Grup d’Innovació Docent de Bioquímica i Biologia Molecular
Contact Information
Department of Biochemistry and Physiology
Facultat de Farmacia, Av. Diagonal 643 934034455 vnoe(a)ub.edu
Academic profile
Profesora de Bioquímica, Biología Molecular y Genómica e Ingeniería Genética
Academic training
Licenciada en Farmacia
Doctora en Farmacia
Research interests
Reparación GénicaSilenciamiento génico mediante la tecnología de las pinzas de polipurinas (PPRHs)Edición genómica mediante PPRHs
Projects
Regulation of genes differentially expressed in cells resistant to methotrexate: Control by miRNAs, and Gene Therapy using polypurine hairpins
.
2009 - 2011
. Ref.SAF08-043
. Ministerio de Ciencia e Innovación (MICINN)
. PI: Carlos Julian Ciudad GomezAplicaciones Biomédicas de Pinzas de Polipurinas de tipo Hoogsteen Reverso: Silenciamiento Génico en Cáncer y Reparación
.
2012 - 2014
. Ref.SAF2011-23582
. Ministerio de Ciencia e Innovación (MICINN)
. PI: Verónica Noé MataPPRHs: Diseño avanzado, vehiculización, ómica y aplicaciones terapéuticas en linfomas, inmunoterapia y reparación génica
.
2015 - 2017
. Ref.SAF2014-51825-R
. Ministerio de Economia y Competitividad
. PI: Veronica Noe Mata; Carlos Julian Ciudad GomezTerápia génica mediada por PPRHs: Vehiculización, Silenciamiento, Reparación y aproximaciones in vivo
.
2019 - 2021
. Ref.RTI2018-093901-B-I00
. Ministerio de Ciencia, Innovación y Universidades
. PI: Veronica Noe Mata; Carlos Julian Ciudad Gomez
Relevant publications
Villalobos, X.; Rodriguez, L.; Prevot, J.; Oleaga, C.; Ciudad, C.; Noe, V. Stability and immunogenicity properties of the gene-silencing Polypurine Reverse Hoogsteen Hairpins.
In
Molecular Pharmaceutics.
Volume 11.
2014
. https://doi.org/10.1021/mp400431fSole, A.; Villalobos, X.; Ciudad, C.J.; Noe, V. Repair of single point mutations by Polypurine Reverse Hoogsteen Hairpins.
In
Human Gene Therapy Methods.
2014
. http://www.ncbi.nlm.nih.gov/pubmed/25222154Villalobos, X.; Rodríguez, L.; Solé, A.; Lliberós, C.; Mencia, N.; Ciudad, C.J.; Noé, V. Effect of Polypurine Reverse Hoogsteen Hairpins on relevant cancer target genes in different human cell lines.
In
Nucleic Acid Therapeutics.
2015Félix, A.J.; Ciudad, C.J.; Noé, V. Functional pharmacogenomics and toxicity of PolyPurine Reverse Hoogsteen hairpins directed against survivin in human cells.
In
Biochemical Pharmacology.
Volume 155.
2018
. https://doi.org/10.1016/j.bcp.2018.06.020Medina Enríquez, MM.; J. Félix, A.; Ciudad, CJ.; Noé, V. Cancer immunotherapy using PolyPurine Reverse Hoogsteen hairpins targeting the PD-1/PD-L1 pathway in human tumor cells.
In
PLoS One.
Volume 2018.
Number 13.
2018
. Institutional RepositoryCiudad, C.J.; Medina Enriquez, M.M.; Felix A.J.; Bener, G.; Noé, V. Silencing PD-1 and PD-L1: the potential of PolyPurine Reverse Hoogsteen hairpins for the elimination of tumor cells.
In
Immunotherapy.
2019Solé A; Delagoutte E; Ciudad CJ; Noé V; Alberti P. Polypurine reverse-Hoogsteen (PPRH) oligonucleotides can form triplexes with their target sequences even under conditions where they fold into G-quadruplexes.
In
Scientific Reports.
Volume 7 .
Number 39898.
2017
. Institutional RepositoryCiudad CJ; Rodríguez L; Villalobos X; Félix AJ; Noé V. Polypurine Reverse Hoogsteen Hairpins as a Gene Silencing Tool for Cancer.
In
Current Medicinal Chemistry.
Volume 24.
Number 26.
2017
. https://doi.org/10.2174/0929867324666170301114127Aviño, A.; Eritja, R.; Ciudad, C.J.; Noe, V. Parallel Clamps and Polypurine Hairpins (PPRH) for Gene Silencing and Triplex-Affinity Capture: Design, synthesis and use.
In
Current protocols in nucleic acid chemistry.
Volume 77.
Number 1.
2019
. Institutional Repository