Francisco Javier Lopez Soriano

Francisco Javier Lopez Soriano

Full professor

ORCID: 0000-0003-1493-3023
Researcher ID: W-4947-2018
Knowledge area: Bioquímica i Biologia Molecular

Secretary of the Department of Biochemistry and Molecular Biology (1995-2001)
Secretary of the Faculty of Biology (2004-2008)
Coordinator of the Biomedicine and Molecular Pharmacology Section of the Department of Biochemistry and Molecular Biomedicine (2021-present)

Research group:

Grup d'Innovació Docent de Bioquímica i Biologia Molecular (GID-BBM)

Contact Information
Department of Biochemistry and Molecular Biomedicine
Av. Diagonal, 643.
934034605
flopez(a)ub.edu

Teaching

Biochemistry
Metabolic Biochemistry
Regulation of Metabolism
Metabolic Pathways
Laboratory IV

Academic Training

Llicenciat en Biologia . Universitat de Barcelona . 06/1983 . (Diploma / Degree / Activities)
Grau de Llicenciatura (tesina) . Universitat de Barcelona . 19/07/1984 . (Diploma / Degree / Activities)
Doctor en Biologia . Universitat de Barcelona . 07/07/1987 . (Ph.D.)
Màster en Paleontologia . Universitat Autònoma de Barcelona . 06/2012 . (Official Master)

Research interests

Amino acid metabolism in brown adipose tissue
Intestinal transport and metabolism in experimental models of obesity
Molecular mechanisms of tumour necrosis factor-alpha in the development of cancer cachexia
Molecular mechanisms involved in cancer cachexia
Therapy design for the treatment of cancer cachexia

Projects

Papel del factor necrótico tumoral en el desarrollo de la caquexia: mecanismos moleculares . 1990 - 1993 . Ref.90-0663 . Ministerio de Sanidad y Consumo . PI: Jose Maria Argiles Huguet
Proteólisis muscular y caquexia cancerosa: mecanismos implicados y posibles estrategias terapéuticas . 1997 - 2000 . Ref.97/2059 . Ministerio de Sanidad y Consumo . PI: Jose Maria Argiles Huguet
Caquexia cancerosa: Papel de los factores de transcripción y del estrés nitrosativo en el músculo esquelético y posibles implicaciones terapéuticas . 2004 - 2006 . Ref.PI030100 . Ministerio de Sanidad y Consumo . PI: Fco. Javier Lopez Soriano
Estrés oxidativo y caquexia cancerosa: mecanismos moleculares responsables del desencadenamiento de la caquexia y su reversión durante la terapia . 2006 - 2009 . Ref.PI060907 . Ministerio de Sanidad y Consumo . PI: Fco. Javier Lopez Soriano
Regulación de la conversión del tejido adiposo blanco en marrón ('browning') durante la caquexia cancerosa: papel de la interleuquina-15 . 2016 - 2018 . Ref.SAF2015-65589-P . Ministerio de Economia y Competitividad . PI: Jose Maria Argiles Huguet

Journal Publications

Busquets, S.; Ametller, E.; Fuster, G.; Olivan, M.; Raab, V.; Argilés, J.M.; López-Soriano, F.J. (2007). Resveratrol, a natural diphenol, reduces metastatic growth in an experimental cancer model. Cancer Letters, 245(1-2), pp. 144 - 148 . https://doi.org/10.1016/j.canlet.2005.12.035 . ISSN: 0304-3835
Fuster, G.; Busquets, S.; Ametller, E.; Olivan, M.; Almendro, V.; Fontes de Oliveira, C.C.; Figueras, M.; López-Soriano, F.J.; Argilés, J.M. (2007). Are PPARs involved in skeletal muscle wasting during experimental cancer cachexia? Role of ß2-adrenergic agonists. Cancer Research, 67(13), pp. 6512 - 6519 . ISSN: 0008-5472
Almendro, V.; Fuster, G.; Busquets, S.; Ametller, E.; Figueras, M.; Argilés, J.M.; López-Soriano, F.J. (2008). Effects of IL-15 on rat brown adipose tissue: uncoupling proteins and PPARs. Obesity, 16(2), pp. 285 - 289 . https://doi.org/10.1038/oby.2007.47 . ISSN: 1930-7381
Marín-Corral, J.; Fontes, C.C.; Pascual, S.; Sánchez, F.; Olivan, M.; Argilés, J.M.; Busquets, S.; López-Soriano, F.J.; Barreiro, E. (2010). Redox balance and carbonylated protein in limb muscles and heart of cachectic rats. Antioxidants & Redox Signaling, 12(3), pp. 365 - 380 . Institutional Repository . ISSN: 1523-0864
Argilés, J.M.; Busquets, S.; Stemmler, B. López-Soriano, F.J. (2014). Cancer cachexia: understanding the molecular basis. Nature Reviews Cancer, 14(11), pp. 754 - 762 . ISSN: 1474-175X
Toledo, Miriam; Busquets, Silvia; Penna, Fabio; Zhou, Xiaolan; Marmonti, Enrica; Betancourt, Angelica; Massa, David; Lopez-Soriano, Francisco J.; Han, H. Q.; Argiles, Josep M. (2016). Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and-2 agonist. International Journal of Cancer, 138(8), pp. 2021 - 2029 . https://doi.org/10.1002/ijc.29930 . ISSN: 0020-7136
Argiles, Josep M.; Javier Lopez-Soriano, Francisco; Stemmler, Britta; Busquets, Silvia (2017). Novel targeted therapies for cancer cachexia. Biochemical Journal, 474, pp. 2663 - 2678 . https://doi.org/10.1042/BCJ20170032 . ISSN: 0264-6021
Salazar-Degracia, A.; Busquets, S.; Argilés, J.M.; López-Soriano, F.J.; Barreiro, E. (2018). Effects of the beta2 agonist formoterol on atrophy signaling, autophagy, and muscle phenotype in respiratory and limb muscles of rats with cacer-induced cachexia. Biochimie, 149, pp. 79 - 91 . https://doi.org/10.1016/j.biochi.2018.04.009 . ISSN: 0300-9084
Argilés, J.M.; Stemmler, B.; López-Soriano, F.J.; Busquets, S. (2018). Inter-tissue communication in cancer-associated cachexia. Nature Reviews Endocrinology, 15(1), pp. 9 - 20 . ISSN: 1759-5029
Busquets, S.; Pérez-Peiró, S.; Salazar-Degracia, A.; Argilés, J.M.; Serpe, R.; Rojano-Toimil, A.; López-Soriano, F.J.; Barreiro, E. (2019). Differential structural features in soleus and gastrocnemius of carnitine-treated cancer cachectic rats. Journal of Cellular Physiology, 235(1), pp. 526 - 537 . ISSN: 0021-9541

Others Publications

Argilés, J.M.; López-Soriano, F.J. (1998). El Cancer y su prevención. Importancia de la alimentación . In Ediciones de la Universidad de Barcelona. Colección Omnia . (pp. 1 - 182) . ISBN: 843380374 .
Argilés, J.M.; López-Soriano, F.J.; Pallarés-Trujillo, J. (1998). Ubiquitin and Disease . In R.G. Landes Publishing Company (Austin, TX, USA) . (pp. 1 - 174) . ISBN: 1570595433 .
Argilés, J.M.; Busquets, S.; Moore-Carrasco, R.; López-Soriano, F.J. (2006). The role of cytokines in cancer cachexia . In Cachexia and Wasting: A Modern Approach. Mantovani, G., ed. Springer-Verlag Italia . (pp. 467 - 475) . EDF Science. Springer-Verlag . ISBN: 0-387-26282-2 .
Argilés, J.M.; Busquets, S.; Olivan, M.; López-Soriano, F.J. (2012). Nutrition and cachexia . In Supportive Care in Respiratory Diseases (2n edition) . (pp. 185 - 194) . Oxford University Press . ISBN: 9780199591763 .
Argilés, J.M.; Busquets, S.; López-Soriano, F.J. (2016). Muscle protein kinetics in cancer cachexia . In The Molecular Nutrition of Amino Acids and Proteins . Volume. 1 . (pp. 133 - 144) . Elsevier .

Relevant Activities

Member of the Ethical Commitee for Animal Experimentation of the University of Barcelona (2006-present)
Member of the Advisory Commission for the Institutional Project of Educational Policy of the University of Barcelona (2006)
Member of the Equality Commission of the Faculty of Biology of the University of Barcelona (2010-present)