Francisco Ciruela Alferez

Catedràtic d'Universitat

Scopus Author ID: 56946698300

Researcher ID: A-5096-2013

Àrea de coneixement : Farmacologia

Grups d'Innovació Docent: Instrucció i Aprenentatge en Ciències de la Salut

Informació de contacte
Departament de Patologia i Terapèutica Experimental
Dept Patologia i Terapèutica Experimental, Bellvitge, Pavelló de Govern, FEIXA LLARGA, S/N
934024280
fciruela(a)ub.edu

Docència Impartida (actual)

Farmacologia General - Medicina - Universidad de Barcelona.

Farmacologia de Recerca i Innovació - Ciències Biomèdiques - Universidad de Barcelona.

Formació acadèmica

CIENCIAS BIOLÓGICAS . Universidad de Barcelona. . 30/06/1990 . (Diplomatura / Llicenciatura / Grau)

CIENCIAS BIOLÓGICAS . Universidad de Barcelona. . 22/01/1995 . (Doctorat )

Experiència Professional

Rector's Delegate for Strategic Research Actions and Senior Officer of the UB at the LERU. University of Barcelona. Spain. 01/01/2017 - 15/10/2020

Coordinator of the Neuroscience Program at IDIBELL. L'Hospitalet de Llobregat, Spain. 01/01/2016 - 15/01/2023

Board of Directors Member (Vocal). Spanish Society of Pharmacology (SEF). 21/06/2017 - 11/09/2020

Member of the Committee for Animal Experimentation (CEA). Generalitat de Catalunya. Spain. 01/09/2012 - 31/08/2016

Guest Professor. University of Ghent, Belgium. 01/01/2013 - 31/12/2016

Becari Postdoctoral EMBO. MRC. Oxford University. 01/04/1997 - 01/05/1999

BecariPost Wellcome Trust. Dept. Pharmacology, Oxford University. 01/05/1999 - 27/02/2000

Becari F.I. Fac. Quim. Univ. Barcelona. 01/06/1991 - 31/12/1994

Professor Associat. Fac. Quim. Univ. Barcelona. 01/10/1995 - 31/01/1996

Investigador Ramón y Cajal. Fac. Quim. Univ. Barcelona. 01/02/2003 - 23/12/2007

Linies de Recerca

G protein-coupled receptor oligomerization in the basal ganglia and its implications in Parkinson’s disease

Interactions of G protein-coupled receptors and ion channels in the Central Nervous System: implications in neuropsichiatric diseases and pain

Projectes de Recerca

Ecto-GPR37: a potential biomarker for Parkinson’s disease . 2021 - 2023 . Ref.MJFF-001051 . Michael J. Fox Foundation for Parkinson's Research . IP: Francisco Ciruela Alferez

Iluminando los trastornos relacionados con la dopamina: Adaptar la farmacoterapia a los oligómeros de GPCR . 2024 - 2027 . Ref.PID2023-147425OB-I00 . Ministerio de Ciencia e Innovación . IP: Francisco Ciruela Alferez

Neurofarmacologia i Dolor . 2022 - 2026 . Ref.2021 SGR 00698 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . IP: Francisco Ciruela Alferez

Refining sigma-1 receptor screening assays and sigma-2 protein-protein interaction discovery . 2019 - 2020 . Ref.310613 . Laboratorios del Dr. Esteve, S.A . IP: Francisco Ciruela Alferez

Publicacions en revistes

López-Cano, M; Scortichini ,M.; Tosh, DK.; Salmaso , V.; Ko, T.; Salort, G.; Filgaira, I.; Soler, C.; Trauner, D.; Hernando, J.; Jacobson, KA.; Ciruela F. (2025). Photoswitchable Diazocine Derivative for Adenosine A3 Receptor Activation in Psoriasis. Journal of the American Chemical Society, 147(1), pp. 874 - 879 . https://doi.org/10.1021/jacs.4c13558 . ISSN: 0002-7863

Morató, X.; Garcia-Esparcia, P.; Argerich, J.; Llorens, F.; Zerr, I.; Paslawski, W.; Borràs, E.; Sabidó, E.; Petäjä-Repo, U.E.; Fernández-Dueñas, V.; Ferrer, I.; Svenningsson, P.; Ciruela, F. (2021). Ecto-GPR37: a potential biomarker for Parkinson's disease. Translational Neurodegeneration, 10(1), p. 8 . ISSN: 2047-9158

Argerich, J.; Garma, L.D.; López-Cano, M.; Álvarez-Montoya, P.; Gómez-Acero, L.; Fernández-Dueñas, V.; Muñoz-Manchado, A.B.; Aso, E.; Boxer, A.; Andres-Benito, P.; Svenningsson, P.; Ciruela, F. (2024). GPR37 processing in neurodegeneration: a potential marker for Parkinson's Disease progression rate. npj Parkinson's Disease, 10(1) . Repositori Institucional . ISSN: 2373-8057

Valle-León, M.; Callado, L.F., M.; Aso, E.; Cajiao-Manrique, M.M.; Sahlholm, K.; López-Cano, M.; Soler, C.; Altafaj, X.; Watanabe, M.; Ferré, S.; Fernández-Dueñas, V.; Menchón, J.M.; Ciruela, F (2021). Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia. Neuropsychopharmacology(46), pp. 665 - 672 . https://doi.org/10.1038/s41386-020-00872-9 . ISSN: 0893-133X

López-Cano M, Filgaira I, Nolen EG, Cabré G, Hernando J, Tosh DK, Jacobson KA, Soler C, Ciruela F. (2021). Optical control of adenosine A3 receptor function in psoriasis. Pharmacological Research . https://doi.org/10.1016/j.phrs.2021.105731 . ISSN: 1043-6618

Hüll, K.; Fernández-Dueñas, V.; Schönberger, M.; López-Cano, M.; Trauner, D.; Ciruela, F. (2021). Optical Control of Adenosine-Mediated Pain Modulation. Bioconjugate Chemistry, 32(9), pp. 1 - 5 . Repositori Institucional . ISSN: 1043-1802

López-Cano, M.; Font, J.; Aso, E.; Sahlholm, K.; Cabré, G.; Giraldo, J.; De Koninck, Y.; Hernando, J.; Llebaría, A.; Fernández-Dueñas, V.; Ciruela, F.; (2023). Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects. British Journal of Pharmacology, 180(7), pp. 958 - 974 . https://doi.org/10.1111/bph.15645 . ISSN: 0007-1188

Ferré, S.; Ciruela, F.; Dessauer, C.W.; González-Maeso, J.; Hébert, T.E.; Jockers, R.; Logothetis, D.E.; Pardo, L. (2021). G protein-coupled receptor-effector macromolecular membrane assemblies (GEMMAs). Pharmacology & Therapeutics, 231, p. 107977 . Repositori Institucional . ISSN: 0163-7258

Fernández-Dueñas, V.; Bonaventura, J.; Aso, E.; Luján, R.; Ferré, S.; Ciruela, F. (2022). Overcoming the challenges of detecting gpcr oligomerization in the brain. Current Neuropharmacology, 20(6), pp. 1035 - 1045 . https://doi.org/10.2174/1570159X19666211104145727 . ISSN: 1570-159X

Ciruela, F.; Jacobson, K.A. (2022). Optical control of adenosine A3 receptor signaling: Towards a multimodal phototherapy in psoriasis?. Frontiers in Immunology, 13 . Repositori Institucional . ISSN: 1664-3224

Altres publicacions

Luján, R.; Ciruela, F. (2021). Receptors and Ion Channel Detection in the Brain: Methods and Protocols . En Neuromethods . Volum. 169 . (pp. vii - x) . Springer Nature Switzerland .

Fernández-Dueñas, V.; Durroux, T.; Ciruela, F. (2021). Time resolved-fluorescence resonance energy transfer using fluorescent ligands to study native G protein-coupled receptor heteromerization in brain . En Neuromethods . Volum. 169 . (pp. 107 - 116) . Springer Nature Switzerland .

López-Cano, M.; Fernández-Dueñas, V.; Ciruela, F. (2021). Optical control of brain receptors using photoactive drugs in behaving animals . En Neuromethods . Volum. 169 . (pp. 513 - 522) . Springer Nature Switzerland .