Modesto Orozco Lopez

Full professor

Knowledge area: Bioquímica i Biologia Molecular

Group leader at the Institute for Research in Biomedicine (IRB)

Joint Program Director IRB-BSC

Coordinator of Integrative Research Nodes IRB

Research group: IP MODELITZACIÓ MOLECULAR I BIOINFORMÀTICA

Contact Information
Department of Biochemistry and Molecular Biomedicine
IRBB-PCB C/Baldiri Reixac, 10
934037156
modesto.orozco(a)irbbarcelona.org

Teaching

Estructura de Macromolècules (Grau Bioquimica)

Macromolècules Biològiques (Grau Biotecnología)

Academic Training

Ciencias Químicas . Universitat Autònoma Barcelona . 1985 . (Diploma / Degree / Activities)

Grado Licenciatura . Universitat Autònoma Barcelona . 1986 . (Diploma / Degree / Activities)

Ciencias Químicas . Universitat Autònoma Barcelona . 1990 . (Ph.D.)

Research interests

Anàlisi de l´efecte del solvent en el reconeixement molecular

Estudis teòrics de petits sistemes de models de gran impacte biològic

Estudis de dinàmica molecular i mecànica estadística per examinar formes anòmales d´àcids nucleics

Projects

Multiscale simulation of DNA . 2011 - 2015 . Ref.DIMSIM . European Research Council . PI: Modesto Orozco Lopez

MuG. 'Virtual Research Enviroment for Multidimensional Genomics' . 2015 . European Commission . PI: Modesto Orozco Lopez

BioExcel-2. Centre of Excellence for Computational Biomolecular Research . 2019 - 2021 . European Commission . PI: Modesto Orozco

Simulación de ácidos nucleicos complejos . 2019 - 2021 . Ministerio de Ciencia e Innovación (MICINN) . PI: Modesto Orozco

'SARS-CoV-2 Inhibition, Host Selection and Next-Move Prediction Through High-Performance Computing' . 2020 - 2021 . Instituto de Salud Carlos III . PI: Modesto Orozco

Journal Publications

Dans, P.; Gallego, D.; Balaceanu, A.; Darré, L.; Gómez, H.; Orozco, M. (2019). Modeling, Simulations, and Bioinformatics at the Service of RNA Structure. Chem . https://doi.org/10.1016/j.chempr.2018.09.015 . ISSN: 2451-9294

Terrazas, M.; Sánchez, D.; Battistini, F.; Villegas, M.; Brun-Heath, I.; Orozco, M. (2019). A multifunctional toolkit for target-directed cancer therapy. Chemical Communications, 55, pp. 802 - 805 . https://doi.org/10.1039/c8cc08823c . ISSN: 1359-7345

Aranda, J.; Terrazas, M.; Gómez, G.; Villegas, N.; Orozco, M. (2019). An artificial DNAzyme RNA ligase shows a reaction mechanism resembling that of cellular polymerases. Nature Catalysis, 2, pp. 544 - 552 . ISSN: 2520-1158

Buitrago, D.; Codó, L.; Illa, R.; De Jorge, P.; Battistini, F.; Flores, O.; Bayarri, G.; Royo, R.; Del Pino, M.; Heath, S.; Hospital, A.; Gelpí, J.L.; BrunHeath, I.; Orozco, M. (2019). Nucleosome Dynamics: A new tool for the dynamic analysis of nucleosome positioning. Nucleic Acids Research, 47, pp. 9511 - 9523 . Institutional Repository . ISSN: 0305-1048

Dans, P.; Balaceanu, A.; Pasi, M.; Patelli, A.; Petkeviciute, D.; Walther, J.; Hospital, A.; Bayarri, G.; Lavery, R.; Maddocks, J.; Orozco, M. (2019). The static and dynamic structural heterogeneities of B-DNA: extending Calladine-Dickerson rules. Nucleic Acids Research, 47(21), pp. 11090 - 11102 . Institutional Repository . ISSN: 0305-1048

Escobedo, A.; Topal, B.; Kunze, M.B.; Arandam, J.; Chiesa, G.; Mugirani, D.; Bernardo-Seisdedos, G.; Eftekharzadeh, B.; Gairi, M.; Oierattelli, R.; Felli, I.C.; Diercks, T.; Millet, O.; García, J.; Orozco, M.; Creuhet, R.; Lindorff-Larsen, K. and Salvatella, X. (2019). Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor. Nature Communications, 10, p. 2034 . ISSN: 2041-1723

Zivanovic, S.; Bayarri, G.; Colizzi, F.; Moreno, D.; Gelpí, J.L.; Soliva, R.; Hospital, A. and Orozco, M. (2020). Bioactive conformational ensemble server and database. A public framework to speed up in silico drug discovery. Journal of Chemical Theory and Computation, 16(10), pp. 6586 - 6597 . Institutional Repository . ISSN: 1549-9618

Wiezcór, M.; Hospital, A.; Bayarri, G.; Czub, J. and Orozco, M. (2020). Molywood: streamlining the design and rendering of molecular movies. Bioinformatics, 36(17), pp. 4660 - 4661 . ISSN: 1367-4803

Buitrago, D.; Labrador, M.; Arcon, J.P.; Lema, R.; Flores, O.; Esteve-Codina, A.; Blanc, J.; Villegas, N.; Bellido, D.; Gut.N.; Dans, P.D.; Heath, s.C.; Gut. I.; Brun-Heath. I.; Orozco. M. (2021). Impact of DNA methylation on 3D genome structure. Nature Communications . ISSN: 2041-1723

Colizzi, F.; Orozco, M. (2021). Probing allosteric regulations with coevolution-dirven molecular simulations. Science Advances . ISSN: 2375-2548

Others Publications

Sfriso, P.; Orozco, M. (2017). Methods to trace conformational transitions . In Simulating Enzyme Reactivity: Computational Methods in Enzyme Catalysis. . Volume. 7 . (pp. 215 - 244) . I. Tuñon and V. Moliner (eds.) RSC Ed- . ISBN: 978-1-78262-429-5 .

Goñi, R.; Orozco, M. (2018). The yottaflop frontier of atomístic molecular Dynamics simulations . In Theoretical and Quantum Chemistry at the Dawn of the 21st Century. . CRC Press, Taylor and Francis Group .

Gómez, H.; Walther, J.; Darré, L.; Ivani, I.; Dans. P. and Orozco, M. (2017). Molecular Modelling of Nucleic Acids . In Computational Tools for Chemical Biology. . (pp. 165 - 197) . Royal Society of Chemistry .

Relevant Activities

Referee for grant agencies in fifteen countries and the European Union (more than 10 years in ERC panels)

Advisor of the Spanish Ministry of Science

Associated Editor WIRES Computational Molecular Sciences