Àlex Gonzalez Segura

Àlex Gonzalez Segura

Investigador predoctoral AGAUR-SDUR

Research group: Farmacologia Clínica i Farmacogenètica

Contact Information
Department of Basic Clinical Practice
Carrer Casanova, 143

agonzalezsegura(a)ub.edu

Stays abroad in Research Centers

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona. Barcelona. SPAIN. 2013 (3 Months) . Laboratori de Recerca muscular i Funció mitocondrial . Others (specify)
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Hospital Clínic de Barcelona. Barcelona. SPAIN. 2014 (4 Months) . Unitat de Vasculitis . Others (specify)
Universitätsklinikum Hamburg-Eppendorf. Hamburg. GERMANY. 2015 (5 Months) . Treball de Fi de Grau a Institute for molecular and cellular Cognition . Others (specify)
Max Planck Institute for Experimental Medicine. Göttingen. GERMANY. 2019 (3 Months) . Treball de Fi de Màster a Clinical Neuroscience Department . Pre-Doctoral
Kembril Centre for Neuroinformatics, Centre for Addiction and Mental Health. Toronto. CANADA. 2022 (3 Months) . Estada doctoral a Laboratory for Computational Genomics . Pre-Doctoral

Academic training

Ciències Biomèdiques . Universitat de Barcelona . 01/07/2015 . (Diploma / Degree / Activities)
Antropologia Biològica . Universitat de Barcelona - Univesritat Autònoma de Barcelona . 01/07/2018 . (Official Master)

Participations in Conferences

Alex G Segura; Elena de la Serna; Gisela Sugranyes; Inmaculada Baeza; Isabel Valli; Irene Martínez-Serrano; Covadonga M Díaz-Caneja; Álvaro Andreu-Bernabeu; Dolores M Moreno; Patricia Gassó; Natalia Rodríguez; Albert Martínez-Pinteño; Llucia Prohens; Carla Torrent; Clemente García-Rizo; Sergi Mas; Josefina Castro-Fornieles (2023). Evaluation of the genetic and epigenetic architecture of youth at high familial risk of schizophrenia and bipolar disorder. (Round table) . Schizophrenia International Research Society Congress . Toronto . CANADA
Alex G Segura; Elena de la Serna; Gisela Sugranyes; Inmaculada Baeza; Isabel Valli; Covadonga Díaz-Caneja; Nuria Martín; Dolores M Moreno; Patricia Gassó; Natalia Rodriguez; Josefina Castro-Fornieles; Sergi Mas (2023). Genetic and environmental modulation of the subclinical status in youth at high familial risk for schizophrenia and bipolar disorder. (Invited conference) . Familial High Risk Research Summit . Copenheagen . DENMARK
Alex G Segura; Elena de la Serna; Gisela Sugranyes; Inmaculada Baeza; Isabel Valli; Covadonga Díaz-Caneja; Nuria Martín; Dolores M Moreno; Patricia Gassó; Natalia Rodriguez; Josefina Castro-Fornieles; Sergi Mas (2023). Genetic and environmental modulation of the subclinical status in youth at high familial risk for schizophrenia and bipolar disorder. (Round table) . International Congress of the European Society for Child and Adolescent Psychiatry . Copenhagen . DENMARK

Projects

Interacción genética y ambiente en hijos de pacientes con esquizofrenia o trastorno bipolar (Programa Nacional de Salud) . 2022 - 2024 . Ref.PI21/00519 . Ministerio de Ciencia, Innovación y Universidades . PI: Josefa Castro Fornieles . (1 Researchers)
Disentangling cliNical, neurObiological, and geneTic correlates of fIrst-episOde maNia in BipolarDisorder: The NOTION Project (Salut Mental) . 2023 - 2026 . Ref.274/U/2022 . Fundació La Marató de TV3 . PI: Sergio Mas Herrero
  • Episodio maníaco
  • Processos epigenètics
  • Trastorn bipolar
  • Disfunción cognitiva
  • Comportamiento psicosocial
  • Magnetic Resonance imaging
Farmacologia Clínica i Farmacogenètica (Ajuts de Suport als Grups de Recerca de Catalunya (SGR)) . 2022 - 2024 . Ref.2021SGR00672 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Sergio Mas Herrero
Biomarcadores multi-omics periféricos como predictores de evolución a largo plazo en el Trastorno Obsesivo-Compulsivo: la cohorte TOC Barcelona (OCD-BC) (Sense especificar) . 2023 - 2025 . Ref.PI22/00843 . Instituto de Salud Carlos III . PI: Maria Luisa Lazaro Garcia . (1 Researchers)

Journal Publications

Segura, A.G.; Mitjans, M.; Jiménez, E.; Fatjó-Vilas, M.; Ruiz, V.; Saiz, P.A.; García-Portillae, M.P.; González-Blanco L.; Bobes, J.; Vieta, E.; Benabarre, A.; Arias, B. (2019). Association of childhood trauma and genetic variability of CRH-BP and FKBP5 genes with suicidal behavior in bipolar patients. Journal of Affective Disorders, 255, pp. 15 - 22 . https://doi.org/10.1016/j.jad.2019.05.014 . ISSN: 0165-0327
Barroso, S.; Morén, C.; González-Segura, A.; Riba, N.; Arnaiz, J.A.; Manriquez, M.; Santana, G.; Blanco, J.L.; Larousse, M.; Loncà, M.; de Lazzari, E.; Llopis, J.; Mallolas, J.; Miró, O., Carné, X.; Gatell, J.M.; Garrabou, G.; Martínez, E. (2019). Metabolic, mitochondrial, renal and hepatic safety of enfuvirtide and raltegravir antiretroviral administration: Randomized crossover clinical trial in healthy volunteers. PLoS One, 14(5), p. e0216712 . Institutional Repository . ISSN: 1932-6203
Segura, AG.; Mitjans, M.; Fatjó-Vilas, M.; Garcia-Portilla, M.P.; Garcia-Alvarez, L.; Sarramea, F.; Bobes-Bascaran, T.; de la Fuente-Tomás, L. ; Velasco Iglesia, A.; Martínez-Cao, C.; González-Blanco, L.; Dal Santo, F.; Elizagarat, E. ; Saiz, P.A.; Fañanás, L.; Bobes, J.; Arias, B. (2020). Smoking cessation improves clinical outcome in severe mental disorders and is modulated by genetic variability at CHRNA5 gene. Schizophrenia Research, 222, pp. 516 - 519 . Institutional Repository . ISSN: 0920-9964
Martínez-Pinteño, A.; Gassó, P.; Prohens, LL.; Segura, A.G.; Parellada, M.; Saiz-Ruiz, J.; Cuesta, M.J.; Bernardo, M.; Lafuente, A.; Mas, S.; Rodríguez, N. (2021). Identification of EP300 as a Key Gene Involved in Antipsychotic-Induced Metabolic Dysregulation Based on Integrative Bioinformatics Analysis of Multi-Tissue Gene Expression Data. Frontiers in Pharmacology, 12, p. 729474 . Institutional Repository . ISSN: 1663-9812
Rodríguez, N; Lázaro, L; Ortiz, AE; Morer, A; Martínez-Pinteño, A; Segura, AG; Gassó, P; Mas, S (2022). Gene expression study in monocytes: evidence of inflammatory dysregulation in early-onset obsessive-compulsive disorder. Translational Psychiatry, 12(1), p. 134 . https://doi.org/10.1038/s41398-022-01905-1 . ISSN: 2158-3188
Natalia Rodríguez; Patricia Gassó; Albert Martínez-Pinteño; Àlex-González Segura; Gisela Mezquida; Lucia Moreno-Izco; Javier González-Peñas; Iñaki Zorrilla; Marta Martin; Roberto Rodriguez-Jimenez; Iluminada Corripio; Salvador Sarró; Angela Ibáñez; Anna Butjosa; Fernando Contreras; Miquel Bioque; Manuel-Jesús Cuesta; Mara Parellada; Ana González-Pinto; Esther Berrocoso; Miquel Bernardo; Sergi Mas; 2EPS group (2022). Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients. npj Schizophrenia, 8, p. 42 . https://doi.org/10.1038/s41537-022-00215-1 . ISSN: 2334-265X
Segura ÀG, Martínez-Pinteño A, Gassó P, Rodríguez N, Bioque M, Cuesta MJ, González-Peñas J, García-Rizo C, Lobo A, González-Pinto A, García-Alcón A, Roldán A, Vieta E, Castro-Fornieles J, Mané A, Saiz J, Bernardo M, Mas S; PEPs Group. (2022). Metabolic polygenic risk scores effect on antipsychotic-induced metabolic dysregulation: A longitudinal study in a first episode psychosis cohort. Schizophrenia Research, 244, pp. 101 - 110 . Institutional Repository . ISSN: 0920-9964
Valli I; De la Serna E; Segura AG; Pariente JC; Calvet-Mirabent A; Borras R; Ilzarbe D; Moreno D; Martín-Martínez N; Baeza I; Rosa-Justicia M; Garcia-Rizo C; Díaz-Caneja CM; Crossley NA; Young AH; Vieta E; Mas S; Castro-Fornieles J; Sugranyes G. (2022). Genetic and Structural Brain Correlates of Cognitive Subtypes Across Youth at Family Risk for Schizophrenia and Bipolar Disorder. Journal of the American Academy of Child and Adolescent Psychiatry . https://doi.org/10.1016/j.jaac.2022.05.011 . ISSN: 0890-8567
Segura, AG; Mezquida, G; Martínez-Pinteño, A; Gassó, P; Rodriguez, N; Moreno-Izco, L; Amoretti, S; Bioque, M; Lobo, A; González-Pinto, A; García-Alcon, A; Roldán-Bejarano, A; Vieta, E; de la Serna, E; Toll, A; Cuesta, MJ; Mas, S; Bernardo, M; PEPs Group (2022). Link between cognitive polygenic risk scores and clinical progression after a first-psychotic episode. Psychological Medicine . https://doi.org/10.1017/S0033291722001544 . ISSN: 0033-2917
Segura ÀG, Prohens L, Mezquida G, Amoretti S, Bioque M, Ribeiro M, Gurriarán-Bas X, Rementería L, Berge D, Rodriguez-Jimenez R, Roldán A, Pomarol-Clotet E, Ibáñez A, Usall J, García-Portilla MP, Cuesta MJ, Parellada M, González-Pinto A, Berrocoso E, Bernardo M, Mas S; 2EPS group. (2022). Epigenetic clocks in relapse after a first episode of schizophrenia. npj Schizophrenia, 8(1), p. 61 . https://doi.org/10.1038/s41537-022-00268-2 . ISSN: 2334-265X
Gassó, P.; Martínez-Pinteño, A.; Rodríguez, N.; Madero, S.; Gómez, M.; Segura, AG.; García-Rizo, C.; Morén, C.; Mas, S.; Parellada, E. (2023). Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures. International Journal of Molecular Sciences, 24(3), p. 2054 . Institutional Repository . ISSN: 1661-6596
Valli, I.; Segura, A. G.; Verdolini, N.; Garcia-Rizo, C.; Berge, D.; Baeza, I.; Cuesta, M. J.; Gonzalez-Pinto, A.; Lobo, A.; Martinez-Aran, A.; Mezquida, G.; Pina-Camacho, L.; Bejarano, A. R.; Mas, S.; McGuire, P.; Bernardo, M.; Vieta, E.; PEPs group (2023). Obstetric complications and genetic risk for schizophrenia: differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatrica Scandinavica . https://doi.org/10.1111/acps.13546 . ISSN: 0001-690X
Alex G Segura; Elena de la Serna; Gisela Sugranyes; Inmaculada Baeza; Isabel Valli; Covadonga Díaz-Caneja; Nuria Martín; Dolores M Moreno; Patricia Gassó; Natalia Rodriguez; Sergi Mas; Josefina Castro-Fornieles (2023). Epigenetic age deacceleration in youth at familial risk for schizophrenia and bipolar disorder. Translational Psychiatry . https://doi.org/10.1038/s41398-023-02463-w . ISSN: 2158-3188
Alex G Segura; Anna Mané; Llucia Prohens; Natalia Rodriguez; Gisela Mezquida; Manuel J Cuesta; Eduard Vieta; Silvia Amoretti; Antonio Lobo; Ana González-Pinto; Covadonga M Diaz-Caneja; Alexandra Roldán Bejarano; Esther Jimenez; Immaculada Baeza; Teresa Legido; Jeronimo Saiz-Ruiz; Miguel Bernardo; Sergi Mas; PEPs Group (2023). Exploration of cannabis use and polygenic risk scores on the psychotic symptom progression of a FEP cohort. Psychiatry Research . https://doi.org/10.1016/j.psychres.2023.115249 . ISSN: 0165-1781