Carlos Sebastián Muñoz

Carlos Sebastián Muñoz

Professor agregat

ORCID: 0000-0001-6623-8028
Scopus Author ID: 8584599200
Researcher ID: H-8014-2018
Àrea de coneixement : Immunologia

Group Leader, Laboratory of Metabolic Dynamics in Cancer

Grup de Recerca: Inflamació: recerca bàsica i traslacional

Informació de contacte
Departament de Biologia Cel·lular, Fisiologia i Immunologia
Parc Científic de Barcelona, S1B53 Institut de Biomedicina de la Universitat de Barcelona (IBUB)
+34 93 403 71 66
csebastian(a)ub.edu

Formació acadèmica

Bioquímica . Universitat de Barcelona . (Diplomatura / Llicenciatura / Grau)
Bioquímica/Immunologia . Universitat de Barcelona . (Doctorat )

Linies de Recerca

Metabolic regulation of stem cell fate during tissue homeostasis and tumorigenesis
Metabolic heterogeneity and evolution of cancer
Immunometabolism in the tumor microenvironment

Projectes

Metabolic dynamics of colorectal cancer . 2018 - 2020 . Ref.797464 . European Commission . IP: Carlos Sebastián
La regulación metabólica de la actividad de las células madre como factor determinante en el cáncer colorrectal . 2021 - 2024 . Ref.PID2020-114783RB-I00 . Ministerio de Ciencia e Innovación . IP: Carlos Sebastian Muñoz
Tumor metabolic heterogeneity as a driver of colorectal cancer metastasis and response to therapies . 2022 - 2024 . Fundación BBVA . IP: Carlos Sebastian Muñoz
Defining metabolic heterogeneity as a mechanism of immune evasion in colorectal cancer . 2024 - 2025 . Fundación Olga Torres . IP: Carlos Sebastian Muñoz
Caracterización funcional de los cambios espacio-temporales en el metabolismo celular durante la tumorigénesis . 2024 - 2027 . Ref.PID2023-149228OB-I00 . Ministerio de Ciencia e Innovación . IP: Carlos Sebastian Muñoz

Publicacions en revistes

Kowalik MA, Puliga E, Cabras L, Sulas P, Petrelli A, Perra A, Ledda-Columbano GM, Morandi A, Merlin S, Orrù C, Sanchez-Martin C, Fornari F, Gramantieri L, Parri M, Rasola A, Bellomo SE, Sebastian C, Follenzi A, Giordano S, Columbano A. (2020). Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming. Journal of Hepatology . ISSN: 0168-8278
La Vecchia S, Sebastián C. (2019). Metabolic pathways regulating colorectal cancer initiation and progression. Seminars in Cell & Developmental Biology . ISSN: 1084-9521
Kugel S, Sebastián C, Fitamant J, Ross KN, Saha SK, Jain E, Gladden A, Arora KS, Kato Y, Rivera MN, Ramaswamy S, Sadreyev RI, Goren A, Deshpande V, Bardeesy N, Mostoslavsky R. (2016). SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell . ISSN: 0092-8674
Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. (2014). Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell . ISSN: 0092-8674
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. (2012). The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell . ISSN: 0092-8674
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. (2010). The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell . ISSN: 0092-8674
Pöltl, L.; Kitsera, M.; Raffl, S.; Schild, S.; Cosic, A.; Kienesberger, S.; Unterhauser, K.; Raber, G.; Lembacher-Fadum, C.; Breinbauer, R.; Gorkiewicz, G.; Sebastian, C.; Hoefler, G.; Zechner, E.L. (2023). Microbiota-derived Genotoxin Tilimycin Generates Colonic Stem Cell Mutations. Cell Reports . ISSN: 2211-1247
Sebastian C; Ferrer C; Serra M; Choi JE; Ducano N; Mira A; Shah MS; Stopka SA; Perciaccante AJ; Isella C; Moya-Rull D; Vara-Messler M; Giordano S; Maldi E; Desai N; Capen DE; Medico E; Cetinbas M, Sadreyev RI; Brown D; Rivera MN; Sapino A; Breault DT; Agar NYR; Mostoslavsky R. (2022). A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nature Communications . ISSN: 2041-1723
Fortuny, L.; Sebastian, C. (2021). Sirtuins as Metabolic Regulators of Immune Cells Phenotype and Function. Genes . ISSN: 2073-4425
Choi JE; Sebastian C; Ferrer CM; Lewis CA; Sade-Feldman M; LaSalle T; Gonye A; Lopez BGC; Abdelmoula WM; Regan MS; Cetinbas M; Pascual G; Wojtkiewicz GR; Silveira GG; Boon R; Ross KN; Tirosh I; Saladi SV; Ellisen LW; Sadreyev RI; Benitah SA; Agar NYR; Hacohen N; Mostoslavsky R. (2021). A unique subset of tumor-propagating cells drives squamous cell carcinoma. Nature Metabolism . ISSN: 2522-5812

Més Informació: https://sites.google.com/view/carlossebastianlab/home