martínez-Pinilla, E.; Reyes-Resina, I.; Navarro, G.; Franco, R. (2020). Adenosine A_2A and A₃ Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling. International Journal of Molecular Sciences, 21(14), p. 5070 . Institutional Repository . ISSN: 1661-6596

Martinez-Pinilla, Eva; Rico, Alberto J.; Rivas-Santisteban, Rafael; Lillo, Jaume; Roda, Elvira; Navarro, Gemma; Luis Lanciego, Jose; Franco, Rafael (2020). Expression of GPR55 and either cannabinoid CB(1)or CB(2)heteroreceptor complexes in the caudate, putamen, and accumbens nuclei of control, parkinsonian, and dyskinetic non-human primates. Brain Structure and Function, 225(7), pp. 2153 - 2164 . https://doi.org/10.1007/s00429-020-02116-4 . ISSN: 1863-2653

Franco, R; Rivas-Santisteban, R; Reyes-Resina, I; Casanovas, M; Pérez-Olives, C; Ferreiro-Vera, C; Navarro, G; Sánchez de Medina, V; Nadal, X. (2020). Pharmacological potential of varinic-, minor-, and acidic phytocannabinoids. Pharmacological Research, 158(104801), pp. 1 - 15 . https://doi.org/10.1016/j.phrs.2020.104801 . ISSN: 1043-6618

Rafael Rivas-Santisteban; Ana I. Rodriguez-Perez; Ana Muñoz; Irene Reyes-Resina; José Luis Labandeira-García; Gemma Navarro; Rafael Franco (2020). Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson's disease that increases with levodopa-induced dyskinesia. Journal of Neuroinflammation . Institutional Repository . ISSN: 1742-2094

Franco, Rafael; Rivas-Santisteban, Rafael; Serrano-Marin, Joan; Rodriguez-Perez, Ana, I; Labandeira-Garcia, Jose L.; Navarro, Gemma (2020). SARS-CoV-2 as a Factor to Disbalance the Renin-Angiotensin System: A Suspect in the Case of Exacerbated IL-6 Production. Journal of Immunology, 205(5), pp. 1198 - 1206 . https://doi.org/10.4049/jimmunol.2000642 . ISSN: 0022-1767

Navarro, G.; Varanic, K.; Lillo, A.; Vincenzi, F.; Rivas-Santisteban, R.; Raïch, I.;Reyes-Resina, I.;Ferreiro-Vera, C.;Andrea Borea, P.; Sánchez de Medina, V.; Nadal, X.;Franco, R. (2020). Pharmacological data of cannabidiol- and cannabigerol-type phytocannabinoids acting on cannabinoid CB₁, CB₂ and CB₁/CB₂ heteromer receptors. Pharmacological Research, 159:104940, pp. 1 - 12 . https://doi.org/10.1016/j.phrs.2020.104940 . ISSN: 1043-6618

Gemma Navarro; Angel Gonzalez; Stefano Campanacci; Rafael Rivas-Santisteban; Irene Reyes-Resina; Nil Casajuana-Martin; Arnau Cordomí; Leonardo Pardo; Rafael Franco (2020). Experimental and computational analysis of biased agonism on full-length and a C-terminally truncated adenosine A2A receptor. Computational And Structural Biotechnology Journal, 18, pp. 2723 - 2732 . Institutional Repository . ISSN: 2001-0370

Martínez-Pinilla, E.; Rico, A.;Rivas-Santisteban, R.; Lillo, J.; Roda, E.; Navarro, G.; Lanciego, J.L.; Franco, R. (2020). Expression of GPR55 and either cannabinoid CB1 or CB2 heteroreceptor complexes in the caudate, putamen and accumbens nuclei of control, parkinsonian and dyskinetic non-human primates. Brain Structure and Function . ISSN: 1863-2653

Serrano-Marin, Joan; Reyes-Resina, Irene; Martinez-Pinilla, Eva; Navarro, Gemma; Franco, Rafael (2020). Natural Compounds as Guides for the Discovery of Drugs Targeting G-Protein-Coupled Receptors. Molecules, 25(21), pp. 1 - 14 . Institutional Repository . ISSN: 1420-3049

Morales, Paula; Navarro, Gemma; Gomez-Autet, Marc; Redondo, Laura; Fernandez-Ruiz, Javier; Perez-Benito, Laura; Cordomi, Arnau; Pardo, Leonardo; Franco, Rafael; Jagerovic, Nadine (2020). Discovery of Homobivalent Bitopic Ligands of the Cannabinoid CB2 Receptor**. Chemistry-A European Journal, 26(68), pp. 15839 - 15842 . Institutional Repository . ISSN: 0947-6539

Franco, Rafael; Lillo, Alejandro; Rivas-Santisteban, Rafael; Rodríguez-Pérez, Ana I. ; Reyes-Resina, Irene; Labandeira-García, José L.; Navarro, Gemma (2020). Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue. International Journal of Molecular Sciences, 21(24)(9602) . Institutional Repository . ISSN: 1661-6596

Catalina Pérez-Olives; Rafael Rivas-Santisteban; Jaume Lillo; Gemma Navarro; Rafael Franco (2020). Recent Advances in the Potential of Cannabinoids for Neuroprotection in Alzheimer's, Parkinson's, and Huntington's Diseases. Advances in Experimental Medicine and Biology, 1264, pp. 81 - 92 . https://doi.org/10.1007/978-3-030-57369-0_6 . ISSN: 0065-2598

Casanovas, M.; Jiménez-Rosés, M.; Cordomí, A.; Lillo, A.; Vega-Quiroga, I.; Izquierdo, J.; Medrano, M.; Gysling, K.; Pardo, L.; Navarro, G.; Franco, R. (2021). Discovery of a macromolecular complex mediating the hunger suppressive actions of cocaine: Structural and functional properties. Addiction Biology . https://doi.org/10.1111/adb.13017 . ISSN: 1355-6215

Franco, R. (2021). Science plus technology to address challenges in determining the efficacy of neuroprotective/neurorestorative therapies. Explorations of Neuroprotective Therapy, 1, pp. 1 - 6 . https://doi.org/10.37349/ent.2021.00001 . ISSN: 2769-6510

Miralpeix, C.; Reguera, A.C.; Fosch, A.; Casas, M.; Lillo, J.; Navarro, G.; Franco, R.; Casas, J.; Alexander, S.P.H; Casals N.; Rodríguez-Rodríguez R. (2021). Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status. British Journal of Pharmacology, 178(7), pp. 1507 - 1523 . https://doi.org/10.1111/bph.15377 . ISSN: 0007-1188

Rafael Rivas-Santisteban; Jaume Lillo; Ana Muñoz; Ana I. Rodríguez-Pérez,;José Luís Labandeira-García; Gemma Navarro; Rafael Franco (2021). Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia. Neurotherapeutics, 18(2), pp. 998 - 1016 . https://doi.org/10.1007/s13311-020-00986-4 . ISSN: 1933-7213

Franco, R.; Reyes-Resina, I.; Navarro, G. (2021). Dopamine in health and disease: much more than a neurotransmitter. Biomedicines, 9(2), p. 109 . Institutional Repository . ISSN: 2227-9059

Rafael Franco; Rafael R. Santisteban; Irene Reyes-Resina; Gemma Navarro (2021). The old and new visions of biased agonism through the prism of adenosine receptor signaling and receptor/receptor and receptor/protein interactions. Frontiers in Pharmacology, 11 . Institutional Repository . ISSN: 1663-9812

Franco, R (2021). Geoffrey Burnstock (1929-2020): the finest pharmacologist and an inspiring scientist. Purinergic Signalling, 17, pp. 135 - 135 . https://doi.org/10.1007/s11302-021-09769-8 . ISSN: 1573-9538

Franco, R.; Cordomí, A.; Llinas del Torrent, C.; Lillo, A.; Serrano-Marín, J.; Navarro G.; Pardo, L. (2021). Structure and function of adenosine receptor heteromers. Cellular and Molecular Life Sciences, 78(8), pp. 3957 - 3968 . https://doi.org/10.1007/s00018-021-03761-6 . ISSN: 1420-682X

Pedrosa, M.A.; Valenzuela, R.; Garrido-Gil, P.; Labandeira, C.M.; Navarro, G.; Franco, R.; Labandeira-Garcia, J.L.; Rodriguez-Perez, A.I. (2021). Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical Science . https://doi.org/10.1042/CS20201511 . ISSN: 0143-5221

Martínez-Pinilla, E.; Rubio-Sardón, N.; Villar-Conde, S.; Navarro, G.; Del Valle, E.; Tolivia, J.; Franco , R.; Navarro, A. (2021). Cuprizone-Induced Neurotoxicity in Human Neural Cell Lines Is Mediated by a Reversible Mitochondrial Dysfunction: Relevance for Demyelination Models. Brain Sciences . Institutional Repository . ISSN: 2076-3425

Casanovas, M.; Reyes-Resina, I.; Lillo, A.; Lillo, J.; López-Arnau, R.; Camarasa, J.; Escubedo, E.; Navarro *, G.; Franco, R. (2021). Methamphetamine blocks adenosine A2A receptor activation via sigma 1 and cannabinoid CB1 receptors. International Journal of Molecular Sciences . Institutional Repository . ISSN: 1661-6596

Franco, R. (2021). Qué es el estrés oxidativo y cómo afecta al envejecimiento. The Conversation . Institutional Repository . ISSN: 2201-5639

Pedrosa, M.A.; Valenzuela, R.; Garrido-Gil, P.; Labandeira, C.M.; Navarro, G.; Franco, R.; Labandeira-Garcia J.L.; Rodriguez-Perez, A.I.; (2021). Interactions between ibuprofen, ACE2, renin-angiotensin system, and spike protein in the lung. Implications for COVID-19. Clinical and Translational Medicine . https://doi.org/10.1002/ctm2.371 . ISSN: 2001-1326

Franco, R.; Ribas-Santisteban, R.; Lillo, J.; Camps, J.; Navarro, G.; Reyes-Resina, I. (2021). 5-Hydroxytryptamine, Glutamate, and ATP: Much More Than Neurotransmitters. Frontiers In Cell And Developmental Biology, 9(667815) . Institutional Repository . ISSN: 2296-634X

Osorio-Barrios, Francisco; Navarro, Gemma; Campos, Javier; Ugalde, Valentina; Prado, Campos; Raïch, Iu; Contreras, Frnacisco; López, Ernesto; Espinoza, Alexandra; Lladser, Alvaro; Franco, Rafael; Pacheco, Rodrigo (2021). The Heteromeric Complex Formed by Dopamine Receptor D 5 and CCR9 Leads the Gut Homing of CD4 + T Cells Upon Inflammation. Cellular and Molecular Gastroenterology and Hepatology, 12(2), pp. 489 - 506 . Institutional Repository . ISSN: 2352-345X

Rafael Franco; Rafael Rivas-Santisteban; Gemma Navarro; Annalisa Pinna, Irene Reyes-Resina. (2021). Genes Implicated in Familial Parkinson's Disease Provide a Dual Picture of Nigral Dopaminergic Neurodegeneration with Mitochondria Taking Center Stage. International Journal of Molecular Sciences, 22(9), pp. 1 - 26 . Institutional Repository . ISSN: 1661-6596

Franco, Rafael; Lillo, Alejandro; Rivas-Santisteban, Rafael; Reyes-Resina, Irene; Navarro, Gemma (2021). Microglial Adenosine Receptors: From Preconditioning to Modulating the M1/M2 Balance in Activated Cells. Cells, 10(5), pp. 1 - 18 . Institutional Repository . ISSN: 2073-4409

Franco, R. (2021). Current Issues in Molecular Biology Journal Enters a New Era. Current Issues In Molecular Biology, 43(1), pp. 384 - 388 . https://doi.org/10.3390/cimb43010031 . ISSN: 1467-3037

Mallo-Abreu, Ana; Reyes-Resina, Irene; Azuaje, Jhonny; Franco, Rafael; Garcia-Rey, Aitor; Majellaro, Maria; Miranda-Pastoriza, Dario; Garcia-Mera, Xerardo; Jespers, Willem; Gutierrez-de-Teran, Hugo; Navarro, Gemma; Sotelo, Eddy (2021). Potent and Subtype-Selective Dopamine D-2 Receptor Biased Partial Agonists Discovered via an Ugi-Based Approach. Journal of Medicinal Chemistry, 64(12), pp. 8710 - 8726 . https://doi.org/10.1021/acs.jmedchem.1c00704 . ISSN: 0022-2623

Franco, R.; Casanovas, B.; Camps, J.; Navarro, G.; Martínez-Pinilla, E. (2021). Health benefits are not afforded by antioxidants but by poten-tiating the innate detoxification molecular mechanisms. Current Issues In Molecular Biology . ISSN: 1467-3037

Navarro, Gemma; Gonzalez, Angel; Sanchez-Morales, Adria; Casajuana-Martin, Nil; Gomez-Ventura, Marc; Cordomi, Arnau; Busque, Felix; Alibes, Ramon; Pardo, Leonardo; Franco, Rafael (2021). Design of Negative and Positive Allosteric Modulators of the Cannabinoid CB2 Receptor Derived from the Natural Product Cannabidiol. Journal of Medicinal Chemistry, 64(13), pp. 9354 - 9364 . https://doi.org/10.1021/acs.jmedchem.1c00561 . ISSN: 0022-2623

Franco, R.; Casanovas, B.; Camps, J.; Navarro, G.; Martínez-Pinilla, E. (2021). Antioxidant Supplements versus Health Benefits of Brief/Intermittent Exposure to Potentially Toxic Physical or Chemical Agents. Current Issues In Molecular Biology, 43(2), pp. 650 - 664 . Institutional Repository . ISSN: 1467-3037

Valenzuela, R.; Rodriguez-Perez, A.I.; Costa-Besada, M.A.; Rivas-Santisteban, R.; Garrido-Gil, P.; Lopez-Lopez, A.; Navarro, G.; Lanciego, J.K.; Franco, R.; Labandeira-Garcia, J.L (2021). An ACE2/Mas-related receptor MrgE axis in dopaminergic neuron mitochondria. Redox Biology . https://doi.org/10.1016/j.redox.2021.102078 . ISSN: 2213-2317

Lillo, Jaume; Lillo, Alejandro; Zafra, David A.; Miralpeix, Cristina; Rivas-Santisteban, Rafael; Casals, Núria; Navarro, Gemma; Franco, Rafael (2021). Identification of the Ghrelin and Cannabinoid CB2 Receptor Heteromer Functionality and Marked Upregulation in Striatal Neurons from Offspring of Mice under a High-Fat Diet. International Journal of Molecular Sciences, 22(16), pp. 1 - 17 . Institutional Repository . ISSN: 1661-6596

Rafael Franco; Rafael Rivas-Santisteban; Gemma Navarro Brugal; Irene Reyes-Resina. (2021). Adenosine Receptor Antagonists to Combat Cancer and to Boost Anti-Cancer Chemotherapy and Immunotherapy. Cells . https://doi.org/10.3390/cells10112831 . ISSN: 2073-4409

Raïch I, Rivas-Santisteban R, Lillo A, Lillo J, Reyes-Resina I, Nadal X, Ferreiro-Vera C, de Medina VS, Majellaro M, Sotelo E, Navarro G, Franco R. (2021). Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors. Pharmacological Research, 174, p. 105970 . Institutional Repository . ISSN: 1043-6618

Rivas-Santisteban, Rafael; Lillo, Alejandro; Lillo, Jaume; Rebassa, Joan-Biel; Contesti, Joan S.; Saura, Carlos A.; Franco, Rafael; Navarro, Gemma (2021). N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors. Alzheimers Research & Therapy, 13(1), pp. 1 - 15 . Institutional Repository . ISSN: 1758-9193

Brugal, G.N.; Rivas-Santisteban, R.; Reyes, I.; Marquez, A.L.; Raïch, I.; Franco, R. (2021). PrNP-induced effect over NMDA expression and signalling. Alzheimer's & Dementia, 17 . https://doi.org/10.1002/alz.053486 . ISSN: 1552-5260

Lillo, A.; Lillo, J.; Raïch, I.; Miralpeix, C.; Dosrius, F.; Franco, R.; Navarro, G. (2021). Ghrelin and Cannabinoid Functional Interactions Mediated by Ghrelin/CB1 Receptor Heteromers That Are Upregulated in the Striatum From Offspring of Mice Under a High-Fat Diet. Frontiers in Cellular Neuroscience, 15(786597) . Institutional Repository . ISSN: 1662-5102

Lillo, A.; Raïch, I.; Lillo, J.; Pérez-Olives, C.; Navarro, G.; Franco, R. (2022). Expression of the Adenosine A2A-A3 Receptor Heteromer in Different Brain Regions and Marked Upregulation in the Microglia of the Transgenic APPSw,Ind Alzheimers Disease Model. Biomedicines, 10(2), pp. 1 - 16 . Institutional Repository . ISSN: 2227-9059

Franco R; Morales P; Navarro G; Jagerovic N; and Reyes-Resina I (2022). The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors. Frontiers in Pharmacology, 13, p. 852631 . https://doi.org/10.3389/fphar.2022.852631 . ISSN: 1663-9812

Franco, R.; Serrano-Marín, J (2022). Robustness of the Krebs Cycle under Physiological Conditions and in Cancer: New Clues for Evaluating Metabolism-Modifying Drug Therapies. Biomedicines, 10(5), pp. 1 - 14 . Institutional Repository . ISSN: 2227-9059

Lillo, A.*; Marin, S.*; Serrano-Marín, J.; Binetti, N.; Navarro, G.; Cascante, M.; Sánchez-Navés, J.*; Franco R.* (*: equal contribution) (2022). Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients. Frontiers in Medicine, 9, p. 935084 . Institutional Repository . ISSN: 2296-858X

Lillo J; Raïch I; Silva L; Zafra DA; Lillo A; Ferreiro-Vera C; Sánchez de Medina V; Martínez-Orgado J; Franco R*; Navarro G* (2022). Regulation of Expression of Cannabinoid CB2 and Serotonin 5HT1A Receptor Complexes by Cannabinoids in Animal Models of Hypoxia and in Oxygen/Glucose-Deprived Neurons. International Journal of Molecular Sciences, 23(17), pp. 1 - 15 . Institutional Repository . ISSN: 1661-6596

Rafael Franco; Alejandro Lillo; Gemma Navarro; Irene Reyes-Resina (2022). The adenosine A2A receptor is a therapeutic target in neurological, heart and oncogenic diseases. Expert Opinion On Therapeutic Targets, 9, pp. 791 - 800 . https://doi.org/10.1080/14728222.2022.2136570 . ISSN: 1472-8222

Lillo A; Marin S, Serrano-Marín J; Bernal-Casas D; Binetti N; Navarro G; Cascante M; Sánchez-Navés J; Franco R. (2022). Biogenic Amine Levels Markedly Increase in the Aqueous Humor of Individuals with Controlled Type 2 Diabetes. International Journal of Molecular Sciences, 23(21), pp. 1 - 11 . Institutional Repository . ISSN: 1661-6596

Raïch, I.; Rebassa, J.B.; Lillo, J.; Cordomi, A.; Rivas-Santisteban, R.; Lillo, A.; Reyes-Resina, I.; Franco, R.; Navarro, G (2022). Antagonization of OX1 Receptor Potentiates CB2 Receptor Function in Microglia from APPSw/Ind Mice Model. International Journal of Molecular Sciences, 21, p. 12801 . https://doi.org/10.3390/ijms232112801 . ISSN: 1661-6596

Franco Fernández, Rafael (2022). On the Mechanistic Perceptions of Consciousness: From Quantum Mechanics to Consciousness and Free Will and from David Bohm to Benjamin Libet. Journal Of Integrative Neuroscience, 21(6), pp. 153 - 156 . Institutional Repository . ISSN: 0219-6352

Franco, R. (2022). Editorial: Rising stars in clinical microbiology: 2022. Frontiers in Cellular and Infection Microbiology, 12 . https://doi.org/10.3389/fcimb.2022.1066181 . ISSN: 2235-2988

Casajuana-Martin N; Navarro G; Gonzalez A; Llinas Del Torrent C; Gómez-Autet M; Quintana García A; Franco R; Pardo L. (2022). A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB2 Receptor via the Lipid Bilayer. Journal of Chemical Information and Modeling, 62(22), pp. 5771 - 5779 . Institutional Repository . ISSN: 1549-9596

Rivas-Santisteban, R.; Raïch, I.; Aguinaga, D.; Saura, C.A.; Franco, R.; Navarro, G. (2023). The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons. Cells, 12(2) . https://doi.org/10.3390/cells12020283 . ISSN: 2073-4409

Rafael Franco; Joan Serrano-Marín (2023). The unbroken Krebs cycle. Hormonal-like regulation and mitochondrial signaling to control mitophagy and prevent cell death. BioEssays, 45(3), p. e2200194 . Institutional Repository . ISSN: 0265-9247

Rivas-Santisteban, R.; Lillo, J.; Raïch, I.; Muñoz, A.; Lillo, A.; Rodríguez-Pérez, A.I.; Labandeira-García, J.L.; Navarro, G.; Franco, R. (2023). The cannabinoid CB1 receptor interacts with the angiotensin AT2 receptor. Overexpression of AT2-CB1 receptor heteromers in the striatum of 6-hydroxydopamine hemilesioned rats. Experimental Neurology, 362 . https://doi.org/10.1016/j.expneurol.2023.114319 . ISSN: 0014-4886

Rafael Rivas-Santisteban; Alejandro Lillo; Jaume Lillo; Joan-Biel Rebassa; Joan S. Contestí; Carlos A. Saura; Rafael Franco*; Gemma Navarro*. (2021). N-Methyl-D-Aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in neural cells. Insights into the therapeutic potential of neuronal and microglial NMDA receptors. Alzheimers Research & Therapy, 13(184), pp. 1 - 15 . https://doi.org/10.1186/s13195-021-00920-6 . ISSN: 1758-9193

Tarifa, C.; Jiménez-Sábado, V.; Franco, R.; José Montiel, J.; Guerra, J.; Ciruela, F.; Hove-Madsen, L. (2023). Expression and impact of Adenosine A3 receptors on calcium homeostasis in human right atrium. International Journal of Molecular Sciences, 24, p. 4404 . ISSN: 1661-6596