María Isabel Hernández Alvarez
Researcher Ramon i Cajal program
GRUP D'ESTUDI DE LES BASES MOLECULARS DE PATOLOGIES ASSOCIADES A TRANSPORTADORS DE MEMBRANA (GENEXARTIS: PATOLOGÍA I TERAPIA MOLECULAR EN ENFERMETATS HETEROGÉNICAS I POLIGÉNICAS)
Projects
Nuevos conocimientos moleculares sobre la homeostasis de los fosfolípidos entre la mitocondria y el retículo endoplasmico en el desarrollo de daño hepatico
.
2020 - 2023
. Ref.PID2019-105466RA-I00
. Ministerio de Ciencia, Innovación y Universidades
. PI: Maria Isabel Hernandez Alvarez
Phospholipid biosynthesis and transport between endoplasmic reticulum and mitochondria: understanding their essential role in liver disorders
.
2021 - 2024
. Ref.HR21-00430
. Fundación Bancaria la Caixa
. PI: María Isabel Hernández Alvarez; Antonio Zorzano ; Jorge Joven
Contracte del Programa Ramon y Cajal
.
2020 - 2025
. Ref.RYC-2018-024345-I
. Ministerio de Economia y Competitividad
. PI: Antonio Zorzano Olarte; Maria Isabel Hernandez Alvarez
Institut de Recerca Biomèdica (IRB)
.
2012 - 2016
. Ref.SEV-2011-0066
. Ministerio de Ciencia e Innovación (MICINN)
. PI: Joan Josep Guinovart Cirera
Mención de Excelencia Severo Ochoa al Institut de Recerca Biomèdica (IRB)
.
2016 - 2019
. Ref.SEV-2015-0500
. Ministerio de Economia y Competitividad
. PI: Joan Josep Guinovart Cirera
Therapeutic effects of Mitofusin 2 re-expression in a nonalcoholic steatohepatitis mouse model
.
2018 - 2019
. Fundación Bancaria la Caixa
. PI: María Isabel Hernández Alvarez; Antonio Zorzano
Cancer Tec 2013 Mitofusin 2 ablation confers susceptibility to hepatocellular carcinoma
.
2013
. Fundación Bancaria la Caixa
. PI: María Isabel Hernández Alvarez; Antonio Zorzano
ABP a l'assignatura d'Enginyeria Genètica: Disseny d’una vacuna contra el SARS-Cov-2
.
2022 - 2024
. Ref.2022PMD-UB/015
. Universitat de Barcelona
. PI: Joana Fort Baixeras
Análisis del efecto del ciclo menstrual en las acciones del eje hígado-cerebro en el desarrollo de NAFLD y diabetes tipo 2
.
2023 - 2025
. Ref.CNS2022-135708
. Ministerio de Ciencia e Innovación (MICINN)
. PI: Maria Isabel Hernandez Alvarez
GIDC-BBM. Grup d'Innovació Docent de Bioquímica i Biologia Molecular
.
2016 - 2025
. Ref.GINDO-UB/052
. Universitat de Barcelona
. PI: Francisco Javier Lopez Soriano
Journal Publications
Zamudio-Vázquez, R.; Ivanova, S.; Moreno, M.; Hernandez-Alvarez, M.I.; Giralt, E.; Bidon-Chanal, A.; Zorzano, A.; Albericio, F.; Tulla-Puche, J.
A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation.
In
Chemical Science.
Number 6.
2015
. Institutional Repository
Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez M;, Serrano A; Palacín M; Zorzano A.
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.
In
The EMBO Journal.
2016
. https://doi.org/10.15252/embj.201593084
Naon, D; Zaninello, M; Giacomello, M; Varanita, T; Grespi, F; Lakshminaranayan, S; Serafini, A; Semenzato, M; Herkenne, S; Hernández-Alvarez, MI; Zorzano, A; De Stefani, D; Dorn, GW 2nd; Scorrano, L.
Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether.
In
Proceedings of the National Academy of Sciences of the United States of America - PNAS.
2016
Kulkarni, Sameer S.; Joffraud, Magali; Boutant, Marie; Ratajczak, Joanna; Gao, Arwen W.; Maclachlan, Catherine; Hernandez-Alvarez, Maria Isabel; Raymond, Frederic; Metairon, Sylviane; Descombes, Patrick; Houtkooper, Riekelt H.; Zorzano, Antonio; Canto, Caries.
Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin.
In
Diabetes.
Volume 65.
Number 12.
2016
. https://doi.org/10.2337/db15-1725
Maillo, C; Martín, J; Sebastián, D; Hernández-Alvarez, M; García-Rocha, M; Reina, O; Zorzano, A; Fernandez, M; Méndez, R.
Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress.
In
Nature Cell Biology.
2017
. https://doi.org/10.1038/ncb3461
Naon; M Zaninello; M Giacomello; T Varanita; F Grespi; S Lakshminaranayan; A Serafini; M Semenzato; S Herkenne; MI Hernández-Alvarez; A Zorzano; D De Stefani; GW Dorn; L Scorrano. Reply to Filadi et al.
Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?.
In
Proceedings of the National Academy of Sciences of the United States of America - PNAS.
2017
Soukupova, J.; Malfettone, A.; Hyrossová, P.; Hernández-Alvarez, MI.; Peñuelas-Haro, I.; Bertran, E.; Junza, A.; Capellades, J.; Giannelli, G.; Yanes, O.; Zorzano, A.; Perales, JC.; Fabregat, I.
Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.
In
Scientific Reports.
Volume 7.
Number 12486.
2017
. Institutional Repository
Hernandez-Alvarez, Maria Isabel; Diaz-Ramos, Angels; Berdasco, Maria; Cobb, Jeff; Planet, Evarist; Cooper, Diane; Pazderska, Agnieszka; Wanic, Krzystof; O'Hanlon, Declan; Gomez, Antonio; de la Ballina, Laura R.; Esteller, Manel; Palacin, Manuel; O'Gorman, Donal J.; Nolan, John J.; Zorzano, Antonio.
Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism.
In
Scientific Reports.
Volume 7.
2017
. Institutional Repository
Barbier-Torres, L; Iruzubieta, P; Fernández-Ramos, D; Delgado, TC; Taibo, D; Guitiérrez-de-Juan, V; Varela-Rey, M; Azkargorta, M; Navasa, N; Fernández-Tussy, P; Zubiete-Franco, I; Simon, J; Lopitz-Otsoa, F; Lachiondo-Ortega, S; Crespo, J; Masson, S; McCain, MV; Villa, E; Reeves, H; Elortza; F; Lucena, MI; Hernández-Alvarez, MI; Zorzano, A; Andrade, RJ; Lu, SC; Mato, JM; Anguita, J; Rincón, M; Martínez-Chantar, ML.
The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
In
Nature Communications.
2017
. https://doi.org/10.1038/s41467-017-01970-x
Veiga, Sonia R.; Ge, Xuemei; Mercer, Carol A.; Hernandez-Alvarez, Maria I.; Elnakat Thomas, Hala; Hernandez-Losa, Javier; Ramon y Cajal, Santiago; Zorzano, Antonio; Thomas, George; Kozma, Sara C.
Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR.
In
Clinical Cancer Research.
Volume 24.
Number 15.
2018
. https://doi.org/10.1158/1078-0432.CCR-18-0177
Ivanova, S.; Polajnar, M, Hernandez Alvarez M.I.; Slobodnyuk, K.; Plana, N.; Nebreda, A.R.; Palacin, M.; Gomis, R.; Behrends, C.; Zorzano, A.
Regulation of death receptor signaling by the autophagy protein TP53INP2.
In
The EMBO Journal.
Volume 38.
Number 10.
2019
. Institutional Repository
Keiran, Noelia; Ceperuelo-Mallafre, Victoria; Calvo, Enrique; Isabel Hernandez-Alvarez, Maria; Ejarque, Miriam; Nunez-Roa, Catalina; Horrillo, Daniel; Maymo-Masip, Elsa; Mar Rodriguez, M.; Fradera, Rosa; Vladimir de la Rosa, Juan; Jorba, Rosa; Megia, Ana; Zorzano, Antonio; Medina-Gomez, Gema; Serena, Carolina; Castrillo, Antonio; Vendrell, Joan; Fernandez-Veledo, Sonia.
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.
In
Nature Immunology.
Volume 20.
Number 5.
2019
. https://doi.org/10.1038/s41590-019-0372-7
Hernandez-Alvarez, MI.; Sebastian, D.; Vives, S.; Ivanova, S .; Bartoccioni, P.; Kakimoto, P.; Plana, N .; Veiga, SR.; Hernandez, V.; Vasconcelos, N.; Peddinti, G.; Adrover, A.; Jove, M.; Pamplona, R.; Gordaliza-Alaguero, I.; Calvo, E.; Cabre, N.; Castro, R.; Kuzmanic, A.; Boutant, M.; Sala, D.; Hyotylainen, T.; Oresic, M.; Fort, J. ; Errasti-Murugarren, E.; Rodrigues, CMP.; Orozco, M.; Joven, J.; Canto, C. ; Palacin, M.; Fernandez-Veledo, S.; Vendrell, J.; Zorzano, A.
Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease.
In
Cell.
Volume 177.
Number 4.
2019
. Institutional Repository
Juan Tur; Selma Pereira-Lopes; Tania Vico; Eros A. Marín; Juan P. Muñoz; Maribel Hernández-Álvarez; Pere-Joan Cardona; Antonio Zorzano; Jorge Lloberas; Antonio Celada.
Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.
In
Cell Reports.
Volume 32.
Number 8.
2020
. Institutional Repository
Jorge Lloberas; Juan P. Muñoz; María Isabel Hernández-Álvarez; Pere-Joan Cardona; Antonio Zorzano; Antonio Celada.
Macrophage mitochondrial MFN2 (mitofusin 2) links immune stress and immune response through reactive oxygen species (ROS) production.
In
Autophagy.
Volume 16.
Number 12.
2020
. https://doi.org/10.1080/15548627.2020.1839191
Testoni, G; Olmeda, B; Duran, J; López-Rodríguez, E; Aguilera, M; Hernández-Alvarez MI; Prats, N; Pérez-Gil, J; Guinovart JJ.
Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome.
In
Human Molecular Genetics.
2020
Cisa-Wieczorek, S.; Hernández-Alvarez, M.I.
Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases.
In
Cells.
2020
Soukupova, J; Malfettone, A; Bertran, E; Hernández-Alvarez, MI; Peñuelas-Haro, I; Dituri, F; Giannelli, G; Zorzano, A; Fabregat, I.
Epithelial-Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism.
In
International Journal of Molecular Sciences.
Volume 22.
Number 11.
2021
. Institutional Repository
Hernández-Alvarez MI and Zorzano A.
Mitochondrial Dynamics and Liver Cancer.
In
Cancers.
2021
Díaz-Sáez, F.;Blanco-Sinfreu, C.; Archilla-Ortega,A.; Sebastian, D.; Romero, M.;Hernández-Alvarez, M.I.; Mora, S.;Testar, X.; Ricart, W.; Fernández-Real,J.M.; Moreno-Navarrete, J.M.; Aragonés, J.; Camps, M.; Zorzano, A.; Gumà, A.
Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles.
In
International Journal of Molecular Sciences.
Volume 22.
Number 23.
2021
. Institutional Repository
Ventura, Raúl ;Martínez-Ruiz, Inma ;Hernández Alvarez, María Isabe.
Phospholipid Membrane Transport and Associated Diseases.
In
Biomedicines.
Volume 10.
Number 5.
2022
. Institutional Repository
Iliana López-Soldado; Adrian Gabriel Torres; Raúl Ventura; Inma Martínez-Ruiz; Angels Díaz-Ramos; Evarist Planet; Diane Cooper; Agnieszka Pazderska; Krzysztof Wanic; Declan O'Hanlon; Donal J O'Gorman; Teresa Carbonell; Lluís Ribas de Pouplana; John J Nolan; Antonio Zorzano; María Isabel Hernández-Alvarez.
Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle.
In
Redox Biology.
Volume 61.
2023
. Institutional Repository
Naón, D.; Hernández-Alvarez, M.I.; Shinjo, S.; Wieczor, M.; Ivanova, S.; Martins de Brito, O.; Quintana, A.; Hidalgo, J.; Palacín, M.; Aparicio, P.; Castellanos, J.; Lores, L.; Sebastián, D.; Fernández-Velado, S.; Vendrell, J.; Joven. J.; Orozco, M.; Zorzano, A. and Sorrano, L.
Splice variants of mitofusin 2 shape the endoplasmatic reticulum and tether it to mitochondria.
In
Science.
Number 380.
2023
. https://doi.org/10.1126/science.adh9351
Marc Leiro; Raúl Ventura; Nil Rojo-Querol; María Isabel Hernández-Alvarez.
Endoplasmic Reticulum Isolation: An Optimized Approach into Cells and Mouse Liver Fractionation.
In
Bio-protocol.
2023
. https://doi.org/10.21769/BioProtoc.4803
Bórquez JC; Díaz-Castro F; La Fuente FP; Espinoza K; Figueroa AM; Martínez-Ruíz I; Hernández V; López-Soldado I; Ventura R; Domingo JC; Bosch M; Fajardo A; Sebastián D; Espinosa A; Pol A; Zorzano A; Cortés V; Hernández-Alvarez MI; Troncoso R.
Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD.
In
Metabolism-Clinical and Experimental.
2023
. https://doi.org/10.1016/j.metabol.2023.155765
Andrea Jiménez-Franco, Helena Castañé, Cristian Martínez-Navidad, Cristina Placed-Gallego, Anna Hernández-Aguilera, Salvador Fernández-Arroyo, Iris Samarra, Marta Canela-Capdevila, Meritxell Arenas, Antonio Zorzano, María Isabel Hernández-Alvarez, Daniel Del Castillo, Marta Paris, Javier A Menendez, Jordi Camps, Jorge Joven.
Metabolic adaptations in severe obesity: Insights from circulating oxylipins before and after weight loss.
In
Clinical Nutrition.
2024
. https://doi.org/10.1016/j.clnu.2023.12.002
Thesis, minor thesis and research reports
Susana Raquel Barros
. (2019)
. Metabolic adaptations in liver-specific OPA1 knockout mouse model
(Ph.D. Thesis)
. Universitat de Barcelona.
Estel Solsona I Vilarrasa
. (2018)
. Studying the metabolic role of Mfn2 splicing variants
(Master's Thesis)
. MMD Netherlands.
Inmaculada Martínez Ruiz
. (2021)
. Role of the mitochondrial fusion proteins in the development of autophagy
(Master's Thesis)
. Universitat de Barcelona.
María Zapata Nicolàs
. (2021)
. Analysis of whether the effect of Mfn2 is gender dependent
(Degree work)
. Universitat de Barcelona.
Raúl Ventura Sánchez
. (2021)
. The implication of a non-mitochondrial Mfn2 subcellular localization and its possible activity outside the mitochondria
(Degree work)
. Universitat de Barcelona.
Albert Piquer Ruiz
. (2022)
. The role of Mfn1 in lipophagy
(Undergraduate thesis)
. .
Anna Casado i Esteban
. (2022)
. Role of mitochondrial fusion proteins in modulating phospholipid homeostasis
(Undergraduate thesis)
. .
Marc Leiro Gracía
. (2023)
. Study of mitochondrial fusion proteins in phospholipid metabolism
(Master's Thesis)
. Universitat de Barcelona.
Albert Piquer Ruiz
. (2023)
. Mitofusin 1 mediates mitochondrial lipid droplet contact, ensuring fatty acid trafficking and oxidation
(Master's Thesis)
. Universitat de Barcelona.
Other Achievements
Catalan Society of Biology Award to the 2019 top scientific article
Ramon y Cajal Researcher grant (RYC2018-024345-I) - 'Ministerio de Ciencia Innovación y Universidades'
EMBO short-term fellowship 2019
Travel award EMBO 2018
Tenure-track Miguel Servet program - Spanish National Health Research System Carlos III Institute of Health, ISCIII 2019. This grant was rejected by the candidate, because of incompatibility with the Ramon y Cajal grant
Postdoctorate 'Juan de la Cierva Incorporación' grant - "Ministerio de economía industria y competitividad", Spain
PhD Scholarship - CONACYT ('Consejo Nacional de Ciencia y Tecgnología'), México
Master Scholarship - CONACYT ('Consejo Nacional de Ciencia y Tecgnología') México
Prize AgroBio 2006 for the best master thesis
I3 Certification
Lectures
XIII Reunión del GEIRLI
. (Invited speaker).
22/07/2022.
Sevilla.
SPAIN
2ND International Symposium on Food, Nutrition, Physical Fitness and Health
. (Invited speaker).
15/06/2022.
Santiago de Chile.
CHILE
The 39th Congress of the International Union of Physiological Sciences
. (Invited speaker).
10/05/2022.
Beijing.
CHINA
11th CIBERDEM ANNUAL MEETING 2020
. (Invited speaker).
05/11/2020.
Barcelona.
SPAIN
MetNet Satellite Symposium
. (Invited speaker).
05/12/2019.
Barcelona.
SPAIN
53rd ESCI2019 Annual scientific meeting of the European Society for clinical investigation
. (Invited speaker).
24/05/2019.
Coimbra.
PORTUGAL
EMBO Workshop Membrane Contact Sites in Health and Disease
. (Oral Flash presentation and poster session).
21/09/2018.
Arosa.
SWITZERLAND
Reunión Anual CIBERDEM 2018
. (Oral communication).
25/05/2018.
Barcelona.
SPAIN
CIBERDEM ANNUAL MEETING 2016
. (oral communication).
13/05/2016.
Barcelona.
SPAIN
3rd annual meeting of CIBERDEM
. (Oral communication).
10/2021.
Prullans.
SPAIN
Cafès cientifics de la UB
. (Sexe i gènera en recerca (invited speaker)).
30/09/2022.
Barcelona.
SPAIN
Un nuevo centro en el metabolismo de fosfolípos
. (IV Congreso Nacional de Posgrado de Ingeniería Bioquímica (invited speaker)).
13/10/2022.
Celaya.
MEXICO
The complication of the metabolism in females
. (Día Internacional de la Dona i la Nena en la Ciència Xerrada i col·loqui 'Dones investigadores: qui són i què fan?').
15/02/2023.
SPAIN
Mitochondrial fusion proteins are a hub in phospholipid synthesis and metabolism
. (Conferencia Magistral en el XXIII Congreso de Bioenergética y Biomembranas).
25/10/2023.
Atlixco, Puebla.
MEXICO
Mfn2 localized in peroxisomes promotes their biogenesis and function
. (CIBERDEM14th ANNUAL MEETING).
16/11/2023.
Mataró Barcelona.
SPAIN
