Andreea Larisa Turcu

Andreea Larisa Turcu

Lecturer Professor

Knowledge area: Química Orgànica

Contact Information
Department of Pharmacology, Toxicology and Medicinal Chemistry
Faculty of Pharmacy and Food Sciences University of Barcelona Av. de Joan XXIII, 27-31
+34 934024533
aturcu(a)ub.edu

Academic training

Farmacia
Química Orgànica

Research interests

Advancing drug discovery through purinergic receptor modulation
Novel strategies in antiviral drug development

Projects

Síntesis de compuestos con mecanismos innovadores contra enfermedades neurodegenerativas y dolor neuropático . 2021 - 2024 . Ref.PID2020-118127RB-I00 . Ministerio de Ciencia e Innovación (MICINN) . PI: Diego Muñoz-Torrero López-Ibarra; Santiago Vazquez Cruz
Descobriment de fàrmacs innovadors contra infeccions víriques respiratòries (MARATO TV3 201832-30) . 2019 - 2022 . Ref.201832-30 . Fundació La Marató de TV3 . PI: Santiago Vazquez Cruz
Treballs d’optimització de processos de síntesiorgànica d’intermediaris i/o principis actiusfarmacèutics . 2023 - 2024 . Ref.312494 . Biopharma Synergies, S.L. . PI: Santiago Vázquez
Optimització de processos de síntesi orgànica d'intermediaris i/o principis actius farmacèutics . 2023 - 2024 . Ref.312494 . Biopharma Synergies, S.L. . PI: Santiago Vazquez Cruz; Maria Carmen Escolano Miron
Technology Evaluation and Option Agreement . 2021 - 2022 . Ref.311268 . Neuraly, Inc. . PI: Santiago Vazquez Cruz; Rosana Leiva Martinez; Carlos Galdeano Cantador; Andreea Larisa Turcu; Elena Valverde Murillo; Sandra Codony Gisbert
Química mèdica i farmacologia de malalties neurodegeneratives/ Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases . 2017 - 2021 . Ref.2017SGR106 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Diego Muñoz-Torrero López-Ibarra

Relevant publications

Alonso, Jose M.; Quiroga, Sabela; Codony, Sandra; Turcu, Andreea L.; Barniol-Xicota, Marta; Perez, Dolores; Guitian, Enrique; Vazquez, Santiago; Pena, Diego. Palladium-catalyzed cocyclotrimerization of arynes with a pyramidalized alkene. In Chemical Communications. Volume 54. Number 47. 2018 . https://doi.org/10.1039/c8cc03188f
Leiva R, Phillips MB, Turcu AL, Gratacòs-Batlle E, León-García L, Sureda FX, Soto D, Johnson JW, Vázquez S. Pharmacological and Electrophysiological Characterization of Novel NMDA Receptor Antagonists. In ACS Chemical Neuroscience. Volume 9. 2018
Pérez-Areales, F. J.; Turcu, A. L.; Barniol-Xicota, M.; Pont, C.; Pivetta, D.; Espargaró, A.; Bartolini, M.; De Simone, A.; Andrisano, V.; Pérez, B.; Sabate, R.; Sureda, F. X.; Vázquez, S.; Muñoz-Torrero, D. A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors. In European Journal of Medicinal Chemistry. 2019 . Institutional Repository
Turcu, A. L.; Companys-Alemany, J.; Phillips, M. B.; Patel, D. S.; Griñán-Ferré, C.; Loza, M. I.; Brea, J. M.; Pérez, B.; Soto, D.; Sureda, F. X.; Kurnikova, M. G.; Johnson, J. W.; Pallàs, M.; Vázquez, S. Design, synthesis, and in vitro and in vivo characterization of new memantine analogs for Alzheimer's disease. In European Journal of Medicinal Chemistry. Volume 236. 2022 . Institutional Repository
Wilcox, M. R.; Nigam, A.; Glasgow, N. G.; Narangoda, C.; Phillips, M. B.; Patel, D. S.; Mesbahi-Vasey, S.; Turcu, A. L.; Vázquez, S.; Kurnikova, M. G.; Johnson, J. W. Inhibition of NMDA receptors through a membrane-to-channel path. In Nature Communications. Volume 13. 2022 . Institutional Repository
Turcu, A. L; Versini, A.; Khene, N; Gaillet, C.; Cañeque, T.; Müller, S.; Rodriguez, R. DMT1 inhibitors kill cancer stem cells by blocking lysosomal iron translocation. In Chemistry-A European Journal. Volume 26. Number 33. 2020
Peyman, M.; Barroso, E.; Turcu, A. L.; Estrany, F. Jr.; Smith, D.; Jurado-Aguilar, J.; Rada, P.; Morisseau, C.; Hammock, B. D.; Valverde, A. M.; Palomer, X.; Galdeano, C.; Vázquez, S.; Vázquez-Carrera, M. Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress. In Biomedicine & Pharmacotherapy. Volume 168. 2023 . https://doi.org/10.1016/j.biopha.2023.115667

Patents, Software and Database

Polycyclic compounds as soluble epoxide hydrolase inhibitors (European Patent Convention Countries, 20/06/2018)
Polycyclic compounds as soluble epoxide hydrolase inhibitors (Patent Cooperation Treaty Countries, 19/06/2019)
Polycyclic compounds as soluble epoxide hydrolase inhibitors (European Patent Convention Countries, 04/12/2020)
Polycyclic compounds as soluble epoxide hydrolase inhibitors (UNITED STATES, 16/12/2020)
Polycyclic compounds as soluble epoxide hydrolase inhibitors (CHINA, 19/01/2021)

More Information: https://orcid.org/0000-0001-9732-2249