Vicente Marchán Sancho

University Full professor

ORCID: 0000-0002-1905-2156

Researcher ID: K-9751-2014

Knowledge area: Química Orgànica

Research group: IP Bioimatge, bioconjugació, estructura i teràpies amb molècules de mida petita, pèptids i oligonucleòtids

Contact Information
Department of Inorganic and Organic Chemistry
Section of Organic Chemistry, Department of Inorganic and Organic Chemistry, University of Barcelona, Martí i Franquès 1-11, E-08028, Barcelona, SPAIN
+34 934021249
vmarchan(a)ub.edu

Previous Tasks

Professor Agregat. Dep. Química Orgànica-Universitat de Barcelona. 01/02/2007

Professor Lector. Dep. Química Orgànica-Universitat de Barcelona. 15/09/2004 - 31/01/2007

Professor Associat. Dep. Química Orgànica-Universitat de Barcelona. 01/02/2004 - 14/09/2004

Ajudant LRU. Dep. Química Orgànica-Universitat de Barcelona. 08/02/2001 - 31/01/2004

Professor Associat. Dep. Química Orgànica-Universitat de Barcelona. 01/10/2000 - 07/02/2001

Investigador Post-doctoral. Center for Biologics Evaluation and Research-Food and Drug Administration (CBER-FDA), Bethesda, USA. 01/03/2002 - 31/03/2003

Academic training

Llicenciatura en Ciencies Químiques . Universitat de Barcelona . 31/07/1996 . (Diploma / Degree / Activities)

Doctorat en Química . Departament de Química Orgànica-Universitat de Barcelona . 28/11/2000 . (Ph.D.)

Màster en Química Experimental . Universitat de Barcelona . 09/1997 . (Official Master)

Research interests

Solid phase synthesis of peptides, oligonucleotides (DNA, RNA) and oligonucleotide analogs (PNA). Synthesis of peptide-oligonucleotide and drug-biomolecule conjugates. Conjugation methodologies (click chemistry, Diels-Alder, etc.)

Development of fluorophores based on organic molecules and their applications in bioimaging. Synthesis of photolabile protecting groups removable with visible light and NIR

Development of new photosensitizers based on organic chromophores and/or metal complexes and their application in photodynamic therapy

Synthesis of new anticancer drugs based on transition metals (platinum, ruthenium, iridium). Synthesis of metallodrug-peptide conjugates. Targeted drug delivery strategies. Development of photoactivatable anticancer compounds (metal complexes, 'caged peptides', etc.)

Development of ligands of therapeutically relevant RNA structures. Dynamic combinatorial chemistry

Journal Publications

Marchán, V.; Gibert, M.; Messeguer, A.; Pedroso, E.; Grandas, A. (1999). Use of dimethyldioxirane for the oxidation of 1,2-dithiolan-3-ones to 1-oxides or 1,1-dioxides. Preparation of 3H-1,2-benzodithiole-3-one 1,1- dioxide (Beaucage sulfurising reagent). Synthesis. Journal of Synthetic Organic Chemistry, 1, pp. 43 - 45 . ISSN: 0039-7881

Marchán, V.; Debéthune, L.; Beltrán, M.; Robles, J.; Travesset, I.; Fábregas, G.; Pedroso, E.; Grandas, A. (1999). The stepwise solid-phase synthesis methodology is suitable for the preparation of a great variety of nucleopeptides. Nucleosides & Nucleotides, 18(6-7), pp. 1493 - 1494 . ISSN: 0732-8311

Robles, J.; Beltrán, M.; Marchán, V.; Pérez, Y.; Travesset, I.; Pedroso, E.; Grandas, A. (1999). Towards nucleopeptides containing any trifunctional amino acid. Tetrahedron, 55, pp. 13251 - 13264 . ISSN: 0040-4020

Marchán, V.; Rodríguez-Tanty, C.; Estrada, M.; Pedroso, E.; Grandas, A. (2000). Alternative procedures for the synthesis of methionine-containing peptide- oligonucleotide hybrids. European Journal of Organic Chemistry, 13, pp. 2495 - 2500 . ISSN: 1434-193X

Albericio, F.; Cruz, M.; Debéthune, L.; Eritja, R.; Giralt, E.; Grandas, A.; Marchán, V.; Pastor, J. J.; Pedroso, E.; Rabanal, F.; Royo, M. (2001). Improved synthesis of N-[(9-hydroxymethyl)-2-fluorenyl]succinamic acid (HMFS), a versatile handle for the solid-phase synthesis of biomolecules. Synthetic Communications, 31, pp. 225 - 232 . ISSN: 0039-7911

Marchán, V.; Moreno, V.; Pedroso, E.; Grandas, A. (2001). Towards a better understanding of cisplatin mode of action. Chemistry-A European Journal, 7, pp. 808 - 815 . ISSN: 0947-6539

Debéthune, L.; Marchán, V.; Fábregas, G.; Pedroso, E.; Grandas, A. (2002). Towards nucleopeptides containing any trifunctional amino acid (II). Tetrahedron, 58, pp. 6965 - 6978 . ISSN: 0040-4020

Gómez-Pinto, I.; Marchán, V.; Gago, F.; Grandas, A.; González, C. (2003). Solution structure and stability of tryptophan-containing nucleopeptide duplexes. ChemBioChem, 4, pp. 40 - 49 . ISSN: 1439-4227

Gómez-Pinto, I.; Marchán, V.; Gago, F.; Grandas, A.; González, C. (2003). Solution structure and stability of a disulfide cross-linked nucleopeptide duplex. Journal of the Chemical Society. D-Chemical Communications, 20, pp. 2558 - 2559 . ISSN: 0022-4936

Marchán, V.; Debéthune, L.; Pedroso, E.; Grandas, A. (2004). Stabilization of DNA duplexes by covalently-linked peptides. Tetrahedron, 60, pp. 5461 - 5469 . ISSN: 0040-4020

Marchán, V.; Pedroso, E.; Grandas, A. (2004). Insights into the reaction of transplatin with DNA and proteins: methionine-mediated formation of histidine-guanine trans-Pt(NH3)2 cross-links. Chemistry-A European Journal, 10, pp. 5369 - 5375 . ISSN: 0947-6539

Jaumot, J.; Marchán, V.; Gargallo, R.; Grandas, A.; Tauler, R. (2004). Multivariate Curve Resolution applied to the analysis and resolution of two-dimensional [¹H,¹⁵N]-NMR data. Analytical Chemistry, 76(23), pp. 7094 - 7101 . ISSN: 0003-2700

S.L. Beaucage, M.K. Chmielewski, J. Cieślak, A. Grajkowski, V. Marchán, L.R. Phillips, A. Wilk (2003). Conceptual 'Heat-driven' Approach to the Synthesis of DNA Oligonucleotides on Microarrays. Annals of the New York Academy of Sciences, 1002, pp. 1 - 11 . ISSN: 0077-8923

M.K. Chmielewski, V. Marchán, J. Cieslak, Livengood, V.; U. Münch, A. Wilk, S.L. Beaucage (2003). Thermolytic Carbonates for Potential 5’-Hydroxyl Protection of Deoxyribonucleosides. Journal of Organic Chemistry, 68, pp. 10003 - 10012 . ISSN: 0022-3263

V. Marchán, J. Cieślak, V. Livengood, S.L. Beaucage (2004). The 2,2,5,5-Tetramethylpyrrolidin-3-one-1-sulfinyl Group for 5’-Hydroxyl Protection of Deoxyribonucleoside Phosphoramidites in the Solid Phase Preparation of DNA Oligonucleotides. Journal of the American Chemical Society, 126, pp. 9601 - 9610 . ISSN: 0002-7863

Marchan, V.; Pulido, D.; Pedroso, E.; Grandas, A. (2006). Linking the 3' ends of oligonucleotide duplexes with cystine disulfide bridges. European Journal of Organic Chemistry, pp. 958 - 963 . ISSN: 1434-193X

Marchan, V.; Ortega, S.; Pulido, D.; Pedroso, E.; Grandas, A. (2006). Diels-Alder cycloadditions in water for the straightforward preparation of peptide-oligonucleotide conjugates. Nucleic Acids Research, 34, pp. e24(1) - e24(9) . ISSN: 0305-1048

Algueró, B.; López de la Osa, J.; González, C.; Pedroso, E.; Marchán, V.; Grandas, A. (2006). Selective platination of modified oligonucleotides and duplex cross-links. Angewandte Chemie-International Edition, 45, pp. 8194 - 8197 . ISSN: 1433-7851

Algueró, B.; Pedroso, E.; Marchán, V.; Grandas, A. (2007). Incorporation of two modified nucleosides allows selective platination of an oligonucleotide making it suitable for duplex cross-linking. Journal of Biological Inorganic Chemistry, 12(6), pp. 901 - 911 . ISSN: 0949-8257

Pulido, D..; López-Alonso, J. P.; .; Marchán, V.; González, C.;.; Grandas, A.; Laurents, D. V. (2008). Preparation of Ribonuclease S domain-swapped dimers conjugated with DNA and PNA: modulating the activity of ribonucleases. Bioconjugate Chemistry, 19, pp. 263 - 270 . ISSN: 1043-1802

Barragán, F.; Moreno, V.; Marchán, V. (2009). Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs. Chemical Communications, pp. 4705 - 4707 . Institutional Repository . ISSN: 1359-7345

López-Senín, P.; Gómez-Pinto, I.; Grandas, A.; Marchán, V. (2011). Identification of Ligands for the Tau Exon 10 Splicing Regulatory Element RNA Using Dynamic Combinatorial Chemistry. Chemistry-A European Journal, 17, pp. 1946 - 1953 . Institutional Repository . ISSN: 0947-6539

Barragán, F.; López-Senín, P.; Salassa, L.; Betanzos-Lara, S.; Habtemariam, A.; Moreno, V.; Sadler, P.J.; Marchán, V. (2011). Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex. Journal of the American Chemical Society, 133(35), pp. 14098 - 14108 . Institutional Repository . ISSN: 0002-7863

Barragá, F.; Carrion-Salip, D.; Gómez-Pinto, I.; González-Cantó, A.; Sadler, P.J.; de Llorens, R.; Moreno, V.; González, C.; Massaguer, A.; Marchán, V. (2012). Somatostatin Subtype‑2 Receptor-Targeted Metal-Based Anticancer Complexes. Bioconjugate Chemistry, 23, pp. 1838 - 1855 . Institutional Repository . ISSN: 1043-1802

López-Senín, P.; Artigas, G.; Marchán, V. (2012). Exploring the effect of aminoglycoside guanidinylation on ligands for Tau exon 10 splicing regulatory element RNA. Organic & Biomolecular Chemistry, 10, pp. 9243 - 9254 . Institutional Repository . ISSN: 1477-0520

Grau-Campistany, A.; Massaguer, A.; Carrion-Salip, D.; Barragán, F.; Artigas, G.; López-Senín, P.; Moreno, V.; Marchán, V. (2013). Conjugation of a Ru(II) Arene Complex to Neomycin or to Guanidinoneomycin Leads to Compounds with Differential Cytotoxicities and Accumulation between Cancer and Normal Cells. Molecular Pharmaceutics, 10(5), pp. 1964 - 1976 . Institutional Repository . ISSN: 1543-8384

Artigas, G.; Marchán, V. (2013). Synthesis of Janus compounds for the recognition of G-U mismatched nucleobase pairs. Journal of Organic Chemistry, 78(21), pp. 10666 - 10677 . Institutional Repository . ISSN: 0022-3263

Fernández, M.; Shaili, E.; González Cantó, A.; Artigas, G.; Sánchez, C.; Woods, J.A.; Sadler, P.J.; Marchán, V. (2014). Photo-targeted platinum conjugates as selective anticancer drugs. Journal of Biological Inorganic Chemistry, 19(Suppl 2), p. S782 . https://doi.org/10.1007/s00775-014-1162-1 . ISSN: 0949-8257

Massaguer, A.; González-Cantó, A.; Escribano, E.; Barrabés, S.; Artigas, G.; Moreno, V.; Marchán, V. (2015). Integrin-targeted delivery into cancer cells of a Pt(IV) pro-drug through conjugation to RGD-containing peptides. Dalton Transactions, 44, pp. 202 - 212 . Institutional Repository . ISSN: 1477-9226

Artigas, G.; Marchán, V. (2015). Synthesis and Tau RNA Binding Evaluation of Ametantrone-Containing Ligands. Journal of Organic Chemistry, 80(4), pp. 2155 - 2164 . Institutional Repository . ISSN: 0022-3263

Artigas, G.; López-Senín, P.; González, C.; Escaja, N.; Marchán, V. (2014). Ametantrone-based compounds as potential regulators of Tau pre-mRNA alternative splicing. Organic & Biomolecular Chemistry, 13, pp. 452 - 464 . Institutional Repository . ISSN: 1477-0520

Gandioso, A.; Shaili, E.; Massaguer, A.; Artigas, G.; González-Cantó, A.; Woods, J. A.; Sadler, P. J.; Marchán, V. (2015). An integrin-targeted photoactivatable Pt(IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies. Chemical Communications, 51, pp. 9169 - 9172 . Institutional Repository . ISSN: 1359-7345

Shaili, E.; Fernández-Giménez, M.; Rodríguez-Astor, S.; Gandioso, A.; Sandín, L.; García-Vélez, C.; Massaguer, A.; Clarkson, G. J.; Woods, J. A.; Sadler, P. J.; Marchán, V. (2015). A photoactivatable PtIV anticancer complex conjugated to the RNA ligand guanidinoneomycin. Chemistry-A European Journal, 21(50), pp. 18474 - 18486 . Institutional Repository . ISSN: 0947-6539

Gandioso, A.; Cano, M.; Massaguer, A.; Marchán, V. (2016). A Green Light-Triggerable RGD Peptide for Photocontrolled Targeted Drug Delivery: Synthesis and Photolysis Studies. Journal of Organic Chemistry, 81(23), pp. 11556 - 11564 . Institutional Repository . ISSN: 0022-3263

Gandioso, A.; Massaguer, A.; Villegas, N.; Salvans, C.; Sánchez, D.; Brun-Heath, I.; Marchán, V.; Orozco, M.; Terrazas, M. (2017). Efficient siRNA-peptide conjugation for specific targeted delivery to tumor cells. Chemical Communications, 53(19), pp. 2870 - 2873 . Institutional Repository . ISSN: 1359-7345

Albert Gandioso; Marta Palau; Alba Nin-Hill; Ivanna Melnyk; Carme Rovira; Santi Nonell; Dolores Velasco; Jaume García-Amorós; Vicente Marchán (2017). Sequential uncaging with green light can be achieved by fine-tuning the structure of a dicyanocoumarin chromophore. ChemistryOpen, 6(3), pp. 375 - 384 . Institutional Repository . ISSN: 2191-1363

Vojtech Novohradsky; Ana Zamora; Albert Gandioso; Viktor Brabec; José Ruiz; Vicente Marchán (2017). Somatostatin receptor-targeted organometallic iridium(III) complexes as novel theranostic agents. Chemical Communications, 53, pp. 5523 - 5526 . Institutional Repository . ISSN: 1359-7345

A. Gandioso; S. Contreras; I. Melnyk; J. Oliva; S. Nonell; D. Velasco; J. Garcia-Amoros; V. Marchán (2017). Development of green/red-absorbing chromophores based on a coumarin scaffold that are useful as caging groups. Journal of Organic Chemistry, 82(10), pp. 5398 - 5408 . Institutional Repository . ISSN: 0022-3263

Gandioso, A.; Bresoli-Obach, R.; Nin-Hill, A.; Bosch, M.; Palau, M.; Galindo, A.; Contreras, S.; Rovira, A.; Rovira, C.; Nonell, S.; Marchán, V. (2018). Redesigning the coumarin scaffold into small bright fluorophores with far-red to NIR emission and large Stokes' shifts useful for cell imaging. Journal of Organic Chemistry, 83(3), pp. 1185 - 1195 . Institutional Repository . ISSN: 0022-3263

Zamora, A.; Gandioso, A.; Massaguer, A.; Buenestado, S.; Calvis, A.; Hernández, J. L.; Mitjans, F.; Rodríguez, V.; Ruiz, J.; Marchán, V. (2018). Toward Angiogenesis Inhibitors Based on the Conjugation of Organometallic Platinum(II) Complexes to RGD Peptides. ChemMedChem, 13(17), pp. 1755 - 1762 . Institutional Repository . ISSN: 1860-7179

Gandioso, A.; Palau, M.; Bresolí-Obach, R.; Galindo, A.; Rovira, A.; Bosch, M.; Nonell, S.; Marchán, V. (2018). High photostability in non-conventional coumarins with far-red/NIR emission through azetidinyl substitution. Journal of Organic Chemistry, 83(19), pp. 11519 - 11531 . Institutional Repository . ISSN: 0022-3263

Rovira, A.; Gandioso, A.; Goñalons, M.; Galindo, A.; Massaguer, A.; Bosch, M.; Marchan, V. (2019). Solid-phase approaches for labelling targeting peptides with far-red emitting coumarin fluorophores. Journal of Organic Chemistry, 84(4), pp. 1808 - 1817 . Institutional Repository . ISSN: 0022-3263

Novohradsky, V.; Rovira, A.; Hally, C.; Galindo, A.; Vigueras, G.; Gandioso, A.; Svitelova, M.; Bresolí-bach, R.; Kostrhunova, H.; Markova, L.; Kasparkova, J.; Nonell, S.; Ruiz, J.; Brabec, V.; Marchán, V. (2019). Towards novel photodynamic anticancer agents generating superoxide anion radicals: A cyclometalated IrIII complex conjugated to a far-red emitting coumarin. Angewandte Chemie-International Edition, 58(19), pp. 6311 - 6315 . Institutional Repository . ISSN: 1433-7851

Rovira, A.; Pujals, M.; Gandioso, A.; López-Corrales, M.; Bosch, M.; Marchán, V. (2020). Modulating photostability and mitochondria selectivity in far-red/NIR emitting coumarin fluorophores through replacement of pyridinium by pyrimidinium. Journal of Organic Chemistry, 85(9), pp. 6086 - 6097 . Institutional Repository . ISSN: 0022-3263

López-Corrales, M.; Rovira, A.; Gandioso, A.; Bosch, M.; Nonell, S.; Marchán, V. (2020). Transformation of COUPY fluorophores into a novel class of visible light-cleavable photolabile protecting groups. Chemistry-A European Journal, 26 . Institutional Repository . ISSN: 0947-6539

Gandioso, A.; El Fakiri, M.; Rovira, A.; Marchán, V. (2020). A simple method for the synthesis of N-difluoromethylated pyridines and 4-pyridones/quinolones by using BrCF2COOEt as the difluoromethylation reagent. RSC Advances, 10, pp. 29829 - 29834 . Institutional Repository . ISSN: 2046-2069

Gandioso, A.; Rovira, A.; Shi, H.; Sadler, P. J. ; Marchán, V. (2020). Unexpected photoactivation pathways in a folate-receptor-targeted trans-diazido Pt(iv) anticancer pro-drug. Dalton Transactions, 49, pp. 11828 - 11834 . Institutional Repository . ISSN: 1477-9226

Martin-Gómez, H.; Oliver-Cervelló, L.; Sánchez-Campillo, I.; Marchán, V.; Ginebra, M.-P.; Mas-Moruno, C. (2021). A versatile click chemistry-based approach for functionalizing biomaterials of diverse nature with bioactive peptides. Chemical Communications, 57(8), pp. 982 - 985 . Institutional Repository . ISSN: 1359-7345

Novohradsky, V.; Markova, L.; Kostrhunova, H.; Kasparkova, J.; Ruiz, J.; Marchán, V.; Brabec, V. (2021). A cyclometallated IrIII complex conjugated to a coumarin derivative is a potent photodynamic agent against prostate differentiated and tumorigenic cancer stem cells. Chemistry-A European Journal, 27, pp. 8547 - 8556 . Institutional Repository . ISSN: 0947-6539

Ortega-Forte, E.; Rovira, A.; Gandioso, A.; Bonelli, J.; Bosch, M.; Ruiz, J.; Marchán, V. (2021). COUPY Coumarins as Novel Mitochondria-Targeted Photodynamic Therapy Anticancer Agents. Journal of Medicinal Chemistry, 64(23), pp. 17209 - 17220 . Institutional Repository . ISSN: 0022-2623

Bonelli, Joaquín ; Ortega Forte, Enrique ; Vigueras, Gloria ; Bosch, Manel ; Cutillas, Natalia; Rocas, Josep ; Ruiz, José ; Vicente Marchán, Vicente (2022). Polyurethane-polyurea hybrid nanocapsules as efficient delivery systems of anticancer Ir(III) metallodrugs. Inorganic Chemistry Frontiers, 9(10), pp. 2123 - 2138 . Institutional Repository . ISSN: 2052-1553

Bonelli, J.; Ortega-Forte, E.; Rovira, A.; Bosch, M.; Torres, O.; Cuscó, C.; Rocas, J.; Ruiz, J.; Marchán, V. (2022). Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier. Biomacromolecules, 23(7), pp. 2900 - 2913 . Institutional Repository . ISSN: 1525-7797

Simba Lahuasi, Alvaro; Cantero Camacho, Ángel; Rosales, Rosales; McGovern, Briana Lynn; Rodríguez, M. Luis; Marchán Sancho, Vicente; White, Kris M.; García Sastre, Adolfo; Gallego, José (2022). SARS-CoV-2 Inhibitors Identified by Phenotypic Analysis of a Collection of Viral RNA-Binding Molecules. Pharmaceuticals, 15, p. 1448 . Institutional Repository . ISSN: 1424-8247

Izquierdo, E.; López-Corrales, M. Abad-Montero, D.; Rovira, A.; Fabriàs, G.; Bosch, M.; Abad, J.-L.; Marchán, V. (2022). Fluorescently-labelled ceramides and 1-deoxyceramides: Synthesis, characterization and cellular distribution studies. Journal of Organic Chemistry, 87, pp. 16351 - 16367 . Institutional Repository . ISSN: 0022-3263

Bonelli, J.; Velasco-de-Andrés, M.; Isidro, N.; Bayó, C.; Chumillas, S.; Carrillo-Serradell, L.; Casadó-Llombart, S.; Mok, C.; Benítez-Ribas, D.; Lozano, F.; Rocas, J.; Marchán, V. (2022). Novel tumor-targeted self-nanostructured and compartmentalized water-in-oil-in-water polyurethane-polyurea nanocapsules for cancer theragnosis. Pharmaceutics, 15(1), p. 58 . Institutional Repository . ISSN: 1999-4923

Rovira, A.; Ortega-Forte, E.; Hally, C.; Jorda-Redondo, M.; Abad-Montero, D.; Vigueras, G.; Martinez, J. I.; Bosch, M.; Nonell, S.; Ruiz, J.; Marchán, V. (2023). Exploring Structure-Activity Relationships in Photodynamic Therapy Anticancer Agents Based on Ir(III)-COUPY Conjugates. Journal of Medicinal Chemistry, 66(12), pp. 7849 - 7867 . Institutional Repository . ISSN: 0022-2623

López-Corrales, M.; Rovira, A.; Gandioso, A.; Nonell, S.; Bosch, M.; Marchán, V. (2023). Mitochondria-Targeted COUPY Photocages: Synthesis and Visible-Light Photoactivation in Living Cells. Journal of Organic Chemistry, 88(11), pp. 7128 - 7140 . Institutional Repository . ISSN: 0022-3263

Ortega-Forte, E.; Rovira, A.; López-Corrales, M.; Hernández-García, A.; Ballester, F. J.; Izquierdo-García, E. Jorda-Redondo, M.; Bosch, M.; Nonell, S.; Santana, M. D.; Ruiz, J.; Marchán, V.; Gasser, G. (2023). A near-infrared light-activatable Ru(II)-coumarin photosensitizer active under hypoxic conditions. Chemical Science, 14(26), pp. 7170 - 7184 . Institutional Repository . ISSN: 2041-6520

Izquierdo-García, E.; Rovira, A.; Forcadell, J.; Bosch, M.; Marchán, V (2023). Exploring Structural–Photophysical Property Relationships in Mitochondria-Targeted Deep-Red/NIR-Emitting Coumarins. International Journal of Molecular Sciences, 24, p. 17427 . ISSN: 1661-6596

Gandioso, A.; Izquierdo-García, E.; Mesdom, P.; Arnoux, P.; Demeubayeva, N.; Burckel, P.; Saubaméa, B.; Bosch, M.; Frochot, C.; Marchán, V.; Gasser, G. (2023). Ru(II)-Cyanine Complexes as Promising Photodynamic Photosensitizers for the Treatment of Hypoxic Tumours with Highly Penetrating 770 nm Near-Infrared Light. Chemistry-A European Journal, 29, p. e202301742 . ISSN: 0947-6539

Chumillas, S.; Loharch, S.; Beltrán, M.; Szewczyk, M.; Bernal, S.; Puertas, M. C.; Martínez-Picado, J.; Alcamí, J.; Bedoya, L. M.; Marchán, V.; Gallego, J. (2023). Exploring the HIV-1 RRE-Rev inhibitory capacity and antiretroviral action of benfluronanalogs. Molecules, 28, p. 7031 . ISSN: 1420-3049

Other publications

Grandas, A.; Marchán, V.; Debéthune, L.; Pedroso, E. (2004). Stepwise Solid-Phase Synthesis of Nucleopeptides Chapter 4: Synthesis of Modified Oligonucleotides and Conjugates . In Current Protocols in Nucleic Acid Chemistry . Volume. Unit 4.22 . (pp. 4.22.1 - 4.22.54) . John Wiley & Sons . ISBN: 0-471-24662-X .

Marchán, V.; Grandas, A. (2007). Synthesis of peptide-oligonucleotide conjugates by Diels-Alder cycloaddition in water. Chapter 4: Synthesis of modified oligonucleotides and conjugates . In Current Protocols in Nucleic Acid Chemistry . Volume. Unit 4.32 . (pp. 4.32.1 - 4.32.31) . John Wiley & Sons . ISBN: 0-471-24662-X .

Marchán, V.; Grandas, A. (2008). Platinated oligonucleotides: Synthesis and applications for the control of gene expression . In Metal Complex-DNA Interactions . (pp. 273 - 295) . Blackwell Publishing Inc. [etc.] . ISBN: 978-1-4051-7629-3 .

Thesis, minor thesis and research reports

Berta Algueró Cama . (2006) . Anàlegs oligonucleotídics que incorporen grups tioèter i/o imidazole: Reacció amb transplatí i entrecreuament amb la cadena complementària (Ph.D. Thesis) . Universitat de Barcelona.

López Senín, P . (2011) . Desarrollo de ligandos estabilizantes de la estructura de RNA implicada en el procesado alternativo del exón 10 de la proteína tau mediante química combinatoria dinámica (Ph.D. Thesis) . Universitat de Barcelona.

Barragán Clavero, F . (2011) . Vehiculización de compuestos metálicos hacia células tumorales mediante conjugación a análogos de octreotide (Ph.D. Thesis) . Universitat de Barcelona.

Artigas Sole, G . (2013) . Desenvolupament de lligands de l'estructura secundària d'RNA implicada en el processat alternatiu de l'exó 10 de la proteïna tau (Ph.D. Thesis) . Universitat de Barcelona.

Gandioso Ubieto, A . (2018) . Novel chemical tools for Cancer therapy and imaging: from targeted photoactivatable Pt(IV) complexes to coumarin-based fluorophores and caging groups (Ph.D. Thesis) . Universitat de Barcelona.

Rovira Vidal, A . (2023) . COUPY coumarins as privileged scaffolds for the development of novel targeted fluorophores and metal-based PDT anticancer agents (Ph.D. Thesis) . Universitat de Barcelona.

Bonelli Blasco, J . (2022) . Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis (Ph.D. Thesis) . Universitat de Barcelona.

López Corrales, M . (2019) . Synthesis and biological applications of COUPY-based caging groups (ongoing thesis) (Ph.D. Thesis) . Universitat de Barcelona.

Chumillas Vicedo, Sergi . (2021) . RNA-targeted small-molecule agents against SARS-CoV-2 and HIV-1 (ongoing thesis) (Ph.D. Thesis) . Universitat de Barcelona.

Abad Montero, Diego . (2022) . Desarrollo de nuevos agentes teranósticos basados en cumarinas COUPY de utilidad en cáncer (ongoing thesis) (Ph.D. Thesis) . Universitat de Barcelona.

Santiago Domínguez, Neus . (2023) . Desenvolupament de noves nanomedicines basades en nanocàpsules híbrides de poliuretàpoliurea pel tractament oncològic (ongoing thesis) (Ph.D. Thesis) . Universitat de Barcelona.

Patents, Software and Database

Gallego, José; Cantero Camacho, Ángel; Simba, Álvaro; García Sastre, Adolfo; Rosales Ramírez, Romel; White, Kris; Marchán Sancho, Vicente Ref. EP21382127.5. Small-molecule agents with antiviral activity against RNA viruses (European Patent Convention Countries, 17/02/2021 ) . Universidad Católica de Valencia San Vicente Mártir / Icahn Scool of Medicine at Mount Sinai / Universitat de Barcelona

Gallego, José; Cantero Camacho, Ángel; Simba, Álvaro; García Sastre, Adolfo; Rosales Ramírez, Romel; White, Kris; Marchán Sancho, Vicente; Chumillas Vicedo, Sergi Ref. PCT/EP2022/053938. Small-molecule agents with antiviral activity against RNA viruses (Patent Cooperation Treaty Countries, 17/02/2022 ) . Universidad Católica de Valencia San Vicente Mártir / Icahn Scool of Medicine at Mount Sinai / Universitat de Barcelona

Marchán Sancho, Vicente; Gandioso, Albert; Gasser, Gilles Albert; Chumillas Vicendo, Sergi; Castaño Duro, Davor; López Corrales, Marta; Abad Montero, Diego Ref. EP23382155.2. Metal complex compounds as photosensitizers for photodynamic therapy (European Patent Convention Countries, 20/02/2023 ) . Universitat de Barcelona / ECOLE NATIONALE SUPERIEURE DE CHIMIE DE PARIS / Centre National de la Recherche Scientifique (CNRS) / PARIS SCIENCES ET LETTRES

Research projects (last 5 years)

Nuevos agentes terapéuticos y de bioimagen basados en fluoróforos COUPY . 2021 - 2024 . Ref.PID2020-117508RB-I00 . Ministerio de Ciencia e Innovación (MICINN) . PI: Vicente Marchán Sancho

RNA-targeted small-molecule agents against SARS-CoV2 (CONSOLIDATE COV 19) . 2020 - 2022 . Ref.CF01-00010 . Fundació Caixa de Pensions 'La Caixa' . PI: Vicente Marchán Sancho

Nuevas herramientas químicas con aplicación en bioimagen, bioconjugación y en vehiculización fotocontrolada y dirigida de fármacos . 2018 - 2021 . Ref.CTQ2017-84779-R . Ministerio de Economía y Competitividad . PI: Vicente Marchán Sancho

Multifunctional polymeric nanosystems for the controlled and intelligent release of active pharmaceutical ingredients . 2018 - 2021 . Ref.2017 DI 072 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Vicente Marchán Sancho

Análogos de oligonucleótidos y pequeñas moléculas para modular la expresión génica y combatir enfermedades . 2015 - 2017 . Ref.CTQ2014-52658-R . Ministerio de Ciencia e Innovación (MICINN) . PI: Ana Maria Grandas Sagarra

New anticancer agents for photodynamic therapy. 2021 LLAV 00083 . 2022 - 2023 . Ref.2021 LLAV 00083 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Vicente Marchán Sancho

Novel metal-based anticancer agents for photodynamic therapy. F2I-PdC_2022-007 . 2023 - 2024 . Ref.F2I-PdC_2022-007 . Fundació Bosch i Gimpera de la Universitat de Barcelona . PI: Vicente Marchán Sancho

Discovery of novel HIV-1 RNA biogenesis inhibitors based on disrupting the RRE-Rev ribonucleoprotein . 2021 - 2024 . Ref.PROMETEO/2021/036 . Generalitat Valenciana . PI: Jose Gallego Sala

Novel far-red/NIR-activatable PDT agents for combating hypoxic tumors . 2023 - 2025 . Ref.CI23-20067 . Fundació Caixa de Pensions 'La Caixa' . PI: Vicente Marchán Sancho