Francisco Javier Pérez Areales
Professor lector
Àrea de coneixement : Química Orgànica
Perfil acadèmic
Organic and Medicinal Chemistry
Chemical Biology
Formació acadèmica
Licenciado en Farmacia
Máster en Química Orgánica Experimental e Industrial
Doctor en Química Orgánica y Farmacéutica
Línies de recerca
Revolving around the ubiquitin-proteasome system: USP2-TD
Projectes
Revolving around the ubiquitin‒proteasome system: USP2-targeted degrader
.
2021 - 2023
. Ref.101025271
. Unió Europea
. IP: Francisco Javier Perez Areales
TET2 modulation for myelodysplastic syndrome (MDS) and other diseases Acronim TET2_plus F21-FVal_2018_007
.
2018 - 2019
. Fundació Bosch i Gimpera de la Universitat de Barcelona
. IP: Xavier Barril Alonso
Development of TET2 modulators for cancer treatment
.
2019 - 2020
. Ref.310258
. Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron (VHIO)
. IP: Xavier Barril Alonso
Synthesis of compounds with innovative mechanisms against neurodegenerative diseases
.
2018 - 2021
. Ref.SAF2017-82771-R
. Ministerio de Economía y Competitividad
. IP: Diego Muñoz-Torrero López-Ibarra; Santiago Vázquez Cruz
QUÍMICA FARMACÈUTICA
.
2014 - 2017
. Ref.2014SGR52
. Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR)
. IP: Diego Muñoz-Torrero López-Ibarra
Exploration of novel targets and multitarget strategies for the design of compounds against infectious and prevalent diseases
.
2014 - 2017
. Ref.SAF2014-57094-R
. Ministerio de Economía y Competitividad
. IP: Francisco Javier Luque Garriga; Diego Muñoz-Torrero López-Ibarra
NUEVOS COMPUESTOS DE POTENCIAL INTERÉS INDUSTRIAL
.
2012 - 2014
. Ref.CTQ2011-22433
. Ministerio de Economía y Competitividad
. IP: Pelayo Camps García
Publicacions rellevants
Mia Kapun, F. Javier Pérez-Areales, Nicola Ashman, Pamela J. E. Rowling, Tim Schober, Elaine Fowler, Laura S. Itzhaki, David R. Spring.
Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution.
En
RSC Chemical Biology.
Volum 5.
2024
. https://doi.org/10.1039/D3CB00176H
Sampietro, A.; Pérez-Areales, F.J.; Martínez, P.; Arce, E.M.; Galdeano, C.; Muñoz-Torrero, D.
Unveiling the multitarget anti-Alzheimer drug discovery landscape: A bibliometric analysis.
En
Pharmaceuticals.
Volum 15.
Número 5.
2022
. Repositori Institucional
Christian JG Tessier; Raymond M Sturgeon; Johnathon R Emlaw; Gregory D McCluskey; F Javier Pérez-Areales; Corrie JB daCosta.
Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously.
En
eLife.
Volum 11.
2022
. https://doi.org/10.7554/eLife.76504
Pérez-Areales, F.J.; Di Pietro. O.; Espargaró, A.; Vallverdú-Queralt, A.; Galdeano, C.; Ragusa, I.M.; Viayna, E.; Guillou, C.; Clos, M.V.; Pérez, B.; Sabaté, R.; Lamuela-Raventós, R.M.; Luque, F.J.; Muñoz-Torrero, D.
Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties.
En
Bioorganic & Medicinal Chemistry.
Volum 22.
Número 19.
2014
. Repositori Institucional
Di Pietro, O.; Pérez-Areales, F.J.; Juárez-Jiménez, J.; Espargaró, A.; Clos, M.V.; Pérez, B.; Lavilla, R.; Sabaté, R.; Luque, F.J.; Muñoz-Torrero, D.
Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies.
En
European Journal of Medicinal Chemistry.
Volum 84.
2014
. Repositori Institucional
Radu Costin Bizga Nicolescu; Zoe R Maylin; Francisco Javier Pérez-Areales; Jessica Iegre; Hardev S Pandha; Mohammad Asim; David R Spring.
Hybrid androgen receptor inhibitors outperform enzalutamide and EPI-001 in in vitro models of prostate cancer drug resistance.
En
ChemMedChem.
Volum 18.
2022
. https://doi.org/10.1002/cmdc.202200548
Pérez-Areales, F. J.; Turcu, A. L.; Barniol-Xicota, M.; Pont, C.; Pivetta, D.; Espargaró, A.; Bartolini, M.; De Simone, A.; Andrisano, V.; Pérez, B.; Sabate, R.; Sureda, F. X.; Vázquez, S.; Muñoz-Torrero, D.
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors.
En
European Journal of Medicinal Chemistry.
2019
. Repositori Institucional
Peŕez-Areales,F. J.; Garrido, M.; Aso, E.; Bartolini, M.; DeSimone,A.; Espargaro, A.,́ Ginex, T.; Sabate,R.; Peŕez, B.; Andrisano, V.; Puigoriol-Illamola, D.; Pallas̀, M.; Luque, F. J.; Loza, M. I.; Brea, J.; Ferrer, I.; Ciruela, F.; Messeguer, A.; Muñoz-Torrero, D.
Centrally active multitarget anti-Alzheimer agents derived from the antioxidant lead CR‐6.
En
Journal of Medicinal Chemistry.
Volum 63.
2020
. https://doi.org/10.1021/acs.jmedchem.0c00528
Pérez-Areales, F. J.; Betari, N.; Viayna, A.; Pont, C.; Espargaró, A.; Bartolini, M.; De Simone, A.; Rinaldi Alvarenga, J. F.; Pérez, B.; Sabate, R.; Lamuela-Raventós, R. M.; Andrisano, V.; Luque, F. J.; Muñoz-Torrero, D.
Design, synthesis, and multitarget biological profiling of second generation anti-Alzheimer rhein-huprine hybrids.
En
Future Medicinal Chemistry.
Volum 9.
Número 10.
2017
. https://doi.org/10.4155/fmc-2017-0049
Jethro E Prinston; Johnathon R Emlaw; Mathieu F Dextraze; Christian J G Tessier; F Javier Pérez-Areales; Melissa S McNulty; Corrie J B daCosta.
Ancestral reconstruction approach to acetylcholine receptor structure and function.
En
Structure.
Volum 25.
2017
. https://doi.org/10.1016/j.str.2017.06.005
Més Informació: RESEARCH GROUP WEBSITE (https://www.ub.edu/portal/web/dp-farmacologia/chemical-probes-based-on-proximity-inducing-pharmacology)
