Ofelia M. Martínez Estrada

Senior lecturer

ORCID: 0000-0002-1814-1974

Scopus Author ID: 6602737783

Researcher ID: V-4733-2017

Knowledge area: Biologia Cel.lular

Research group:

Bases cel·lulars i moleculars en neurodegeneració i neuroregeneració (CMBNN)
CELLTEC UB

Contact Information
Department of Cell Biology, Physiology and Immunology
Departament de Biologia Cel·lular, Facultat de Biologia, Av. Diagonal 643,
934021535
ofeliamartinez(a)ub.edu

Teaching

Docència als Graus de Biomedicina, Bioquímica i Biotecnologia i als Màsters de Biomedicina i Biotecnologia Molecular

Citologia

Cultius i Enginyeria Cel·lular

Academic Training

Microbiologia . Universidad de la Habana . 10/07/1993 . (Diploma / Degree / Activities)

Interacciones Moleculares de JAM . Universitat de Barcelona . 26/10/2001 . (Ph.D.)

Research interests

Wt1 in cell plasticity

Identification of novel pathways involved in epicardium formation

Metabolic regulation of epicardium cell plasticity during heart development and repair

Projects

Identification of new targets of Wt1 during cardiovascular development . 2012 - 2016 . Ref.303926 . Marie Curie European Reintegration Grants (ERG) . PI: Ofelia M. Martínez Estrada

Identificación de las funciones del gen Wt1 en la enfermedad de Hugtinton . 2015 - 2017 . Fundación Ramón Areces . PI: Ofelia Maria Martinez Estrada

Identificación de una nueva vía implicada en el desarrollo del epicardio embrionario a partir de los análisis de microarrays de células aisladas in vivo . 2016 - 2018 . Ref.BFU2015-68135-P . Ministerio de Economia y Competitividad . PI: Ofelia Maria Martinez Estrada; Manuel Reina del Pozo

Study and manipulation of the embryonic epicardium program, a new approach for heart repair . 2016 - 2018 . Ref.20152210 . Fundació La Marató de TV3 . PI: Ofelia Maria Martinez Estrada

Dissecting the functional role of the epicardium metabolism during heart development and repair after myocardial infarction . 2018 - 2021 . Ref.HR17-00627 . Fundació Caixa de Pensions 'La Caixa' . PI: Ofelia Maria Martinez Estrada

Journal Publications

Martínez-Estrada, O.M.; Lettice, L.A.; Essafi, A.; Guadix, J.A.; Slight, J.; Velecela, V.; Hall, E.; Reichmann, J.; Devenney, P.S.; Hohenstein, P.; Hosen, N.; Hill, R.E.; Muñoz-Chapuli, R.; Hastie, N.D. (2010). Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nature Genetics, 42, pp. 89 - 93 . ISSN: 1061-4036

Essafi, A.; Webb, A.; Berry, R.L.; Slight, J.; Burn, S.F.; Spraggon, L.; Velecela, V.; Martinez-Estrada, O.M.; Wiltshire, J.H.; Roberts, S.G.; Brownstein, D.; Davies, J.A.; Hastie, N.D.; Hohenstein, P. (2011). A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression. Developmental Cell, 21(3), pp. 559 - 574 . ISSN: 1534-5807

Guadix, J.A.; Ruiz-Villalba, A.; Muñoz-Chapuli, R.; Hastie, N.D.; Perez-Pomares, J.M.; Martínez-Estrada, O.M. (2011). Wt1 control retinoic acid signalling in embryonic epicardium through activation of the Raldh2 emzyme. Development, 138(6), pp. 1093 - 1097 . ISSN: 0950-1991

Velecela, V; Lettice, L.A.; Chau, Y.Y.; Slight, J; Berry, B.L.; Thombum, A.; Gunst, Q.D.;van den Hoff, M., Reina, M.; Martínez, F.O.; Hastie, N.D.; Martínez-Estrada, O.M. (2013). Wt1 regulates the expression of inhibitory chemokynes during heart development. Human Molecular Genetics, 22(25), pp. 5083 - 5095 . ISSN: 0964-6906

Chau, Y.Y.; Bandiera, R.; Serrels,A.; Martínez-Estrada, OM.; Qing, W.; Lee, M.; Slight, J.; Thornburn, A.; Berry, R.; McHaffie, S.; Stimson, RH.; Walker, BR.; Muñoz-Chapuli, R.; Schedl, A.; Hastie N. (2014). Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nature Cell Biology, 16(4), pp. 367 - 375 . Institutional Repository . ISSN: 1465-7392

Martorell-Riera, A.; Segarra-Mondejar, M., Reina, M.; Martínez-Estrada, O.M.; Soriano, F.X. (2015). Mitochondrial fragmentation in excitotoxicity requires ROCK activation. Cell Cycle, 14(9), pp. 1365 - 1369 . Institutional Repository . ISSN: 1538-4101

Cano, E.; Carmona, R.; Velecela, V.; Martínez-Estrada, OM.; Muñoz-Chápuli, R. (2015). The proepicardium keeps a potential for glomerular marker expression which supports its evolutionary origin from the pronephros. Evodevo, 17(4), pp. 224 - 230 . https://doi.org/10.1111/ede.12130 . ISSN: 2041-9139

Segarra-Mondejar, Marc; Casellas-Diaz, Sergi; Ramiro-Pareta, Marina; Mueller-Sanchez, Claudia; Martorell-Riera, Alejandro; Hermelo, Ismail; Reina, Manuel; Aragones, Julian; Martinez-Estrada, Ofelia M.; Soriano, Francesc X. (2018). Synaptic activity-induced glycolysis facilitates membrane lipid provision and neurite outgrowth. The EMBO Journal, 37(9) . Institutional Repository . ISSN: 0261-4189

Velecela, Victor; Torres-Cano, Alejo; Garcia-Melero, Ana; Ramiro-Pareta, Marina; Muller-Sanchez, Claudia; Segarra-Mondejar, Marc; Chau, You-Ying; Campos-Bonilla, Begona; Reina, Manuel; Soriano, Francesc X.; Hastie, Nicholas D.; Martinez, Fernando O.; Martinez-Estrada, Ofelia M. (2019). Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Development, 146(20) . Institutional Repository . ISSN: 0950-1991

Others Publications

Velecela, V.; Fazal-Salom, J.; Martínez-Estrada, OM. (2016). Biological systems and methods for studying wt1 in the epicardium . In The Wilms' Tumor (WT1) Gene. Methods and Protocols . Volume. 1467 . (pp. 61 - 71) . Humana Press. . ISBN: ISBN 978-1-4939-4 .

More Information: http://www.ub.edu/ibub/research-group/ofelia-m-martinez/