Lucia Prohens Coll

Investigador predoctoral en formació BRD

Grup de Recerca: Farmacologia Clínica i Farmacogenètica

Informació de contacte
Departament de Fonaments Clínics

prohens(a)ub.edu

Estades a Centres de Recerca

ESPANYA. 2021 . Unitat de Farmacologia, Departament de Fonaments Clínics, Facultat de Medicina, Universitat de Barcelona. Desde 2021. Tesi doctoral. . Doctorand

ESPANYA. 2020 (9 Mesos) . Vall d'Hebron Institut d'Oncologia (VHIO), Hospital Universitari Vall d'Hebron. 2020. Treball de fi de Màster al Grup de Factors de Creixement (Dr. Joaquín Arribas). . Altres (especificar)

ESPANYA. 2019 (9 Mesos) . Unitat de Farmacologia, Departament de Fonaments Clínics, Facultat de Medicina, Universitat de Barcelona. 2019. Treball de fi de grau al grup de farmacogenètica (Dr. Sergi Mas Herrero) . Altres (especificar)

Formació acadèmica

Ciències Biomèdiques . Universitat de Barcelona . 01/07/2020 . (Diplomatura / Llicenciatura / Grau)

Recerca Biomèdica Traslacional . Universitat Autònoma de Barcelona . 01/07/2021 . (Màster Oficial)

Participacions a Congressos

Llucia Prohens ;Àlex-González Segura; Gisela Mezquida; Silvia Amoretti; Miquel Bioque; María Ribeiro; Xaquin Gurriarán-Bas; Lide Rementería; Daniel Berge; Roberto Rodriguez-Jimenez; Alexandra Roldán; Edith Pomarol-Clotet; Angela Ibáñez; Judith Usall; Maria Paz García-Portilla; Manuel J. Cuesta; Mara Parellada; Ana González-Pinto; Esther Berrocoso; Miquel Bernardo; Sergi Mas (2022). Epigenetic clocks in relapse after a first episode of schizophrenia. (Poster) . 35th ECNP Congress . ÀUSTRIA

Gonzalez-Segura, A.; De la Serna, E.; Sugranyes, G.; Baeza, I.; Valli, I.; Prohens, L.; Rodríguez, N.; Martinez-Pinteño, A.; Gassó, P.; Castro-Fornieles, J.; Mas, S. (2022). Increased genetic risk and epigenetic age deacceleration in bipolar disorder and schizophrenia offspring. (Poster) . 35th ECNP Congress . Neuroscience Applied 2022; 1 (suppl 2): 100112 100528 . Vienna . ÀUSTRIA

Rodríguez, N.; Gassó, P.; Blázquez, A.; Martínez-Pinteño, A.; Segura, A.G.; Prohens, L.; Mas, S.; Lázaro, L. (2022). Association between polygenic risk scores for psychiatric disorders and fluoxetine response in children and adolescent patients. (Poster) . 35th ECNP Congress . Vienna . ÀUSTRIA

Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Segura, ÀG.; Prohens, L.; García-Rizo, C.; Mas, S.; Morén, C.; Parellada, E.; Gassó, P. (2022). Early stage treatment with positive allosteric modulator of the mGlu2 receptor JNJ-46356479 partially improves cognitive deficits and schizophrenia-like behaviors in a postnatal ketamine mice model. (Poster) . Congress of the Schizophrenia International Research Society (SIRS) . Florencia . ITÀLIA

Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Segura, A.G.; Prohens, L.; García-Rizo, C.; Mas, S.; Morén, C.; Parellada, E.; Gassó, P. (2022). Early treatment with positive allosteric modulator of the mGlu2 receptor JNJ-46356479 partially improves cognitive deficits and schizophrenia-like behaviors in a postnatal ketamine mice model. (Poster) . 35th ECNP Congress . Vienna . ÀUSTRIA

Rodríguez, N.; Gassó, P., Blázquez, A.; Martínez-Pinteño, A.; Segura, AG.; Prohens, L.; Mas, S.; Lázaro, L. (2022). Association between polygenic risk scores for psychiatric disorders and fluoxetine response in children and adolescent patients. (Poster) . 19th International Congress of ESCAP . Maastricht . PAÏSOS BAIXOS

Gassó, P.; Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Segura, ÀG.; Prohens, L.; García-Rizo, C.; Morén, C.; Mas, S.; Parellada, E. (2022). Neuroprotective effect of the positive allosteric modulator of the mGluR2 JNJ-46356479 in human neuroblastoma cell cultures. (Poster) . Congress of the Schizophrenia International Research Society (SIRS) . Florencia . ITÀLIA

Alex G Segura; Elena de la Serna; Gisela Sugranyes; Inmaculada Baeza; Isabel Valli; Irene Martínez-Serrano; Covadonga M Díaz-Caneja; Álvaro Andreu-Bernabeu; Dolores M Moreno; Patricia Gassó; Natalia Rodríguez; Albert Martínez-Pinteño; Llucia Prohens; Carla Torrent; Clemente García-Rizo; Sergi Mas; Josefina Castro-Fornieles (2023). Evaluation of the genetic and epigenetic architecture of youth at high familial risk of schizophrenia and bipolar disorder. (Taula rodona) . Schizophrenia International Research Society Congress . Toronto . CANADÀ

Projectes

Farmacologia Clínica i Farmacogenètica (Ajuts de Suport als Grups de Recerca de Catalunya (SGR)) . 2022 - 2024 . Ref.2021SGR00672 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Sergio Mas Herrero

Biomarcadores multi-omics periféricos como predictores de evolución a largo plazo en el Trastorno Obsesivo-Compulsivo: la cohorte TOC Barcelona (OCD-BC) (Sense especificar) . 2023 - 2025 . Ref.PI22/00843 . Instituto de Salud Carlos III . IP: Maria Luisa Lazaro Garcia . (1 Investigadors)

Estudi prospectiu dels biomarcadors i predictors clínics de levolució a llarg termini i la resposta a tractamenten el Trastorn Obsessiu-Compulsiu: la cohort Barcelona. (B- OCDC) (Salut Mental) . 2023 - 2026 . Ref.463/U/2022 . Fundació La Marató de TV3 . IP: Natalia Rodriguez Ferret

compulsiu
Avaluació ecològica momentània
Neuroimatge funcional
Genotip
Medicina de Precisión

Study of the hypothesis of accelerated aging in schizophrenia: analysis of epigenetic regulation in advanced age: the ENCLOSE-Age (EpigeNetic CLOck in SchizophrEnia- in Aged adults) Study () . 2023 - 2026 . Fundació La Marató de TV3 . IP: Dr. Rafael Penadés Rubio

Publicacions en revistes

Martínez-Pinteño, A.; Gassó, P.; Prohens, LL.; Segura, A.G.; Parellada, M.; Saiz-Ruiz, J.; Cuesta, M.J.; Bernardo, M.; Lafuente, A.; Mas, S.; Rodríguez, N. (2021). Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data. Frontiers in Pharmacology, 12, p. 729474 . Repositori Institucional . ISSN: 1663-9812

Gassó, P; Martínez-Pinteño, A; Prohens, L; Segura, AG; Parellada, M; Saiz-Ruiz, J; Cuesta, MJ; Bernardo, M; Lafuente, A; Mas, S; Rodríguez, N (2021). Identification of key genes involved in antipsychotic-induced metabolic dysregulation based on integrative bioinformatics analysis of multi-tissue gene expression data. European Neuropsychopharmacology, 53(suppl 1), p. S445 . ISSN: 0924-977X

Segura ÀG, Prohens L, Mezquida G, Amoretti S, Bioque M, Ribeiro M, Gurriarán-Bas X, Rementería L, Berge D, Rodriguez-Jimenez R, Roldán A, Pomarol-Clotet E, Ibáñez A, Usall J, García-Portilla MP, Cuesta MJ, Parellada M, González-Pinto A, Berrocoso E, Bernardo M, Mas S; 2EPS group. (2022). Epigenetic clocks in relapse after a first episode of schizophrenia. npj Schizophrenia, 8(1), p. 61 . https://doi.org/10.1038/s41537-022-00268-2 . ISSN: 2334-265X

Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Prohens, L.; García-Rizo, C.; Mas, S.; Morén, C.; Parellada, E.; Gassó, P. (2022). Early treatment with JNJ-46356479, a mGluR2 modulator, improves behavioral and neuropathological deficits in a postnatal ketamine mouse model of schizophrenia. Biomedicine & Pharmacotherapy, 24(2), p. 1022 . Repositori Institucional . ISSN: 0753-3322

Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Segura, ÀG.; Prohens, L.; García-Rizo, C.; Mas, S.; Morén, C.; Parellada, E.; Gassó, P. (2022). Early treatment with positive allosteric modulator of the mGlu2 receptor JNJ-46356479 partially improves cognitive deficits and schizophrenia-like behaviors in a postnatal ketamine mice model. Neuroscience Applied, 1 supp 2, p. 1000954 . ISSN: 2772-4085

Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Segura, A.G.; Prohens, L.; García-Rizo, C.; Mas, S.; Morén, C.; Parellada, E.; Gassó, P. (2022). Early stage treatment with positive allosteric modulator of the mGlu2 receptor JNJ‑46356479 partially improves cognitive deficits and schizophrenia-like behaviors in a postnatal ketamine mice model. Neuroscience Applied, 1(suppl 2), p. 1000954 . ISSN: 2772-4085

Gassó, P.; Martínez-Pinteño, A.; Rodríguez, N.; Olivares, D.; Madero, S.; Gómez, M.; Segura, ÀG.; Prohens, L.; García-Rizo, C.; Morén, C.; Mas, S.; Parellada, E (2022). Neuroprotective effect of the positive allosteric modulator of the mGluR2 JNJ-46356479 in human neuroblastoma cell cultures. Neuroscience Applied, 1 supp 2, p. 1000965 . ISSN: 2772-4085

Rodríguez, N.; Gassó, P.; Blázquez, A.; Martínez-Pinteño, A.; Segura, AG.; Prohens, L.; Mas, S.; Lázaro, L. (2022). Association between polygenic risk scores for psychiatric disorders and fluoxetine response in children and adolescent patients. Neuroscience Applied, 1 supp 2, p. 1000773 . ISSN: 2772-4085

Segura AG; Prohens L; Gassó P; Rodríguez N; Garcia-Rizo C; Moreno-Izco L; Andreu-Bernabeu A; Zorrillac I; Mane A, Rodriguez-Jimenezc R; Roldánc A; Sarróc S; Ibáñez A; Usall J; A Sáizc P; J. Cuesta M; Parellada M; González-Pinto A; Berrocoso E; Bernardo M; Mas S; Mezquida G; Arbelo N; De Matteis M; Galvañ J; Duque Guerra A; Arias i Queralt L; Perez-Bacigalupe M; Gonzalez-Ortega I; Toll A; Casanovas F; Sanchez-Pastor L; Valtueña M; Pomarol-Clotet E; García-León MA; Butjosa A; Rubio-Abadalt E; Ribeiro M; López-Ilunda JM; Saiz-Ruiz J; León-Quismondo L; Rivero O; Ruiz P; Segarra Echevarría R; García-Portilla MP (2023). The polygenic basis of relapse after a first episode of schizophrenia. European Neuropsychopharmacology, 75, pp. 80 - 92 . https://doi.org/10.1016/j.euroneuro.2023.06.003 . ISSN: 0924-977X

Tècniques o especialitats que domina

CELL CULTURE: viral cell infection, tumor disgregation and culture, fluorescence-activated cell sorting, cytotoxicity assays, immunopanning.

BIOMOLECULAR BIOLOGY TECHNIQUES: DNA/RNA/protein isolation from blood, cells and spit; protein quantification; Western Blot; RT-qPCR; genotyping genetic polymorphisms with Taqman; detection of glutathione in plasma samples, immunoquemistry

HANDLING OF EXPERIMENTAL ANIMALS (mice): care; euthanasia (CO2, cervical luxation, ketamine/xilacine injection); subcutaneous and intraperitoneal injections, blood extraction, conduct experiments (open field, novel object recognition, three-chamber test, five-trial social memory test, rotarod test, Y-maze test, sensorial tests)