Eva Estébanez-Perpiñá

Associate professor

Knowledge area: Bioquímica i Biologia Molecular

Principal Investigator

Associate Professor

Coordinator and Professor of Design and Evaluation of Bioactive Molecules (Biochemistry)

Research group: IP Bases Moleculars de Processos Fisiopatològics Fonamentals

Contact Information
Department of Biochemistry and Molecular Biomedicine
INSTITUT DE BIOMEDICINA DE LA UNIVERSITAt DE BARCELONA (IBUB-UB) CARRER BALDIRI REIXAC 15-21 PARC CIENTIFIC DE BARCELONA
934031119
evaestebanez(a)ub.edu

Teaching

Design and evaluation of bioactive molecules

Structure of Macromolecules

Tutor of Practicum I, Practicum II and TFG

Tutor of PhD students

Academic Training

LLicenciada Bioquimica . Universitat Autonoma de Barcelona . 01/09/1998 . (Diploma / Degree / Activities)

Doctora en Bioquimica . UAB + Max Planck Institut . 15/05/2002 . (Ph.D.)

Llicenciada Psicologia . Universitat Autonoma de Barcelona . 30/06/1995 . (Diploma / Degree / Activities)

Research interests

STRUCTURAL BIOLOGY OF HUMAN LIGAND-DEPENDENT NUCLEAR RECEPTORS

THE MOLECULAR SOCIOLOGY OF HUMAN ANDROGEN RECEPTOR

MOLECULAR DETERMINANTS UNDERLYING ANDROGEN RECEPTOR AGGREGATION IN MOTONEURONS AND NEURODEGENERATION IN SPINAL-BULBAR MUSCULAR ATROPHY (KENNEDY´S DISEASE)

INTERACTION SURFACES OF THE ANDROGEN RECEPTOR AS OFF-SITES THERAPEUTIC TARGETS FOR ALLOSTERIC MODULATORS

Projects

Oncología Estructural del Receptor de Andrógenos: Arquitectura Multi-dominio y Diseño Racional de Inhibidores de la Dimerización para el Cáncer de Próstata . 2018 - 2020 . Ref.BFU2017-86906-R . Ministerio de Economia y Competitividad . PI: Eva Estebanez Perpiña

Red temática de Mecanismos Moleculares del Cáncer Urológico (URONCOMOL) . 2020 - 2023 . Ref.RED2018-102769-T . Ministerio de Economia y Competitividad . PI: Annabel Valledor Fernandez

Small-molecule inhibitors of AR-LBD dimerization interface to treat castration-resistant prostate cancer . 2016 - 2017 . Ref.2016-08-1833 . Bayer Healthcare . PI: Eva Estebanez Perpiña

First-in-class Dimerization Inhibitors of the Androgen Receptor as Novel Therapeutics against Prostate Cancer . 2018 - 2020 . Ref.CI18-00018 . Fundació Caixa de Pensions 'La Caixa' . PI: Eva Estebanez Perpiña

Journal Publications

Estébanez-Perpiñá, E.; Hink-Schauer, C.; Bode, W. ;Jenne, D. (2003). Crystal Structure of the Apoptosis-inducing Granzyme A Dimer. Nature Structural Biology(10), pp. 535 - 540 . ISSN: 1072-8368

Nadal, M.; Prekovic, S.; Gallastegui, N.; Helsen, C.; Abella, M.; Zielinska, K.; Gay, M.; Vilaseca, M.; Taulès, M.; Houtsmuller, A.B.; van Royen, M.E.; Claessens, F.; Fuentes-Prior, P.; Estébanez-Perpiñá E. (2017). Structure of the Homodimeric androgen receptor ligand-binding domain. Nature Communications, 8, pp. 14388 - 14398 . Institutional Repository . ISSN: 2041-1723

de Bosscher, K.; Desmet, S.J.; Clarisse, D.; Estebanez-Perpiña, E.; Brunsveld, L. (2020). Nuclear Receptor cross-talk: defining the mechanisms for therapeutic innovation. Nature Reviews Endocrinology, s41574 . https://doi.org/10.1038/s41574-020-0349-5 . ISSN: 1759-5029

Estébanez-Perpiñá, E.; Moore; J., Mar, E.; Delgado-Rodrigues, E.; Nguyen, P.; Webb, P.; Baxter, J.; Buehrer, B.; Fletterick R.J.; and K. R. Guy. (2005). The molecular mechanisms of coactivator utilization in ligand dependent transactivation by the androgen receptor. Journal of Biological Chemistry(280), pp. 8060 - 8068 . ISSN: 0021-9258

Estébanez-Perpiñá, E.; Hink-Schauer, C.; Wilharm, E.; Fuentes-Prior, P.; Klinkert, W.; Bode, W.; and Jenne, D. (2002). The 2.2-Å Crystal Structure of Human Pro-granzyme K Reveals a Rigid Zymogen with Unusual Features. Journal of Biological Chemistry(277), pp. 50923 - 50933 . ISSN: 0021-9258

Jiménez-Panizo, A.; Pérez, P.; Rojas, A.; Fuentes-Prior, P.; Estebanez-Perpiña, E. (2019). Non-canonical Dimerization of the androgen receptor and other nuclear receptors: Implications for human disease. Endocrine-Related Cancer, 26, pp. R1 - R20 . ISSN: 1351-0088

Mackinnon, J.A.; Gallastegui, N.; Osguthorpe, D.J.; Hagler, A.T.; Estébanez-Perpiñá E. (2014). Allosteric mechanisms of nuclear receptors: insights from computational simulations. Molecular and Cellular Endocrinology, 14, pp. S0303 - 7207 . https://doi.org/10.1016/j.mce.2014.05.017 . ISSN: 0303-7207

Gallastegui, N.; Fletterick, R.J.; Estébanez-Perpiñá, E. (2015). Advances in our structural understanding of orphan nuclear receptors. Trends in Biochemical Sciences, 40(1), pp. 25 - 35 . https://doi.org/10.1016/j.tibs.2014.11.002 . ISSN: 0968-0004

More Information: Structural Biology of Nuclear Receptors (http://www.ub.edu/ibub/research-group/structural-biology-of-human-nuclear-receptors/)