Vicente Marchán Sancho

Vicente Marchán Sancho

Catedràtic d'Universitat

Researcher ID: K-9751-2014
Àrea de coneixement : Química Orgànica

Grup de Recerca: IP Bioimatge, bioconjugació, estructura i teràpies amb molècules de mida petita, pèptids i oligonucleòtids

Informació de contacte
Departament de Química Inorgànica i Orgànica
Section of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Martí i Franquès 1-11, E-08028, Barcelona, SPAIN
+34 934021249
vmarchan(a)ub.edu

Activitats anteriors

Professor Agregat. Dep. Química Orgànica-Universitat de Barcelona. 01/02/2007
Professor Lector. Dep. Química Orgànica-Universitat de Barcelona. 15/09/2004 - 31/01/2007
Professor Associat. Dep. Química Orgànica-Universitat de Barcelona. 01/02/2004 - 14/09/2004
Ajudant LRU. Dep. Química Orgànica-Universitat de Barcelona. 08/02/2001 - 31/01/2004
Professor Associat. Dep. Química Orgànica-Universitat de Barcelona. 01/10/2000 - 07/02/2001
Investigador Post-doctoral. Center for Biologics Evaluation and Research-Food and Drug Administration (CBER-FDA), Bethesda, USA. 01/03/2002 - 31/03/2003

Formació acadèmica

Llicenciatura en Ciencies Químiques . Universitat de Barcelona . 31/07/1996 . (Diplomatura / Llicenciatura / Grau)
Doctorat en Química . Departament de Química Orgànica-Universitat de Barcelona . 28/11/2000 . (Doctorat )
Màster en Química Experimental . Universitat de Barcelona . 09/1997 . (Màster Oficial)

Línies de recerca

Síntesi en fase sòlida de pèptids, oligonucleòtids (DNA, RNA) i anàlegs oligonucleotídics (PNA). Síntesi de conjugats pèptid-oligonucleòtid i fàrmac-biomolècula. Mètodes de conjugació (química click, Diels-Alder, etc.)
Desenvolupament de fluoròfors basats en molècules orgàniques i les seves aplicacions en bioimatge. Síntesi de grups protectors fotolàbils eliminables amb llum visible i NIR
Desenvolupament de nous fotosensibilitzadors basats en cromòfors orgànics i/o complexos metàl·lics i la seva aplicació en teràpia fotodinàmica
Síntesi de nous fàrmacs anticancerígens basats en metalls de transició (platí, ruteni, iridi). Síntesi de conjugats metalofàrmac-pèptid.Estratègies de vehiculització dirigida de fàrmacs. Desenvolupament de compostos anticancerígens fotoactivables (complexos metàl·lics, 'caged peptides', etc.)
Desenvolupament de lligands d'estructures de RNA terapèuticament rellevants. Química combinatoria dinámica

Publicacions en revistes

Marchán, V.; Gibert, M.; Messeguer, A.; Pedroso, E.; Grandas, A. (1999). Use of dimethyldioxirane for the oxidation of 1,2-dithiolan-3-ones to 1-oxides or 1,1-dioxides. Preparation of 3H-1,2-benzodithiole-3-one 1,1- dioxide (Beaucage sulfurising reagent). Synthesis. Journal of Synthetic Organic Chemistry, 1, pp. 43 - 45 . ISSN: 0039-7881
Marchán, V.; Debéthune, L.; Beltrán, M.; Robles, J.; Travesset, I.; Fábregas, G.; Pedroso, E.; Grandas, A. (1999). The stepwise solid-phase synthesis methodology is suitable for the preparation of a great variety of nucleopeptides. Nucleosides & Nucleotides, 18(6-7), pp. 1493 - 1494 . ISSN: 0732-8311
Robles, J.; Beltrán, M.; Marchán, V.; Pérez, Y.; Travesset, I.; Pedroso, E.; Grandas, A. (1999). Towards nucleopeptides containing any trifunctional amino acid. Tetrahedron, 55, pp. 13251 - 13264 . ISSN: 0040-4020
Marchán, V.; Rodríguez-Tanty, C.; Estrada, M.; Pedroso, E.; Grandas, A. (2000). Alternative procedures for the synthesis of methionine-containing peptide- oligonucleotide hybrids. European Journal of Organic Chemistry, 13, pp. 2495 - 2500 . ISSN: 1434-193X
Albericio, F.; Cruz, M.; Debéthune, L.; Eritja, R.; Giralt, E.; Grandas, A.; Marchán, V.; Pastor, J. J.; Pedroso, E.; Rabanal, F.; Royo, M. (2001). Improved synthesis of N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acid (HMFS), a versatile handle for the solid-phase synthesis of biomolecules. Synthetic Communications, 31, pp. 225 - 232 . ISSN: 0039-7911
Marchán, V.; Moreno, V.; Pedroso, E.; Grandas, A. (2001). Towards a better understanding of cisplatin mode of action. Chemistry-A European Journal, 7, pp. 808 - 815 . ISSN: 0947-6539
Debéthune, L.; Marchán, V.; Fábregas, G.; Pedroso, E.; Grandas, A. (2002). Towards nucleopeptides containing any trifunctional amino acid (II). Tetrahedron, 58, pp. 6965 - 6978 . ISSN: 0040-4020
Gómez-Pinto, I.; Marchán, V.; Gago, F.; Grandas, A.; González, C. (2003). Solution structure and stability of tryptophan-containing nucleopeptide duplexes. ChemBioChem, 4, pp. 40 - 49 . ISSN: 1439-4227
Gómez-Pinto, I.; Marchán, V.; Gago, F.; Grandas, A.; González, C. (2003). Solution structure and stability of a disulfide cross-linked nucleopeptide duplex. Journal of the Chemical Society. D-Chemical Communications, 20, pp. 2558 - 2559 . ISSN: 0022-4936
Marchán, V.; Debéthune, L.; Pedroso, E.; Grandas, A. (2004). Stabilization of DNA duplexes by covalently-linked peptides. Tetrahedron, 60, pp. 5461 - 5469 . ISSN: 0040-4020
Marchán, V.; Pedroso, E.; Grandas, A. (2004). Insights into the reaction of transplatin with DNA and proteins: methionine-mediated formation of histidine-guanine trans-Pt(NH3)2 cross-links. Chemistry-A European Journal, 10, pp. 5369 - 5375 . ISSN: 0947-6539
Jaumot, J.; Marchán, V.; Gargallo, R.; Grandas, A.; Tauler, R. (2004). Multivariate Curve Resolution applied to the analysis and resolution of two-dimensional [1H,15N]-NMR data. Analytical Chemistry, 76(23), pp. 7094 - 7101 . ISSN: 0003-2700
S.L. Beaucage, M.K. Chmielewski, J. Cieślak, A. Grajkowski, V. Marchán, L.R. Phillips, A. Wilk (2003). Conceptual 'Heat-driven' Approach to the Synthesis of DNA Oligonucleotides on Microarrays. Annals of the New York Academy of Sciences, 1002, pp. 1 - 11 . ISSN: 0077-8923
M.K. Chmielewski, V. Marchán, J. Cieslak, Livengood, V.; U. Münch, A. Wilk, S.L. Beaucage (2003). Thermolytic Carbonates for Potential 5’-Hydroxyl Protection of Deoxyribonucleosides. Journal of Organic Chemistry, 68, pp. 10003 - 10012 . ISSN: 0022-3263
V. Marchán, J. Cieślak, V. Livengood, S.L. Beaucage (2004). The 2,2,5,5-Tetramethylpyrrolidin-3-one-1-sulfinyl Group for 5’-Hydroxyl Protection of Deoxyribonucleoside Phosphoramidites in the Solid Phase Preparation of DNA Oligonucleotides. Journal of the American Chemical Society, 126, pp. 9601 - 9610 . ISSN: 0002-7863
Marchan, V.; Pulido, D.; Pedroso, E.; Grandas, A. (2006). Linking the 3' ends of oligonucleotide duplexes with cystine disulfide bridges. European Journal of Organic Chemistry, pp. 958 - 963 . ISSN: 1434-193X
Marchan, V.; Ortega, S.; Pulido, D.; Pedroso, E.; Grandas, A. (2006). Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugates. Nucleic Acids Research, 34, pp. e24(1) - e24(9) . ISSN: 0305-1048
Algueró, B.; López de la Osa, J.; González, C.; Pedroso, E.; Marchán, V.; Grandas, A. (2006). Selective platination of modified oligonucleotides and duplex cross-links. Angewandte Chemie-International Edition, 45, pp. 8194 - 8197 . ISSN: 1433-7851
Algueró, B.; Pedroso, E.; Marchán, V.; Grandas, A. (2007). Incorporation of two modified nucleosides allows selective platination of an oligonucleotide making it suitable for duplex cross-linking. Journal of Biological Inorganic Chemistry, 12(6), pp. 901 - 911 . ISSN: 0949-8257
Pulido, D..; López-Alonso, J. P.; .; Marchán, V.; González, C.;.; Grandas, A.; Laurents, D. V. (2008). Preparation of Ribonuclease S domain-swapped dimers conjugated with DNA and PNA: modulating the activity of ribonucleases. Bioconjugate Chemistry, 19, pp. 263 - 270 . ISSN: 1043-1802
Barragán, F.; Moreno, V.; Marchán, V. (2009). Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs. Chemical Communications, pp. 4705 - 4707 . Repositori Institucional . ISSN: 1359-7345
López-Senín, P.; Gómez-Pinto, I.; Grandas, A.; Marchán, V. (2011). Identification of Ligands for the Tau Exon 10 Splicing Regulatory Element RNA Using Dynamic Combinatorial Chemistry. Chemistry-A European Journal, 17, pp. 1946 - 1953 . Repositori Institucional . ISSN: 0947-6539
Barragán, F.; López-Senín, P.; Salassa, L.; Betanzos-Lara, S.; Habtemariam, A.; Moreno, V.; Sadler, P.J.; Marchán, V. (2011). Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex. Journal of the American Chemical Society, 133(35), pp. 14098 - 14108 . Repositori Institucional . ISSN: 0002-7863
Barragá, F.; Carrion-Salip, D.; Gómez-Pinto, I.; González-Cantó, A.; Sadler, P.J.; de Llorens, R.; Moreno, V.; González, C.; Massaguer, A.; Marchán, V. (2012). Somatostatin Subtype‑2 Receptor-Targeted Metal-Based Anticancer Complexes. Bioconjugate Chemistry, 23, pp. 1838 - 1855 . Repositori Institucional . ISSN: 1043-1802
López-Senín, P.; Artigas, G.; Marchán, V. (2012). Exploring the effect of aminoglycoside guanidinylation on ligands for Tau exon 10 splicing regulatory element RNA. Organic & Biomolecular Chemistry, 10, pp. 9243 - 9254 . Repositori Institucional . ISSN: 1477-0520
Grau-Campistany, A.; Massaguer, A.; Carrion-Salip, D.; Barragán, F.; Artigas, G.; López-Senín, P.; Moreno, V.; Marchán, V. (2013). Conjugation of a Ru(II) Arene Complex to Neomycin or to Guanidinoneomycin Leads to Compounds with Differential Cytotoxicities and Accumulation between Cancer and Normal Cells. Molecular Pharmaceutics, 10(5), pp. 1964 - 1976 . Repositori Institucional . ISSN: 1543-8384
Artigas, G.; Marchán, V. (2013). Synthesis of Janus compounds for the recognition of G-U mismatched nucleobase pairs. Journal of Organic Chemistry, 78(21), pp. 10666 - 10677 . Repositori Institucional . ISSN: 0022-3263
Fernández, M.; Shaili, E.; González Cantó, A.; Artigas, G.; Sánchez, C.; Woods, J.A.; Sadler, P.J.; Marchán, V. (2014). Photo-targeted platinum conjugates as selective anticancer drugs. Journal of Biological Inorganic Chemistry, 19(Suppl 2), p. S782 . https://doi.org/10.1007/s00775-014-1162-1 . ISSN: 0949-8257
Massaguer, A.; González-Cantó, A.; Escribano, E.; Barrabés, S.; Artigas, G.; Moreno, V.; Marchán, V. (2015). Integrin-targeted delivery into cancer cells of a Pt(IV) pro-drug through conjugation to RGD-containing peptides. Dalton Transactions, 44, pp. 202 - 212 . Repositori Institucional . ISSN: 1477-9226
Artigas, G.; Marchán, V. (2015). Synthesis and Tau RNA Binding Evaluation of Ametantrone-Containing Ligands. Journal of Organic Chemistry, 80(4), pp. 2155 - 2164 . Repositori Institucional . ISSN: 0022-3263
Artigas, G.; López-Senín, P.; González, C.; Escaja, N.; Marchán, V. (2014). Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing. Organic & Biomolecular Chemistry, 13, pp. 452 - 464 . Repositori Institucional . ISSN: 1477-0520
Gandioso, A.; Shaili, E.; Massaguer, A.; Artigas, G.; González-Cantó, A.; Woods, J. A.; Sadler, P. J.; Marchán, V. (2015). An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies. Chemical Communications, 51, pp. 9169 - 9172 . Repositori Institucional . ISSN: 1359-7345
Shaili, E.; Fernández-Giménez, M.; Rodríguez-Astor, S.; Gandioso, A.; Sandín, L.; García-Vélez, C.; Massaguer, A.; Clarkson, G. J.; Woods, J. A.; Sadler, P. J.; Marchán, V. (2015). A photoactivatable PtIV anticancer complex conjugated to the RNA ligand guanidinoneomycin. Chemistry-A European Journal, 21(50), pp. 18474 - 18486 . Repositori Institucional . ISSN: 0947-6539
Gandioso, A.; Cano, M.; Massaguer, A.; Marchán, V. (2016). A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies. Journal of Organic Chemistry, 81(23), pp. 11556 - 11564 . Repositori Institucional . ISSN: 0022-3263
Gandioso, A.; Massaguer, A.; Villegas, N.; Salvans, C.; Sánchez, D.; Brun-Heath, I.; Marchán, V.; Orozco, M.; Terrazas, M. (2017). Efficient siRNA-peptide conjugation for specific targeted delivery to tumor cells. Chemical Communications, 53(19), pp. 2870 - 2873 . Repositori Institucional . ISSN: 1359-7345
Albert Gandioso; Marta Palau; Alba Nin-Hill; Ivanna Melnyk; Carme Rovira; Santi Nonell; Dolores Velasco; Jaume García-Amorós; Vicente Marchán (2017). Sequential uncaging with green light can be achieved by fine-tuning the structure of a dicyanocoumarin chromophore. ChemistryOpen, 6(3), pp. 375 - 384 . Repositori Institucional . ISSN: 2191-1363
Vojtech Novohradsky; Ana Zamora; Albert Gandioso; Viktor Brabec; José Ruiz; Vicente Marchán (2017). Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents. Chemical Communications, 53, pp. 5523 - 5526 . Repositori Institucional . ISSN: 1359-7345
A. Gandioso; S. Contreras; I. Melnyk; J. Oliva; S. Nonell; D. Velasco; J. Garcia-Amoros; V. Marchán (2017). Development of green/red-absorbing chromophores based on a coumarin scaffold that are useful as caging groups. Journal of Organic Chemistry, 82(10), pp. 5398 - 5408 . Repositori Institucional . ISSN: 0022-3263
Gandioso, A.; Bresoli-Obach, R.; Nin-Hill, A.; Bosch, M.; Palau, M.; Galindo, A.; Contreras, S.; Rovira, A.; Rovira, C.; Nonell, S.; Marchán, V. (2018). Redesigning the coumarin scaffold into small bright fluorophores with far-red to NIR emission and large Stokes' shifts useful for cell imaging. Journal of Organic Chemistry, 83(3), pp. 1185 - 1195 . Repositori Institucional . ISSN: 0022-3263
Zamora, A.; Gandioso, A.; Massaguer, A.; Buenestado, S.; Calvis, A.; Hernández, J. L.; Mitjans, F.; Rodríguez, V.; Ruiz, J.; Marchán, V. (2018). Toward Angiogenesis Inhibitors Based on the Conjugation of Organometallic Platinum(II) Complexes to RGD Peptides. ChemMedChem, 13(17), pp. 1755 - 1762 . Repositori Institucional . ISSN: 1860-7179
Gandioso, A.; Palau, M.; Bresolí-Obach, R.; Galindo, A.; Rovira, A.; Bosch, M.; Nonell, S.; Marchán, V. (2018). High photostability in non-conventional coumarins with far-red/NIR emission through azetidinyl substitution. Journal of Organic Chemistry, 83(19), pp. 11519 - 11531 . Repositori Institucional . ISSN: 0022-3263
Rovira, A.; Gandioso, A.; Goñalons, M.; Galindo, A.; Massaguer, A.; Bosch, M.; Marchan, V. (2019). Solid-phase approaches for labelling targeting peptides with far-red emitting coumarin fluorophores. Journal of Organic Chemistry, 84(4), pp. 1808 - 1817 . Repositori Institucional . ISSN: 0022-3263
Novohradsky, V.; Rovira, A.; Hally, C.; Galindo, A.; Vigueras, G.; Gandioso, A.; Svitelova, M.; Bresolí-bach, R.; Kostrhunova, H.; Markova, L.; Kasparkova, J.; Nonell, S.; Ruiz, J.; Brabec, V.; Marchán, V. (2019). Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin. Angewandte Chemie-International Edition, 58(19), pp. 6311 - 6315 . Repositori Institucional . ISSN: 1433-7851
Rovira, A.; Pujals, M.; Gandioso, A.; López-Corrales, M.; Bosch, M.; Marchán, V. (2020). Modulating photostability and mitochondria selectivity in far-red/NIR emitting coumarin fluorophores through replacement of pyridinium by pyrimidinium. Journal of Organic Chemistry, 85(9), pp. 6086 - 6097 . Repositori Institucional . ISSN: 0022-3263
López-Corrales, M.; Rovira, A.; Gandioso, A.; Bosch, M.; Nonell, S.; Marchán, V. (2020). Transformation of COUPY fluorophores into a novel class of visible light-cleavable photolabile protecting groups. Chemistry-A European Journal, 26 . Repositori Institucional . ISSN: 0947-6539
Gandioso, A.; El Fakiri, M.; Rovira, A.; Marchán, V. (2020). A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent. RSC Advances, 10, pp. 29829 - 29834 . Repositori Institucional . ISSN: 2046-2069
Gandioso, A.; Rovira, A.; Shi, H.; Sadler, P. J. ; Marchán, V. (2020). Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drug. Dalton Transactions, 49, pp. 11828 - 11834 . Repositori Institucional . ISSN: 1477-9226
Martin-Gómez, H.; Oliver-Cervelló, L.; Sánchez-Campillo, I.; Marchán, V.; Ginebra, M.-P.; Mas-Moruno, C. (2021). A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides. Chemical Communications, 57(8), pp. 982 - 985 . Repositori Institucional . ISSN: 1359-7345
Novohradsky, V.; Markova, L.; Kostrhunova, H.; Kasparkova, J.; Ruiz, J.; Marchán, V.; Brabec, V. (2021). A cyclometallated IrIII complex conjugated to a coumarin derivative is a potent photodynamic agent against prostate differentiated and tumorigenic cancer stem cells. Chemistry-A European Journal, 27, pp. 8547 - 8556 . Repositori Institucional . ISSN: 0947-6539
Ortega-Forte, E.; Rovira, A.; Gandioso, A.; Bonelli, J.; Bosch, M.; Ruiz, J.; Marchán, V. (2021). COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. Journal of Medicinal Chemistry, 64(23), pp. 17209 - 17220 . Repositori Institucional . ISSN: 0022-2623
Bonelli, Joaquín ; Ortega Forte, Enrique ; Vigueras, Gloria ; Bosch, Manel ; Cutillas, Natalia; Rocas, Josep ; Ruiz, José ; Vicente Marchán, Vicente (2022). Polyurethane-polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(III) metallodrugs. Inorganic Chemistry Frontiers, 9(10), pp. 2123 - 2138 . Repositori Institucional . ISSN: 2052-1553
Bonelli, J.; Ortega-Forte, E.; Rovira, A.; Bosch, M.; Torres, O.; Cuscó, C.; Rocas, J.; Ruiz, J.; Marchán, V. (2022). Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier. Biomacromolecules, 23(7), pp. 2900 - 2913 . Repositori Institucional . ISSN: 1525-7797
Simba Lahuasi, Alvaro; Cantero Camacho, Ángel; Rosales, Rosales; McGovern, Briana Lynn; Rodríguez, M. Luis; Marchán Sancho, Vicente; White, Kris M.; García Sastre, Adolfo; Gallego, José (2022). SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules. Pharmaceuticals, 15, p. 1448 . Repositori Institucional . ISSN: 1424-8247
Izquierdo, E.; López-Corrales, M. Abad-Montero, D.; Rovira, A.; Fabriàs, G.; Bosch, M.; Abad, J.-L.; Marchán, V. (2022). Fluorescently-labelled ceramides and 1-deoxyceramides: Synthesis, characterization and cellular distribution studies. Journal of Organic Chemistry, 87, pp. 16351 - 16367 . Repositori Institucional . ISSN: 0022-3263
Bonelli, J.; Velasco-de-Andrés, M.; Isidro, N.; Bayó, C.; Chumillas, S.; Carrillo-Serradell, L.; Casadó-Llombart, S.; Mok, C.; Benítez-Ribas, D.; Lozano, F.; Rocas, J.; Marchán, V. (2022). Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis. Pharmaceutics, 15(1), p. 58 . Repositori Institucional . ISSN: 1999-4923
Rovira, A.; Ortega-Forte, E.; Hally, C.; Jorda-Redondo, M.; Abad-Montero, D.; Vigueras, G.; Martinez, J. I.; Bosch, M.; Nonell, S.; Ruiz, J.; Marchán, V. (2023). Exploring Structure-Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Journal of Medicinal Chemistry, 66(12), pp. 7849 - 7867 . Repositori Institucional . ISSN: 0022-2623
López-Corrales, M.; Rovira, A.; Gandioso, A.; Nonell, S.; Bosch, M.; Marchán, V. (2023). Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells. Journal of Organic Chemistry, 88(11), pp. 7128 - 7140 . Repositori Institucional . ISSN: 0022-3263
Ortega-Forte, E.; Rovira, A.; López-Corrales, M.; Hernández-García, A.; Ballester, F. J.; Izquierdo-García, E. Jorda-Redondo, M.; Bosch, M.; Nonell, S.; Santana, M. D.; Ruiz, J.; Marchán, V.; Gasser, G. (2023). A near-infrared light-activatable Ru(II)-coumarin photosensitizer active under hypoxic conditions. Chemical Science, 14(26), pp. 7170 - 7184 . Repositori Institucional . ISSN: 2041-6520
Izquierdo-García, E.; Rovira, A.; Forcadell, J.; Bosch, M.; Marchán, V (2023). Exploring Structural–Photophysical Property Relationships in Mitochondria-Targeted Deep-Red/NIR-Emitting Coumarins. International Journal of Molecular Sciences, 24, p. 17427 . ISSN: 1661-6596
Gandioso, A.; Izquierdo-García, E.; Mesdom, P.; Arnoux, P.; Demeubayeva, N.; Burckel, P.; Saubaméa, B.; Bosch, M.; Frochot, C.; Marchán, V.; Gasser, G. (2023). Ru(II)-Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near-Infrared Light. Chemistry-A European Journal, 29, p. e202301742 . ISSN: 0947-6539
Chumillas, S.; Loharch, S.; Beltrán, M.; Szewczyk, M.; Bernal, S.; Puertas, M. C.; Martínez-Picado, J.; Alcamí, J.; Bedoya, L. M.; Marchán, V.; Gallego, J. (2023). Exploring the HIV-1 RRE-Rev inhibitory capacity and antiretroviral action of benfluronanalogs. Molecules, 28, p. 7031 . ISSN: 1420-3049

Altres Publicacions

Grandas, A.; Marchán, V.; Debéthune, L.; Pedroso, E. (2004). Stepwise Solid-Phase Synthesis of Nucleopeptides Chapter 4: Synthesis of Modified Oligonucleotides and Conjugates . En Current Protocols in Nucleic Acid Chemistry . Volum. Unit 4.22 . (pp. 4.22.1 - 4.22.54) . John Wiley & Sons . ISBN: 0-471-24662-X .
Marchán, V.; Grandas, A. (2007). Synthesis of peptide-oligonucleotide conjugates by Diels-Alder cycloaddition in water. Chapter 4: Synthesis of modified oligonucleotides and conjugates . En Current Protocols in Nucleic Acid Chemistry . Volum. Unit 4.32 . (pp. 4.32.1 - 4.32.31) . John Wiley & Sons . ISBN: 0-471-24662-X .
Marchán, V.; Grandas, A. (2008). Platinated oligonucleotides: Synthesis and applications for the control of gene expression . En Metal Complex-DNA Interactions . (pp. 273 - 295) . Blackwell Publishing Inc. [etc.] . ISBN: 978-1-4051-7629-3 .

Tesis, tesines i treballs

Berta Algueró Cama . (2006) . Anàlegs oligonucleotídics que incorporen grups tioèter i/o imidazole: Reacció amb transplatí i entrecreuament amb la cadena complementària (Tesi Doctoral) . Universitat de Barcelona.
López Senín, P . (2011) . Desarrollo de ligandos estabilizantes de la estructura de RNA implicada en el procesado alternativo del exón 10 de la proteína tau mediante química combinatoria dinámica (Tesi Doctoral) . Universitat de Barcelona.
Barragán Clavero, F . (2011) . Vehiculización de compuestos metálicos hacia células tumorales mediante conjugación a análogos de octreotide (Tesi Doctoral) . Universitat de Barcelona.
Artigas Sole, G . (2013) . Desenvolupament de lligands de l'estructura secundària d'RNA implicada en el processat alternatiu de l'exó 10 de la proteïna tau (Tesi Doctoral) . Universitat de Barcelona.
Gandioso Ubieto, A . (2018) . Novel chemical tools for Cancer therapy and imaging: from targeted photoactivatable Pt(IV) complexes to coumarin-based fluorophores and caging groups (Tesi Doctoral) . Universitat de Barcelona.
Rovira Vidal, A . (2023) . COUPY coumarins as privileged scaffolds for the development of novel targeted fluorophores and metal-based PDT anticancer agents (Tesi Doctoral) . Universitat de Barcelona.
Bonelli Blasco, J . (2022) . Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis (Tesi Doctoral) . Universitat de Barcelona.
López Corrales, M . (2019) . Synthesis and biological applications of COUPY-based caging groups (ongoing thesis) (Tesi Doctoral) . Universitat de Barcelona.
Chumillas Vicedo, Sergi . (2021) . RNA-targeted small-molecule agents against SARS-CoV-2 and HIV-1 (ongoing thesis) (Tesi Doctoral) . Universitat de Barcelona.
Abad Montero, Diego . (2022) . Desarrollo de nuevos agentes teranósticos basados en cumarinas COUPY de utilidad en cáncer (ongoing thesis) (Tesi Doctoral) . Universitat de Barcelona.
Santiago Domínguez, Neus . (2023) . Desenvolupament de noves nanomedicines basades en nanocàpsules híbrides de poliuretàpoliurea pel tractament oncològic (ongoing thesis) (Tesi Doctoral) . Universitat de Barcelona.

Patents, Programari i Bases de dades

Gallego, José; Cantero Camacho, Ángel; Simba, Álvaro; García Sastre, Adolfo; Rosales Ramírez, Romel; White, Kris; Marchán Sancho, Vicente Ref. EP21382127.5. Small-molecule agents with antiviral activity against RNA viruses (Països Membres de la Convenció Europea de Patents, 17/02/2021 ) . Universidad Católica de Valencia San Vicente Mártir / Icahn Scool of Medicine at Mount Sinai / Universitat de Barcelona
Gallego, José; Cantero Camacho, Ángel; Simba, Álvaro; García Sastre, Adolfo; Rosales Ramírez, Romel; White, Kris; Marchán Sancho, Vicente; Chumillas Vicedo, Sergi Ref. PCT/EP2022/053938. Small-molecule agents with antiviral activity against RNA viruses (Països membres del Tractat de Cooperació en Matèria de Patents, 17/02/2022 ) . Universidad Católica de Valencia San Vicente Mártir / Icahn Scool of Medicine at Mount Sinai / Universitat de Barcelona
Marchán Sancho, Vicente; Gandioso, Albert; Gasser, Gilles Albert; Chumillas Vicendo, Sergi; Castaño Duro, Davor; López Corrales, Marta; Abad Montero, Diego Ref. EP23382155.2. Metal complex compounds as photosensitizers for photodynamic therapy (Països Membres de la Convenció Europea de Patents, 20/02/2023 ) . Universitat de Barcelona / ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS / Centre National de la Recherche Scientifique (CNRS) / PARIS SCIENCES ET LETTRES

Projectes de recerca (últims 5 anys)

Nuevos agentes terapéuticos y de bioimagen basados en fluoróforos COUPY . 2021 - 2024 . Ref.PID2020-117508RB-I00 . Ministerio de Ciencia e Innovación (MICINN) . IP: Vicente Marchán Sancho
RNA-targeted small-molecule agents against SARS-CoV2 (CONSOLIDATE COV 19) . 2020 - 2022 . Ref.CF01-00010 . Fundació Caixa de Pensions 'La Caixa' . IP: Vicente Marchán Sancho
Nuevas herramientas químicas con aplicación en bioimagen, bioconjugación y en vehiculización fotocontrolada y dirigida de fármacos . 2018 - 2021 . Ref.CTQ2017-84779-R . Ministerio de Economía y Competitividad . IP: Vicente Marchán Sancho
Multifunctional polymeric nanosystems for the controlled and intelligent release of active pharmaceutical ingredients . 2018 - 2021 . Ref.2017 DI 072 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Vicente Marchán Sancho
Análogos de oligonucleótidos y pequeñas moléculas para modular la expresión génica y combatir enfermedades . 2015 - 2017 . Ref.CTQ2014-52658-R . Ministerio de Ciencia e Innovación (MICINN) . IP: Ana Maria Grandas Sagarra
New anticancer agents for photodynamic therapy. 2021 LLAV 00083 . 2022 - 2023 . Ref.2021 LLAV 00083 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Vicente Marchán Sancho
Novel metal-based anticancer agents for photodynamic therapy. F2I-PdC_2022-007 . 2023 - 2024 . Ref.F2I-PdC_2022-007 . Fundació Bosch i Gimpera de la Universitat de Barcelona . IP: Vicente Marchán Sancho
Discovery of novel HIV-1 RNA biogenesis inhibitors based on disrupting the RRE-Rev ribonucleoprotein . 2021 - 2024 . Ref.PROMETEO/2021/036 . Generalitat Valenciana . IP: Jose Gallego Sala
Novel far-red/NIR-activatable PDT agents for combating hypoxic tumors . 2023 - 2025 . Ref.CI23-20067 . Fundació Caixa de Pensions 'La Caixa' . IP: Vicente Marchán Sancho