Eva Estébanez-Perpiñá

Professora agregada

Àrea de coneixement : Bioquímica i Biologia Molecular

Principal Investigator

Associate Professor

Coordinator and Professor of Design and Evaluation of Bioactive Molecules (Biochemistry)

Grup de Recerca: IP Bases Moleculars de Processos Fisiopatològics Fonamentals

Informació de contacte
Departament de Bioquímica i Biomedicina Molecular
INSTITUT DE BIOMEDICINA DE LA UNIVERSITAt DE BARCELONA (IBUB-UB) CARRER BALDIRI REIXAC 15-21 PARC CIENTIFIC DE BARCELONA
934031119
evaestebanez(a)ub.edu

Docència

Design and evaluation of bioactive molecules

Structure of Macromolecules

Tutor of Practicum I, Practicum II and TFG

Tutor of PhD students

Formació acadèmica

LLicenciada Bioquimica . Universitat Autonoma de Barcelona . 01/09/1998 . (Diplomatura / Llicenciatura / Grau)

Doctora en Bioquimica . UAB + Max Planck Institut . 15/05/2002 . (Doctorat )

Llicenciada Psicologia . Universitat Autonoma de Barcelona . 30/06/1995 . (Diplomatura / Llicenciatura / Grau)

Linies de Recerca

BIOLOGIA ESTRUCTURAL DE RECEPTORS NUCLEARS HUMANS ACTIVATS PER LLIGAND

SOCIOLOGIA MOLECULAR DEL RECEPTOR D´ANDROGENS HUMA

DETERMINANTS MOLECULARS SUBJACENTS A L´AGREGACIO DEL RECEPTOR D´ANDROGENS HUMA EN MOTONEURONES DURANT LA NEURODEGENERACIO ESPINAL-BULBAR (MALALTIA DE KENNEDY)

LES SUPERFICIES D´INTERACCIO DEL RECEPTOR D´ANDROGENS COM DIANES TERAPEUTIQUES DE MODULADORS ALOSTERICS

Projectes

Oncología Estructural del Receptor de Andrógenos: Arquitectura Multi-dominio y Diseño Racional de Inhibidores de la Dimerización para el Cáncer de Próstata . 2018 - 2020 . Ref.BFU2017-86906-R . Ministerio de Economia y Competitividad . IP: Eva Estebanez Perpiña

Red temática de Mecanismos Moleculares del Cáncer Urológico (URONCOMOL) . 2020 - 2023 . Ref.RED2018-102769-T . Ministerio de Economia y Competitividad . IP: Annabel Valledor Fernandez

Small-molecule inhibitors of AR-LBD dimerization interface to treat castration-resistant prostate cancer . 2016 - 2017 . Ref.2016-08-1833 . Bayer Healthcare . IP: Eva Estebanez Perpiña

First-in-class Dimerization Inhibitors of the Androgen Receptor as Novel Therapeutics against Prostate Cancer . 2018 - 2020 . Ref.CI18-00018 . Fundació Caixa de Pensions 'La Caixa' . IP: Eva Estebanez Perpiña

Publicacions en revistes

Estébanez-Perpiñá, E.; Hink-Schauer, C.; Bode, W. ;Jenne, D. (2003). Crystal Structure of the Apoptosis-inducing Granzyme A Dimer. Nature Structural Biology(10), pp. 535 - 540 . ISSN: 1072-8368

Nadal, M.; Prekovic, S.; Gallastegui, N.; Helsen, C.; Abella, M.; Zielinska, K.; Gay, M.; Vilaseca, M.; Taulès, M.; Houtsmuller, A.B.; van Royen, M.E.; Claessens, F.; Fuentes-Prior, P.; Estébanez-Perpiñá E. (2017). Structure of the Homodimeric androgen receptor ligand-binding domain. Nature Communications, 8, pp. 14388 - 14398 . Repositori Institucional . ISSN: 2041-1723

de Bosscher, K.; Desmet, S.J.; Clarisse, D.; Estebanez-Perpiña, E.; Brunsveld, L. (2020). Nuclear Receptor cross-talk: defining the mechanisms for therapeutic innovation. Nature Reviews Endocrinology, s41574 . https://doi.org/10.1038/s41574-020-0349-5 . ISSN: 1759-5029

Estébanez-Perpiñá, E.; Moore; J., Mar, E.; Delgado-Rodrigues, E.; Nguyen, P.; Webb, P.; Baxter, J.; Buehrer, B.; Fletterick R.J.; and K. R. Guy. (2005). The molecular mechanisms of coactivator utilization in ligand dependent transactivation by the androgen receptor. Journal of Biological Chemistry(280), pp. 8060 - 8068 . ISSN: 0021-9258

Estébanez-Perpiñá, E.; Hink-Schauer, C.; Wilharm, E.; Fuentes-Prior, P.; Klinkert, W.; Bode, W.; and Jenne, D. (2002). The 2.2-Å Crystal Structure of Human Pro-granzyme K Reveals a Rigid Zymogen with Unusual Features. Journal of Biological Chemistry(277), pp. 50923 - 50933 . ISSN: 0021-9258

Jiménez-Panizo, A.; Pérez, P.; Rojas, A.; Fuentes-Prior, P.; Estebanez-Perpiña, E. (2019). Non-canonical Dimerization of the androgen receptor and other nuclear receptors: Implications for human disease. Endocrine-Related Cancer, 26, pp. R1 - R20 . ISSN: 1351-0088

Mackinnon, J.A.; Gallastegui, N.; Osguthorpe, D.J.; Hagler, A.T.; Estébanez-Perpiñá E. (2014). Allosteric mechanisms of nuclear receptors: insights from computational simulations. Molecular and Cellular Endocrinology, 14, pp. S0303 - 7207 . https://doi.org/10.1016/j.mce.2014.05.017 . ISSN: 0303-7207

Gallastegui, N.; Fletterick, R.J.; Estébanez-Perpiñá, E. (2015). Advances in our structural understanding of orphan nuclear receptors. Trends in Biochemical Sciences, 40(1), pp. 25 - 35 . https://doi.org/10.1016/j.tibs.2014.11.002 . ISSN: 0968-0004

Més Informació: Structural Biology of Nuclear Receptors (http://www.ub.edu/ibub/research-group/structural-biology-of-human-nuclear-receptors/)