Jordi Juarez Jimenez

Lecturer Professor

Researcher ID: ABG-7372-2020

Knowledge area: Química Física

Research group: Biologia Computacional i Disseny de Fàrmacs

Contact Information
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry
Departament Fisicoquímica, Facultat de Farmàcia de la Universitat de Barcelona, Av. Joan XXIII s/n
934035986
jordi.juarez(a)ub.edu

Academic training

Llicenciat en Fàrmacia

Doctorado en Biomedicina

Master en Biomedicina

Projects

Biologia Computacional i Disseny de Fàrmacs . 2017 - 2021 . Ref.2017SGR1746 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Francisco Javier Luque Garriga

Bases Moleculares de Cooperatividad Química en complejos ternarios de interés terápeutico . 2021 - 2024 . Ref.PID2020-115683GA-I00 . Ministerio de Ciencia, Innovación y Universidades . PI: Jordi Juarez Jimenez

Identification of allosteric effectors causing depletion of pathology-related proteins . 2021 - 2021 . Ref.311260 . GT Gain Therapeutics SA . PI: Xavier Barril Alonso; Jordi Juarez Jimenez

Relevant publications

Kuzmanic, A.; Bowman, G.R.; Juárez-Jiménez, J.; Michel, J.; Gervasio, F.L. Investigating Cryptic Binding Sites by Molecular Dynamics Simulations. In Accounts of Chemical Research. Volume 53. Number 3. 2020 . https://doi.org/10.1021/acs.accounts.9b00613

Juárez-Jiménez, J.; Gupta, A.A; Karunanithy, G.; Mey, A.S.J.S.; Georgiou, C.; Ioannidis, H.; De Simone, A.; Barlow, P. N.; Hulme, A. N.; Walkinshaw, M.D.; Baldwin, A.J.; Michel, J. Dynamic design: manipulation of millisecond timescale motions on the energy landscape of cyclophilin A. In Chemical Science. Volume 11. 2020 . Institutional Repository

Llabrés, S.; Juárez-Jiménez, J.; Masetti, M.; Leiva, R.; Vázquez, S.; Gazzarrini, S.; Moroni, A.; Cavalli, A.; Luque, F. J. Mechanism of the pseudo-irreversible binding of amantadine to the M2 proton channel. In Journal of the American Chemical Society. Volume 138. 2016 . https://doi.org/10.1021/jacs.6b07096

Juárez-Jiménez, J.; Barril, X.; Orozco, M.; Pouplana, R.; Luque, F. J. Assessing the Suitability of the Multilevel Strategy for the Conformational Analysis of Small Ligands. In Journal of Physical Chemistry B. Volume 119. Number 3. 2015 . https://doi.org/10.1021/jp506779y

Juárez-Jiménez, J.; Gupta, A.A; Karunanithy, G.; Mey, A.S.J.S.; Georgiou, C.; Ioannidis, H.; De Simone, A.; Barlow, P. N.; Hulme, A. N.; Walkinshaw, M.D.; Baldwin, A.J.; Michel, J. A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors. In Chemical Science. Volume 10. 2018 . Institutional Repository

Codony, S.; Pont, C.; Griñán-Ferré, C.; Di Pede-Mattatelli, A.; Calvó-Tusell, C.; Feixas, F.; Osuna, S.; Jarné-Ferrer, J.; Naldi, M.; Bartolini, M.; Loza, M. I.; Brea, J.; Pérez, B.; Bartra, C.; Sanfeliu, C.; Juárez-Jiménez, J.; Morisseau, C.; Hammock, B. D.; Pallàs, M.; Vázquez, S.; Muñoz-Torrero, D. Discovery and in vivo proof of concept of a highly potent dual inhibitor of soluble epoxide hydrolase and acetylcholinesterase for the treatment of Alzheimer's disease. In Journal of Medicinal Chemistry. Volume 65. Number 6. 2022 . Institutional Repository

Juárez-Jiménez, J.; Tew, P.; O′Connor, M.; Llabrés, S.; Sage, R.; Glowacki, D.; Michel, J. Combining Virtual Reality Visualization with Ensemble Molecular Dynamics to Study Complex Protein Conformational Changes. In Journal of Chemical Information and Modeling. Volume 60. Number 12. 2020 . https://doi.org/10.1021/acs.jcim.0c00221

Scott, J I; Mendive-Tapia, L; Gordon, D; Barth, N D; Thompson, E J; Cheng, Z; Taggart, D; Kitamura, T; Bravo-Blas, A; Roberts, E W; Juarez-Jimenez, J; Michel, J; Piet, B; de Vries, I J; Verdoes, M; Dawson, J; Carragher, N O; O' Connor, R A; Akram, A R; Frame, M; Serrels, A; Vendrell, M. A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies. In Nature Communications. Volume 13. Number 2366. 2022 . https://doi.org/10.1038/s41467-022-29691-w

More Information: Computational Molecular Design Lab website (http://www.ub.edu/cmd_lab)