Francisco Javier Pérez Areales

Francisco Javier Pérez Areales

Lecturer Professor

ORCID: 0000-0001-9525-9346
Scopus Author ID: 56266659800
Researcher ID: GSE-3214-2022
Knowledge area: Química Orgànica

Contact Information
Department of Pharmacology, Toxicology and Medicinal Chemistry
Joan XXIII, 27-31, Faculty of Pharmacy and Food Sciences - 08028 Barcelona
934024530
fjperezareales(a)ub.edu

Academic profile

Organic and Medicinal Chemistry
Chemical Biology

Academic training

Licenciado en Farmacia
Máster en Química Orgánica Experimental e Industrial
Doctor en Química Orgánica y Farmacéutica

Research interests

Revolving around the ubiquitin-proteasome system: USP2-TD

Projects

Revolving around the ubiquitin‒proteasome system: USP2-targeted degrader . 2021 - 2023 . Ref.101025271 . Unió Europea . PI: Francisco Javier Perez Areales
TET2 modulation for myelodysplastic syndrome (MDS) and other diseases Acronim TET2_plus F21-FVal_2018_007 . 2018 - 2019 . Fundació Bosch i Gimpera de la Universitat de Barcelona . PI: Xavier Barril Alonso
Development of TET2 modulators for cancer treatment . 2019 - 2020 . Ref.310258 . Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron (VHIO) . PI: Xavier Barril Alonso
Synthesis of compounds with innovative mechanisms against neurodegenerative diseases . 2018 - 2021 . Ref.SAF2017-82771-R . Ministerio de Economía y Competitividad . PI: Diego Muñoz-Torrero López-Ibarra; Santiago Vázquez Cruz
QUÍMICA FARMACÈUTICA . 2014 - 2017 . Ref.2014SGR52 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Diego Muñoz-Torrero López-Ibarra
Exploration of novel targets and multitarget strategies for the design of compounds against infectious and prevalent diseases . 2014 - 2017 . Ref.SAF2014-57094-R . Ministerio de Economía y Competitividad . PI: Francisco Javier Luque Garriga; Diego Muñoz-Torrero López-Ibarra
NUEVOS COMPUESTOS DE POTENCIAL INTERÉS INDUSTRIAL . 2012 - 2014 . Ref.CTQ2011-22433 . Ministerio de Economía y Competitividad . PI: Pelayo Camps García

Relevant publications

Mia Kapun, F. Javier Pérez-Areales, Nicola Ashman, Pamela J. E. Rowling, Tim Schober, Elaine Fowler, Laura S. Itzhaki, David R. Spring. Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution. In RSC Chemical Biology. Volume 5. 2024 . https://doi.org/10.1039/D3CB00176H
Sampietro, A.; Pérez-Areales, F.J.; Martínez, P.; Arce, E.M.; Galdeano, C.; Muñoz-Torrero, D. Unveiling the multitarget anti-Alzheimer drug discovery landscape: A bibliometric analysis. In Pharmaceuticals. Volume 15. Number 5. 2022 . Institutional Repository
Christian JG Tessier; Raymond M Sturgeon; Johnathon R Emlaw; Gregory D McCluskey; F Javier Pérez-Areales; Corrie JB daCosta. Ancestral acetylcholine receptor β-subunit forms homopentamers that prime before opening spontaneously. In eLife. Volume 11. 2022 . https://doi.org/10.7554/eLife.76504
Pérez-Areales, F.J.; Di Pietro. O.; Espargaró, A.; Vallverdú-Queralt, A.; Galdeano, C.; Ragusa, I.M.; Viayna, E.; Guillou, C.; Clos, M.V.; Pérez, B.; Sabaté, R.; Lamuela-Raventós, R.M.; Luque, F.J.; Muñoz-Torrero, D. Shogaol-huprine hybrids: Dual antioxidant and anticholinesterase agents with beta-amyloid and tau anti-aggregating properties. In Bioorganic & Medicinal Chemistry. Volume 22. Number 19. 2014 . Institutional Repository
Di Pietro, O.; Pérez-Areales, F.J.; Juárez-Jiménez, J.; Espargaró, A.; Clos, M.V.; Pérez, B.; Lavilla, R.; Sabaté, R.; Luque, F.J.; Muñoz-Torrero, D. Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting beta-amyloid, tau, and cholinesterase pathologies. In European Journal of Medicinal Chemistry. Volume 84. 2014 . Institutional Repository
Radu Costin Bizga Nicolescu; Zoe R Maylin; Francisco Javier Pérez-Areales; Jessica Iegre; Hardev S Pandha; Mohammad Asim; David R Spring. Hybrid androgen receptor inhibitors outperform enzalutamide and EPI-001 in in vitro models of prostate cancer drug resistance. In ChemMedChem. Volume 18. 2022 . https://doi.org/10.1002/cmdc.202200548
Pérez-Areales, F. J.; Turcu, A. L.; Barniol-Xicota, M.; Pont, C.; Pivetta, D.; Espargaró, A.; Bartolini, M.; De Simone, A.; Andrisano, V.; Pérez, B.; Sabate, R.; Sureda, F. X.; Vázquez, S.; Muñoz-Torrero, D. A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. In European Journal of Medicinal Chemistry. 2019 . Institutional Repository
Peŕez-Areales,F. J.; Garrido, M.; Aso, E.; Bartolini, M.; DeSimone,A.; Espargaro, A.,́ Ginex, T.; Sabate,R.; Peŕez, B.; Andrisano, V.; Puigoriol-Illamola, D.; Pallas̀, M.; Luque, F. J.; Loza, M. I.; Brea, J.; Ferrer, I.; Ciruela, F.; Messeguer, A.; Muñoz-Torrero, D. Centrally active multitarget anti-Alzheimer agents derived from the antioxidant lead CR‐6. In Journal of Medicinal Chemistry. Volume 63. 2020 . https://doi.org/10.1021/acs.jmedchem.0c00528
Pérez-Areales, F. J.; Betari, N.; Viayna, A.; Pont, C.; Espargaró, A.; Bartolini, M.; De Simone, A.; Rinaldi Alvarenga, J. F.; Pérez, B.; Sabate, R.; Lamuela-Raventós, R. M.; Andrisano, V.; Luque, F. J.; Muñoz-Torrero, D. Design, synthesis, and multitarget biological profiling of second generation anti-Alzheimer rhein-huprine hybrids. In Future Medicinal Chemistry. Volume 9. Number 10. 2017 . https://doi.org/10.4155/fmc-2017-0049
Jethro E Prinston; Johnathon R Emlaw; Mathieu F Dextraze; Christian J G Tessier; F Javier Pérez-Areales; Melissa S McNulty; Corrie J B daCosta. Ancestral reconstruction approach to acetylcholine receptor structure and function. In Structure. Volume 25. 2017 . https://doi.org/10.1016/j.str.2017.06.005

More Information: RESEARCH GROUP WEBSITE (https://www.ub.edu/portal/web/dp-farmacologia/chemical-probes-based-on-proximity-inducing-pharmacology)