Marçal Pastor Anglada

Marçal Pastor Anglada

Catedràtic d'Universitat

Àrea de coneixement : Bioquímica i Biologia Molecular

Grup de Recerca: IP Farmacologia Molecular i Teràpies Experimentals (MPET)

Informació de contacte
Departament de Bioquímica i Biomedicina Molecular
Av. Diagonal, 645.
934021543
mpastor(a)ub.edu

Publicacions en revistes

Cárdenas, A.; Toledo, C.; Oyarzún, C.; Sepúlveda, A.; Quezada, C.; Guillén-Gómez, E.; Díaz-Encarnación, M.M.; Pastor-Anglada, M.; San Martín R. (2013). Adenosine A(2B)receptor-mediated VEGF induction promotes diabetic glomerulopathy. Laboratory Investigation, 93(1), pp. 135 - 144 . ISSN: 0023-6837
Pérez-Torras S; Vidal-Pla, A; Cano-Soldado, P; Huber-Ruano, I; Mazo A., Pastor-Anglada M. (2013). Concentrative nucleoside transporter 1 (hCNT1) promotes phenotypic changes relevant to tumor biology in a translocation¿independent manner. Cell Death and Disease, 4(5), p. e648 . Repositori Institucional . ISSN: 2041-4889
Medina-Pulido, L.; Molina-Arcas, M.; Justicia, C.; Soriano, E.; Burgaya, F.; Planas, A.M.; Pastor-Anglada, M. (2013). Hypoxia and P1 receptor activation regulate the high-affinity concentrative adenosine transporter CNT2 in differentiated neuronal PC12 cells. Biochemical Journal, 454(3), pp. 437 - 445 . https://doi.org/10.1042/BJ20130231 . ISSN: 0264-6021
Pastor-Anglada, M. (2013). Drug transporter pharmacogenetics: do we need function? Do we need motion?. Pharmacogenomics, 14(13), pp. 1537 - 1540 . ISSN: 1462-2416
Pinilla-Macua, I.; Fernández-Calotti, P.; Pérez-Del-Pulgar, S.; Pastor-Anglada M (2014). Ribavirin uptake into human hepatocyte HHL5 cells is enhanced by interferon-α via
up-regulation of the human concentrative nucleoside transporter (hCNT2). Molecular Pharmaceutics, 11, pp. 3223 - 3230 . https://doi.org/10.1021/mp500263p . ISSN: 1543-8384
Arimany-Nardi C, Errasti-Murugarren E, Minuesa G, Martinez-Picado J, Gorboulev V, Koepsell H, Pastor-Anglada M (2014). Nucleoside transporters and human organic cation transporter 1 determine the cellular handling of DNA-methyltransferase inhibitors. British Journal of Pharmacology, 171, pp. 3868 - 3880 . https://doi.org/10.1111/bph.12748 . ISSN: 0007-1188
Wojtal KA, Cee A, Lang S, Götze O, Frühauf H, Geier A, Pastor-Anglada M, Torres-Torronteras J, Martí R, Fried M, Lutz TA, Maggiorini M, Gassmann M, Rogler G, Vavricka SR. (2014). Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humans. American Journal of Physiology-Gastrointestinal and Liver Physiology, 307 (07), pp. G673 - G688 . Repositori Institucional . ISSN: 0193-1857
Godoy V, Banales JM, Medina JF, Pastor-Anglada M (2014). Functional crosstalk between the adenosine transporter CNT3 and purinergic receptors in the biliary epithelia. Journal of Hepatology, 61, pp. 1337 - 1343 . https://doi.org/10.1016/j.jhep.2014.06.036 . ISSN: 0168-8278
Pinilla-Macua I, Claudio-Montero A, Pastor-Anglada M. (2014). rCNT2 extracellular cysteines, Cys(615) and Cys(649), are important for maturation and sorting to the plasma membrane. FEBS Letters, 588, pp. 4382 - 4389 . https://doi.org/10.1016/j.febslet.2014.10.006 . ISSN: 0014-5793
Arimany-Nardi C, Montraveta A, Lee-Vergés E, Puente XS, Koepsell H, Campo E, Colomer D, Pastor-Anglada M. (2015). Human organic cation transporter 1 (hOCT1) as a mediator of bendamustine uptake and cytotoxicity in chronic lymphocytic leukemia (CLL) cells. The Pharmacogenomics Journal, 15(4), pp. 363 - 371 . https://doi.org/10.1038/tpj.2014.77 . ISSN: 1470-269X
Pastor-Anglada M; Pérez-Torras S. (2015). Nucleoside transporter proteins as biomarkers of drug responsiveness and drug targets. Frontiers in Pharmacology, 6, p. 13 . Repositori Institucional . ISSN: 1663-9812
Minami K, Shinsato Y, Yamamoto M, Takahashi H, Zhang S, Nishizawa Y, Tabata S, Ikeda R, Kawahara K, Tsujikawa K, Chijiiwa K, Yamada K, Akiyama S, Pérez-Torras S, Pastor-Anglada M, Furukawa T, Yasuo T (2015). Ribonucleotide reductase is an effective target to overcome gemcitabine resistance in gemcitabine-resistant pancreatic cancer cells with dual resistant factors. Journal Of Pharmacological Sciences, 127, pp. 319 - 325 . https://doi.org/10.1016/j.jphs.2015.01.006 . ISSN: 1347-8613
Claudio-Montero, A.; Pinilla-Macua, I.; Fernández-Calotti, P.; Sancho-Mateo, C.; Lostao, M.P.; Colomer, D.; Grandas, A.; Pastor-Anglada, M. (2015). Fluorescent nucleoside derivatives as a tool for the detection of concentrative nucleoside transporter activity using confocal microscopy and flow citometry. Molecular Pharmaceutics, 12(6), pp. 2158 - 2166 . https://doi.org/10.1021/acs.molpharmaceut.5b00142 . ISSN: 1543-8384
Arimany-Nardi C; Koepsell H; Pastor-Anglada M. (2015). Role of SLC22A1 polymorphic variants in drug disposition, therapeutic responses, and drug-drug interactions. The Pharmacogenomics Journal, 15(6), pp. 473 - 487 . ISSN: 1470-269X
Fernández-Calotti, P.; Casulleras, O.; Antolín, M.; Guarner, F.; Pastor-Anglada, M. (2016). Galectin-4 interacts with the drug transporter human concentrative nucleoside transporter 3 to regulate its function. The FASEB Journal , 30(2), pp. 544 - 554 . ISSN: 0892-6638
Montraveta A; Lee-Vergés E; Roldán J;, Jiménez L; Cabezas S; Clot G; Pinyol M; Xargay-Torrent S; Rosich L; Arimany-Nardí C; Aymerich M; Villamor N; López-Guillermo A; Pérez-Galán P; Roué G; Pastor-Anglada M; Campo E; López-Guerra M; Colomer D. (2015). CD69 expression potentially predicts response to bendamustine and its modulation by ibrutinib or idelalisib enhances cytotoxic effect in chronic lymphocytic leukemia. Oncotarget, 7(5), pp. 5507 - 5520 . Repositori Institucional . ISSN: 1949-2553
Kretschmar, C.; Oyarzún, C.; Villablanca, C.; Jaramillo, C.; Alarcón, S.; Perez, G.; Díaz-Encarnación, M.M.; Pastor-Anglada, M.; Garrido, W.; Quezada, C.; San Martín, R. (2016). Reduced adenosine uptake and its contribution to signaling that mediates profibrotic activation in renal tubular epithelial cells: implication in diabetic nephropathy. PLoS One, 11(1), p. e0147430 . Repositori Institucional . ISSN: 1932-6203
Pérez-Torras, S.; Iglesias, I.; Llopis, M.; Lozano, J.J., Antolín, M.; Guarner, F.; Pastor-Anglada, M. (2016). Transportome profiling identifies profound alterations in Crohn's Disease partially restored by commensal bacteria. Journal of Crohn's and Colitis, 10(7), pp. 850 - 859 . ISSN: 1873-9946
Grañé-Boladeras, N.; Spring, C.M.; Hanna, W.J.; Pastor-Anglada, M.*; Coe, I.R*. (*, co-senior author) (2016). Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir. Cellular and Molecular Life Sciences, 73(23), pp. 4559 - 4575 . ISSN: 1420-682X
Minuesa, Gerard; Arimany-Nardi, Cristina; Erkizia, Itziar; Cedeno, Samandhy; Molto, Jose; Clotet, Bonaventura; Pastor-Anglada, Marcal; Martinez-Picado, Javier (2016). P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp(high) cells and correlates with HIV-1 viral load. Journal of Antimicrobial Chemotherapy, 71(10), pp. 2782 - 2792 . https://doi.org/10.1093/jac/dkw215 . ISSN: 0305-7453
Arimany-Nardi, C.; Minuesa, G.; Keller, T.; Erkizia, I.; Koepsell, H.; Martinez-Picado, J.; Pastor-Anglada, M. (2016). Role of human Organic Cation Transporter 1 (hOCT1) polymorphisms in lamivudine (3TC) uptake and drug-drug interactions. Frontiers in Pharmacology, 7, p. 175 . Repositori Institucional . ISSN: 1663-9812
Grañe-Coladeras, N.; Pérez-Torras, S.; Lozano, J.J.; Romero, M.R.; Mazo, A.; Marín, J.J.; Pastor-Anglada, M. (2016). Pharmacogenomic analizis of the responsiveness of gastrointestinal tumor cell lines to drug therapy: a transportome approach. Pharmacological Research, 113(Pt.A), pp. 364 - 375 . ISSN: 1043-6618
Minuesa, G.; Albert, C.; Pastor-Anglada, M.; Martinez-Picado, J.; Koepsell, H. (2017). Response to 'Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1'. Journal of Pharmacology and Experimental Therapeutics, 360(2), pp. 343 - 345 . ISSN: 0022-3565
Minuesa, Gerard; Arimany-Nardi, Cristina; Erkizia, Itziar; Cedeno, Samandhy; Molto, Jose; Clotet, Bonaventura; Pastor-Anglada, Marcal; Martinez-Picado, Javier (2016). P-glycoprotein (ABCB1) activity decreases raltegravir disposition in primary CD4+P-gp(high) cells and correlates with HIV-1 viral load. Journal of Antimicrobial Chemotherapy, 71(10), pp. 2782 - 2792 . https://doi.org/10.1093/jac/dkw215 . ISSN: 0305-7453
Veyhl-Wichmann, Maike; Friedrich, Alexandra; Vernaleken, Alexandra; Singh, Smriti; Kipp, Helmut; Gorboulev, Valentin; Keller, Thorsten; Chintalapati, Chakravarthi; Pipkorn, Ruediger; Pastor-Anglada, Marcal; Groll, Juergen; Koepsell, Hermann (2016). Phosphorylation of RS1 (RSC1A1) Steers Inhibition of Different Exocytotic Pathways for Glucose Transporter SGLT1 and Nucleoside Transporter CNT1, and an RS1-Derived Peptide Inhibits Glucose Absorption. Molecular Pharmacology, 89(1), pp. 118 - 132 . https://doi.org/10.1124/mol.115.101162 . ISSN: 0026-895X
Catala, Albert; Pastor-Anglada, Marcal; Caviedes-Cardenas, Liska; Malatesta, Roberta; Rives, Susana; Vega-Garcia, Nerea; Camos, Mireia; Fernandez-Calotti, Paula (2016). FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget, 7(31), pp. 49786 - 49799 . https://doi.org/10.18632/oncotarget.10448 . ISSN: 1949-2553
C. Arimany-Nardi; A. Claudio-Montero; A. Viel-Oliva; P. Schmidtke; C. Estarellas; X. Barril; A. Bidon-Chanal; M. Pastor-Anglada (2017). Identification and Characterization of a Secondary Sodium-Binding Site and the Main Selectivity Determinants in the Human Concentrative Nucleoside Transporter 3. Molecular Pharmaceutics, 14, pp. 1980 - 1987 . https://doi.org/10.1021/acs.molpharmaceut.7b00085 . ISSN: 1543-8384
Urtasun, Nerea; Boces-Pascual, Clara; Boix, Loreto; Bruix, Jordi; Pastor-Anglada, Marcal; Perez-Torras, Sandra (2017). Role of drug-dependent transporter modulation on the chemosensitivity of cholangiocarcinoma. Oncotarget, 8(52), pp. 90185 - 90196 . https://doi.org/10.18632/oncotarget.21624 . ISSN: 1949-2553
Pastor-Anglada, M.; Pérez-Torras, S. (2018). Emerging Roles of Nucleoside Transporters. Frontiers in Pharmacology, 9, p. 606 . Repositori Institucional . ISSN: 1663-9812
Pastor-Anglada, M.; Pérez-Torras, S. (2018). Who is who in adenosine transport. Frontiers in Pharmacology, 9, p. 627 . Repositori Institucional . ISSN: 1663-9812
Pastor-Anglada, M.; Urtasun, N.; Pérez-Torras, S. (2018). Intestinal nucleoside transporters: function, expression, and regulation. Comprehensive Physiology, 8(3), pp. 1003 - 1017 . ISSN: 2040-4603
Vasko, Balazs; Juhasz, Viktoria; Toth, Beata; Kurunczi, Anita; Fekete, Zsolt; Zolnerciks, Joseph Krisjanis; Kis, Emese; Magnan, Remi; Bidon-Chanal Badia, Axel; Pastor-Anglada, Marcal; Hazai, Eszter; Bikadi, Zsolt; Fulop, Ferenc; Krajcsi, Peter (2019). Inhibitor selectivity of CNTs and ENTs. Xenobiotica, 49(7), pp. 840 - 851 . https://doi.org/10.1080/00498254.2018.1501832 . ISSN: 0049-8254
Grañe-Boladeras N; Williams D; Tarmakova Z; Stevanovic K; Villani LA; Mehrabi P; Siu KWM; Pastor-Anglada M; Coe IR. (2018). Oligomerization of equilibrative nucleoside transporters: a novel regulatory and functional mechanism involving PKC and PP1. The FASEB Journal , 33(3), pp. 3841 - 3850 . ISSN: 0892-6638
Pérez-Torras, S.; Mata-Ventosa, A.; Drögemöller, B.; Tarailo-Graovac, M.; Meijer, J.; Meinsma, R.; van Cruchten, A.G.; Kulik, W.; Viel-Oliva, A.; Bidon-Chanal, A.; Ross, C.J.; Wassermann, W.W.; van Karnebeek, C.D.M.; Pastor-Anglada, M.*; van Kuilenburg, A.B.P.* (*,co-senior author). (2019). Deficiency of perforin and hCNT1, a novel inborn error of pyrimidine metabolism, associated with a rapidly developing lethal phenotype due to multi-organ failure. Biochimica et Biophysica Acta-Molecular Basis of Disease, 19865(6), pp. 1182 - 1191 . ISSN: 0925-4439
Perelló-Reus, C.M.; Català, A.; Caviedes-Cárdenas, L.; Vega-García, N.; Camós, M.; Pérez-Torras, S.; Pastor-Anglada, M. (2020). FMS-like tyrosine kinase 3 (FLT3) modulates key enzymes of nucleotide metabolism implicated in cytarabine responsiveness in pediatric acute leukemia. Pharmacological Research, 151, pp. 104556 - 104556 . ISSN: 1043-6618
Jaramillo AC; Hubeek I; Broekhuizen R; Pastor-Anglada M; Kaspers GJL; Jansen G; Cloos J; Peters GJ. (2020). Expression of the nucleoside transporters hENT1 (SLC29) and hCNT1 (SLC28) in pediatric acute myeloid leukemia. Nucleosides Nucleotides & Nucleic Acids, 39(10-12), pp. 1379 - 1388 . ISSN: 1525-7770
Boces-Pascual C; Mata-Ventosa A; Martín-Satué M; Boix L; Gironella M; Pastor-Anglada M; Pérez-Torras S. (2021). OncomiRs miR-106a and miR-17 negatively regulate the nucleoside-derived drug transporter hCNT1. Cellular and Molecular Life Sciences, 78(23), pp. 7505 - 7518 . Repositori Institucional . ISSN: 1420-682X
Guillén-Gómez E; Silva I; Serra N; Caballero F; Leal J; Breda A; San Martín R; Pastor-Anglada M; Ballarín JA; Guirado L; Díaz-Encarnación MM. (2020). From Inflammation to the Onset of Fibrosis through A2A Receptors in Kidneys from Deceased Donors. International Journal of Molecular Sciences, 21(22), p. 8826 . Repositori Institucional . ISSN: 1661-6596
Grane-Boladeras, Natalia; Perez-Torras, Sandra; Jose Lozano, Juan; Romero, Marta R.; Mazo, Adela; Marin, Jose J. G.; Pastor-Anglada, Marcal (2016). Pharmacogenomic analyzis of the responsiveness of gastrointestinal tumor cell lines to drug therapy: A transportome approach. Pharmacological Research, 113, pp. 364 - 375 . https://doi.org/10.1016/j.phrs.2016.09.007 . ISSN: 1043-6618
Pastor-Anglada, M.; Mata-Ventosa, A.; Pérez-Torras, S. (2022). Inborn errors of nucleoside transporter (NT)-encoding genes (SLC28 and SLC29). International Journal of Molecular Sciences . https://doi.org/10.3390/ijms23158770 . ISSN: 1661-6596
Pena-Rodríguez E; García-Vega L; Lajarin Reinares M; Pastor-Anglada M; Pérez-Torras S; Fernandez-Campos F. (2022). Latanoprost-loaded nanotransfersomes designed for scalp administration enhance keratinocytes proliferation. Molecular Pharmaceutics . https://doi.org/10.1021/acs.molpharmaceut.2c00796 . ISSN: 1543-8384