Ofelia M. Martínez Estrada

Ofelia M. Martínez Estrada

Senior lecturer

ORCID: 0000-0002-1814-1974
Scopus Author ID: 6602737783
Researcher ID: V-4733-2017
Knowledge area: Biologia Cel.lular

Research group:

  • Bases cel·lulars i moleculars en neurodegeneració i neuroregeneració (CMBNN)
  • CELLTEC UB

Contact Information
Department of Cell Biology, Physiology and Immunology
Departament de Biologia Cel·lular, Facultat de Biologia, Av. Diagonal 643,
934021535
ofeliamartinez(a)ub.edu

Teaching

Docència als Graus de Biomedicina, Bioquímica i Biotecnologia i als Màsters de Biomedicina i Biotecnologia Molecular
Citologia
Cultius i Enginyeria Cel·lular

Academic Training

Microbiologia . Universidad de la Habana . 10/07/1993 . (Diploma / Degree / Activities)
Interacciones Moleculares de JAM . Universitat de Barcelona . 26/10/2001 . (Ph.D.)

Research interests

Wt1 in cell plasticity
Identification of novel pathways involved in epicardium formation
Metabolic regulation of epicardium cell plasticity during heart development and repair

Projects

Identification of new targets of Wt1 during cardiovascular development . 2012 - 2016 . Ref.303926 . Marie Curie European Reintegration Grants (ERG) . PI: Ofelia M. Martínez Estrada
Dissecting the functional role of the epicardium metabolism during heart development and repair after myocardial infarction . 2018 - 2021 . Ref.HR17-00627 . Fundació Caixa de Pensions 'La Caixa' . PI: Ofelia Maria Martinez Estrada
Examinando el impacto de una señalización defectuosa de WT1: desde la formación del corazón embrionario hasta el corazón adulto . 2024 - 2027 . Ref.PID2023-148793NB-I00 . Ministerio de Ciencia e Innovación . PI: Ofelia Maria Martinez Estrada
Identificar el papel de WT1 durante la formación de nuevos vasos sanguíneos . 2021 - 2024 . Ref.PID2020-119315GB-I00 . Ministerio de Ciencia, Innovación y Universidades . PI: Ofelia Maria Martinez Estrada
Study and manipulation of the embryonic epicardium program, a new approach for heart repair . 2016 - 2018 . Ref.20152210 . Fundació La Marató de TV3 . PI: Ofelia Maria Martinez Estrada

Journal Publications

Martínez-Estrada, O.M.; Lettice, L.A.; Essafi, A.; Guadix, J.A.; Slight, J.; Velecela, V.; Hall, E.; Reichmann, J.; Devenney, P.S.; Hohenstein, P.; Hosen, N.; Hill, R.E.; Muñoz-Chapuli, R.; Hastie, N.D. (2010). Wt1 is required for cardiovascular progenitor cell formation through transcriptional control of Snail and E-cadherin. Nature Genetics, 42, pp. 89 - 93 . ISSN: 1061-4036
Essafi, A.; Webb, A.; Berry, R.L.; Slight, J.; Burn, S.F.; Spraggon, L.; Velecela, V.; Martinez-Estrada, O.M.; Wiltshire, J.H.; Roberts, S.G.; Brownstein, D.; Davies, J.A.; Hastie, N.D.; Hohenstein, P. (2011). A wt1-controlled chromatin switching mechanism underpins tissue-specific wnt4 activation and repression. Developmental Cell, 21(3), pp. 559 - 574 . ISSN: 1534-5807
Guadix, J.A.; Ruiz-Villalba, A.; Muñoz-Chapuli, R.; Hastie, N.D.; Perez-Pomares, J.M.; Martínez-Estrada, O.M. (2011). Wt1 control retinoic acid signalling in embryonic epicardium through activation of the Raldh2 emzyme. Development, 138(6), pp. 1093 - 1097 . ISSN: 0950-1991
Velecela, V; Lettice, L.A.; Chau, Y.Y.; Slight, J; Berry, B.L.; Thombum, A.; Gunst, Q.D.;van den Hoff, M., Reina, M.; Martínez, F.O.; Hastie, N.D.; Martínez-Estrada, O.M. (2013). Wt1 regulates the expression of inhibitory chemokynes during heart development. Human Molecular Genetics, 22(25), pp. 5083 - 5095 . ISSN: 0964-6906
Chau, Y.Y.; Bandiera, R.; Serrels,A.; Martínez-Estrada, OM.; Qing, W.; Lee, M.; Slight, J.; Thornburn, A.; Berry, R.; McHaffie, S.; Stimson, RH.; Walker, BR.; Muñoz-Chapuli, R.; Schedl, A.; Hastie N. (2014). Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source. Nature Cell Biology, 16(4), pp. 367 - 375 . Institutional Repository . ISSN: 1465-7392
Segarra-Mondejar, Marc; Casellas-Diaz, Sergi; Ramiro-Pareta, Marina; Mueller-Sanchez, Claudia; Martorell-Riera, Alejandro; Hermelo, Ismail; Reina, Manuel; Aragones, Julian; Martinez-Estrada, Ofelia M.; Soriano, Francesc X. (2018). Synaptic activity-induced glycolysis facilitates membrane lipid provision and neurite outgrowth. The EMBO Journal, 37(9) . Institutional Repository . ISSN: 0261-4189
Velecela, Victor; Torres-Cano, Alejo; Garcia-Melero, Ana; Ramiro-Pareta, Marina; Muller-Sanchez, Claudia; Segarra-Mondejar, Marc; Chau, You-Ying; Campos-Bonilla, Begona; Reina, Manuel; Soriano, Francesc X.; Hastie, Nicholas D.; Martinez, Fernando O.; Martinez-Estrada, Ofelia M. (2019). Epicardial cell shape and maturation are regulated by Wt1 via transcriptional control of Bmp4. Development, 146(20) . Institutional Repository . ISSN: 0950-1991
Casellas-Díaz S, Larramona-Arcas R, Riqué-Pujol G, Tena-Morraja P, Müller-Sánchez C, Segarra-Mondejar M, Gavaldà-Navarro A, Villarroya F, Reina M, Martínez-Estrada OM, Soriano FX. (2021). Mfn2 localization in the ER is necessary for its bioenergetic function and neuritic development. EMBO Reports, 22(9), pp. 1 - 20 . Institutional Repository . ISSN: 1469-221X
Torres-Cano, Alejo; Portella-Fortuny, Rosa; Müller-Sánchez, Claudia; Porras-Marfil, Sonia; Ramiro-Pareta, Marina; Chau, You-Ying; Reina, Manuel; Soriano, Francesc X,; Martínez-Estrada, Ofelia M. (2022). Deletion of Wt1 during early gonadogenesis leads to differences of sex development in male and female adult mice. PLoS Genetics, 18(6), pp. 1 - 23 . Institutional Repository . ISSN: 1553-7390
Ramiro-Pareta, Marina; Müller-Sánchez, Claudia; Portella-Fortuny, Rosa; Soler-Botija, Carolina; Torres-Cano, Alejo; Esteve-Codina, Anna; Bayés-Genís, Antoni; Reina, Manuel; Soriano, Francesc X.; Montanez, Eloi; Martínez-Estrada, Ofelia M. (2023). Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development. Development, 150(6) . Institutional Repository . ISSN: 0950-1991

Others Publications

Velecela, V.; Fazal-Salom, J.; Martínez-Estrada, OM. (2016). Biological systems and methods for studying wt1 in the epicardium . In The Wilms' Tumor (WT1) Gene. Methods and Protocols . Volume. 1467 . (pp. 61 - 71) . Humana Press. . ISBN: ISBN 978-1-4939-4 .

More Information: http://www.ub.edu/ibub/research-group/ofelia-m-martinez/