María Isabel Hernández Alvarez

María Isabel Hernández Alvarez

Researcher Ramon i Cajal program

Scopus Author ID: 26639500700
Researcher ID: Z-4830-2019

GRUP D'ESTUDI DE LES BASES MOLECULARS DE PATOLOGIES ASSOCIADES A TRANSPORTADORS DE MEMBRANA (GENEXARTIS: PATOLOGÍA I TERAPIA MOLECULAR EN ENFERMETATS HETEROGÉNICAS I POLIGÉNICAS)

Contact Information
Department of Biochemistry and Molecular Biomedicine
Dpt. Biochemistry & Molecular Biomedicine - Fac. Biology University of Barcelona Av. Diagonal, 643
934021215
mihernandez(a)ub.edu

Projects

Nuevos conocimientos moleculares sobre la homeostasis de los fosfolípidos entre la mitocondria y el retículo endoplasmico en el desarrollo de daño hepatico . 2020 - 2023 . Ref.PID2019-105466RA-I00 . Ministerio de Ciencia, Innovación y Universidades . PI: Maria Isabel Hernandez Alvarez
Phospholipid biosynthesis and transport between endoplasmic reticulum and mitochondria: understanding their essential role in liver disorders . 2021 - 2024 . Ref.HR21-00430 . Fundación Bancaria la Caixa . PI: María Isabel Hernández Alvarez; Antonio Zorzano ; Jorge Joven
Contracte del Programa Ramon y Cajal . 2020 - 2025 . Ref.RYC-2018-024345-I . Ministerio de Economia y Competitividad . PI: Antonio Zorzano Olarte; Maria Isabel Hernandez Alvarez
Institut de Recerca Biomèdica (IRB) . 2012 - 2016 . Ref.SEV-2011-0066 . Ministerio de Ciencia e Innovación (MICINN) . PI: Joan Josep Guinovart Cirera
Mención de Excelencia Severo Ochoa al Institut de Recerca Biomèdica (IRB) . 2016 - 2019 . Ref.SEV-2015-0500 . Ministerio de Economia y Competitividad . PI: Joan Josep Guinovart Cirera
Therapeutic effects of Mitofusin 2 re-expression in a nonalcoholic steatohepatitis mouse model . 2018 - 2019 . Fundación Bancaria la Caixa . PI: María Isabel Hernández Alvarez; Antonio Zorzano
Cancer Tec 2013 Mitofusin 2 ablation confers susceptibility to hepatocellular carcinoma . 2013 . Fundación Bancaria la Caixa . PI: María Isabel Hernández Alvarez; Antonio Zorzano
ABP a l'assignatura d'Enginyeria Genètica: Disseny d’una vacuna contra el SARS-Cov-2 . 2022 - 2024 . Ref.2022PMD-UB/015 . Universitat de Barcelona . PI: Joana Fort Baixeras
Análisis del efecto del ciclo menstrual en las acciones del eje hígado-cerebro en el desarrollo de NAFLD y diabetes tipo 2 . 2023 - 2025 . Ref.CNS2022-135708 . Ministerio de Ciencia e Innovación (MICINN) . PI: Maria Isabel Hernandez Alvarez
GIDC-BBM. Grup d'Innovació Docent de Bioquímica i Biologia Molecular . 2016 - 2025 . Ref.GINDO-UB/052 . Universitat de Barcelona . PI: Francisco Javier Lopez Soriano

Journal Publications

Zamudio-Vázquez, R.; Ivanova, S.; Moreno, M.; Hernandez-Alvarez, M.I.; Giralt, E.; Bidon-Chanal, A.; Zorzano, A.; Albericio, F.; Tulla-Puche, J. A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation. In Chemical Science. Number 6. 2015 . Institutional Repository
Sebastián D; Sorianello E; Segalés J; Irazoki A; Ruiz-Bonilla V; Sala D; Planet E; Berenguer-Llergo A; Muñoz JP; Sánchez-Feutrie M; Plana N; Hernández-Álvarez M;, Serrano A; Palacín M; Zorzano A. Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway. In The EMBO Journal. 2016 . https://doi.org/10.15252/embj.201593084
Naon, D; Zaninello, M; Giacomello, M; Varanita, T; Grespi, F; Lakshminaranayan, S; Serafini, A; Semenzato, M; Herkenne, S; Hernández-Alvarez, MI; Zorzano, A; De Stefani, D; Dorn, GW 2nd; Scorrano, L. Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum-mitochondria tether. In Proceedings of the National Academy of Sciences of the United States of America - PNAS. 2016
Kulkarni, Sameer S.; Joffraud, Magali; Boutant, Marie; Ratajczak, Joanna; Gao, Arwen W.; Maclachlan, Catherine; Hernandez-Alvarez, Maria Isabel; Raymond, Frederic; Metairon, Sylviane; Descombes, Patrick; Houtkooper, Riekelt H.; Zorzano, Antonio; Canto, Caries. Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin. In Diabetes. Volume 65. Number 12. 2016 . https://doi.org/10.2337/db15-1725
Maillo, C; Martín, J; Sebastián, D; Hernández-Alvarez, M; García-Rocha, M; Reina, O; Zorzano, A; Fernandez, M; Méndez, R. Circadian- and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress. In Nature Cell Biology. 2017 . https://doi.org/10.1038/ncb3461
Naon; M Zaninello; M Giacomello; T Varanita; F Grespi; S Lakshminaranayan; A Serafini; M Semenzato; S Herkenne; MI Hernández-Alvarez; A Zorzano; D De Stefani; GW Dorn; L Scorrano. Reply to Filadi et al. Does Mitofusin 2 tether or separate endoplasmic reticulum and mitochondria?. In Proceedings of the National Academy of Sciences of the United States of America - PNAS. 2017
Soukupova, J.; Malfettone, A.; Hyrossová, P.; Hernández-Alvarez, MI.; Peñuelas-Haro, I.; Bertran, E.; Junza, A.; Capellades, J.; Giannelli, G.; Yanes, O.; Zorzano, A.; Perales, JC.; Fabregat, I. Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism. In Scientific Reports. Volume 7. Number 12486. 2017 . Institutional Repository
Hernandez-Alvarez, Maria Isabel; Diaz-Ramos, Angels; Berdasco, Maria; Cobb, Jeff; Planet, Evarist; Cooper, Diane; Pazderska, Agnieszka; Wanic, Krzystof; O'Hanlon, Declan; Gomez, Antonio; de la Ballina, Laura R.; Esteller, Manel; Palacin, Manuel; O'Gorman, Donal J.; Nolan, John J.; Zorzano, Antonio. Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism. In Scientific Reports. Volume 7. 2017 . Institutional Repository
Barbier-Torres, L; Iruzubieta, P; Fernández-Ramos, D; Delgado, TC; Taibo, D; Guitiérrez-de-Juan, V; Varela-Rey, M; Azkargorta, M; Navasa, N; Fernández-Tussy, P; Zubiete-Franco, I; Simon, J; Lopitz-Otsoa, F; Lachiondo-Ortega, S; Crespo, J; Masson, S; McCain, MV; Villa, E; Reeves, H; Elortza; F; Lucena, MI; Hernández-Alvarez, MI; Zorzano, A; Andrade, RJ; Lu, SC; Mato, JM; Anguita, J; Rincón, M; Martínez-Chantar, ML. The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. In Nature Communications. 2017 . https://doi.org/10.1038/s41467-017-01970-x
Veiga, Sonia R.; Ge, Xuemei; Mercer, Carol A.; Hernandez-Alvarez, Maria I.; Elnakat Thomas, Hala; Hernandez-Losa, Javier; Ramon y Cajal, Santiago; Zorzano, Antonio; Thomas, George; Kozma, Sara C. Phenformin-Induced Mitochondrial Dysfunction Sensitizes Hepatocellular Carcinoma for Dual Inhibition of mTOR. In Clinical Cancer Research. Volume 24. Number 15. 2018 . https://doi.org/10.1158/1078-0432.CCR-18-0177
Ivanova, S.; Polajnar, M, Hernandez Alvarez M.I.; Slobodnyuk, K.; Plana, N.; Nebreda, A.R.; Palacin, M.; Gomis, R.; Behrends, C.; Zorzano, A. Regulation of death receptor signaling by the autophagy protein TP53INP2. In The EMBO Journal. Volume 38. Number 10. 2019 . Institutional Repository
Keiran, Noelia; Ceperuelo-Mallafre, Victoria; Calvo, Enrique; Isabel Hernandez-Alvarez, Maria; Ejarque, Miriam; Nunez-Roa, Catalina; Horrillo, Daniel; Maymo-Masip, Elsa; Mar Rodriguez, M.; Fradera, Rosa; Vladimir de la Rosa, Juan; Jorba, Rosa; Megia, Ana; Zorzano, Antonio; Medina-Gomez, Gema; Serena, Carolina; Castrillo, Antonio; Vendrell, Joan; Fernandez-Veledo, Sonia. SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity. In Nature Immunology. Volume 20. Number 5. 2019 . https://doi.org/10.1038/s41590-019-0372-7
Hernandez-Alvarez, MI.; Sebastian, D.; Vives, S.; Ivanova, S .; Bartoccioni, P.; Kakimoto, P.; Plana, N .; Veiga, SR.; Hernandez, V.; Vasconcelos, N.; Peddinti, G.; Adrover, A.; Jove, M.; Pamplona, R.; Gordaliza-Alaguero, I.; Calvo, E.; Cabre, N.; Castro, R.; Kuzmanic, A.; Boutant, M.; Sala, D.; Hyotylainen, T.; Oresic, M.; Fort, J. ; Errasti-Murugarren, E.; Rodrigues, CMP.; Orozco, M.; Joven, J.; Canto, C. ; Palacin, M.; Fernandez-Veledo, S.; Vendrell, J.; Zorzano, A. Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease. In Cell. Volume 177. Number 4. 2019 . Institutional Repository
Juan Tur; Selma Pereira-Lopes; Tania Vico; Eros A. Marín; Juan P. Muñoz; Maribel Hernández-Álvarez; Pere-Joan Cardona; Antonio Zorzano; Jorge Lloberas; Antonio Celada. Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity. In Cell Reports. Volume 32. Number 8. 2020 . Institutional Repository
Jorge Lloberas; Juan P. Muñoz; María Isabel Hernández-Álvarez; Pere-Joan Cardona; Antonio Zorzano; Antonio Celada. Macrophage mitochondrial MFN2 (mitofusin 2) links immune stress and immune response through reactive oxygen species (ROS) production. In Autophagy. Volume 16. Number 12. 2020 . https://doi.org/10.1080/15548627.2020.1839191
Testoni, G; Olmeda, B; Duran, J; López-Rodríguez, E; Aguilera, M; Hernández-Alvarez MI; Prats, N; Pérez-Gil, J; Guinovart JJ. Pulmonary glycogen deficiency as a new potential cause of respiratory distress syndrome. In Human Molecular Genetics. 2020
Cisa-Wieczorek, S.; Hernández-Alvarez, M.I. Deregulation of Lipid Homeostasis: A Fa(c)t in the Development of Metabolic Diseases. In Cells. 2020
Soukupova, J; Malfettone, A; Bertran, E; Hernández-Alvarez, MI; Peñuelas-Haro, I; Dituri, F; Giannelli, G; Zorzano, A; Fabregat, I. Epithelial-Mesenchymal Transition (EMT) Induced by TGF-β in Hepatocellular Carcinoma Cells Reprograms Lipid Metabolism. In International Journal of Molecular Sciences. Volume 22. Number 11. 2021 . Institutional Repository
Hernández-Alvarez MI and Zorzano A. Mitochondrial Dynamics and Liver Cancer. In Cancers. 2021
Díaz-Sáez, F.;Blanco-Sinfreu, C.; Archilla-Ortega,A.; Sebastian, D.; Romero, M.;Hernández-Alvarez, M.I.; Mora, S.;Testar, X.; Ricart, W.; Fernández-Real,J.M.; Moreno-Navarrete, J.M.; Aragonés, J.; Camps, M.; Zorzano, A.; Gumà, A. Neuregulin 4 Downregulation Induces Insulin Resistance in 3T3-L1 Adipocytes through Inflammation and Autophagic Degradation of GLUT4 Vesicles. In International Journal of Molecular Sciences. Volume 22. Number 23. 2021 . Institutional Repository
Ventura, Raúl ;Martínez-Ruiz, Inma ;Hernández Alvarez, María Isabe. Phospholipid Membrane Transport and Associated Diseases. In Biomedicines. Volume 10. Number 5. 2022 . Institutional Repository
Iliana López-Soldado; Adrian Gabriel Torres; Raúl Ventura; Inma Martínez-Ruiz; Angels Díaz-Ramos; Evarist Planet; Diane Cooper; Agnieszka Pazderska; Krzysztof Wanic; Declan O'Hanlon; Donal J O'Gorman; Teresa Carbonell; Lluís Ribas de Pouplana; John J Nolan; Antonio Zorzano; María Isabel Hernández-Alvarez. Decreased expression of mitochondrial aminoacyl-tRNA synthetases causes downregulation of OXPHOS subunits in type 2 diabetic muscle. In Redox Biology. Volume 61. 2023 . Institutional Repository
Naón, D.; Hernández-Alvarez, M.I.; Shinjo, S.; Wieczor, M.; Ivanova, S.; Martins de Brito, O.; Quintana, A.; Hidalgo, J.; Palacín, M.; Aparicio, P.; Castellanos, J.; Lores, L.; Sebastián, D.; Fernández-Velado, S.; Vendrell, J.; Joven. J.; Orozco, M.; Zorzano, A. and Sorrano, L. Splice variants of mitofusin 2 shape the endoplasmatic reticulum and tether it to mitochondria. In Science. Number 380. 2023 . https://doi.org/10.1126/science.adh9351
Marc Leiro; Raúl Ventura; Nil Rojo-Querol; María Isabel Hernández-Alvarez. Endoplasmic Reticulum Isolation: An Optimized Approach into Cells and Mouse Liver Fractionation. In Bio-protocol. 2023 . https://doi.org/10.21769/BioProtoc.4803
Bórquez JC; Díaz-Castro F; La Fuente FP; Espinoza K; Figueroa AM; Martínez-Ruíz I; Hernández V; López-Soldado I; Ventura R; Domingo JC; Bosch M; Fajardo A; Sebastián D; Espinosa A; Pol A; Zorzano A; Cortés V; Hernández-Alvarez MI; Troncoso R. Mitofusin-2 induced by exercise modifies lipid droplet-mitochondria communication, promoting fatty acid oxidation in male mice with NAFLD. In Metabolism-Clinical and Experimental. 2023 . https://doi.org/10.1016/j.metabol.2023.155765
Andrea Jiménez-Franco, Helena Castañé, Cristian Martínez-Navidad, Cristina Placed-Gallego, Anna Hernández-Aguilera, Salvador Fernández-Arroyo, Iris Samarra, Marta Canela-Capdevila, Meritxell Arenas, Antonio Zorzano, María Isabel Hernández-Alvarez, Daniel Del Castillo, Marta Paris, Javier A Menendez, Jordi Camps, Jorge Joven. Metabolic adaptations in severe obesity: Insights from circulating oxylipins before and after weight loss. In Clinical Nutrition. 2024 . https://doi.org/10.1016/j.clnu.2023.12.002

Thesis, minor thesis and research reports

Susana Raquel Barros . (2019) . Metabolic adaptations in liver-specific OPA1 knockout mouse model (Ph.D. Thesis) . Universitat de Barcelona.
Estel Solsona I Vilarrasa . (2018) . Studying the metabolic role of Mfn2 splicing variants (Master's Thesis) . MMD Netherlands.
Inmaculada Martínez Ruiz . (2021) . Role of the mitochondrial fusion proteins in the development of autophagy (Master's Thesis) . Universitat de Barcelona.
María Zapata Nicolàs . (2021) . Analysis of whether the effect of Mfn2 is gender dependent (Degree work) . Universitat de Barcelona.
Raúl Ventura Sánchez . (2021) . The implication of a non-mitochondrial Mfn2 subcellular localization and its possible activity outside the mitochondria (Degree work) . Universitat de Barcelona.
Albert Piquer Ruiz . (2022) . The role of Mfn1 in lipophagy (Undergraduate thesis) . .
Anna Casado i Esteban . (2022) . Role of mitochondrial fusion proteins in modulating phospholipid homeostasis (Undergraduate thesis) . .
Marc Leiro Gracía . (2023) . Study of mitochondrial fusion proteins in phospholipid metabolism (Master's Thesis) . Universitat de Barcelona.
Albert Piquer Ruiz . (2023) . Mitofusin 1 mediates mitochondrial lipid droplet contact, ensuring fatty acid trafficking and oxidation (Master's Thesis) . Universitat de Barcelona.

Other Achievements

Catalan Society of Biology Award to the 2019 top scientific article
Ramon y Cajal Researcher grant (RYC2018-024345-I) - 'Ministerio de Ciencia Innovación y Universidades'
EMBO short-term fellowship 2019
Travel award EMBO 2018
Tenure-track Miguel Servet program - Spanish National Health Research System Carlos III Institute of Health, ISCIII 2019. This grant was rejected by the candidate, because of incompatibility with the Ramon y Cajal grant
Postdoctorate 'Juan de la Cierva Incorporación' grant - "Ministerio de economía industria y competitividad", Spain
PhD Scholarship - CONACYT ('Consejo Nacional de Ciencia y Tecgnología'), México
Master Scholarship - CONACYT ('Consejo Nacional de Ciencia y Tecgnología') México
Prize AgroBio 2006 for the best master thesis

I3 Certification

Lectures

XIII Reunión del GEIRLI . (Invited speaker). 22/07/2022. Sevilla. SPAIN
2ND International Symposium on Food, Nutrition, Physical Fitness and Health . (Invited speaker). 15/06/2022. Santiago de Chile. CHILE
The 39th Congress of the International Union of Physiological Sciences . (Invited speaker). 10/05/2022. Beijing. CHINA
11th CIBERDEM ANNUAL MEETING 2020 . (Invited speaker). 05/11/2020. Barcelona. SPAIN
MetNet Satellite Symposium . (Invited speaker). 05/12/2019. Barcelona. SPAIN
53rd ESCI2019 Annual scientific meeting of the European Society for clinical investigation . (Invited speaker). 24/05/2019. Coimbra. PORTUGAL
EMBO Workshop Membrane Contact Sites in Health and Disease . (Oral Flash presentation and poster session). 21/09/2018. Arosa. SWITZERLAND
Reunión Anual CIBERDEM 2018 . (Oral communication). 25/05/2018. Barcelona. SPAIN
CIBERDEM ANNUAL MEETING 2016 . (oral communication). 13/05/2016. Barcelona. SPAIN
3rd annual meeting of CIBERDEM . (Oral communication). 10/2021. Prullans. SPAIN
Cafès cientifics de la UB . (Sexe i gènera en recerca (invited speaker)). 30/09/2022. Barcelona. SPAIN
Un nuevo centro en el metabolismo de fosfolípos . (IV Congreso Nacional de Posgrado de Ingeniería Bioquímica (invited speaker)). 13/10/2022. Celaya. MEXICO
The complication of the metabolism in females . (Día Internacional de la Dona i la Nena en la Ciència Xerrada i col·loqui 'Dones investigadores: qui són i què fan?'). 15/02/2023. SPAIN
Mitochondrial fusion proteins are a hub in phospholipid synthesis and metabolism . (Conferencia Magistral en el XXIII Congreso de Bioenergética y Biomembranas). 25/10/2023. Atlixco, Puebla. MEXICO
Mfn2 localized in peroxisomes promotes their biogenesis and function . (CIBERDEM14th ANNUAL MEETING). 16/11/2023. Mataró Barcelona. SPAIN

More Information: http://www.ub.edu/ibub/research-group/molecular-basis-of-metabolic-pathologies-and-associated-to-membrane-transporters/