Xavier Just Baringo

Profesor lector

Scopus Author ID: 22334342600

Researcher ID: AAH-2420-2019

Área de conocimiento: Química Orgánica

Grupo de Investigación: Sustainable Organic Synthesis Group (SOSyn)

Información de contacto
Departamento de Farmacología, Toxicología y Química Terapéutica
Av. Joan XXIII
934024540
xavier.just(a)ub.edu

Publicaciones en revistas

Isidro-Llobet, A. ; Just-Baringo, X.; Ewenson, A.; Álvarez, M.; Albericio, F. (2007). Fmoc-2-Mercaptobenzothiazole (MBT), for the Introduction of the Fmoc Moiety Free of Side-Reactions. Biopolymers, 88(5), pp. 733 - 737 . Repositorio Institucional . ISSN: 0006-3525

Isidro-Llobet, A. ; Just-Baringo, X.; Álvarez, M.; Albericio, F. (2008). EDOTn and MIM, New peptide backbone Protecting groups. Biopolymers, 90(3), pp. 444 - 449 . ISSN: 0006-3525

Just-Baringo, X.; Bruno, P,; Albericio, F.; Álvarez, M. (2011). Highly efficient, multigram and enantiopure synthesis of 2-(2,4'-bithiazol-2-yl)pyrrolidin. Tetrahedron Letters, 52(42), pp. 5435 - 5437 . Repositorio Institucional . ISSN: 0040-4039

Bruno, P.; Peña, S.; Just-Baringo, X.; Albericio, F.; Álvarez, M. (2011). Total synthesis of aeruginazole A. Organic Letters, 13(17), pp. 4648 - 4651 . Repositorio Institucional . ISSN: 1523-7060

Just-Baringo, X.; Bruno, P.; Ottesen, L.K.; Cañedo, L.M.; Albericio, F.; Álvarez, M. (2013). Total synthesis and stereochemical assignment of baringolin. Angewandte Chemie-International Edition, 52, pp. 7818 - 7821 . https://doi.org/10.1002/anie.201302372 . ISSN: 1433-7851

X. Just-Baringo; F. Albericio; M. Álvarez (2013). From 2,6-Dichloronicotinic Acid to Thiopeptide Cores. European Journal of Organic Chemistry, pp. 6404 - 6419 . https://doi.org/10.1002/ejoc.201300877 . ISSN: 1434-193X

Just-Baringo, X.; Albericio, F.; Álvarez, M. (2014). Thiopeptide Engineering: A Multidisciplinary Effort Towards Future Drugs. Angewandte Chemie-International Edition, 53(26), pp. 6602 - 6616 . ISSN: 1433-7851

Just-Baringo, X.; Bruno, P.; Pitart, C.; Vila, J.; Albericio, F.; Álvarez, M. (2014). Dissecting the Structure of Thiopeptides: Assessment of Thiazoline and Tail Moieties of Baringolin and Antibacterial Activity Optimization. Journal of Medicinal Chemistry, 57, pp. 4185 - 4195 . ISSN: 0022-2623

Just-Baringo, X.; Albericio, F.; Álvarez, M. (2014). Thiopeptide Antibiotics: Retrospective and Recent Advances. Marine Drugs, 12(1), pp. 317 - 351 . Repositorio Institucional . ISSN: 1660-3397

Just-Baringo, X.; Albericio, F.; Álvarez, M. (2014). Chiral Thiazoline and Thiazole Building Blocks for the Synthesis of Peptide-Derived Natural Products. Current Topics In Medicinal Chemistry, 14, pp. 1244 - 1256 . ISSN: 1568-0266

Just-Baringo, X.; Albericio, F.; Álvarez, M. (2014). Engineering von thiopeptiden: ein multidisziplin rer weg zu neuen wirkstoffen. Angewandte Chemie, 126, pp. 6720 - 6735 . ISSN: 0044-8249

Just-Baringo, X.; Procter, D. J. (2015). Sm(II)-Mediated Electron Transfer to Carboxylic Acid Derivatives: Design of Complexity Generating Cascades. Accounts of Chemical Research, 48, pp. 1263 - 1275 . ISSN: 0001-4842

Just-Baringo, X.; Morrill, C.; Procter, D. J. (2016). Highly Selective SmI2-H2O-promoted Radical Cyclisation of Five-membered Lactones. Tetrahedron, 72, pp. 7691 - 7698 . ISSN: 0040-4020

Just-Baringo, X.; Clark, J.; Gutmann, M. J.; Procter, D. J. (2016). Selective Synthesis of Cyclooctanoids by Radical Cyclization of Seven-Membered Lactones: Neutron Diffraction Study of the Stereoselective Deuteration of a Chiral Organosamarium. Angewandte Chemie-International Edition, 55, pp. 12499 - 12502 . ISSN: 1433-7851

Plesniak, M. P.; Just-Baringo, X.; Ortu, F.; Mills, D. P.; Procter, D. J. (2016). SmCpR2-Mediated Cross-Couplings of Allyl and Propargyl Ethers with Ketoesters and a Telescoped Approach to Complex Cycloheptanols. Chemical Communications, 52, pp. 13503 - 13506 . ISSN: 1359-7345

Thurow, S.; Lenardão, E. J.; Just-Baringo, X.; Procter, D. J. (2017). Reduction of Selenoamides to Amines Using SmI2-H2O. Organic Letters, 19, pp. 50 - 53 . ISSN: 1523-7060

Morrill, C.; Jensen, C.; Just-Baringo, X.; Grogan, G.; Turner, N.; Procter, D. J. (2018). Biocatalytic Conversion of Cyclic Ketones Bearing -Quaternary Stereocenters to Lactones in an Enantioselective Radical Approach to Medium-Sized Carbocycles. Angewandte Chemie-International Edition, 57, pp. 3692 - 3696 . ISSN: 1433-7851

Just-Baringo, X.; Larrosa, I. (2018). Ketone C-C Bond Activation Meets the Suzuki-Miyaura Cross-Coupling. Chem, 4, pp. 1203 - 1204 . ISSN: 2451-9294

Simonetti, M.; Cannas, D. M.; Just-Baringo, X.; Vitorica-Yrezabal, I. J.; Larrosa, I. (2018). Cyclometallated Ruthenium Catalyst Enables Late-Stage Arylation of Pharmaceuticals. Nature Chemistry, 10, pp. 724 - 731 . ISSN: 1755-4330

Plesniak, M. P.; Castro, M. G.; Lenz, P.; Just-Baringo, X.; Procter, D. J. (2018). Samarium(II) Folding Cascades Involving Hydrogen Atom Transfer for the Synthesis of Complex Polycycles. Nature Communications, 9, p. 4802 . Repositorio Institucional . ISSN: 2041-1723

Shin, Y.; Just-Baringo, X.; Zarattini, M.; Isherwood, L. H.; Baidak, A.; Kostarelos, K.; Larrosa, I.; Casiraghi, C. (2019). Charge-Tunable Graphene Dispersions in Water Made with Amphoteric Pyrene Derivatives. Molecular Systems Design & Engineering, 4, p. 503 . ISSN: 2058-9689

AlSalem, H.; Just-Baringo, X.; Larrosa, I.; Monteverde, U.; Jiang, X.; Feng, Y.; Koehler, S. P. K. (2019). Evidence for Site-Specific Reversible Hydrogen Adsorption on Graphene by Sum-Frequency Generation Spectroscopy and Density Functional Theory. Journal of Physical Chemistry C, 123, p. 25883 . ISSN: 1932-7447

Just-Baringo, X.; Boyes, M.; Panigrahi, A.; Zarattini, M.; Chen, Y.; Liu, X.; Morris, G.; Prestat, E.; Kostarelos, K.; Vranic, S.; Larrosa, I.; Casiraghi, C. (2020). Enhanced Liquid Phase Exfoliation of Graphene in Water Using an Insoluble Bis-Pyrene Stabiliser. Faraday Discussions . https://doi.org/10.1039/C9FD00114J . ISSN: 1359-6640

Just-Baringo, X.; Shin, Y.; Zarattini, M.; Nagyte, V.; Zhao, L.; Kostarelos, K.; Casiraghi, C.; Larrosa, I. (2020). Palladium Catalysed C-H Arylation of Pyrenes: Access to a New Class of Exfoliating Agents for Water-Based Graphene Dispersions. Chemical Science, 11, pp. 2472 - 2478 . ISSN: 2041-6520

Shin, Y.; Vranic, S.; Just-Baringo, X.; Gali, S. M.; Gkoutzidou, A.; Prestat, E.; Beljonne, D.; Larrosa, I; Kostarelos, K.; Casiraghi, C. (2020). Stable, Concentrated, Biocompatible, and Defect-free Graphene Dispersions with Positive Charge. Nanoscale, 12, pp. 12383 - 12394 . ISSN: 2040-3364

Just-Baringo, X; Yeste-Vázquez, A.; Moreno-Morales, J.; Ballesté-Delpierre, C.; Vila, J.; Giralt, E. (2021). Controlling Antibacterial Activity Exclusively with Visible Light: Introducing a Tetra-ortho-Chloro-Azobenzene Amino Acid. Chemistry-A European Journal, 27, pp. 12987 - 12991 . Repositorio Institucional . ISSN: 0947-6539

Read, O.; Shin, Y.; Hu, C.-X.; Zarattini, M.; Boyes, M.; Just-Baringo, X.; Panigrahi, A.; Larrosa, I., Casiraghi, C. (2022). Insights into the exfoliation mechanism of pyrene-assisted liquid phase exfoliation of graphene from lateral size-thickness characterisation. Carbon, 186, pp. 550 - 559 . https://doi.org/10.1016/j.carbon.2021.09.075 . ISSN: 0008-6223

Proyectos

QUÍMICA COMBINATÒRIA PER AL DESENVOLUPAMENT DE NPUS COMPOSTOS (Projectes de recerca per potenciar els grups de recerca consolidats ) . 2009 - 2013 . Ref.2009SGR1024 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Fernando Albericio Palomera . (1 Investigadores)

Citotóxicos
Péptidos
Química combinatoria
Heterocíclos nitrogenados

Sustainable Organic Synthesis Group (SOSyn) (Projectes de recerca per potenciar els grups de recerca consolidats ) . 2022 - 2024 . Ref.2021SGR00268 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Albert Moyano Baldoire . (18 Investigadores)

Beatriu de Pinós Xavier Just (Sense especificar) . 2019 - 2020 . Ref.2017BP_00116 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Ernest Giralt Lledo; Xavier Just Baringo . (2 Investigadores)

Estudio del mecanismo de acción de péptidos cíclicos (CP1 y CP3) como potenciales inhibidores de bombas de expulsión activa en Pseudomonas aeruginosa (Accions CIBER) . 2023 . Ref.IM22/INF/4 . Consorcio CIBER de Enfermedades Infecciosas (CIBERINFEC) . IP: Clara Ballesté Delpierre . (8 Investigadores)

Síntesis Total Enantioselectiva de Productos Naturales Bioactivos Estructuralmente Diversos y de Análogos a Partir de "Scaffolds" Comunes (Programa estatal de fomento de la investigación científica y técnica de excelencia. Subprograma Estatal de generación de conocimiento.) . 2019 - 2021 . Ref.RTI2018-093974-B-I00 . Ministerio de Ciencia e Innovación . IP: Mercedes Amat Tusón . (10 Investigadores)

European Network for diagnosis and treatment of antibiotic-resistant bacterial infections (EURESTOP) (Cost Action) . 2022 - 2026 . Ref.CA21145 . European Cooperation in Science and Technology . IP: Mattia Mori (Università di Siena) and Patricia Rijo (Universidade Lusófona)

#Università degli Studi di Siena (European Cooperation in Science and Technology) . . IP:

Formación académica

Chemistry Degree . Universitat de Barcelona . 2008 . (Diplomatura / Licenciatura / Grado)

PhD in Organic Chemistry . Universitat de Barcelona . 2013 . (Doctorado)

Master in Advanced Chemistry . Universitat de Barcelona . 2010 . (Máster Oficial)

Otros Méritos o aclaraciones

Premio GEPRONAT 2020 al INVESTIGADOR NOVEL DEL GRUPO ESPECIALIZADO EN
QUÍMICA DE PRODUCTOS NATURALES (Méritos relacionados con la actividad investigadora)

Finalista Reaxys PhD Prize 2014 (Méritos relacionados con la actividad investigadora)

IRB Kids Day (2012): Organisation of general public activities for kids visiting the Institute for Research in Biomedicine (Barcelona). The activities were design to show children of very early ages (5-10) some simple but visually attractive chemical phenomena that would spur their interest in science (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

Institut Salesians de Sarrià, discussions in Martí Codolar (2009-2021): Participation in round table discussions with students from the "Institut Salesians de Sarria" (Barcelona) at the beginning of the 2nd year of "Batxillerat" to offer them support and expertise in defining their future careers. The discussions are mainly aimed at answering the students' questions about the choices they will need to make during the upcoming years (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

TV appearance in TV3 (2014): After the publication of the total synthesis of baringolin (Angew. Chem. Int. Ed. 2013, 52, 7818), the public Catalan TV, TV3, prepared an episode of "El Medi Ambient" on the synthesis of marine natural products (available at: http://www.tv3.cat/videos/4696876/Sintesi-quimica-de-farmacs-marins) (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

Reaxys Guidance Team (2014-2016): As a finalist of the Reaxys PhD Prize in 2014 I had the opportunity to join the Reaxys Guidance Team. The activities of the Guidance Team consisted on monthly meetings on Skype with other members of the Guidance Team and representative of Reaxys (Pieder Caduff, Senior Manager Enabling Technologies & Innovation). The aim of the meetings was to help in the development of new tools for Reaxys as well as improving the existing ones (Méritos relacionados con la actividad investigadora)

PubHD (2015): PubHD consisted of a series of talks taking place weekly in pubs in Manchester where PhD students and post-docs could explain to the general public their research. As part of this activity, I presented my PhD research regarding the synthesis of natural products as a sustainable source of therapeutic compounds (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

3rd National Retrosynthesis Competition (2015-2016): Member of the finalist Team Dalton Towers (University of Manchester), which presented their proposal in the final that took place in London (UK) in 11th March 2016 (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

Institut Salesians de Sarrià, lecture on the scientific method (2016, 2019, 2020): I was invited to lecture students of the IB Diploma Programme ('Batxillerat Internacional') from the 'Institut Salesians de Sarrià' (Barcelona) where I explained the Scientific Method and how I applied it during my PhD and Post-Doctoral studies. The aim of the talk and the discussion that followed was to illustrate how the Scientific Method works and how it is used in real research activities (Méritos no clasificados)

British Science Week (March 2018): Participation in the graphene stall at Manchester during this country-wide (UK) celebration of science. The stall displayed all sorts of objects and devices incorporating graphene. The aim of this stand was to show to visitors of all ages how graphene is already used and which is its potential for future applications (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

Bluedot (20th-22nd July 2018): Preparation of a stand for the exhibition of props to explain the properties of graphene and its applications in material science and biomedicine to the general public attending the Bluedot music and science festival in the UK. This was organised along with other PDRA in the 2D Health and CDT projects (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

Batx2Lab (July 2019): Participated in the Batx2Lab program by Barcelona Science Park (PCB) to serve as tutor of a "batxillerat" student (Aina Morros) during her research project (treball de recerca). Also supervised the experimental work carried out in the lab at IRB Barcelona (Méritos no clasificados)

Barcelona Science Fest (Festival de la Ciència de Barcelona 2019): Preparation of games and activities to explain what things around us are made of from a chemical point of view. This was made in the context of the International Year of the Periodic Table to familiarise young members of the public with the periodic table and the elements (Méritos no clasificados)

Interview with Leadwire.com (January 2022): Interview about the group's work on visible light-active antimicrobial peptides and photoswitchable antibiotics in general (https://leadwire.com/stream/61d49122340e3d001e11ae23) (Méritos relacionados con la calidad y difusión de resultados de la actividad Investigadora)

Estancias en Centros de Investigación

Universitat de Manchester. Manchester. REINO UNIDO. 2013 (3 Años) . Estada post-doctoral al grup del Prof. David Procter de la Universitat de Manchester, Regne Unit. . Post-doctoral

Universitat de Manchester. Manchester. REINO UNIDO. 2017 (2 Años) . Estada post-doctoral al grup del Prof. Igor Larrosa de la Universitat de Manchester, Regne Unit. . Post-doctoral

Institut de Recerca Biomèdica (IRB Barcelona). Barcelona. ESPAÑA. 2019 (2 Años 1 Meses 15 Dias) . Estada post-doctoral al grup del Prof. Ernest Giralt de l'Institut de Recerca Biomèdica (IRB Barcelona) amb un ajut Beatriu de Pinòs (AGAUR). . Post-doctoral

Tesis, tesinas y trabajos

Alejandro Yeste . (2020) . Synthesis and Biological Evaluation of Visible Light Photoswitchable Tyrocidine A Analogues (Tesis de Masters) . Universitat de Barcelona.

Mireia Belil . (2021) . New Tools for Biological Chemistry. Synthesis of Pyridyl Bromo Tetrazines (Tesis de Masters) . Universitat de Barcelona.

Irene Carbonell Rodriguez-Marín . (2022) . Palladium-Catalysed Directed C-H Sulfonation of Aromatics (Tesis de Masters) . Universitat de Barcelona.

María Pilar Trallero Pueyo . (2022) . Synthesis of Visible Light Photoswitchable Analogues of WHO's Critical Antibiotics (Trabajo de Grado) . Universitat de Barcelona.

Mireia Ferrando Riba . (2022) . Conjugació de Sulfadimidina amb un Foto-Commutador Operat amb Llum Visible per a la Regulació de l'Activitat Antibiòtica (Trabajo de Grado) . Universitat de Barcelona.

Pol Escuté i Pozo . (2022) . Síntesi de Foto-Commutadors d'Azobenzé Operats amb Llum Visible Solubles en Aigua (Treball Dirigit del Grau de Farmàcia) (Trabajo de Investigación) . Universitat de Barcelona.

Albert Ruiz Soriano . (2021) . Tesi encara en curs: Synthesis of Functional Tetramethoxyazobenzene Photoswitches for the Regulation of Antibacterial Activity (Tesis Doctoral) . Universitat de Barcelona.

Más Información: Just-Baringo group website (http://justbaringochem.com)