Santiago Imperial Rodenas

Santiago Imperial Rodenas

Associate professor

ORCID: 0000-0001-8749-1428
Scopus Author ID: 6701683262
Researcher ID: K-4963-2017
Knowledge area: Bioquímica i Biologia Molecular

Teaching Innovation Groups: Metabolisme al grau de Química (QuiMet)

Contact Information
Department of Biochemistry and Molecular Biomedicine
Facultat de Biologia, Avda Diagonal 643, Edifici Prevosti, planta -1
934021873
simperial(a)ub.edu

Teaching

Metabolism
Molecular Recognition and Interactions
Industrial Biochemistry and Microbiology
Biocatalysis and Enzyme Technology (Master in Molecular Biotechnology). Coordinator

Academic Training

Ciencias Químicas . Universidad de Barcelona . 1982 . (Diploma / Degree / Activities)
Ciencias Químicas . Universidad de Barcelona . 1986 . (Ph.D.)

Research interests

Organization and regulation of isoprenoid biosynthesis in plants and microorganisms
Development of new antitubercular and antimalarial drugs
Selection of aptamers specífic for enzymes from Plasmodium. Therapeutical and diagnostic applications

Projects

Caracterización de la actividad del inhibidor de la agregación proteica YAT2150 como nuevo mecanismo antimalárico . 2022 - 2025 . Ref.PID2021-128325OB-I00 . Ministerio de Ciencia e Innovación (MICINN) . PI: Xavier Fernandez Busquets
Discovery of new antiparasitic agents . 2019 - 2021 . Ref.USP-05-2019 . Unión Iberoamericana de Universidades . PI: Santiago Imperial Rodenas
Metabolisme i Enginyeria Metabòlica . 2017 - 2021 . Ref.2017SGR710 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Manuel Rodriguez Concepcion
Investigación de la agregación proteica como nueva diana antimalárica . 2019 - 2021 . Ref.RTI2018-094579-B-I00 . Ministerio de Ciencia, Innovación y Universidades . PI: Xavier Fernandez Busquets
Engineering of nanovectors for the delivery of antimalarial drugs to Plasmodium transmission forms . 2015 - 2017 . Ref.BIO2014-52872-R . Ministerio de Economia y Competitividad . PI: Xavier Fernandez Busquets

Journal Publications

Roca C; Avalos-Padilla Y; Prieto-Simón B; Iglesias V; Ramírez M; Imperial S; Fernàndez-Busquets X. (2022). Selection of an aptamer against the enzyme 1-deoxy-D-xylulose-5-phosphate reductoisomerase from Plasmodium falciparum. Pharmaceutics, 14(11), p. 2515 . Institutional Repository . ISSN: 1999-4923
Biosca, A.; Ramírez, M.; Gomez-Gomez, A.; Lafuente, A.; Iglesias, V.; Pozo, O.J.; Imperial, S.; Fernàndez-Busquets, X. (2022). Characterization of domiphen bromide as a new fast-acting antiplasmodial agent inhibiting the apicoplastidic methyl erythritol phosphate pathway. Pharmaceutics, 14(7), p. 1320 . Institutional Repository . ISSN: 1999-4923
Gacemi, S.; Benarous, K.; Imperial, S.; Yousfi, M. (2020). Lepidine B 84 E as new target inhibitors from Lepidium settivum seeds against four enzymes of the pathogen Candida albicans: In vitro and in silico studies. Endocrine Metabolic & Immune Disorders - Drug Targets, 20(1), pp. 127 - 138 . https://doi.org/10.2174/1871530319666190415141520 . ISSN: 1871-5303
Biosca, A., Dirscherl, L., Moles, E., Imperial, S., Fernàndez-Busquets, X. (2019). An immunoPEGliposome for targeted antimalarial combination therapy at the nanoscale. Pharmaceutics, 11(7), p. 341 . Institutional Repository . ISSN: 1999-4923
Moles, E.; Marcos, J.; Imperial, S.; Pozo, O.; Fernàndez-Busquets, X. (2017). 2-Picolylamine derivatization for high sensitivity detection of abscisic acid in apicomplexan blood-infecting parasites. Talanta, 168, pp. 130 - 135 . https://doi.org/10.1016/j.talanta.2017.03.030 . ISSN: 0039-9140
Sisquella, X.; de Pourcq, K.; Alguacil, J.; Robles, J.; Sanz, F.; Anselmetti, D.; Imperial, S.; Fernández-Busquets, X. (2010). A single-molecule force spectroscopy nanosensor for
the identification of new antibiotics and antimalarials. The FASEB Journal , 24, pp. 4203 - 4217 . ISSN: 0892-6638
Obiol-Pardo, C.; Rubio-Martinez, J., Imperial, S. (2011). The methylerythritol phosphate (MEP) pathway for isoprenoid biosynthesis as a target for the development of new drugs against tuberculosis. Current Medicinal Chemistry, 18, pp. 1325 - 1338 . ISSN: 0929-8673
Pérez-Gil, J.; Bergua, M.; Boronat, A., and Imperial, S (2010). Cloning and functional characterization of an enzyme from Helicobacter pylori that catalyzes two steps of the methylerythritol phosphate pathway for isoprenoid biosynthesis. Biochimica et Biophysica Acta-General Subjects, 1800, pp. 919 - 928 . ISSN: 0304-4165

Others Publications

Pérez-Gil, J.; Miralles, J.; Bergua, M.; Boronat, A.; Rubio-Martínez, J.; Imperial, S. (2013). The biosíntesis of isoprenoid precursors as a new target for the development of specific antibiotics for the treatment of Helicobacter pylori-associated diseases . In Helicobacter pylori, Detection Methods, Diseases and Health Implications (Marco Manfredi and Gian Luigi de Angelis, Editors). . (pp. 363 - 379) . Nova Science Publishers . http://www.novapublishers.com