Marina Corbella Morato

Marina Corbella Morato

Lecturer Professor

ORCID: 0000-0001-9209-868X
Knowledge area: Química Física

Research group: Estructura i Functió en Macromolècules

Contact Information
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry


marinacorbella(a)ub.edu

Projects

Dissecting and Engineering Allosteric Activation in a Biosynthetic Enzyme . 2020 . Ref.890562 . European Commission . PI: Marina Corbella Morató, Shina Carolin Lynn Kamerlin
Extended ABO antigens: the missing link for the enzymatic production of universal donor blood  . 2023 - 2027 . Ref.0077684 . Novo Nordisk Foundation . PI: Maher Abou Hachem
Engineering substrate specificities towards the enzymatic production of universal type O blood . 2025 - 2025 . Ref.BCV-2025-2-0022 . Red Española de Supercomputación . PI: Marina Corbella Morato
Understanding the birth of new enzymes on old scaffolds  . 2019 - 2024 . Ref.KAW2018.0140 . The Knut and Alice Wallenberg Foundation . PI: Shina Caroline Lynn Kamerlin
Biologia Computacional i Disseny de Fàrmacs . 2017 - 2021 . Ref.2017SGR1746 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Francisco Javier Luque Garriga
Simulación atomística de la dinámica de transferencia de energía en complejos pigmento-proteína fotosintéticos . 2013 - 2015 . Ref.CTQ2012-36195 . Ministerio de Economía y Competitividad . PI: Carles Eduard Curutchet Barat


Structure-based modeling of the role of the environment in photosynthetic light harvesting and protein fluorescence 

 . 2018 . Ref.CTQ2017-89924-P . Ministerio de Ciencia Innovación y Universidades del Gobierno de España . PI: Carles Eduard Curutchet Barat
Physical Constraints for Accessing Genomic Information  . 2017 - 2022 . Ref.KAW2016.0077 . The Knut and Alice Wallenberg Foundation . PI: Johan Elf
Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society . 2021 . Ref.951231 . European Research Council . PI: Carme Rovira Virgili

Relevant publications

Fisher, G.; Corbella, M.; Alphey, M. S.; Nicholson, J.; Read, B. J.; Kamerlin, S. C. L.; da Silva, R. G. Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation. In Nature Communications. Volume 13. 2022 . https://doi.org/10.1038/s41467-022-34960-9
Pinto, G. P.; Corbella, M.; Demkiv, A. O.; Kamerlin, S. C. L. Exploiting enzyme evolution for computational protein design. In Trends in Biochemical Sciences. Volume 47. Number 5. 2021 . https://doi.org/10.1016/j.tibs.2021.08.008
Corbella, M.; Liao, Q.; Moreira, C.; Parracino, A.; Kasson, P. M.; Kamerlin, S. C. L. The N-terminal helix-turn-helix motif of transcription factors MarA and Rob drives DNA recognition. In Journal of Physical Chemistry B. Volume 125. Number 25. 2021 . https://doi.org/10.1021/acs.jpcb.1c00771
Corbella, M.; Moreira, C.; Bello-Madruga, R.; Torrent, M.; Kamerlin, S. C. L.; Blair, J. M. A.; Sancho-Vaello, E. Targeting MarA N-terminal domain dynamics to prevent DNA binding. In Protein Science. Volume 34. Number 1. 2024 . https://doi.org/10.1002/pro.5258
Romero-Rivera, A.; Corbella, M.; Parracino, A.; Patrick, W. M.; Kamerlin, S. C. L. Complex loop dynamics underpin activity, specificity, and evolvability in the (βα)8 barrel enzymes of histidine and tryptophan biosynthesis. In JACS Au. Volume 2. Number 4. 2022 . https://doi.org/10.1021/jacsau.2c00063
Corbella, M.; Bravo, J.; Demkiv, A. O.; Calixto, A. R.; Sompiyachoke, K.; Bergonzi, C.; Brownless, A. L. R.; Elias, M. H.; Kamerlin, S. C. L. Catalytic redundancies and conformational plasticity drives selectivity and promiscuity in quorum quenching lactonases. In JACS Au. Volume 4. Number 9. 2024 . https://doi.org/10.1021/jacsau.4c00404
Corbella, M.; Voityuk, A.A.; Curutchet, C. Single amino acid mutation controls hole transfer dynamics in DNA-methyltransferase HhaI complexes. In Journal of Physical Chemistry Letters. Volume 6. Number 18. 2015 . Institutional Repository
Corbella, M.; Voityuk, A.A.; Curutchet, C. How abasic sites impact hole transfer dynamics in GC-rich DNA sequences. In Physical Chemistry Chemical Physics. Volume 20. Number 35. 2018 . Institutional Repository

Patents, Software and Database

Process for the Preparation of Solifenacin and Salts Thereof (---, 22/06/2011)