Marco Mariotti

Marco Mariotti

Researcher Ramon i Cajal program

ORCID: 0000-0002-7411-4161
Researcher ID: AAB-7136-2019

Research group: Molecular Evolutionary Genetics

Contact Information
Department of Genetics, Microbiology and Statistics
Avinguda Diagonal, 643 Departament de Genètica, Microbiologia i Estadística Facultat de Biologia; Universitat de Barcelona

marco.mariotti(a)ub.edu

Academic Training

Bachelor's degree in Biotechnologies . Università di Bologna . 16/07/2006 . (Diploma / Degree / Activities)
PhD in Biomedicine . Centre de Regulació Genòmica . 13/12/2013 . (Ph.D.)
Master in Bioinformatics . Università di Bologna . 13/10/2008 . (Official Master)

Research interests

Comparative genomics of selenocysteine, the 21st amino acid
Evolution, function and mechanism of stop codon readthrough in eukaryotes
Computational methods for visualization and analysis of evolutionary data

Projects

Contracte del Programa Ramon y Cajal 2019 . 2021 - 2026 . Ref.RYC-2019-027746-I . Ministerio de Economia y Competitividad . PI: Montserrat Corominas Guiu; Marco Mariotti
Diversidad del Stop Codon Readthrough en insectos y otros metazoos . 2021 - 2024 . Ref.PID2020-115122GA-I00 . Ministerio de Ciencia, Innovación y Universidades . PI: Marco Mariotti
Genètica Molecular Evolutiva . 2017 - 2021 . Ref.2017SGR1287 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Julio Antonio Rozas Liras
Targeting clinical nonsense mutations through translational recoding . 2020 - 2020 . Ref.Hearst Young Investigator . Brigham and Womens Hospital, Harvard Medical School . PI: Marco Mariotti
Molecular Evolutionary Genetics . 2022 - 2024 . Ref.2021SGR00279 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Julio Antonio Rozas Liras

Journal Publications

Santesmasses, D.; Mariotti, M.; Gladyshev, V.N. (2020). Tolerance to selenoprotein loss differs between human and mouse. Molecular Biology and Evolution, 37(2), pp. 341 - 354 . Institutional Repository . ISSN: 0737-4038
Santesmasses, D.; Mariotti, M.; Gladyshev, V.N. (2020). Bioinformatics of selenoproteins. Antioxidants & Redox Signaling, 33(7), pp. 525 - 536 . Institutional Repository . ISSN: 1523-0864
Mariotti, M.; Salinas, G.; Gabaldón, T.; Gladyshev, V.N. (2019). Utilization of selenocysteine in early-branching fungal phyla. Nature Microbiology, 4(5), pp. 759 - 765 . Institutional Repository . ISSN: 2058-5276
Baclaocos, J.; Santesmasses, D.; Mariotti, M.; Bierła, K.; Vetick, M.B.; Lynch, S.; McAllen, R.; Mackrill, J.J.; Loughran, G.; Guigó, R.; Szpunar, J.; Copeland, P.R.; Gladyshev, V.N.; Atkins, J.F. (2019). Processive recoding and metazoan evolution of Selenoprotein P: up to 132 UGAs in molluscs. Journal of Molecular Biology, 431(22), pp. 4381 - 4407 . Institutional Repository . ISSN: 0022-2836
Yordanova, M.M.; Loughran, G.; Zhdanov, A.V.; Mariotti, M.; Kiniry, S.J.; O'Connor, P.B.F.; Andreev, D.E.; Tzani, I.; Saffert, P.; Michel, A.M.; Gladyshev, V.N.; Papkovsky, D.B.; Atkins, J.F.; Baranov, P.V. (2018). AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation. Nature, 553(7688), pp. 356 - 360 . https://doi.org/10.1038/nature25174 . ISSN: 0028-0836
Mariotti, M.; Shetty, S.; Baird, L.; Wu, S.; Loughran, G.; Copeland, P.R.; Atkins, J.F.; Howard, M.T. (2017). Multiple RNA structures affect translation initiation and UGA redefinition efficiency during synthesis of selenoprotein P. Nucleic Acids Research, 45(22), pp. 13004 - 13015 . https://doi.org/10.1093/nar/gkx982 . ISSN: 0305-1048
Mariotti, M.; Lobanov, A.V.; Manta, B.; Santesmasses, D.; Bofill, A.; Guigó, R.; Gabaldón, T.; Gladyshev, V.N. (2016). Lokiarchaeota marks the transition between the archaeal and eukaryotic selenocysteine encoding systems. Molecular Biology and Evolution, 33(9), pp. 2441 - 2453 . https://doi.org/10.1093/molbev/msw122 . ISSN: 0737-4038
Heaphy, S.M.; Mariotti, M.; Gladyshev, V.N.; Atkins, J.F.; Baranov, P.V. (2016). Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum. Molecular Biology and Evolution, 33(11), pp. 2885 - 2889 . https://doi.org/10.1093/molbev/msw166 . ISSN: 0737-4038
Mariotti, M.; Santesmasses, D.; Capella-Gutierrez, S.; Mateo, A.; Arnan, C.; Johnson, R.; D'Aniello, S.; Hee-Yim, S.; Gladyshev, V.N.; Serras, F.; Corominas, M.; Gabaldón, T.; Guigó, R (2015). Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization. Genome Research, 25(9), pp. 1256 - 1267 . Institutional Repository . ISSN: 1088-9051
Mariotti, M.; Lobanov, A.V.; Guigo, R.; Gladyshev, V.N. (2013). SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins. Nucleic Acids Research, 41(15), p. e149 . https://doi.org/10.1093/nar/gkt550 . ISSN: 0305-1048

Others Publications

Mariotti, M. (2016). Selenocysteine extinctions in insects . In Short Views on Insect Genomics and Proteomics . (pp. 113 - 140) . Springer International Publishing . ISBN: ISBN 978-3-319-24 . https://www.springer.com/gp/book/9783319242422
Mariotti, M.; Santesmasses, D.; Guigó, R. (2016). Evolution of Selenophosphate Synthetase . In Selenium. Its Molecular Biology and Role in Human Health . (pp. 85 - 99) . Springer International Publishing . ISBN: 978-3-319-41283-2 . https://www.springer.com/gp/book/9783319412818
Santesmasses, D.; Mariotti, M.; Guigó, R. (2018). Selenoprofiles: A Computational Pipeline for Annotation of Selenoproteins . In Selenoproteins. Methods in Molecular Biology. . Volume. 1661 . (pp. 17 - 28) . Springer Humana Press . ISBN: 978-1-4939-7257-9 . https://link.springer.com/protocol/10.1007/978-1-4939-7258-6_2

More Information: https://www.mariottigenomicslab.com/