Laia Guardia Escoté

Professora lectora

Scopus Author ID: 57201457496

Researcher ID: K-8960-2017

Àrea de coneixement : Toxicologia

Grup de Recerca en Toxicologia

Informació de contacte
Departament de Farmacologia, Toxicologia i Química Terapèutica
Av. Joan XXIII, 27-31

laia.guardia(a)ub.edu

Perfil acadèmic

Toxicologia

Formació acadèmica

Grau Ciències Biomèdiques

Máster Universitario en Salud Mental

Doctorat en Salut, Psicologia i Psiquiatria

Publicacions rellevants

Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo JL; Colomina MT. Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner. En Food and Chemical Toxicology. Volum 122. 2018 . https://doi.org/10.1016/j.fct.2018.09.069

Basaure P; Guardia-Escote L; Biosca-Brull J; Blanco J; Cabré M; Peris-Sampedro F; Sánchez-Santed F; Domingo JL; Colomina MT. Exposure to chlorpyrifos at different ages triggers APOE genotype-specific responses in social behavior, body weight and hypothalamic gene expression. En Environmental Research. Volum 178:108684. 2019 . https://doi.org/10.1016/j.envres.2019.108684

Guardia-Escote L; Basaure P; Peris-Sampedro F; Biosca-Brull J; Cabré M; Sánchez-Santed F; Domingo JL; Colomina MT. APOE genetic background and sex confer different vulnerabilities to postnatal chlorpyrifos exposure and modulate the response to cholinergic drugs. En Behavioural Brain Research. Volum 376:112195. 2019 . https://doi.org/10.1016/j.bbr.2019.112195

Guardia-Escote L; Basaure P; Biosca-Brull J; Cabré M; Blanco J; Pérez-Fernández C; Sánchez-Santed F; Domingo JL; Colomina MT. APOE genotype and postnatal chlorpyrifos exposure modulate gut microbiota and cerebral short-chain fatty acids in preweaning mice. En Food and Chemical Toxicology. Volum 135:110872. 2020 . https://doi.org/10.1016/j.fct.2019.110872

Pérez-Fernández C; Morales M; Guardia-Escote L; Garrido JA; Colomina MT; Giménez E; Sánchez-Santed F. Long-term effects of low doses of Chlorpyrifos Organophosphate exposure at preweaning stages: a locomotor, pharmacological, brain gene expression and gut microbiome analysis. En Food and Chemical Toxicology. Volum 135:110865. 2020 . https://doi.org/10.1016/j.fct.2019.110865

Blanco J; Guardia-Escote L; Mulero M; Basaure P; Biosca-Brull J; Cabré M; Colomina MT; Domingo JL; Sánchez DJ. Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes. En Food and Chemical Toxicology. Volum 137:111171. 2020 . https://doi.org/10.1016/j.fct.2020.111171

Guardia-Escote L; Blanco J; Basaure P; Biosca-Brull J; Verkaik-Schakel RN; Cabré M; Peris-Sampedro F; Pérez-Fernández C; Sánchez-Santed F; Plösch T; Domingo JL; Colomina MT. Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a Transgenic APOE Mouse Model: Long-Term Implications on Body Weight after a High-Fat Diet. En International Journal of Environmental Research and Public Health. Volum 18. Número 1. 2020 . https://doi.org/10.3390/ijerph18010184

Pla L, Kühne BA, Guardia-Escote L, Vázquez-Aristizabal P, Loreiro C, Flick B, Gratacós E, Barenys M, Illa M. Protocols for the evaluation of neurodevelopmental alterations in rabbit models in vitro and in vivo. En Frontiers in Toxicology. 2022 . https://doi.org/10.3389/ftox.2022.918520

Biosca-Brull J; Guardia-Escote L; Blanco J; Basaure P; Cabré M; Sánchez-Santed F; Domingo J; Colomina MT. Prenatal, but not postnatal exposure to chlorpyrifos affects social behavior of mice and the excitatory-inhibitory balance in a sex-dependent manner. En Food and Chemical Toxicology. Volum 169:113423. 2022 . https://doi.org/10.1016/j.fct.2022.113423

Biosca-Brull J; Guardia-Escote L; Basaure P; Cabré M; Blanco J; Pérez-Fernández C; Sánchez-Santed F; Domingo JL; Colomina MT. Exposure to chlorpyrifos during pregnancy differentially affects social behavior and GABA signaling elements in an APOE- and sex-dependent manner in a transgenic mouse model. En Environmental Research. Volum 115461. 2023 . https://doi.org/10.1016/j.envres.2023.115461