CARMEN ESCOLANO MIRON

University Full professor

Scopus Author ID: 6603704436

Researcher ID: F-3073-2016

Knowledge area: Química Orgànica

Research group: IP Medicinal Chemistry and Pharmacology of Neurodegenerative diseases

Teaching Innovation Groups: IP Grup d’innovació per a la millora de les competències professionals al Grau de Farmàcia

Contact Information
Department of Pharmacology, Toxicology and Medicinal Chemistry
Lab. Química Farmacèutica. Departament de Farmacologia, Toxicologia i Química Terapèutica. Facultat de Farmàcia i Ciències de l'Alimentació. U.B.
934024540
cescolano(a)ub.edu

Academic training

Licenciado en Farmacia

Doctor en Farmacia

Research interests

Síntesis de compuestos heterocíclicos con interés en el tratamiento de la enfermedad de Alzheimer

Síntesis enantioselectiva de alcaloides y compuestos nitrogenados bioactivos a partir de lactamas derivadas del fenilglicinol

Cooperative catalysis for reaction of isocyanoacetates to a,b-unsaturated ketones

Synthesis of bicyclic a-aminophosphonates by [3+2]cycloaddition reactions

Synthesis of 2-imidazolines assisted by microwaves

Projects

Síntesi d'amides inverses d'anàlegs del AVX-012 . 2015 - 2015 . Ref.308347 - FBG3655 . Avizorex Pharma, S.L. . PI: Carmen Escolano Mirón

Subvenció per a estada en centres estrangers, inclòs programa 'Salvador de Madariaga'. Estada a: The Institute of Cancer Research(Regne Unit). . 2016 - 2016 . Ref.PRX15-00377 . Ministerio de Educación, Cultura y Deporte . PI: Maria Carmen Escolano Miron

CI18-00002- Novel compounds for the treatment of neurodegenerative disorders . 2018 - 2020 . Ref.CI18-00002 . La Caixa . PI: Maria Carmen Escolano Miron

Estudio de una nueva diana farmacológica para la enfermedad de Alzheimer: modulación del estrés oxidativo y la función mitocondrial . 2016 - 2019 . Ref.SAF2016-77703-C2-1-R . Ministerio de Economia y Competitividad . PI: Merce Pallas Lliberia

Química mèdica i farmacologia de malalties neurodegeneratives/ Medicinal Chemistry and Pharmacology of Neurodegenerative Diseases . 2017 - 2021 . Ref.2017SGR106 . Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) . PI: Diego Muñoz-Torrero López-Ibarra

Relevant publications

Escolano, C. Stephacidin B, tha avrainvillamide dimmer: A Formidable synthetic challenge. In Angewandte Chemie-International Edition. Volume 44. 2005

Soteras, I.; Lozano, O; Gómez-Esqué, A.; Escolano, C.; Orozco, M.; Amat, M.; Bosch, J.; Luque, F. J. On the origin of stereoselectivity in the alkylation of oxazolopiperidone enolates. In Journal of the American Chemical Society. Volume 128. Number 20. 2006

Amat, M.; Semak, V.; Escolano, C.; Molins, E.; Bosch, J. Enantioselective, protecting group-free synthesis of 1S-ethyl-4-substituted quinolizidines. In Organic & Biomolecular Chemistry. Volume 10. 2012 . Institutional Repository

Aso, E.; Semakova, J.; Joda, L.; Semak, V.; Halbaut, L.; Calpena, A.; Escolano, C.; Perales, J.C.; Ferrer I. Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in app/ps1 mice used as a model of familial Alzheimer's disease. In Current Alzheimer Research. Volume 10. Number 3. 2013 . https://doi.org/10.2174/15672050112099990128

Arróniz, C.; Molina, J.; Abás, S.; Molins, E.; Campanera, J.M.; Luque, F.J; Escolano, C. First diastereoselective [3+2] cycloaddition reaction of diethyl isocyanomethylphosphonate and maleimides. In Organic & Biomolecular Chemistry. Volume 11. Number 10. 2013 . https://doi.org/10.1039/C3OB26766K

Abas, S.; Estarellas, C.; Luque, F. J.; Escolano, C. Easy access to (2-imidazolin-4-yl)phosphonates by a microwave assisted multicomponent reaction. In Tetrahedron. Volume 71. 2015 . https://doi.org/10.1016/j.tet.2015.03.065

Zarei, M.; Barroso, E.; Leiva, R.; Barniol-Xicota, M.; Pujol, E.; Escolano, C.; Vázquez, S.; Palomer, X.; Pardo, V.; González-Rodríguez, Á.; Valverde, Á.M.; Quesada-López, T.; Villarroya, F.; Wahli, W.; Vázquez-Carrera, M. Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency. In Diabetes. Volume 65. Number 10. 2016 . https://doi.org/10.2337/db16-0155

Abás, S.; Moens, U.; Escolano, C. Facile microwave-assisted synthesis of thioformamides from isocyanides and carbon disulfide. In Tetrahedron Letters. Volume 58. 2017 . https://doi.org/10.1016/j.tetlet.2017.06.001

Griñán-Ferré, C.; Vasilopoulou, F.; Abás, S.; Rodríguez-Arévalo, S.; Bagán, A.; Sureda, F.X.; Pérez, B., Callado, L. F.; García-Sevilla, A.; García-Fuster, M. J.; Escolano, C.; Pallàs, M. Behavioural and cognitive improvement induced by novel imidazoline I2 receptor ligans in female SAMP8 mice. In Neurotherapeutics. 2018 . Institutional Repository

Other activities

Estades de recerca

Department of Chemistry of University College London (Honorary Fellow) 1998

Department of Chemistry of Kingston University-Surrey (Marie Curie Contract) 2000-2001

Institute of Cancer Research Sutton (Salvador de Maradiaga Grant) summer 2016

Contracte Ramon y Cajal 2003-2007

More Information: http://www.ub.edu/ibub/research-group/group-of-medicinal-chemistry-for-unmet-medical-needs/