MíRIAM NEUS TARRADO CASTELLARNAU

MíRIAM NEUS TARRADO CASTELLARNAU

CIBER Researcher

ORCID: 0000-0001-9757-2686
Researcher ID: E-4419-2018

Research group: Grup de Bioquímica Integrativa

Contact Information
Department of Biochemistry and Molecular Biomedicine
Avinguda Diagonal 643, Facultat de Biologia, Edifici Prevosti planta -2
934021217
mtarrado(a)ub.edu

Academic Training

Bachelor of Science degree in Chemical Engineering . Facultat de Química, Universitat de Barcelona . 06/2011 . (Diploma / Degree / Activities)
Bachelor of Science degree in Biochemistry . Facultat de Biologia, Universitat de Barcelona . 06/2009 . (Diploma / Degree / Activities)
PhD in Biotechnology . Facultat de Biologia, Universitat de Barcelona . 11/12/2015 . (Ph.D.)
Master in Molecular Biotechnology . Facultat de Farmàcia, Universitat de Barcelona . 09/2010 . (Official Master)

Research interests

Targeting metabolic reprogramming associated to cancer cells: search of novel targets and combined therapies in cancer treatment
Overcoming acquired drug resistance driven by metabolic reprogramming in colorectal and prostate cancer
Caracterització de les adaptacions metabòliques en càncer de còlon i de l'efecte antitumoral de nous inhibidors sintètics i/o derivats de productes naturals

Projects

Análisis de la reprogramación metabólica metastásica en la búsqueda de nuevas estrategias terapéuticas en cáncer . 2015 - 2017 . Ref.SAF2014-56059-R . Ministerio de Economia y Competitividad . PI: Marta Cascante Serratosa
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (CIBER) . 2018 - 2023 . Ref.CB17/04/00023 . Ministerio de Economia y Competitividad . PI: Marta Cascante Serratosa
Targeting metabolic reprogramming to overcome acquired therapeutic resistance in colorectal cancer . 2020 - 2023 . Ref.EHD20PI03 . Consorcio CIBER del área de Enfermedades Hepáticas y Digestivas (CIBEREHD) . PI: Míriam Tarrado Castellarnau
NEUTRALIZACIÓN DE LA REPROGRAMACIÓN METABÓLICA ASOCIADA A LA METÁSTASIS Y A LA RESISTENCIA AL TRATAMIENTO PARA PREVENIR EL FRACASO TERAPÉUTICO EN CANCER DE PROSTATA Y COLON . 2018 - 2020 . Ref.SAF2017-89673-R . Ministerio de Ciencia, Innovación y Universidades . PI: Marta Cascante Serratosa
Identificación de los subtipos metabólicos de cáncer colorrectal para el desarrollo de medicina personalizada . 2021 - 2024 . Ref.PID2020-115051RB-I00 . Ministerio de Ciencia e Innovación (MICINN) . PI: Marta Cascante Serratosa; Pedro Ramon de Atauri Carulla

Journal Publications

Tarrado-Castellarnau, M.; Cortés, R.; Zanuy, M.; Tarragó-Celada, J.; Polat, I.H.; Hill, R.; Fan, T.W.; Link, W.; Cascante, M. (2015). Methylseleninic acid promotes Antitumour effects via nuclear FOXO3a translocation through Akt inhibition. Pharmacological Research, 102, pp. 218 - 234 . Institutional Repository . ISSN: 1043-6618
Cortes, R.; Tarrado-Castellarnau, M.; Talancón, D.; López, C.; Link, W.; Ruiz, D.; D.; Centelles, J.; Quirantee, J.; Cascante, M. (2014). A novel cyclometallated Pt(II) ferrocene complex induces nuclear FOXO3a localization and Q2 apoptosis and synergizes with cisplatin to inhibit lung cancer cell proliferation. Metallomics, 6(3), pp. 622 - 633 . https://doi.org/10.1039/c3mt00194f . ISSN: 1756-5901
Diaz-Moralli, S.; Tarrado-Castellarnau, M.; Miranda, A.; Cascante, M. (2013). Targeting Cell cycle regulation in cancer therapy. Pharmacology & Therapeutics, 138(2), pp. 255 - 271 . https://doi.org/10.1016/j.pharmthera.2013.01.011 . ISSN: 0163-7258
Tarrado-Castellarnau, M.; de Atauri, P.; Cascante, M. (2016). Oncogenic regulation of tumor metabolic reprogramming. Oncotarget, 7(38), pp. 62726 - 62753 . Institutional Repository . ISSN: 1949-2553
Tarrado-Castellarnau, M.; Diaz-Moralli, S.; Polat, I.H.; Sanz-Pamplona, R.; Alenda, C.; Moreno, V.; Castells, A.; Cascante, M. (2017). Glyceraldehyde-3-phosphate dehydrogenase is overexpressed in colorectal cancer onset. Translational Medicine Communications, 2(6), pp. 1 - 9 . Institutional Repository . ISSN: 2396-832X
Tarrado-Castellarnau, M.; de Atauri, P.; Tarragó-Celada, J.; Perarnau, J.; Yuneva, M.; Thomson T.M.; Cascante, M. (2017). De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition. Molecular Systems Biology, 13(10), p. 940 . Institutional Repository . ISSN: 1744-4292
Tarragó-Celada,Josep; Foguet,Carles; Tarrado-Castellarnau,Míriam ; Marin, Silvia; Hernández-Alias,Xavier; Perarnau, Jordi; Morrish,Fionnuala; Hockenbery, David; Gomis,Roger R.; Ruppin,Eytan; Yuneva,Mariia; Atauri, Pedro de; Cascante,Marta (2021). Cysteine and Folate metabolism are targetable vulnerabilities of metastatic colorectal cancer. Cancers, 13(3), p. 425 . Institutional Repository . ISSN: 2072-6694
Polat, Ibrahim H.; Tarrado-Castellarnau, Míriam; Bharat, Rohit; Perarnau, Jordi; Benito, Adrian; Cortés, Roldán; Sabatier, Philippe; Cascante, Marta (2021). Oxidative pentose phosphate pathway enzyme 6-phosphogluconate dehydrogenase plays a key role in breast cancer metabolism. Biology, 10(2), p. 85 . Institutional Repository . ISSN: 2079-7737
de Atauri P.; Tarrado-Castellarnau M.; Tarragó-Celada J.; Foguet C.; Karakitsou E.; Centelles J.J.; Cascante M. (2021). Integrating systemic and molecular levels to infer key drivers sustaining metabolic adaptations. PLoS Computational Biology, 17(7), p. e1009234 . Institutional Repository . ISSN: 1553-734X
Polat, Ibrahim H.; Tarrado Castellarnau, Míriam Neus; Benito Mauricio, Adrián; Hernández Carro, Claudia; Centelles Serra, Josep Joan; Marin, Silvia; Cascante i Serratosa, Marta (2021). Glutamine modulates expression and function of glucose 6-phosphate dehydrogenase via NRF2 in colon cancer cells. Antioxidants, 10(9), pp. 1 - 16 . Institutional Repository . ISSN: 2076-3921