SANTIAGO VAZQUEZ CRUZ

University Full professor

Researcher ID: R-3551-2016

Knowledge area: Química Orgànica

Secretari del Institut de Biomedicina de la Universitat de Barcelona (IBUB)

Research group: Medicinal Chemistry and Pharmacology of Neurodegenerative diseases

Grup d’innovació per a la millora de les competències professionals al Grau de Farmàcia

Contact Information
Department of Pharmacology, Toxicology and Medicinal Chemistry
Laboratori de Química Farmacèutica
934024533
svazquez(a)ub.edu

Academic profile

Química Farmacéutica Síntesis de Fármacos

Academic training

Licenciado en Farmacia

Doctor en Farmacia

Research interests

Síntesis de poliquinanos

Síntesis asimètrica de fármacos y compuestos potencialmente activos quirales

Síntesis de aminas policíclicas como antagonistas del receptor NMDA del ácido glutámico

Síntesis de aminas policíclicas con potencial actividad antivírica

Diseño y síntesis de inhibidores de la epóxido hidrolasa soluble

Projects

Exploración de nuevas dianas y estrategias multidiana para el diseño de compuestos contra enfermedades infecciosas y prevalentes . 2015 - 2017 . Ref.SAF2014-57094-R . Ministerio de Economia y Competitividad . PI: Fco.Javier Luque Garriga; Diego Muñoz-Torrero Lopez-Ibarra

Conveni de col·laboració en el marc del projecte 'Síntesi i Avaluació Farmacològica de noves molècules amb propietats antidiabètiques (SAFNAD)' . 2014 - 2016 . CIDQO 2012, S.L. . PI: Santiago Vazquez Cruz

Drugs for inflammatory & cardiovascular disorders. Fase 2. CI15-00020. Ayuda a la valorización . 2016 - 2017 . Ref.308661 . Fundació Caixa de Pensions 'La Caixa' . PI: Santiago Vazquez Cruz

Efficacy and safety assessment of novel soluble epoxide hydrolase inhibitors for the prevention and treatment of acute pancreatitis . 2016 - 2017 . Ref.HS-2016-SPAIN-04 . Unió Europea . PI: Santiago Vazquez Cruz

Síntesis de compuestos con mecanismos innovadores contra enfermedades neurodegenerativas . 2018 - 2020 . Ref.SAF2017-82771-R . Ministerio de Economia y Competitividad . PI: Diego Muñoz-Torrero López-Ibarra; Santiago Vazquez Cruz

Relevant publications

Rey-Carrizo, M.; Gazzarrini, S.; Llabrés, S.; Frigolé-Vivas, M.; Juárez-Jiménez, J.; Font-Bardia, M.; Naesens, L.; Moroni, A.; Luque, F. J.; Vázquez, S. New polycyclic dual inhibitors of the wild type and the V27A mutant M2 channel of the influenza A virus with unexpected binding mode. In European Journal of Medicinal Chemistry. Volume 96. 2015 . Institutional Repository

Rey-Carrizo, M.; Barniol-Xicota, M.; Font-Bardia, M.; Vázquez, S. Dimerization of highly pyramidalized 3,4,8,9-tetramethyltetracyclo[4.4.0.0^3,9.0^4,8]dec-1(6)-ene to a hydrocarbon featuring four cyclohexane rings in boat conformation. In Angewandte Chemie-International Edition. Volume 53. Number 31. 2014 . Institutional Repository

Rey-Carrizo, M.; Barniol-Xicota, M.; Ma, C.; Frigolé-Vivas, M.; Torres, E.; Naesens, L.; Llabrés, S.; Juárez-Jiménez, J.; Luque, F. J.; DeGrado, W.; Lamb, R.; Pinto, L.; Vazquez, S. Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus. In Journal of Medicinal Chemistry. Volume 57. Number 13. 2014 . https://doi.org/10.1021/jm5005804

Torres, E.; Duque, M. D.; Vanderlinden, E.; Ma, C.; Pinto, L. H.; Camps, P.; Froeyen, M.; Vázquez, S.; Naesens, L. Role of the viral hemagglutinin in the anti-influenza virus activity of newly synthesized polycyclic amine compounds. In Antiviral Research. Volume 99. 2013 . https://doi.org/10.1016/j.antiviral.2013.06.006

Rey-Carrizo, M.; Torres, E.; Ma, C.; Barniol-Xicota, M.; Wang, J.; Wu, Y.; Naesens, L.; DeGrado, W. F.; Lamb, R. A.; Pinto, L. H.; Vázquez, S. M2 ion channel of influenza A virus: from wild-type inhibitors to compounds with potent activity against the V27A mutant. In Journal of Medicinal Chemistry. Volume 56. Number 22. 2013 . https://doi.org/10.1021/jm401340p

Llabrés, S.; Juárez-Jiménez, J.; Masetti, M.; Leiva, R.; Vázquez, S.; Gazzarrini, S.; Moroni, A.; Cavalli, A.; Luque, F. J. Mechanism of the pseudo-irreversible binding of amantadine to the M2 proton channel. In Journal of the American Chemical Society. Volume 138. 2016 . https://doi.org/10.1021/jacs.6b07096

Barniol-Xicota, M.; Gazzarrini, S.; Torres, E.; Hu, Y.; Wang, J.; Naesens, L.; Moroni, A.; Vázquez, S. Slow but steady wins the race: dissimilarities among new dual inhibitors of the wild-type and the V27A mutant M2 channels of influenza A virus. In Journal of Medicinal Chemistry. Volume 60. 2017 . https://doi.org/10.1021/acs.jmedchem.6b01758

Leiva, Rosana; Grinan-Ferre, Christian; Seira, Constanti; Valverde, Elena; McBride, Andrew; Binnie, Margaret; Perez, Belen; Javier Luque, F.; Pallas, Merce; Bidon-Chanal, Axel; Webster, Scott P.; Vazquez, Santiago. Design, synthesis and in vivo study of novel pyrrolidine-based 11 beta-HSD1 inhibitors for age-related cognitive dysfunction. In European Journal of Medicinal Chemistry. Volume 139. 2017 . https://doi.org/10.1016/j.ejmech.2017.08.003

Alonso, Jose M.; Quiroga, Sabela; Codony, Sandra; Turcu, Andreea L.; Barniol-Xicota, Marta; Perez, Dolores; Guitian, Enrique; Vazquez, Santiago; Pena, Diego. Palladium-catalyzed cocyclotrimerization of arynes with a pyramidalized alkene. In Chemical Communications. Volume 54. Number 47. 2018 . https://doi.org/10.1039/c8cc03188f

Leiva, R.; Barniol-Xicota, M.; Codony, S.; Ginex, T.; Vanderlinden, E.; Montes, M.; Caffrey, M.; Luque, F. J.; Naesens, L.; Vázquez, S. Aniline-Based Inhibitors of Influenza H1N1 Virus Acting on Hemagglutinin-Mediated Fusion. In Journal of Medicinal Chemistry. Volume 61. Number 1. 2018 . https://doi.org/10.1021/acs.jmedchem.7b00908

Patents, Software and Database

Beta-amyloid-directed multitarget compounds for the treatment of Alzheimer’s disease (SPAIN, 09/05/2013)

Analogs of adamantylureas as soluble epoxide hydrolase inhibitors (SPAIN, 28/07/2015)

New aza-tetracyclo derivatives (SPAIN, 19/04/2016)

Process for obtaining 3,14-diacetyloxymorphone from oripavine (SPAIN, 31/05/2016)

HRI activators useful for the treatment of metabolic diseases (SPAIN, 13/07/2016)

More Information: https://www.ub.edu/medicinalchemistrypharmacology/research-group/santiago-vazquez/