Carlos Sebastián Muñoz

Carlos Sebastián Muñoz

Investigador programa Beatriz Galindo

ORCID: 0000-0001-6623-8028
Scopus Author ID: 8584599200
Researcher ID: H-8014-2018

Group Leader, Laboratory of Metabolic Dynamics in Cancer
Contact Information
Department of Cell Biology, Physiology and Immunology
Parc Científic de Barcelona, S1B53 Institut de Biomedicina de la Universitat de Barcelona (IBUB)
+34 93 403 71 66
csebastian(a)ub.edu

Academic Training

Bioquímica . Universitat de Barcelona . (Diploma / Degree / Activities)
Bioquímica/Immunologia . Universitat de Barcelona . (Ph.D.)

Research interests

Metabolic regulation of stem cell fate during tissue homeostasis and tumorigenesis
Metabolic heterogeneity and evolution of cancer
Immunometabolism in the tumor microenvironment

Projects

A study on the mechanisms through which tumor cells escape intrinsic and extrinsic control systems . 2017 - 2020 . Ref.MIUR 2011/2014-STAR . Fondazione Piemontese per la Ricerca sul Cancro (FPRC) . PI: Carlos Sebastián
Metabolic dynamics of colorectal cancer . 2018 - 2020 . Ref.797464 . European Commission . PI: Carlos Sebastián
The role of metabolic reprogramming in driving colorectal carcinoma by regulating stemness and tumorigenesis in the intestine . 2020 - 2022 . Ref.GR-2018-12365776 . Ministerio della Salute . PI: Carlos Sebastián
MIUR 5x1000-STRATEGY . 2020 - 2022 . Fondazione Piemontese per la Ricerca sul Cancro (FPRC) . PI: Carlos Sebastián
The role of SIRT6 in metabolic reprogramming during colorectal carcinoma . 2013 - 2016 . Ref.CA120342 . Department of Defense. USA . PI: Carlos Sebastián

Journal Publications

Kowalik MA, Puliga E, Cabras L, Sulas P, Petrelli A, Perra A, Ledda-Columbano GM, Morandi A, Merlin S, Orrù C, Sanchez-Martin C, Fornari F, Gramantieri L, Parri M, Rasola A, Bellomo SE, Sebastian C, Follenzi A, Giordano S, Columbano A. (2020). Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming. Journal of Hepatology . ISSN: 0168-8278
La Vecchia S, Sebastián C. (2019). Metabolic pathways regulating colorectal cancer initiation and progression. Seminars in Cell & Developmental Biology . ISSN: 1084-9521
Sebastián C, Mostoslavsky R. (2017). The Various Metabolic Sources of Histone Acetylation. Trends in Endocrinology and Metabolism . ISSN: 1043-2760
Kugel S, Sebastián C, Fitamant J, Ross KN, Saha SK, Jain E, Gladden A, Arora KS, Kato Y, Rivera MN, Ramaswamy S, Sadreyev RI, Goren A, Deshpande V, Bardeesy N, Mostoslavsky R. (2016). SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Cell . ISSN: 0092-8674
Sebastián C, Mostoslavsky R. (2015). The role of mammalian sirtuins in cancer metabolism. Seminars in Cell & Developmental Biology . ISSN: 1084-9521
Sebastián C, Mostoslavsky R. (2014). Untangling the fiber yarn: butyrate feeds Warburg to suppress colorectal cancer. Cancer Discovery . ISSN: 2159-8274
Sebastian C. (2014). Tracking down the origin of cancer: metabolic reprogramming as a driver of stemness and tumorigenesis. Critical Reviews in Oncogenesis . ISSN: 0893-9675
Masri S, Rigor P, Cervantes M, Ceglia N, Sebastian C, Xiao C, Roqueta-Rivera M, Deng C, Osborne TF, Mostoslavsky R, Baldi P, Sassone-Corsi P. (2014). Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell . ISSN: 0092-8674
Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R. (2012). The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell . ISSN: 0092-8674
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R. (2010). The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell . ISSN: 0092-8674

More Information: https://sites.google.com/view/carlossebastianlab/home